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Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma
Lenvatinib plus either pembrolizumab or everolimus was compared with sunitinib as first-line therapy for advanced renal cell cancer. Progression-free survival was significantly longer with lenvatinib plus pembrolizumab than with sunitinib. Lenvatinib plus everolimus was also more effective than sunitinib, but the difference was smaller.
Journal Article
NTP security : a quick-start guide
\"Learn the risks associated with Network Time Protocol (NTP) security and how to minimize those risks in daily deployment. Disruption of NTP services can interrupt communication between servers on the network and take an entire network offline. Beyond disrupting communication, flaws in the NTP daemon itself can make servers vulnerable to external attack--attacks that often go unnoticed. NTP is being used more frequently in Distributed Denial of Service (DDoS) attacks. It is a User Datagram Protocol (UDP) with encryption schemes that are not often used or are poorly implemented, making it susceptible to spoofing. Despite all of the security challenges, the fact is that NTP is critical to most modern networks. It is one of those \"set it and forget it\" protocols that network administrators and even security professionals don't understand in depth. However, an attacker who does understand the security flaws can wreak havoc on an insecure network. NTP Security: A Quick-Start Guide provides a deeper understanding of the protocol itself and how to deploy a strategy using the protocol throughout a network in a secure manner. Your security team will be able to provide better guidance to the system and network teams who will then be able to better manage the day-to-day implementation. This succinct resource offers practical guidance to an underserved topic (actually, not served at all). Coverage includes: an understanding of NTP and the importance of time synchronization in modern networks; issues in NTP security, including an analysis of NTP traffic; a review of the vulnerabilities and flaws in the protocol; practical solutions for securing NTP and building a robust infrastructure; effective alternatives to NTP\"--Back cover.
Book
Ex vivo qualitative and quantitative analysis of fluorescently-labeled Hsp90 drug in human tumors
Heat shock protein 90 (Hsp90) stabilizes numerous oncogenic proteins, making it a key therapeutic target in cancer. This protocol details an ex vivo method using freshly resected human renal cell carcinoma tissues to evaluate fluorescently labeled Hsp90 inhibitor ganetespib accumulation in tumor versus normal tissue. By preserving the native tumor architecture, this method offers a physiologically relevant alternative to xenograft models. This protocol combines flow cytometry and confocal microscopy to quantitatively and visually assess ganetespib uptake, providing insight into drug distribution and therapeutic response in human cancers. For complete details on the use and execution of this protocol, please refer to Dunn et al. and Woodford et al.
Journal Article
Psilocybin and Motor Function: A Triple‐Blind, Dose‐Finding Study in Healthy Participants
Background There has been a resurgence of research into the potential therapeutic benefits of psychedelics for neuropsychiatric disorders. Classic psychedelics, such as psilocybin, exert complex effects on higher cognitive functions such as perception and awareness, but their impact on motor function remains unexplored. Moreover, there is a theoretical rationale for using psychedelics to promote motor retraining in certain neuropsychiatric conditions associated with motor dysfunction. This protocol paper outlines the first study to investigate the feasibility and safety of performing movement tasks during the acute effects of psilocybin in healthy participants. The findings from this study will further our understanding of the impact of psychedelics on motor function, and inform future studies that combine classic psychedelics with motor retraining in clinical populations. Methods 12 healthy participants will each receive three doses of psilocybin (between 5 and 20 mg) in a randomized order, with each dose administered at least 1 week apart. Participants, the trial physiotherapists, and statisticians will remain blinded to the psilocybin dose. A battery of measures assessing motor function will be completed during the acute drug effects. In addition, measures of safety, pre‐ and post‐dose resting‐state brain activity via functional magnetic resonance imaging, and participants' subjective experience will be assessed. Highlights Psychedelics may promote motor retraining in certain neuropsychiatric disorders. No clinical studies have investigated the impact of psychedelics on motor function. This study will assess the performance of movement tasks during the acute effects of psilocybin in healthy participants. This will inform the design of a follow‐up study of psilocybin‐assisted physiotherapy in motor functional neurological disorder. The findings will inform future trials exploring psychedelics to assist motor retraining in other neuropsychiatric disorders with associated motor dysfunction.
Journal Article
