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Soaking up the rays : light therapy and visual culture in Britain, c. 1890-1940
Soaking up the rays forges a new path for exploring Britain's fickle love of the light by investigating the beginnings of light therapy in the country from c.1890-1940. Despite rapidly becoming a leading treatment for tuberculosis, rickets and other infections and skin diseases, light therapy was a contentious medical practice. Bodily exposure to light, whether for therapeutic or aesthetic ends, persists as a contested subject to this day: recommended to counter skin conditions as well as Seasonal Affective Disorder and depression; closely linked to notions of beauty, happiness and well-being, fuelling tourism abroad and the tanning industry at home; and yet with repeated health warnings that it is a dangerous carcinogen. By analysing archival photographs, illustrated medical texts, advertisements, lamps, and goggles and their visual representation of how light acted upon the body, Woloshyn assesses their complicated contribution to the founding of light therapy.
Book
Taking phototherapeutics from concept to clinical launch
More than four decades have passed since the first example of a light-activated (caged) compound was described. In the intervening years, a large number of light-responsive derivatives have been reported, several of which have found utility under a variety of in vitro conditions using cells and tissues. Light-triggered bioactivity furnishes spatial and temporal control, and offers the possibility of precision dosing and orthogonal communication with different biomolecules. These inherent attributes of light have been advocated as advantageous for the delivery and/or activation of drugs at diseased sites for a variety of indications. However, the tissue penetrance of light is profoundly wavelength-dependent. Only recently have phototherapeutics that are photoresponsive in the optical window of tissue (600-900 nm) been described. This Review highlights these recent discoveries, along with their limitations and clinical opportunities. In addition, we describe preliminary in vivo studies of prospective phototherapeutics, with an emphasis on the path that remains to be navigated in order to translate light-activated drugs into clinically useful therapeutics. Finally, the unique attributes of phototherapeutics is highlighted by discussing several potential disease applications.
Journal Article
The validity and safety of multispectral light emitting diode (LED) treatment on grade 2 pressure ulcer: Double-blinded, randomized controlled clinical trial
The management of pressure ulcers (PUs) poses challenges due to their chronic nature and the lack of established conservative treatment methods. In this clinical trial, our objective was to examine the validity and safety of using a light-emitting diode device contained four wavelengths in the treatment of grade 2 sacral PUs.
A total of 38 patients were randomly assigned to two groups: sham device (Sham) and experimental device (LED) group. The treatment sessions were conducted over a period of four weeks, with a frequency of three times per week. The study was conducted in a double-blinded manner. The study assessed the primary validity by measuring wound size and re-epithelialization after 0 and 4 weeks. Secondary evaluations included epidermal regeneration, collagen density, and immunological markers. Safety was evaluated by monitoring adverse reactions throughout the trial.
The presence of eschar was found to have a significant impact on wound healing. Sham consisted of 15 wounds without eschar, while LED had nine. After treatment in without eschar situation, the post-treatment size of wounds in Sham was 13.80 ± 20.29%, while it was 3.52 ± 6.68% in LED. However, there was no significant difference (p = 0.070). And analysis of epidermal thickness showed a significant increase in LED (495.62 ± 327.09 μm) compared to Sham (195.36 ± 263.04 μm) (p < 0.0001).
While LED treatment had a potential for wound reduction in PUs without eschar, we could not uncover evidence to support the efficacy of LED treatment in grade 2 PUs.
Journal Article
Living light : the art of using light for health and happiness
\"In this groundbreaking guide to maximizing the restorative and regenerative benefits of light, psychologist Karl Ryberg explains how to use different types of light--sun, fire, and even artificial lighting--in order to create ultimate health and a happy mind\"-- Provided by publisher.
Book
The Effectiveness of Low‐Level LED Light Therapy for Sleep Problems, Psychological Symptoms, and Heart Rate Variability in Shift‐Work Nurses: A Randomized Controlled Trial
Background: Shift‐work schedules can cause sleep and psychological problems among nurses, negatively affecting their health and quality of life. This trial examined the effects of low‐energy light therapy on sleep, psychological symptoms, and heart rate variability among shift‐work nurses. Methods: This randomized controlled trial was conducted from July 2021 to June 2022. The inclusion criteria were nurses with self‐reported insomnia who worked in shifts in the last 6 months in a medical center in northern Taiwan. Block randomization was used to assign the study participants to two groups: experimental ( n = 32) and control ( n = 32). A portable Meridian Aura Cap equipped with a low‐level light‐emitting diode was used to provide red and near‐infrared light (660 and 850 nm) for 30 min, three times a week for 4 weeks; the control group did not receive any intervention. The Depression Anxiety Stress Scale‐21 and Insomnia Severity Index were used to measure psychological symptoms and sleep problems, respectively. Heart rate variability was measured by the ANSWatch. Results: No significant differences were reported in preintervention scores. After the 4‐week intervention, the intervention group scored significantly lower in insomnia (4.3 vs. 12.6, respectively; p < 0.001), depression (2.5 vs. 7.9, p < 0.001), anxiety (3.1 vs. 9.2, p < 0.001), and stress (5.6 vs. 12, p < 0.001) than those in the controls. No significant differences were observed in heart rate variability between the two groups. Conclusion: Low‐level light‐emitting diode light therapy improved sleep quality in shift‐work nurses with insomnia and alleviated depression, anxiety, and stress symptoms; however, it did not improve heart rate variability, possibly because of the short intervention duration and the ongoing shift‐work schedule. Implications for Nursing Management: Employers could consider providing phototherapy for shift nurses to improve their health. Trial Registration: ClinicalTrials.gov identifier: NCT05146596
Journal Article
Efficacy and Safety of a Home‐Use Light‐Emitting Diode Neck Device for Improvement in Neck Wrinkles: A Multicenter, Randomized, Double‐Blind, Sham Device, Superiority Verification, Confirmatory Clinical Trial
Background Light‐emitting diode (LED) light sources have become an increasingly popular choice for the treatment and rejuvenation of various dermatological conditions. Aims This study aimed to evaluate the effects of neck rejuvenation, patient satisfaction, and the safety of LED application to the neck in an Asian population. Methods This was a multicenter, randomized, double‐blind, sham device study. Seventy participants were enrolled in the study. The participants wore the home‐use LED neck device for 9 min a day, 5 times a week, for a total of 60 sessions. The Lemperle Wrinkle Scale (LWS) and Global Aesthetic Improvement Scale (GAIS) were used to evaluate the results of both investigators and participants. The thyroid gland was examined using ultrasonography to evaluate the safety of the investigational device. Results The percentage of participants with improved LWS at Week 12 was significantly higher in the study group. Additionally, the percentage of participants with improved LWS was significantly higher in the study group at Weeks 8, 12, and 16. The LWS at Week 12 corrected with baseline values was found to be significantly different between the two groups. GAIS showed significant differences at 8, 12, and 16 weeks in the investigators' evaluation but not in the participants' evaluation. Repeated‐measures analysis of variance at Weeks 4, 8, 12, and 16 also confirmed a significant difference between the two groups only in investigator assessment. No significant thyroid‐related complications were observed. Conclusion LED application to the neck may be considered a satisfactory and safe procedure for neck rejuvenation.
Journal Article
Shining light on chest shielding
Impact
Key message: Chest shielding during phototherapy does not reduce the incidence of symptomatic PDA in preterm infants and does not affect phototherapy’s efficacy.
This study adds to the existing literature by providing a double-blinded RCT confirming previous inconsistent findings on the impact of chest shielding on PDA incidence. However, phototherapy may exert cardiovascular changes, including vasodilatation.
Impact: Chest shielding should not be recommended to be routinely performed in preterm infants during phototherapy.
Journal Article