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Background Krummhübel (after 1945, Karpacz) in the Sudety Mountains (now SW Poland) was called “the village of pharmacists”. At the end of the seventeenth century, there were 57 households, of which about 40 were inhabited by herbalists. Krummhübel herbalists were the first in the Sudety region who applied medicinal mixtures for the treatment of various diseases (using, among others, plants, oils, minerals and even viper venom) in contrast to previous herbalists who only indicated the use of individual plant species for specific diseases. Riesengebirge (in Polish Karkonosze) potions were sold in Austria, the Czech Republic, Poland and Russia, and some of them could even be purchased in Scandinavia and England. The purpose of this paper is an ethnopharmacological analysis of historical texts of herbalists from Krummhübel. Based on their recipes, we analysed the use reports of drugs. Recently, research on ethnobotany and ethnopharmacological analyses of historical materials or egodocuments related to formulations used in folk medicine have become an important source of acquiring knowledge about new medicines. Methods Based on 46 recipes of Krummhübel herbalists re-written by Reitzig (1943), we analysed the use reports of drugs which included plant taxa and other constituents such as animal formulations, fungi, inorganic and organic substances and minerals as well as tinctures (with alcohol/spirit) and elixirs (without alcohol/spirit). For each usage mentioned in the text, we recorded (i) the putative botanical identity of the taxon; (ii) the plant family or origin of other than the plant constituent; (iii) the reported plant part; (iv) the number of the recipe; (v) the name of the recipe; (vi) the vernacular name of ingredient; (vii) the described symptom, ailment or specific use; (viii) our modern (viz. biomedical) interpretation of the described symptom or ailment; (ix) the mode of administration; and (x) the category of use under which we filed the specific use. We also cross-checked the medicinal plants of Krummhübel herbalists with the species described in old manuscripts and regional surveys and compared their use with contemporary plant use. Results The paper introduces the generated database comprising 348 use reports of 46 drugs based on 70 plant taxa and other constituents. Besides, we address patterns such as the frequent recommendation of Fabaceae herbs for respiratory system issue and gynaecology and Asteraceae for respiratory system and cardiovascular problems. Gastrointestinal use reports are based on Asphodelaceae, Burseraceae and Rosaceae species. Conclusions Remedies that lost importance over time as well as drugs used for diseases now controlled by conventional medicine may be interesting starting points for research on herbal medicine and drug discovery. It seems to be important to attempt to reproduce therapeutic mixtures from the preserved recipes of Krummhübel herbalists, which offers an opportunity to learn more about the real effects of the former medicines and their therapeutic activity. The obtained data can also be used to search for new drugs.

Tue describes working with investigators on the extraction and isolation of constitutents with possible antimalarial activities from Chinese herbal materials. During the first stage of their work, they investigated more than 2,000 Chinese herb preparations and identified 640 hits that had possible antimalarial activities. More than 380 extracts obtained from ~200 Chinese herbs were evaluated against a mouse model of malaria. The turning point came when an Artemisia annua L. extract showed a promising degree of inhibition against parasite growth.

For thousands of years cannabis has been valued as a versatile herbal medicine. In the twentieth century, prescription gave way to proscription. Might this ancient remedy be about to regain its healing reputation? By Stephanie Pain

Background Romanian ethnopediatrics has a long history of medicinal plant use. The main objective of the present review was to identify, collect, systematize, and prioritize the available bibliographical data related to medicinal plants traditionally used to treat various pediatric diseases in Romania during the 1860s–1970s. Methods Information was mainly obtained by manual systematic search in various relevant historical works focused on the traditional use of medicinal plants in Romania (1860s–1970s), found in the Archives of Romanian Academy Library and National Romanian Library. Results A total of 153 medicinal plants belonging to 52 families were identified as having ethnopediatric significance. The plant traditional indications, targeted body systems, parts used, and way of administration were provided. We have also proposed one index (expressed as percentage) in order to assess the ethnopediatric applicability area of species: ethnopediatric relative therapeutic versatility (ERTV), which was calculated on the basis of the number of distinct uses mentioned for a species. The species identified to have the highest ERTV scores were Dryopteris filix-mas (100%), Gratiola officinalis (85.71%), Allium sativum (71.42%), Eryngium planum (71.42%), Juglans regia (71.42%), Matricaria chamomilla (71.42%), Plantago major (71.42%). Conclusions The present study exposed for the first time to the international scientific community important ethnopediatric information contained in several local Romanian bibliographical resources that could guide the local and international researchers towards new directions of plant valorization.

Background Toward the end of the late Middle Ages and into the early modern era, a variety of elixirs and potions for longevity with claimed medical effects were advertised by pharmacists and distributed throughout Europe. At the same time, there was an increasing emergence of handwritten commonplace books of home remedies, first among the aristocrats and rich merchants, then later among other populations, providing basic recipes for all types of common medical disorders. From a historical–pharmacological perspective, this study seeks to analyze a handwritten note encompassing a recipe detailing an herbal elixir for prolonged life that was written by a Swedish physician named Germes. It was discovered by the authors in an old herbal book purchased at a flea market in Germany. The note, composed of three pages, appears to be written in a type of German cursive handwriting. One study objective was to transcribe this note into Latin alphabet-based German and then further translate the document into modern English. Furthermore, this study aimed (a) to estimate the period of the note’s creation; (b) to contextualize Germes’ recipe in history regarding the contemporary understanding of the nature and effectiveness of such formulations; (c) to assess its uniqueness, and (d) to examine the criteria used by the original practitioner, and later by consumers, in order to evaluate the efficacy of such home remedies, while also analyzing how these perceptions evolved before and after creation of the handwritten primary source.. Methods The transcription process was performed through manual reading and inputting into a word processing software, with guidance from several manuals. Historical placement of the note was achieved through the assessment of the calligraphic handwriting and analysis of terms and words that were specific for a certain time period. Contextualization was performed through a review of various primary sources on plant medicine and contemporary pharmacy. Results The analysis of the transcribed note made it possible to narrow down its creation to 1770–1820. It tells the story of Germes, whose secret elixir recipe was found in his jacket after he fatally fell off his horse at the age of 104, with his family members also living exceptionally long, which all accredits to the panacea described. The note contains accurate descriptions of its preparation and methods of administration, and Germes’ elixir can be used in the treatment of a variety of medical disorders. Several similar recipes for elixirs for longevity were identified in the literature, with a contemporary remedy called “Swedish Bitters” being nearly identical in terms of ingredient composition. The origins of “Swedish Bitters” were traced back to the late seventeenth century or early eighteenth century, where it rapidly gained popularity in the European market, particularly in Germany. This may accredit the handwritten note’s creation, modification, and embellishment through retelling.

Background This work reunites many women naturalists who registered knowledge about native flora in scientific expeditions around the globe between the seventeenth and nineteenth centuries. Since male naturalists are more recognized in this period of time, we aimed to list female naturalists that published plant descriptions and observations, focusing on the work of Maria Sibylla Merian and to analyze her trajectory as an example to discuss the patterns of the suppression of women scientists. A second aim was to inventory the useful plants described in Maria Sibylla’s Metamorphosis Insectorum Surinamensium and find pharmacological evidence about the traditional uses described for those plants cited as medicinal and toxic. Methods A survey of female naturalists was carried out by searching information in Pubmed, Scielo, Google Scholar and Virtual Health Library. Once Maria Sibylla published her book Metamorphosis Insectorum Surinamensium by her own, without male co-authors, and also this book is one of the only to have text and illustrations altogether and there are reports indicating information on useful plants in this work, she and her book were chosen as subject of this research. All the information was tabulated by dividing the plants into food, medicinal, toxic, aromatic or other uses. Finally, with the combinations of the scientific name of medicinal and toxic plants with information about their popular uses, a search was carried out in databases in order to indicate current pharmacological studies that reported evidences about the traditional uses described. Results We found 28 women naturalists who participated in scientific expeditions or trips, or in a curiosity cabinet, or who were collectors of Natural History between the seventeenth and nineteenth centuries. All these women illustrated botanical species and/or recorded their everyday or medicinal use or reported their observations in the form of a published work, letters or diaries. Also, the trajectory of Maria Sibylla Merian revealed that her scientific relevance has been neglected from the eighteenth century by mechanisms of suppression, most of the time by male depreciation, which can be seen as a pattern for suppression of women in science. However, Maria Sibyllas’ contributions have been valued again in the twenty-first century. In Maria Sibylla’s work, 54 plants were identified, 26 of them used for food, 4 of them aromatic, 8 medicinal, 4 toxic and 9 other uses. Conclusion This study evidences that there are female naturalists whose work could be an important source for ethnopharmacological studies. Researching about women scientists, talking about them and highlighting the gender bias present in the scientific academy about the way the history of science is told is essential for the construction of a more diverse and richer scientific academy. The traditional use of 7 of 8 medicinal plants and 3 of 4 toxic plants reported was correlated with pharmacological studies, highlighting the importance of this historical record and its potential to direct strategic research in traditional medicine.

Background Frederico José de Santa-Anna Nery (1848–1901) was a Brazilian Baron who referred to himself as a \"volunteer propagandist\" for Brazil in Europe, serving as an immigration agent to publicize the living conditions in the Amazon region, advocating for its development and modernization at the end of the nineteenth century. Santa-Anna Nery’s most famous book is \"Le Pays des Amazones\" (The Lands of the Amazons), first published in 1885, which the author dedicated a chapter to introduce and report on the Amazonian useful plant species and its relationship with humans. The aim of this work is to understand the historical context and ethnobotanical value of the plant species in the Brazilian Amazon at the end of the nineteenth century through an analysis of the book “Le Pays des Amazones” (1885) by Baron de Santa-Anna Nery, as well as to bring to light the historical importance of this very influential propagandist, who has been forgotten nowadays. Methods The original book “Le Pays des Amazones” (1885), as well as the original 3rd edition and its translated version into Portuguese, was carefully analyzed and all information about plants was systematized, with botanical names being updated. Finally, using the scientific name of medicinal plants alone or in combination with their traditional use, a search was carried out in databases in order to indicate current pharmacological studies that provide evidence about the described traditional uses. Results A total of 156 plant species were identified in the book, although 132 species had their scientific names updated. These species belong to 45 different families, with Fabaceae and Arecaceae the most represented, and 109 plants are Brazilian native. Considering only the 36 medicinal plants, the main medicinal indications reported were astringent, purgative/laxative, stimulant and tonic, vermifuge, febrifuge, sudorific, emetic, diuretic and antidysenteric. Regarding other useful plants (non-medicinal), 97 species were cited for food, constructions and buildings, spices and condiments, ornaments and objects, carpentry, textile fibers, gums, oils, balms and essences, pigments and tanning, hunting and fishing. Conclusions When the book “Le Pays des Amazones” is analyzed from a timeless perspective, with a particular focus on historical ethnobotany, it is possible to observe the economic, social, and political importance of many useful plants for the Amazon at the end of the nineteenth century and how the relationship between local people, indigenous communities, and immigrants was established with plant biodiversity.

In this textual comparison of seventeenth-century herbals, I show in detail that most of the descriptions and medicinal uses of English herbs included in Culpeper’s small folio The English Physitian (1652) and its enlargement of the following year were lifted straight out of the works of John Parkinson, apothecary. This was a deliberate act by Culpeper, to make available to the people of England the best information on native plant medicines for use in treating their illnesses. He attacked the College of Physicians of London, whom the great majority of the population could not afford to engage, for trying to keep this knowledge secret. Among later historians of the herbal tradition, Culpeper’s work was not accorded the same status as the great English herbals of William Turner, John Gerard, and John Parkinson, not because this borrowing was recognised but because its astrological content worked to divert attention from the quality and source of much of its guidance on treatment. Even contemporaries of Culpeper did not recognise the extent of the borrowing. Comparisons also reveal the limitations of Culpeper’s powers of plant description and his lack of interest in the developing science of botany. The editorial decisions Culpeper made to reduce a great folio herbal to a much smaller book to be sold for 3d touch on domestic and other non-medical uses, while points of discussion common to both authors such as the doctrine of signatures and superstitious beliefs about plants are explored.