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Evidence regarding whether imaging can be used effectively to select patients for endovascular thrombectomy (EVT) is scarce. We aimed to investigate the association between baseline imaging features and safety and efficacy of EVT in acute ischaemic stroke caused by anterior large-vessel occlusion. In this meta-analysis of individual patient-level data, the HERMES collaboration identified in PubMed seven randomised trials in endovascular stroke that compared EVT with standard medical therapy, published between Jan 1, 2010, and Oct 31, 2017. Only trials that required vessel imaging to identify patients with proximal anterior circulation ischaemic stroke and that used predominantly stent retrievers or second-generation neurothrombectomy devices in the EVT group were included. Risk of bias was assessed with the Cochrane handbook methodology. Central investigators, masked to clinical information other than stroke side, categorised baseline imaging features of ischaemic change with the Alberta Stroke Program Early CT Score (ASPECTS) or according to involvement of more than 33% of middle cerebral artery territory, and by thrombus volume, hyperdensity, and collateral status. The primary endpoint was neurological functional disability scored on the modified Rankin Scale (mRS) score at 90 days after randomisation. Safety outcomes included symptomatic intracranial haemorrhage, parenchymal haematoma type 2 within 5 days of randomisation, and mortality within 90 days. For the primary analysis, we used mixed-methods ordinal logistic regression adjusted for age, sex, National Institutes of Health Stroke Scale score at admission, intravenous alteplase, and time from onset to randomisation, and we used interaction terms to test whether imaging categorisation at baseline modifies the association between treatment and outcome. This meta-analysis was prospectively designed by the HERMES executive committee but has not been registered. Among 1764 pooled patients, 871 were allocated to the EVT group and 893 to the control group. Risk of bias was low except in the THRACE study, which used unblinded assessment of outcomes 90 days after randomisation and MRI predominantly as the primary baseline imaging tool. The overall treatment effect favoured EVT (adjusted common odds ratio [cOR] for a shift towards better outcome on the mRS 2·00, 95% CI 1·69–2·38; p<0·0001). EVT achieved better outcomes at 90 days than standard medical therapy alone across a broad range of baseline imaging categories. Mortality at 90 days (14·7% vs 17·3%, p=0·15), symptomatic intracranial haemorrhage (3·8% vs 3·5%, p=0·90), and parenchymal haematoma type 2 (5·6% vs 4·8%, p=0·52) did not differ between the EVT and control groups. No treatment effect modification by baseline imaging features was noted for mortality at 90 days and parenchymal haematoma type 2. Among patients with ASPECTS 0–4, symptomatic intracranial haemorrhage was seen in ten (19%) of 52 patients in the EVT group versus three (5%) of 66 patients in the control group (adjusted cOR 3·94, 95% CI 0·94–16·49; pinteraction=0·025), and among patients with more than 33% involvement of middle cerebral artery territory, symptomatic intracranial haemorrhage was observed in 15 (14%) of 108 patients in the EVT group versus four (4%) of 113 patients in the control group (4·17, 1·30–13·44, pinteraction=0·012). EVT achieves better outcomes at 90 days than standard medical therapy across a broad range of baseline imaging categories, including infarcts affecting more than 33% of middle cerebral artery territory or ASPECTS less than 6, although in these patients the risk of symptomatic intracranial haemorrhage was higher in the EVT group than the control group. This analysis provides preliminary evidence for potential use of EVT in patients with large infarcts at baseline. Medtronic.

This paper describes a generic Taylor series-based continuation method, the so-called asymptotic numerical method, to compute the bifurcation diagrams of nonlinear systems. The key point of this approach is the quadratic recast of the equations as it allows to treat in the same way a wide range of dynamical systems and their solutions. Implicit differential-algebraic equations, forced or autonomous, possibly with time-delay or fractional-order derivatives are handled in the same framework. The static, periodic and quasi-periodic solutions can be continued and also transient solutions.

In this paper we survey the primary research, both theoretical and applied, in the area of robust optimization (RO). Our focus is on the computational attractiveness of RO approaches, as well as the modeling power and broad applicability of the methodology. In addition to surveying prominent theoretical results of RO, we also present some recent results linking RO to adaptable models for multistage decision-making problems. Finally, we highlight applications of RO across a wide spectrum of domains, including finance, statistics, learning, and various areas of engineering.

We address the problem of sparse selection in linear models. A number of nonconvex penalties have been proposed in the literature for this purpose, along with a variety of convex-relaxation algorithms for finding good solutions. In this article we pursue a coordinate-descent approach for optimization, and study its convergence properties. We characterize the properties of penalties suitable for this approach, study their corresponding threshold functions, and describe a df-standardizing reparametrization that assists our pathwise algorithm. The MC+ penalty is ideally suited to this task, and we use it to demonstrate the performance of our algorithm. Certain technical derivations and experiments related to this article are included in the Supplementary Materials section.

The fractional differential equations involving different types of fractional derivatives are currently used in many fields of science and engineering. Therefore, the first purpose of this study is to investigate the qualitative properties including the stability, asymptotic stability, as well as Mittag–Leffler stability of solutions of fractional differential equations with the new generalized Hattaf fractional derivative, which encompasses the popular forms of fractional derivatives with non-singular kernels. These qualitative properties are obtained by constructing a suitable Lyapunov function. Furthermore, the second aim is to develop a new numerical method in order to approximate the solutions of such types of equations. The developed method recovers the classical Euler numerical scheme for ordinary differential equations. Finally, the obtained analytical and numerical results are applied to a biological nonlinear system arising from epidemiology.

How can price elasticities be identified when agents face optimization frictions such as adjustment costs or inattention? I derive bounds on structural price elasticities that are a function of the observed effect of a price change on demand, the size of the price change, and the degree of frictions. The degree of frictions is measured by the utility losses agents tolerate to deviate from the frictionless optimum. The bounds imply that frictions affect intensive margin elasticities much more than extensive margin elasticities. I apply these bounds to the literature on labor supply. The utility costs of ignoring the tax changes used to identify intensive margin labor supply elasticities are typically less than 1% of earnings. As a result, small frictions can explain the differences between micro and macro elasticities, extensive and intensive margin elasticities, and other disparate findings. Pooling estimates from existing studies, I estimate a Hicksian labor supply elasticity of 0.33 on the intensive margin and 0.25 on the extensive margin after accounting for frictions.

In the presented research, vibrational, and amplitude behaviors of a sandwich spinning disk made of two laminated layers and graphene nanoplatelets reinforced composite (GPLRC) core has been reported. The Coriolis and centrifugal impacts have been taken into account due to its rotational feature. The stresses and strains have been obtained through the high-order shear deformable theory (HSDT). The structure’s boundary conditions (BCs) are determined using laminated rotating disk’s governing equations employing energy methods and ultimately have been solved via a computational approach called generalized differential quadrature method (GDQM). The rotational disk’s vibrations with different BCs have been explained using the curves drawn by MATLAB programming. Moreover, the hinged BCs have been considered to edges θ=3π/2, and θ=π/2. Furthermore, cantilever (clamped–free) BCs, respectively, are taken into account in R = Ri, and R0. In addition to computational approach, a 3-D finite element (FE) simulation has been conducted via ABAQUS software employing the FE package to model the laminated cantilevered disk’s response. The outcomes determined by a FE simulation demonstrate a decent agreement with the semi-numerical approach’s results. Thereby the results reveal, disk’s angle of ply, number of layers, length scale, angular velocity, and nonlocal elements, and geometrical features have a significant influence on the vibration and amplitude characteristics of a sandwich spinning Clamped-Free disk. As a practical outcome in pertained industries, If the structure is manufactured of an even layers’ number, the system’s frequency response would be much better, specifically in a small radius ratio amount.

We study numerical methods for solving a non-stationary mixed Stokes-Darcy problem that models coupled fluid flow and porous media flow. A decoupling approach based on interface approximation via temporal extrapolation is proposed for devising decoupled marching algorithms for the mixed model. Error estimates are derived and numerical experiments are conducted to demonstrate the computational effectiveness of the decoupling approach.

Total Contributing Area (TCA) has been extensively accepted as a crucial terrain attribute in digital terrain analysis and geological simulations. However, existing flow direction algorithms work poorly in the accuracy of TCA estimation due to the irrationality of their empirically designed strategies. To solve this problem, our work proposes a novel method for TCA calculation in a fundamentally different way from existing algorithms. Firstly, general equation of Specific Contributing Area (SCA) along one‐dimensional slope line is deduced based on the constitutive relations between SCA and plane curvature. Its finite difference is revised to enable the calculation of the SCA by just an upslope trace of slope line with only two temporary variables. Secondly, Bicubic B‐spline (BBS) surface is constructed to approximate the terrain surface represented by a digital elevation model (DEM). Finally, the Back‐Trace Numerical (BTN) method is proposed for calculating the TCA of a DEM pixel based on the mathematical relations between pixel‐scale TCA and point‐scale SCA. Particularly note that the outcome of BTN method is the numerical solution of true TCA, which is fundamentally different from the TCAs estimated by existing algorithms based on empirical strategies. Three cases are designed to assess the performances of the BTN method on various terrain surfaces. If fine BTN parameters are adopted, BTN TCAs show extremely high accuracy on all synthetic surfaces with the mean absolute relative errors of <0.20%. Meanwhile, various basin characteristics (e.g., river, valley and ridge lines) could be accurately recognized based on the BTN TCAs for the DEMs of real‐world terrains.