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Understanding the molecular basis and pathogenesis of hereditary optic neuropathies: towards improved diagnosis and management
Hereditary optic neuropathies result from defects in the human genome, both nuclear and mitochondrial. The two main and most recognised phenotypes are dominant optic atrophy and Leber hereditary optic neuropathy. Advances in modern molecular diagnosis have expanded our knowledge of genotypes and phenotypes of inherited disorders that affect the optic nerve, either alone or in combination, with various forms of neurological and systemic degeneration. A unifying feature in the pathophysiology of these disorders appears to involve mitochondrial dysfunction, suggesting that the retinal ganglion cells and their axons are especially susceptible to perturbations in mitochondrial homoeostasis. As we better understand the pathogenesis behind these genetic diseases, aetiologically targeted therapies are emerging and entering into clinical trials, including treatments aimed at halting the cascade of neurodegeneration, replacing or editing the defective genes or their protein products, and potentially regenerating damaged optic nerves, as well as preventing generational disease transmission.
Journal Article
Introduction to adaptive lenses
\"This is the first book to address the fundamental operation principles, device characteristics, and potential applications of various types of adaptive lenses. Setting out from basic material properties to device structures and performance, this volume covers solid lens, membrane lens, electro-wetting lens, dielectric lens, mechanical-wetting lens, and liquid crystal lenses. Potential applications of these adaptive lenses are also investigated, including image processing and zooming, optical communications, and biomedical imaging. This is an important reference for optical engineers, research scientists, graduate students and undergraduate seniors\"--
eBook
Fundamentals of micro-optics
\"From optical fundamentals to advanced applications, this comprehensive guide to micro-optics covers all the key areas for those who need an in-depth introduction to micro-optic devices, technologies, and applications. Topics covered range from basic optics, optical materials, refraction, and diffraction, to micro-mirrors, micro-lenses, diffractive optics, optoelectronics, and fabrication. Advanced topics, such as tunable and nano-optics, are also discussed. Real-world case studies and numerous worked examples are provided throughout, making complex concepts easier to follow, whilst an extensive bibliography provides a valuable resource for further study. With exercises provided at the end of each chapter to aid and test understanding, this is an ideal textbook for graduate and advanced undergraduate students taking courses in optics, photonics, micro-optics, microsystems, and MEMs. It is also a useful self-study guide for research engineers working on optics development\"-- Provided by publisher.
Book
Quantum teleportation across the Danube
Efficient long-distance quantum teleportation is crucial for quantum communication and quantum networking schemes. Here we describe the high-fidelity teleportation of photons over a distance of 600 metres across the River Danube in Vienna, with the optimal efficiency that can be achieved using linear optics. Our result is a step towards the implementation of a quantum repeater, which will enable pure entanglement to be shared between distant parties in a public environment and eventually on a worldwide scale.
Journal Article
Light
\"This book details the science of light. It explains where this energy comes from, how it affects life on Earth, what uses people have found for it, and more\"-- Provided by publisher.
Book
Chip-integrated metasurface full-Stokes polarimetric imaging sensor
Abstract Polarimetric imaging has a wide range of applications for uncovering features invisible to human eyes and conventional imaging sensors. Chip-integrated, fast, cost-effective, and accurate full-Stokes polarimetric imaging sensors are highly desirable in many applications, which, however, remain elusive due to fundamental material limitations. Here we present a chip-integratedMetasurface-based Full-StokesPolarimetricImaging sensor (MetaPolarIm) realized by integrating an ultrathin (~600 nm) metasurface polarization filter array (MPFA) onto a visible imaging sensor with CMOS compatible fabrication processes. The MPFA is featured with broadband dielectric-metal hybrid chiral metasurfaces and double-layer nanograting polarizers. This chip-integrated polarimetric imaging sensor enables single-shot full-Stokes imaging (speed limited by the CMOS imager) with the most compact form factor, records high measurement accuracy, dual-color operation (green and red) and a field of view up to 40 degrees. MetaPolarIm holds great promise to enable transformative applications in autonomous vision, industry inspection, space exploration, medical imaging and diagnosis.
Journal Article
Alternating Current Stimulation for Vision Restoration after Optic Nerve Damage: A Randomized Clinical Trial
Vision loss after optic neuropathy is considered irreversible. Here, repetitive transorbital alternating current stimulation (rtACS) was applied in partially blind patients with the goal of activating their residual vision.
We conducted a multicenter, prospective, randomized, double-blind, sham-controlled trial in an ambulatory setting with daily application of rtACS (n = 45) or sham-stimulation (n = 37) for 50 min for a duration of 10 week days. A volunteer sample of patients with optic nerve damage (mean age 59.1 yrs) was recruited. The primary outcome measure for efficacy was super-threshold visual fields with 48 hrs after the last treatment day and at 2-months follow-up. Secondary outcome measures were near-threshold visual fields, reaction time, visual acuity, and resting-state EEGs to assess changes in brain physiology.
The rtACS-treated group had a mean improvement in visual field of 24.0% which was significantly greater than after sham-stimulation (2.5%). This improvement persisted for at least 2 months in terms of both within- and between-group comparisons. Secondary analyses revealed improvements of near-threshold visual fields in the central 5° and increased thresholds in static perimetry after rtACS and improved reaction times, but visual acuity did not change compared to shams. Visual field improvement induced by rtACS was associated with EEG power-spectra and coherence alterations in visual cortical networks which are interpreted as signs of neuromodulation. Current flow simulation indicates current in the frontal cortex, eye, and optic nerve and in the subcortical but not in the cortical regions.
rtACS treatment is a safe and effective means to partially restore vision after optic nerve damage probably by modulating brain plasticity. This class 1 evidence suggests that visual fields can be improved in a clinically meaningful way.
ClinicalTrials.gov NCT01280877.
Journal Article