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Search for resonant and nonresonant new phenomena in high-mass dilepton final states at s = 13 TeV
A
bstract
A search is presented for physics beyond the standard model (SM) using electron or muon pairs with high invariant mass. A data set of proton-proton collisions collected by the CMS experiment at the LHC at
s
= 13 TeV from 2016 to 2018 corresponding to a total integrated luminosity of up to 140 fb
−
1
is analyzed. No significant deviation is observed with respect to the SM background expectations. Upper limits are presented on the ratio of the product of the production cross section and the branching fraction to dileptons of a new narrow resonance to that of the Z boson. These provide the most stringent lower limits to date on the masses for various spin-1 particles, spin-2 gravitons in the Randall-Sundrum model, as well as spin-1 mediators between the SM and dark matter particles. Lower limits on the ultraviolet cutoff parameter are set both for four-fermion contact interactions and for the Arkani-Hamed, Dimopoulos, and Dvali model with large extra dimensions. Lepton flavor universality is tested at the TeV scale for the first time by comparing the dimuon and dielectron mass spectra. No significant deviation from the SM expectation of unity is observed.
Journal Article
Dark photons and axion-like particles at the electron-ion collider in China
A
bstract
The Electron-Ion Collider in China (EicC), a proposed high-luminosity facility with advanced charged particle and photon detection capabilities, provides unique opportunities to uncover new physics beyond the Standard Model. We analyze its sensitivity to dark photons produced through electron bremsstrahlung in coherent scattering. Thanks to its beam energy settings, it has the potential to comprehensively probe the previously unexplored parameter space between the constraints from meson decays and beam dumps below
O
1
GeV with displaced-vertex search. Additionally, the EicC has the potential to probe axion-like particles (ALPs) in the mass range 0
.
1 GeV ≲
m
a
≲ 5 GeV, with a coupling reach of Λ ≲ 10
6
GeV, by combining the prompt-decay and displaced-vertex searches. The projected sensitivities to ALPs exceed the current bounds.
Journal Article
New Approaches in Breast Cancer Therapy Through Green Nanotechnology and Nano-Ayurvedic Medicine – Pre-Clinical and Pilot Human Clinical Investigations
The overarching objective of this investigation was to investigate the intervention of green nanotechnology to transform the ancient holistic Ayurvedic medicine scientifically credible through reproducible formulations and rigorous pre-clinical/clinical evaluations.
We provide, herein, full details: (i) on the discovery and full characterization of gold nanoparticles-based Nano Swarna Bhasma (henceforth referred to as NSB drug); (ii) In vitro anti-tumor properties of NSB drug in breast tumor cells; (iii) pre-clinical therapeutic efficacy studies of NSB drug in breast tumor bearing SCID mice through oral delivery protocols and (iv) first results of clinical translation, from mice to human breast cancer patients, through pilot human clinical trials, conducted according to the Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy (abbreviated as AYUSH) regulatory guidelines of the Government of India in metastatic breast cancer patients.
The preclinical in vitro and in vivo investigations, in breast tumor bearing mice, established unequivocally that the NSB Nano-Ayurvedic medicine-gold nanoparticles-based drug is highly effective in controlling the growth of breast tumors in a dose dependent fashion in vivo. These encouraging pre-clinical results prompted us to seek permission from the Indian Government's holistic medicine approval authority, AYUSH, for conducting clinical trials in human patients. Patients treated with the NSB drug capsules along with the \"standard of care treatment\" (Arm B) exhibited 100% clinical benefits when compared to patients in the treatment Arm A, thus indicating the tremendous clinical benefits of NSB drug in adjuvant therapy.
We have succeeded in clinically translating, from mice to humans, in using proprietary combinations of gold nanoparticles and phytochemicals to develop the Nano-Ayurvedic drug: Nano Swarna Bhasma (NSB), through innovative green nanotechnology, for treating human metastatic breast cancer patients.
Journal Article
Synthesis, Properties, and Biological Applications of Metallic Alloy Nanoparticles
Metallic alloy nanoparticles are synthesized by combining two or more different metals. Bimetallic or trimetallic nanoparticles are considered more effective than monometallic nanoparticles because of their synergistic characteristics. In this review, we outline the structure, synthesis method, properties, and biological applications of metallic alloy nanoparticles based on their plasmonic, catalytic, and magnetic characteristics.
Journal Article
Dust : the modern world in a trillion particles
\"Dust may seem inconsequential, so tiny and mundane as to slip below the threshold of thought. Yet within the next one hundred years, life on Earth will be profoundly changed by heat and drought - and that means dust. In this ground-breaking book, Jay Owens argues that dust is a legacy of twentieth-century progress and a toxic threat to life in the twenty-first. Dust: The Modern World in a Trillion Particles tells the gripping story of how the relentless drive for profit and power has turned the world to powder. Combining history and science, travel and nature writing, Owens shows how the modern world was made through environmental devastation - and then brushed the consequences under the carpet. From particle air pollution and nuclear fallout to desertification, dried-up seas and melting glaciers, we've profoundly altered the planet we live on. The cost to human health - and to the natural world - proves immense. From the California desert and the Dust Bowl in Oklahoma to the desiccated remains of the Aral Sea and the edge of the Greenland ice sheet, we are shown that some of the planet's most remote and forgotten places are central to the modern world. With clarity and insight, Dust: The Modern World in a Trillion Particles helps us understand our legacy and discovers the big ideas found within the smallest particles\"-- Publisher's description.
Book
Inorganic Nanoparticles and Composite Films for Antimicrobial Therapies
The development of drug-resistant microorganisms has become a critical issue for modern medicine and drug discovery and development with severe socio-economic and ecological implications. Since standard and conventional treatment options are generally inefficient, leading to infection persistence and spreading, novel strategies are fundamentally necessary in order to avoid serious global health problems. In this regard, both metal and metal oxide nanoparticles (NPs) demonstrated increased effectiveness as nanobiocides due to intrinsic antimicrobial properties and as nanocarriers for antimicrobial drugs. Among them, gold, silver, copper, zinc oxide, titanium oxide, magnesium oxide, and iron oxide NPs are the most preferred, owing to their proven antimicrobial mechanisms and bio/cytocompatibility. Furthermore, inorganic NPs can be incorporated or attached to organic/inorganic films, thus broadening their application within implant or catheter coatings and wound dressings. In this context, this paper aims to provide an up-to-date overview of the most recent studies investigating inorganic NPs and their integration into composite films designed for antimicrobial therapies.
Journal Article