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\"Legendary actor Nick Nolte delivers his most revealing performance yet. This intimate memoir is a tale of art, passion, commitment, addiction, and the quest for personal enlightenment as intense and hypnotic as the man himself. In a career spanning five decades and hundreds of roles, Nick Nolte has become a true Hollywood icon. Rising from a difficult childhood in the rural Midwest to leading roles and a trio of Oscar nominations in the golden West, he has been both celebrated and vilified; survived marriages, divorces, and a string of romances; was named People magazine's 'Sexiest Man Alive'; and suffered public humiliation over his addiction issues, including a drug-fueled trip down the Pacific Coast Highway that resulted in his infamous arrest. Despite these ups and downs, Nolte has remained true to the craft he loves, portraying a diverse range of characters with his trademark physicality and indelible gravelly voice ...\"--Jacket.

National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to health care only focused on high-income countries and faced several methodological challenges. In the present analysis, we use the highly standardised cause of death and risk factor estimates generated through the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to improve and expand the quantification of personal health-care access and quality for 195 countries and territories from 1990 to 2015. We mapped the most widely used list of causes amenable to personal health care developed by Nolte and McKee to 32 GBD causes. We accounted for variations in cause of death certification and misclassifications through the extensive data standardisation processes and redistribution algorithms developed for GBD. To isolate the effects of personal health-care access and quality, we risk-standardised cause-specific mortality rates for each geography-year by removing the joint effects of local environmental and behavioural risks, and adding back the global levels of risk exposure as estimated for GBD 2015. We employed principal component analysis to create a single, interpretable summary measure–the Healthcare Quality and Access (HAQ) Index–on a scale of 0 to 100. The HAQ Index showed strong convergence validity as compared with other health-system indicators, including health expenditure per capita (r=0·88), an index of 11 universal health coverage interventions (r=0·83), and human resources for health per 1000 (r=0·77). We used free disposal hull analysis with bootstrapping to produce a frontier based on the relationship between the HAQ Index and the Socio-demographic Index (SDI), a measure of overall development consisting of income per capita, average years of education, and total fertility rates. This frontier allowed us to better quantify the maximum levels of personal health-care access and quality achieved across the development spectrum, and pinpoint geographies where gaps between observed and potential levels have narrowed or widened over time. Between 1990 and 2015, nearly all countries and territories saw their HAQ Index values improve; nonetheless, the difference between the highest and lowest observed HAQ Index was larger in 2015 than in 1990, ranging from 28·6 to 94·6. Of 195 geographies, 167 had statistically significant increases in HAQ Index levels since 1990, with South Korea, Turkey, Peru, China, and the Maldives recording among the largest gains by 2015. Performance on the HAQ Index and individual causes showed distinct patterns by region and level of development, yet substantial heterogeneities emerged for several causes, including cancers in highest-SDI countries; chronic kidney disease, diabetes, diarrhoeal diseases, and lower respiratory infections among middle-SDI countries; and measles and tetanus among lowest-SDI countries. While the global HAQ Index average rose from 40·7 (95% uncertainty interval, 39·0–42·8) in 1990 to 53·7 (52·2–55·4) in 2015, far less progress occurred in narrowing the gap between observed HAQ Index values and maximum levels achieved; at the global level, the difference between the observed and frontier HAQ Index only decreased from 21·2 in 1990 to 20·1 in 2015. If every country and territory had achieved the highest observed HAQ Index by their corresponding level of SDI, the global average would have been 73·8 in 2015. Several countries, particularly in eastern and western sub-Saharan Africa, reached HAQ Index values similar to or beyond their development levels, whereas others, namely in southern sub-Saharan Africa, the Middle East, and south Asia, lagged behind what geographies of similar development attained between 1990 and 2015. This novel extension of the GBD Study shows the untapped potential for personal health-care access and quality improvement across the development spectrum. Amid substantive advances in personal health care at the national level, heterogeneous patterns for individual causes in given countries or territories suggest that few places have consistently achieved optimal health-care access and quality across health-system functions and therapeutic areas. This is especially evident in middle-SDI countries, many of which have recently undergone or are currently experiencing epidemiological transitions. The HAQ Index, if paired with other measures of health-system characteristics such as intervention coverage, could provide a robust avenue for tracking progress on universal health coverage and identifying local priorities for strengthening personal health-care quality and access throughout the world. Bill & Melinda Gates Foundation.

Background Neutropenia is the most common dose‐limiting side effect of cytotoxic chemotherapy in cancer‐bearing dogs. Biodynamic imaging (BDI) is a functional imaging technology that measures dynamic light scattering from living, three‐dimensional tissues to characterize intracellular motion within those tissues. Previous studies have associated BDI biomarkers with tumour sensitivity to chemotherapy agents in dogs with naturally occurring cancer. We hypothesized that BDI, performed ex vivo on bone marrow aspirate samples, would identify dynamic biomarkers associated with the occurrence of specific degrees of neutropenia in tumour‐bearing dogs receiving doxorubicin chemotherapy. Materials and Methods Bone marrow aspirates were collected from 10 dogs with naturally occurring cancers prior to initiation of doxorubicin treatment. BDI was performed on bone marrow samples treated ex vivo with doxorubicin at 0.1, 1, 10 and 100 μM along with 0.1% DMSO as a control. Dogs then were treated with doxorubicin (30 mg/m2, intravenously). Peripheral blood neutrophil counts were obtained on the day of treatment and again 7 days later. Receiver operating characteristic curves identified provisional breakpoints for BDI biomarkers that correlated with specific changes in neutrophil counts between the two time points. Results Provisional breakpoints for several BDI biomarkers were identified, specifying dogs with the largest proportionate change in neutrophils and with neutropenia that was grade 2 or higher following doxorubicin treatment. Conclusions Biodynamic imaging of bone marrow aspirates may identify those dogs at greater risk for neutropenia following doxorubicin chemotherapy. This approach may be useful for pre‐emptively modifying chemotherapy dosing in dogs to avoid unacceptable side effects. Biodynamic imaging is a form of Doppler spectroscopy that records temporal fluctuations in back‐scattered light from living tissues as a surrogate measure of changes in intracellular motion within those tissues, which are induced by drug exposure. This drug response spectrogram illustrates a phenotypic, intracellular motion‐based response of canine bone marrow tissue to the cytotoxic agent, doxorubicin.

Nietzsche, the Godfather of Fascism?What can Nietzsche have in common with this murderous ideology? Frequently described as the \"radical aristocrat\" of the spirit, Nietzsche abhorred mass culture and strove to cultivate an Übermensch endowed with exceptional mental qualities. What can such a thinker have in common with the fascistic manipulation of the masses for chauvinistic goals that crushed the autonomy of the individual? The question that lies at the heart of this collection is how Nietzsche came to acquire the deadly \"honor\" of being considered the philosopher of the Third Reich and whether such claims had any justification. Does it make any sense to hold him in some way responsible for the horrors of Auschwitz? The editors present a range of views that attempt to do justice to the ambiguity and richness of Nietzsche's thought. First-rate contributions by a variety of distinguished philosophers and historians explore in depth Nietzsche's attitudes toward Jews, Judaism, Christianity, anti-Semitism, and National Socialism. They interrogate Nietzsche's writings for fascist and anti-Semitic proclivities and consider how they were read by fascists who claimed Nietzsche as their intellectual godfather. There is much that is disturbingly antiegalitarian and antidemocratic in Nietzsche, and his writings on Jews are open to differing interpretations. Yet his emphasis on individualism and contempt for German nationalism and anti-Semitism put him at stark odds with Nazi ideology. The Nietzsche that emerges here is a tragic prophet of the spiritual vacuum that produced the twentieth century's totalitarian movements, the thinker who best diagnosed the pathologies of fin-de-siècle European culture. Nietzsche dared to look into the abyss of modern nihilism. This book tells us what he found. The contributors are Menahem Brinker, Daniel W. Conway, Stanley Corngold, Kurt Rudolf Fischer, Jacob Golomb, Robert C. Holub, Berel Lang, Wolfgang Müller-Lauter, Alexander Nehamas, David Ohana, Roderick Stackelberg, Mario Sznajder, Geoffrey Waite, Robert S. Wistrich, and Yirmiyahu Yovel.

[...]Wade embodies the negative counterexample to a proper neoliberal subject who is predominately defined in terms of economic success and personal aptitude, a particular kind of masculinity not necessarily aligned with muscle and brawn.2 But although Wade's actions at the end of the narrative may be dismissed as an \"isolated explosion of homicidal rage in a small American town\" committed by a man who is not a neoliberal subject \"like you and me,\" his brother Rolfe refuses to let the assumed reader's tendency to \"forget all about it\" erase the significance of his brother's actions (Banks 354). According to David Harvey, this uneven development occurs because \"the globe never has been a level playing-field upon which capital accumulation could play out its destiny. [...]the ephemeral nature of such denigration becomes a presence of which one is always aware but is unable to directly pinpoint. [...]when a self-assured character such as Mel Gordon simply states, with a snap of the fingers, that he can have Wade fired \"with just one phone call\"-in contrast to the novel, all direct reference to Wade's country position omitted-it is a demonstration of power that is implicitly tied to the superiority of urban wealth over rural need. [...]our position becomes tied to LaRiviere's own machinations at the expense of the town, and the sentiment of Wade's critique, although ultimately lost in incoherent rage, becomes part of the assault against us.