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"Opioids Fiction."
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Robert B. Parker's The bitterest pill
\"When a popular high school cheerleader dies of a suspected heroin overdose, it becomes clear that the opioid epidemic has spread even to the idyllic town of Paradise. It will be up to police chief Jesse Stone to unravel the supply chain and unmask the criminals behind it, and the investigation has a clear epicenter: Paradise High School\"-- Provided by publisher.
Book
The 2016 NBCC Awards in Photos
Books that touch on some of the most pressing issues facing America today won two of the major honors at the National Book Critics Circle awards program. Paul Beatty's novel The Sellout took the fiction prize, while Dreamland: The True Story of America's Opiate Epidemic by Sam Quinones won in the nonfiction category.
Trade Publication Article
Medication Development for Narcotic Addiction
Addiction and abuse of prescription narcotics such as OxyContin® has become a major health crisis and has been widely documented. Commonly abused prescription analgesics are hydrocodone (Vicodin®), oxycodone (OxyContin®), oxymorphone (Opana®), hydromorphone (Dilaudid®), propoxyphene (Darvon®), meperidine (Demerol®), fentanyl (Duragesic®), and diphenoxylate (Lomotil®). Approved medications for opioid abuse are methadone, levo‐alpha‐acetylmethadol (LAAM), buprenorphine, naltrexone, and lofexidine (UK). The first three act as µ‐opioid partial agonists and have proven effective in long‐term maintenance treatment for preventing relapse. Tramadol (Rybiz®, Ryzolt®, Ultram®) is used to relieve moderate to moderately severe pain. Memantine (Namenda®) is used for the treatment of moderate to severe Alzheimer's disease.
Book Chapter
Medication Development for the Treatment of Drug Addiction
This chapter examines pharmacological approaches that are used to treat addiction to opioids, stimulants, depressants, nicotine, and marijuana. Drug discovery for the treatment of addiction can be approached by two basic strategies. The first approach starts with in vitro models while the second uses in vivo models. Pharmacological assays to test the potency of drugs have ranged from using live animals, using tissues that contain the receptors, and the modern binding and functional assays that use whole cells or cell membrane fragments in which the cloned receptors of interest have been expressed. The drugs that have been approved by the FDA for the clinical treatment of drug addiction tend to share a common pharmacological mechanism of action by acting as partial agonists. The chapter also discusses physicochemical properties of central nervous system (CNS) drugs, and the blood‐brain barrier (BBB) — one of the three barriers that protect the brain.
Book Chapter
Greed to do Good: The Untold Story of CDC's Disastrous War on Opioids
Greed to Do Good: The Untold Story of CDC's Disastrous War on Opioids: A CDC Physician's Personal Account, by Charles Lebaron is reviewed.
Book Review
