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Schoolgirl Audrey starts suffering from panic attacks after a lie she told left one of her classmates dead, but she finds hope in the form of Rad, a boy who could turn her life around, but their romance may be ill-timed and push her closer to the edge.

Context The scarcity of cross‐national reports and the changes in Diagnostic and Statistical Manual version 5 (DSM‐5) regarding panic disorder (PD) and panic attacks (PAs) call for new epidemiological data on PD and PAs and its subtypes in the general population. Objective To present representative data about the cross‐national epidemiology of PD and PAs in accordance with DSM‐5 definitions. Design and setting Nationally representative cross‐sectional surveys using the World Health Organization Composite International Diagnostic Interview version 3.0. Participants Respondents (n = 142,949) from 25 high, middle, and lower‐middle income countries across the world aged 18 years or older. Main outcome measures PD and presence of single and recurrent PAs. Results Lifetime prevalence of PAs was 13.2% (SE 0.1%). Among persons that ever had a PA, the majority had recurrent PAs (66.5%; SE 0.5%), while only 12.8% fulfilled DSM‐5 criteria for PD. Recurrent PAs were associated with a subsequent onset of a variety of mental disorders (OR 2.0; 95% CI 1.8–2.2) and their course (OR 1.3; 95% CI 1.2–2.4) whereas single PAs were not (OR 1.1; 95% CI 0.9–1.3 and OR 0.7; 95% CI 0.6–0.8). Cross‐national lifetime prevalence estimates were 1.7% (SE 0.0%) for PD with a median age of onset of 32 (IQR 20–47). Some 80.4% of persons with lifetime PD had a lifetime comorbid mental disorder. Conclusions We extended previous epidemiological data to a cross‐national context. The presence of recurrent PAs in particular is associated with subsequent onset and course of mental disorders beyond agoraphobia and PD, and might serve as a generic risk marker for psychopathology.

\"Growing up, Kate Priddy was always a bit neurotic, experiencing momentary bouts of anxiety that exploded into full-blown panic attacks after an ex-boyfriend kidnapped her and nearly ended her life. When Corbin Dell, a distant cousin in Boston, suggests the two temporarily swap apartments, Kate, an art student in London, agrees, hoping that time away in a new place will help her overcome the recent wreckage of her life. But soon after her arrival at Corbin's grand apartment on Beacon Hill, Kate makes a shocking discovery: his next-door neighbor, a young woman named Audrey Marshall, has been murdered\"--Amazon.com.

Panic attack prediction remains a critical challenge in mental health care due to the high interindividual variability of physiological responses and the limitations of subjective psychological assessments. This study aims to develop a multimodal deep learning framework that integrates real-time physiological signals from wearable electrocardiogram (ECG) monitors and psychological assessments to improve the accuracy of panic attack prediction. We adapted the ConvNetQuake architecture, originally designed for seismic detection, to extract temporal patterns from ECG signals. The model was pretrained on the PTB-XL ECG dataset and fine-tuned using wearable ECG data collected from adult participants. In parallel, psychological profiles based on the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria and Panic Disorder Severity Scale assessments were encoded as auxiliary inputs. The multimodal framework was evaluated using standard performance metrics. The proposed model achieved an accuracy of 71.43%, precision of 83.72%, recall of 70.59%, and F1 score of 76.60% in detecting heart rate variability anomalies associated with panic episodes. Experimental comparisons demonstrated that the integration of physiological and psychological modalities significantly outperformed unimodal baselines in prediction reliability. This study provides empirical support for wearable-based early warning systems for panic attacks. The proposed approach demonstrates the feasibility of just-in-time digital interventions and underscores the potential of wearable artificial intelligence in advancing affective computing and digital psychiatry.

After he falls into Scarecrow's trap, Batman's fitted with a helmet that slowly releases a fear-inducing gas, leaving him terrified of everything around him--even Robin and Nightwing, who are trying to save him.

Cardiologists’ attitudes towards the patients with panic attack (PA) symptoms can be affected by many variables. This study was aimed to examine the practices and attitudes of cardiologists actively practicing in Turkey through an internet-based survey. An internet-based, cross-sectional, and observational survey was administered to actively practicing adult cardiologists. The sample size was calculated (minimum 135 participants). The survey draft was created by the conductor of the study and the final version of the survey items was decided by psychiatrists and cardiologists. Cronbach’s alpha based on standardized items of the survey in the pilot (0.747) and final samples (0.742) was calculated. The survey, which included the characteristics on the landing page, was delivered to participants working in the Turkey via WhatsApp and Yahoo groups. All analyses were performed using IBM SPSS Statistics version 26.0. Ethical approval and informed consent was obtained. One hundred forty-five participants (87 males (60.00%) and 58 females (40.00%); 89 cardiology resident (61.37%) and 56 cardiology specialist (38.63%)) were included in the study. In patients presenting with symptoms of PA, when no cardiac/organic etiology was detected, 83 (57.24%) of the cardiologists directly referred the patients to psychiatry, while 62 (42.76%) of them started the treatment themselves. The most common symptom in patients presenting with non-cardiac PA symptoms was palpitations (86.20%). The number of cardiologists who had experience in starting escitalopram with a preliminary diagnosis of panic disorder (PD) was 50 (31.00%). Forty-three (29.7%) of cardiologists thought that antidepressants (ADs) were addictive. Thirty-five (24.1%) of cardiologists thought that ADs caused forgetfulness. According to 61 cardiologists, ADs should be used in the morning, while according to 64 cardiologists, ADs should be used in the evening. Forty-four (30.3%) cardiologists did not think benzodiazepines were addictive. The number of cardiologists who thought that patients who admitted to any physician other than cardiology with PA symptoms should be routinely referred to cardiology was 71 (49.00%). The difference between PA and PD was not known to any of the participants ( n  = 145). While gender had a limited effect on the findings, it was found that being cardiology specialist or not had a significant relationship with many variables. Binary logistic regression analysis was used to predict approach in the presence of non-cardiac PA symptoms and five variables (specialization status, routine echocardiogram examination, minimum usage time of ADs, association of ADs with addiction, and routine cardiology consultation by a non-cardiologist) were included given their contribution to the model (sensitivity = 86.70%, specificity = 83.90%; Beginning block − 2 Log likelihood 197.961; Block one − 2 Log likelihood 100.083 a , Cox & Snell R 2  = 0.491, Nagelkerke R 2  = 0.659; Hosmer and Lemeshow Test p value 0.254; constant p  = 0.001). Non-cardiac PA symptoms are detected in approximately one sixth of those who apply to cardiology outpatient clinics, and it is recommended that cardiologists refer these patients to psychiatry to be evaluated for PD and receive appropriate treatment. PD treatment is a teamwork, and collaboration between cardiology and psychiatry is an integral part of this process.

The girls in the coding club are preparing their voting app for the school talent show, but when they discover Erin's secretly suffering from anxiety they band together to find her help.

IntroductionThe curious effect of an increase of the placebo effect across year of publication has been shown for depression, schizophrenia, obsessive-compulsive disorder, as well as for some medical conditions like hypertension and pain.ObjectivesWe aimed to observe how randomised clinical trials with a placebo control behave at this respect in panic disorder trials.MethodsWe searched the PubMed database using the strategy: (panic disorder OR panic attack disorder) AND placebo, which on 3 November 2020 produced 779 records. Inclusion criteria were the above stated, excluded were all studies focusing on the same patients as others and those not providing intelligible data. In our selection we used the PRISMA statement and reached agreement with Delphi rounds.ResultsWe identified through other sources further 3 studies. The finally eligible studies were 82, excluded were 700 studies, mainly consisting of reviews (176), challenge studies (173), not dealing with panic disorder (67), studies with unsuitable designs to detect placebo effect (53), studies using same populations as others (36), those with misfocused outcomes (57), those lumping diagnoses and not allowing to separate data for panic disorder (22), and those not using placebo at all (21). Mean response to placebo in included panic disorder studies was 36.01±19.812, ranging from 0 to 76.19%; the correlation with year of publication was positive and significant (Pearson’s r= 0.246; p=0.026).ConclusionsThe effect of placebo in randomised control trials has increased across the years, but this field of research appears to be idle in recent years.DisclosureNo significant relationships.

Eighth-grader Hester Greene suffers from Attention-deficit hyperactivity disorder, plus anxiety, which is why she loves making movies where she is behind the camera and in complete control of the action--but if she cannot improve her language arts grade she will not be allowed to enter her video in The Hoot (a showcase of student work) and write a satisfactory ending to her middle school career.

Background Physical activity has been discussed as a therapeutic alternative or add‐on for the treatment of anxiety disorders. We studied whether aerobic exercise compared to physical activity with low impact can improve the effect of cognitive behavioral therapy (CBT) in patients with panic disorder (PD) with/without agoraphobia. Methods Forty‐seven patients received group CBT treatment over 1 month, which was augmented with an 8‐week protocol of either aerobic exercise (three times/week, 30 min, 70% VO2max; n = 24) or a training program including exercises with very low intensity (n = 23) in a randomized controlled double‐blind design. The primary outcome measure was the total score on the Hamilton Anxiety Scale (Ham‐A). A 2 × 3 analysis of covariance (ANCOVA) with baseline value as a covariate was conducted for data analysis. Results Time × group interaction for the Ham‐A revealed a significant effect (P = .047, η2p = .072), which represented the significant group difference at a 7‐month follow‐up. For the other clinical outcome measures no statistical significance emerged, although improvement was more sustained in the exercise group. Conclusions For patients with PD, regular aerobic exercise adds an additional benefit to CBT. This supports previous results and provides evidence about the intensity of exercise that needs to be performed.