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Background The picosecond neodymium yttrium aluminum garnet laser (PNYL) has been successfully used in treating acquired bilateral nevus of Ota‐like macules (ABNOM). The 730‐nm picosecond titanium sapphire laser (PTSL) is an emerging tool for pigmentary disorders. However, no studies have compared two different wavelengths of picosecond laser for the treatment of ABNOM. Aims To compare the efficacy and safety of the 730‐nm PTSL with the 1064‐nm PNYL in the treatment of ABNOM. Methods Fifteen participants with ABNOM were randomized to undergo a single session of either the 730‐nm PTSL on one side of the face and 1064‐nm PNYL on the other side. Efficacy and safety assessments were performed by blinded visual evaluations at baseline, 12 weeks, and 24 weeks posttreatment. Participants' satisfaction and adverse effects were recorded. Results Compared to baseline, The 730‐nm PTSL‐treated side showed better improvement than that of the 1064‐nm PNYL‐treated side at 24 weeks posttreatment (1.67 ± 1.047 vs. 0.87 ± 0.640, p = 0.027). There were no significant differences in pain sensation and participants' satisfaction between the two laser treatments. Conclusions The 730‐nm PTSL is more effective than the 1064‐nm PNYL in the treatment of ABNOM.

The rapid expansion of Internet of Things (IoT) applications requires robust mechanisms to ensure the security, reliability, and maintainability of embedded software throughout its lifecycle. Over-the-Air (OTA) update systems play a central role in enabling the continuous evolution of IoT deployments. Despite their importance, OTA solutions are often designed in an ad hoc manner, supported by fragmented guidelines that lack a structured basis for selecting mechanisms and techniques aligned with the quality needs of IoT systems. This work presents a consolidated catalog for designing OTA update systems in IoT environments, developed through a review of academic and industrial literature. The catalog comprises 34 techniques organized into six mechanisms, each with representative use cases and a mapping to relevant quality attributes that make beneficial and adverse impacts explicit. The catalog was evaluated through a controlled industrial experiment involving 10 engineers, balanced between novices and experts, who designed an OTA update system for a real application scenario using either their prior knowledge and experience or the catalog. This work offers four contributions: (1) a catalog of 34 OTA techniques structured into six mechanisms; (2) clarified architectural definitions of technique and mechanism; (3) a controlled industrial experiment evaluating the catalog in a realistic setting; and (4) a quality-attribute trade-off analysis for each technique. Together, these contributions establish a coherent foundation for systematic and quality-aware OTA update system design.

This paper presents a comprehensive design tutorial for four types of single-stage operational transconductance amplifiers (OTAs): (1) five-transistor OTAs, (2) telescopic cascode OTAs, (3) folded cascode OTAs, and (4) current mirror OTAs. These OTAs serve as fundamental building blocks in analog circuits. The operational principles of each OTA are reviewed, and the key performance metrics are derived through a hand analysis. These performance metrics encompass most crucial parameters, including small-signal parameters, frequency response, input and output swing ranges, rising and falling slew rates, nonidealities, and bias circuit simplicity. All of these metrics are verified and compared using the simulation. Furthermore, the practical applications of each OTA are summarized, and a case study demonstrates the enhancement of a neural recording amplifier’s performance through appropriate OTA selection. A thorough review of the essential building blocks will become a stepping stone to design high-performance analog amplifiers across diverse applications.

Background The therapeutic efficacy of laser treatments for acquired bilateral nevus of Ota‐like macules (ABNOM) varies among studies, and few studies have evaluated the factors affecting therapeutic effects. Aims To evaluate the efficacy and safety of 1064‐nm Q‐switched Nd:YAG laser (QSNYL) therapy for ABNOM and to identify the factors influencing the outcome. Methods A total of 110 patients with ABNOM were retrospectively evaluated and received two‐to‐nine treatment sessions. The effects of different factors on the therapeutic effect were analyzed on the basis of the number of treatments, age at first treatment, skin type, lesion color, affected area, number of lesion sites, and presence of concomitant melasma. Results The curative effect was positively correlated with the treatment time and negatively correlated with the increasing age at first treatment (p < 0.05). The curative effect was better in patients with skin type III than those with type IV ( p < 0.05) and in patients with a lesion area of less than 10 cm2 than those with a larger affected area (p < 0.05). Additionally, the treatment effect was poorer in patients with concomitant melasma (p < 0.05). The treatment effect was not significantly correlated with the lesion color or number of affected sites (p > 0.05). Eleven patients (10%) developed postinflammatory hyperpigmentation (PIH). Conclusions Early and repeated QSNYL therapy achieved satisfactory results for ABNOM. The risk of PIH after laser treatment is highest among patients with older age, darker lesion color, and darker skin color. For patients with ABNOM with concurrent melasma, low‐energy laser therapy is recommended to reduce the risk of melasma aggravation.

Abstract PurposeTo provide a review of the literature on oculodermal melanocytosis (ODM) with a focus on the diagnostic and therapeutic implications of multimodal imaging techniques in the management of ophthalmic complications.MethodsThe authors carried out a literature search on PubMed, Medline, and Scopus of English language articles published on ODM through August 2021. This review presents traditional and novel diagnostic methods in the diagnosis and follow-up of patients with particular emphasis on addressing the role of imaging in the management of the ophthalmic complications of the condition towards improving current practice patterns.ResultsODM is a rare, prevalently unilateral, congenital condition that presents with brown or blue/gray flat asymptomatic lesions of the skin, mucosae, episclera/sclera, and uvea localized within the territory of distribution of the ophthalmic and mandibular branches of the trigeminal nerve. Glaucoma and predisposition to uveal melanoma are the main ophthalmic complications. Diagnosis and management are through comprehensive opthalmological examination and traditional imaging methods such as ultrasonography and fluorescein/indocyanine green angiography as pigmentation of the fundus can conceal subtle retinal and choroidal alterations. Anterior segment optical coherence tomography and ultrasound biomicroscopy are used to evaluate the anterior segment and the ciliary body in the presence of glaucoma or melanoma of the anterior uveal tract. Fundus autofluorescence and retinal pigment epithelium (RPE) alterations are of aid in the differential diagnosis between choroidal nevi and melanoma. Enhanced depth imaging spectral domain optical coherence tomography offers outstanding in vivo evaluation of the dimensions and details of tumors or nevi and surrounding choroidal tissues and small choroidal melanomas may show distortions of the retinal and sub-retinal profile, presence of intra and sub-retinal fluid, abnormalities of the RPE, and compression of the choriocapillaris.ConclusionsNovel multimodal imaging techniques are significant in the diagnosis and management of the ophthalmic complications of ODM. Fundus autofluorescence and enhanced depth spectral domain optical coherence tomography have adjunctive value in the detection of early-stage melanoma and differential diagnosis between nevi and melanoma. Awareness of current and emerging imaging techniques can propagate improved standardized definition and assessment of the complications of ODM.

The statistical properties of the reverberation chamber (RC) provide a theoretical basis for over-the-air (OTA) testing of wireless devices. This paper analyses the effect of different tuner steps on OTA testing by constructing an RC-based OTA test system. The test results show that the mean value of the total radiated power (TRP) gradually converges as the number of tuner steps increases. However, due to the limited number of independent samples provided by the tuner, the measurement accuracy cannot be improved infinitely by just increasing the number of tuner steps. The number of independent samples for one rotation of the tuner at 2437MHz is also calculated.

This paper proposes topological enhancements to increase voltage gain of ultra-low-voltage (ULV) inverter-based OTAs. The two proposed improvements rely on adoption of composite transistors and forward-body-biasing. The impact of the proposed techniques on performance figures is demonstrated through simulations of two OTAs. The first OTA achieves a 39 dB voltage gain, with a power consumption of 600 pW and an active area of 447 μm2. The latter allies the forward-body-bias approach with the benefit of the independently biased composite transistors. By combining both solutions, voltage gain is raised to 51 dB, consuming less power (500 pW) at the cost of an increased area of 727 μm2. The validation has been performed through post-layout simulations with the Cadence Analog Design Environment and the TSMC 180 nm design kit, with the supply voltage ranging from 0.3 V to 0.6 V.

We report herein the development of a polyclonal antibody against ochratoxin A (OTA) using a specially designed synthetic OTA derivative as the immunizing hapten. This OTA derivative contains a tetrapeptide linker (glycyl-glycyl-glycyl-lysine, GGGK), through which it can be linked to a carrier protein and form an immunogenic conjugate. The OTA derivative (OTA-glycyl-glycyl-glycyl-lysine, OTA-GGGK) has been synthesized on a commercially available resin via the well-established Fmoc-based solid-phase peptide synthesis (Fmoc-SPPS) strategy; overall, this approach has allowed us to avoid tedious liquid-phase synthesis protocols, which are often characterized by multiple steps, several intermediate products and low overall yield. Subsequently, OTA-GGGK was conjugated to bovine thyroglobulin through glutaraldehyde, and the conjugate was used in an immunization protocol. The antiserum obtained was evaluated with a simple-format ELISA in terms of its titer and capability of recognizing the natural free hapten; the anti-OTA antibody, as a whole IgG fragment, was successfully applied to three different immunoanalytical systems for determining OTA in various food materials and wine samples, i.e., a multi-mycotoxin microarray bio-platform, an optical immunosensor, and a biotin–streptavidin ELISA, which has proved the analytical effectiveness and versatility of the anti-OTA antibody developed. The same approach may be followed for developing antibodies against other low-molecular-weight toxins and hazardous substances.

This paper deals with a single-stage single-ended inverter-based Operational Transconductance Amplifiers (OTA) with improved composite transistors for ultra-low-voltage supplies, while maintaining a small-area, high power-efficiency and low output signal distortion. The improved composite transistor is a combination of the conventional composite transistor and forward-body-biasing to further increase voltage gain. The impact of the proposed technique on performance is demonstrated through post-layout simulations referring to the TSMC 180 nm technology process. The proposed OTA achieves 54 dB differential voltage gain, 210 Hz gain–bandwidth product for a 10 pF capacitive load, with a power consumption of 273 pW with a 0.3 V power supply, and occupies an area of 1026 μm2. For a 0.6 V voltage supply, the proposed OTA improves its voltage gain to 73 dB, and achieves a 15 kHz gain–bandwidth product with a power consumption of 41 nW.

Since the introduction of selective photothermolysis, Q-switched nanosecond lasers have been used for the treatment of dermal pigmented lesions. Over the past several years, picosecond lasers have been introduced to the cosmetic community. We recently performed a study comparing a 550 picosecond 755 nm laser versus a 50 ns 755 nm laser, with the purpose of evaluating the clinical efficacy and complications of each laser when treating nevus of Ota. Ten Asian patients with nevus of Ota were enrolled in the study. Each lesion was split into 2 parts, and patients were treated with a 755 nm picosecond laser (PSL) and a 755 nm nanosecond laser (NSL). The clinical endpoint for fluence choice was immediate whitening (PSL: 2.33 ~ 3.36 J/cm2, NSL: 5.5 ~ 7 J/cm2) of the treated area. The pulse duration was fixed at 550 picoseconds (PSL) and 50 ns (NSL). The spot size of each laser was 2.5–3 mm. Laser treatments were performed until excellent clinical improvement was observed. Patients were examined 1 week after the first treatment, at each follow-up visit, and 6 months after the last laser treatment. The average number of treatment sessions to achieve excellent clinical improvement was 4.2 treatments using PSL and 5.4 treatments using NSL. One case of hyperpigmentation and one case of hypopigmentation were observed in the NSL treatment group. There were no complications in the PSL treatment group. The 755 nm 550 picosecond laser is significantly more effective than the 755 nm 50 ns laser in the treatment of nevus of Ota. The PSL treatment group also had minimum side effects.