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The Rise of “Localism” and Civic Identity in Post-handover Hong Kong: Questioning the Chinese Nation-state
While it was traditionally accepted that Hongkongers shared a form of pan-Chinese cultural identification that did not contradict their local distinctiveness, over the last decade Hong Kong has seen the rise of new types of local identity discourses. Most recently, “localists” have been a vocal presence. Hong Kong has – quite unexpectedly – developed a strong claim for self-determination. But how new is “localism” with respect to the more traditional “Hong Kong identity” that appeared in the 1970s? The present study takes a two-dimensional approach to study these discourses, examining not only their framework of identification (local versus pan-Chinese) but also their mode of identification (ethno-cultural versus civic). Using three case studies, the June Fourth vigil, the 2012 anti-National Education protest and the 2014 Umbrella movement, it distinguishes between groups advocating civic identification with the local community (Scholarism, HKFS) and others highlighting ethnic identification (Chin Wan). It argues that while local and national identification were traditionally not incompatible, the civic-based identification with a local democratic community, as advocated by most participants in recent movements, is becoming increasingly incompatible with the ethnic and cultural definition of the Chinese nation that is now being promoted by the Beijing government. 根据一般理解, 香港虽然有自己的地方特点, 但同样认同大中华文化。可是, 近十年, 香港出现了新类型的香港身份认同话语。最近 “本土” 论述经常出现, 甚至 “自决” 需求都浮出水面。那么, 这种论述与 1970 年代的传统 “香港人” 论有多大差别? 本文试图从两重角度探索本土身份认同论, 不仅探讨它的认同框架 (地方/大中华), 又分析它的认同方式 (文化–族裔认同/公民认同)。通过三个个案——六四纪念会、2012 年的反国民教育运动、2014 年的雨伞运动——, 本文区分本土认同的两种类型: 基于政治与公民 (civic) 的身份认同 (例如学民思潮, 学联的论述), 和基于族裔与文化 (ethno-cultural) 的身份认同(如陈云等人论述)。如果在过去地方与国家层次的身份认同不矛盾, 那么最近的冲突来自哪里? 本文提出这样的问题: 除了中港 (框架) 矛盾之外, 存在于本地公民的民主群体与北京当局促成的族裔文化民族群体之间的冲突, 是否更加重要?
Journal Article
Structure, function and regulation of the hsp90 machinery
Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone which is essential in eukaryotes. It is required for the activation and stabilization of a wide variety of client proteins and many of them are involved in important cellular pathways. Since Hsp90 affects numerous physiological processes such as signal transduction, intracellular transport, and protein degradation, it became an interesting target for cancer therapy. Structurally, Hsp90 is a flexible dimeric protein composed of three different domains which adopt structurally distinct conformations. ATP binding triggers directionality in these conformational changes and leads to a more compact state. To achieve its function, Hsp90 works together with a large group of cofactors, termed co-chaperones. Co-chaperones form defined binary or ternary complexes with Hsp90, which facilitate the maturation of client proteins. In addition, posttranslational modifications of Hsp90, such as phosphorylation and acetylation, provide another level of regulation. They influence the conformational cycle, co-chaperone interaction, and inter-domain communications. In this review, we discuss the recent progress made in understanding the Hsp90 machinery.
Journal Article
Empowered participation
Every month in every neighborhood in Chicago, residents, teachers, school principals, and police officers gather to deliberate about how to improve their schools and make their streets safer. Residents of poor neighborhoods participate as much or more as those from wealthy ones. All voices are heard. Since the meetings began more than a dozen years ago, they have led not only to safer streets but also to surprising improvements in the city's schools. Chicago's police department and school system have become democratic urban institutions unlike any others in America.
Empowered Participationis the compelling chronicle of this unprecedented transformation. It is the first comprehensive empirical analysis of the ways in which participatory democracy can be used to effect social change. Using city-wide data and six neighborhood case studies, the book explores how determined Chicago residents, police officers, teachers, and community groups worked to banish crime and transform a failing city school system into a model for educational reform. The author's conclusion: Properly designed and implemented institutions of participatory democratic governance can spark citizen involvement that in turn generates innovative problem-solving and public action. Their participation makes organizations more fair and effective.
Though the book focuses on Chicago's municipal agencies, its lessons are applicable to many American cities. Its findings will prove useful not only in the fields of education and law enforcement, but also to sectors as diverse as environmental regulation, social service provision, and workforce development.
eBook
Mapping the Argentine New Left
In recent years, investigation on 1960s/1970s revolutionary activism in Argentina has led to the publication of multiple case studies. Building on this literature, a more general view of what is often called the “new left” indicates that it is characterized by the importance assigned to three issues: social liberation, national liberation, and revolutionary violence. Two differentiating lines within this political space are an ideological divide (Marxism vs. Peronism) and an instrumental division over the strategic status of violence (insurrection vs. protracted people’s war vs. political-military action).
En los últimos años, las investigaciones sobre el activismo revolucionario de la década de 1960–1970 en Argentina han dado lugar a la publicación de múltiples estudios de caso. En base a este material, se propone una visión más general de la a menudo denominada “nueva izquierda”, y cómo esta se caracteriza a partir de la importancia asignada a tres factores: la liberación social, la liberación nacional y la violencia revolucionaria. Hay dos dimensiones dentro de este espacio político: una división ideológica (marxismo vs. peronismo) y una división instrumental en torno al papel estratégico de la violencia (insurrección vs. guerra popular prolongada vs. acción político-militar).
Journal Article
A left lung with four lobes: a new discovery during the thoracotomy for recurrent primary spontaneous pneumothorax
Background
The right and left lung anatomy are similar but asymmetrical. The right lung consists of three lobes, and the left lung consists of two lobes. Our study is unique because of discovering a very rare morphological feature of the left lung which has not been reported yet. By the way, we compared two different available chemical agents for pleurodesis (talc and bleomycin) according to side effects, complications, and pneumothorax recurrence.
Case presentation
We reported a case of bilateral primary spontaneous pneumothorax, who underwent talc slurry and bleomycin pleurodesis at right and left side retrospectively, and then complicate with left-sided recurrent spontaneous pneumothorax, so underwent open thoracotomy and was surprisingly and accidentally found to have 4 lobes and 3 fissures in left lung.
Conclusion
In our case report, there were one main oblique fissure and two accessory fissures which divided the lung into 4 separated lobes, and this discovery in human’s and other animals’ lung anatomy has not been previously reported. In our case study, the talc slurry was more effective in preventing spontaneous pneumothorax recurrence, but with more side effects than bleomycin. We could hypothesize that the morphological variation of the lung might affect spontaneous pneumothorax development and recurrence.
Journal Article
Ending Social Promotion Without Leaving Children Behind
The New York City Department of Education asked RAND to conduct an independent longitudinal evaluation of its 5th-grade promotion policy. The findings of that study, conducted between March 2006 and August 2009, provide a comprehensive view of the policy's implementation and its impact on student outcomes, particularly for students at risk of retention and those who were retained in grade.
eBook
Jewish Radicals of Morocco: Case Study for a New Historiography
The confluence of Jews and Communism has long been noted by scholars. However, most historiography has treated European contexts, with the addition of some work on the Americas and the Yishuv, but neglected the broader Middle East and North Africa (MENA). Works that do purport to survey and compare the phenomenon across contexts have typically given the MENA short shrift. Further, most discussion of leftist Jewish politics halts after World War II, just when the story is gaining momentum in the MENA, particularly within anticolonial movements. In this article, I draw on Hannah Arendt's work on the so-called conscious pariah to bridge historiographies and link leftist Jews in the MENA, the Americas, and Europe. Using archival sources, newspapers, oral histories, and novels, I present Jewish involvement in the Parti Communist Marocain as a case study to examine the complications of Jewish involvement in leftist politics in concentric geographic, temporal, and historiographic circles. In so doing, I seek to complicate the story of Jewish attraction to internationalism and universalism and the reconciliation of Jewish affiliations and identities with the nation-state and the colonial.
Journal Article
Prognostic Significance of Brain-Derived Neurotrophic Factor Levels in Patients with Heart Failure and Reduced Left Ventricular Ejection Fraction
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family. The aim of the present study was to investigate the relationship between BDNF levels and prognostic markers in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF), considering death or rehospitalization due to HF.
Patients with severe left ventricular systolic dysfunction (LVEF ≤35%) and individuals with no history of cardiac disease (control group) were included in the study conducted between 2013 and 2017. Of the included patients, 52 were classified as mildly symptomatic [New York Heart Association (NYHA) I-II], and 108 were classified as severely symptomatic (NYHA III). The control group comprised 50 individuals. The primary endpoints of the study consisted of cardiovascular death during long-term follow-up and hospitalization for worsening of HF.
The mean age of the patient group was 67.60±11.45 years and 58% were male, whereas that of the control group was 66.28±11.30 years and 48% were male. The N-terminal pro-brain-type natriuretic peptide (NT-pro-BNP) serum levels in patients with HF were higher, whereas the BDNF values were lower than those in the control group (NT-pro-BNP: 5010±851 pg/mL vs. 33±11 pg/mL, p<0.001; BDNF: 8.64±1.12 ng/mL vs. 17.58±4.51 ng/mL, p<0.001). Multivariable analysis suggested that there was a significant association between BDNF levels and clinical status, generating the primary endpoints of death [BDNF levels: Odds ratio (OR)=0.17, 95% confidence interval (CI): 0.05-0.53, p=0.002], and rehospitalization (BDNF levels: OR=0.702, 95% CI: 0.54-0.92, p=0.010).
Decreased serum BDNF levels were associated with death and rehospitalization in patients with HF, suggesting that these levels can be useful prognostic biomarkers.
Journal Article
Carbohydrate antigen 125: an emerging prognostic risk factor in acute heart failure?
Objective: To assess whether circulating levels of carbohydrate antigen 125 (CA125) predict subsequent 6-month all-cause mortality in patients after the index hospitalisation for acute heart failure (HF). Design and setting: Prospective cohort study at a single teaching centre in Spain. Methods: 529 consecutive patients with acute HF admitted in a single university centre were analysed. In addition to the traditional clinical information, CA125 (U/ml) was measured during the early course of hospitalisation. The independent association between baseline CA125 and mortality was assessed with Cox regression analysis. The follow-up was limited to 6 months. Results: 349 (66%) patients showed serum levels of CA125 >35 U/ml (established cut-off point value). At a 6-month follow-up, 89 (16.8%) deaths were identified. A positive trend between mortality and CA125 quartiles was observed; 3.8%, 15.2%, 22% and 26.5% of deaths occurred from quartile 1 to 4 of CA125 (p<0.001). Likewise, a monotonic, ascending trend in the risk ratios was estimated from the multivariable Cox model. Compared with the first quartile of CA125, the HRs (95% CI) for the second, third and fourth quartiles were 3.25 (1.20 to 8.79), 4.91 (1.88 to 12.85) and 8.41 (3.24 to 21.79), respectively. Conclusions: Serum levels of CA125 obtained in patients admitted with a diagnosis of acute HF was shown to be an independent predictor of mortality up to the 6-month follow-up.
Journal Article