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To analyze and compare the efficiency of three phaco-emulsifying machines by evaluating parameters related to fluidics and ultrasound time (UST). Pilot, prospective, observational, comparative study conducted at the “Mediterranea” Clinic Ophthalmology Operative Unit, Naples, Italy. A total of 145 consecutive cases of phacoemulsification were included in the study. Patients were randomized into 4 arms and operated using three phaco-emulsifying machines in 4 configurations equipped with three different infusion systems. The phaco machines were: (1) Centurion ® , with and without the Active Sentry ® handpiece (Alcon), (2) Stellaris Elite™ (Bauch & Lomb), and (3) Whitestar Signature ®  Pro (Johnson & Johnson). The primary outcomes were UST and fluid aspiration volume. Centurion, with and without Active Sentry, required less UST compared to other phaco machines ( P  < 0.001). Furthermore, Centurion required lower values of intraocular pressure (IOP) to complete the procedure and aspirated less fluid compared to the Stellaris Elite. No statistical differences in UST, aspirated fluid, and IOP have been found between Centurion and Centurion with Active Sentry. Centurion, with and without Active Sentry required lower UST and IOP for cataract removal compared to Stellaris Elite and Whitestar Signature Pro. Less fluid is necessary to complete the procedure compared to the Stellaris Elite.