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"Pies"
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When pies fly : handmade pastries from strudels to stromboli, empanadas to knishes
\"Includes many types of pastries (both homemade and store-bought), ready for the lunchbox, the dinner table, road trips, and picnics. These handy crusty offerings go from freezer to oven, and will win over everyone at the table. No one will be able to resist Sesame Chicken Hand Pies, Savory Nectarine Marscapone Tarts, Pork Pastor Empanadas, Spiced Apple Strudels, and much more. The perfect mix of nostalgic favorites and new pastry creations, WHEN PIES FLY is a wonderful dive into the world of pies in all of their forms\"--Amazon.
Book
Take It to the Next Level
For several years now I have been working to improve the energy metrics associated with refrigerated warehouses. In fact, this has been a long term fixation; the third column that I wrote in this series (Improving Efficiency, May 2012) defined efficiency as \"the ratio of 'what you want to do' to 'what you need to do.'\" I pointed out that if you are a pie maker then the suitable metric for you will be \"pies per kWh.\"
Journal Article
Rose's baking basics : 100 essential recipes, with more 600 step-by-step photos
\"Whether you're a baking enthusiast or just want to whip up the occasional treat, you will be able to ... make ... brownies, banana bread, holiday pies, birthday cakes, homemade bread, and more, with recipes including: chocolate sheet cake with ganache frosting, peanut butter and jelly thumbprints, beer bread, apple walnut muffins, peach cobbler, milk chocolate caramel tart, and more\"--Publisher marketing.
Book
Immune Resistance in Lung Adenocarcinoma
Lung cancer is the leading cancer killer worldwide, imposing grievous challenges for patients and clinicians. The incidence of lung adenocarcinoma (LUAD), the main histologic subtype of lung cancer, is still increasing in current-, ex-, and even non-smokers, whereas its five-year survival rate is approximately 15% as the vast majority of patients usually present with advanced disease at the time of diagnosis. The generation of novel drugs targeting key disease driver mutations has created optimism for the treatment of LUAD, but, as these mutations are not universal, this therapeutic line benefits only a subset of patients. More recently, the advent of targeted immunotherapies and their documented clinical efficacy in many different cancers, including LUAD, have started to change cancer management. Immunotherapies have been developed in order to overcome the cancer’s ability to develop mechanisms of immune resistance, i.e., to adapt to and evade the host inflammatory and immune responses. Identifying a cancer’s immune resistance mechanisms will likely advance the development of personalized immunotherapies. This review examines the key pathways of immune resistance at play in LUAD and explores therapeutic strategies which can unleash potent antitumor immune responses and significantly improve therapeutic efficacy, quality of life, and survival in LUAD.
Journal Article
Tiny pie
Ellie the elephant is the only kid at a party, where the food meant for the grown-ups is out of reach--but she spies a tiny chef in his mouse hole baking a small apple pie that is just the right size for her. Includes a recipe by Alice Waters for a child-size apple pie.
Book
Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management
Chronic venous disease (CVD) is a multifactorial condition affecting an important percentage of the global population. It ranges from mild clinical signs, such as telangiectasias or reticular veins, to severe manifestations, such as venous ulcerations. However, varicose veins (VVs) are the most common manifestation of CVD. The explicit mechanisms of the disease are not well-understood. It seems that genetics and a plethora of environmental agents play an important role in the development and progression of CVD. The exposure to these factors leads to altered hemodynamics of the venous system, described as ambulatory venous hypertension, therefore promoting microcirculatory changes, inflammatory responses, hypoxia, venous wall remodeling, and epigenetic variations, even with important systemic implications. Thus, a proper clinical management of patients with CVD is essential to prevent potential harms of the disease, which also entails a significant loss of the quality of life in these individuals. Hence, the aim of the present review is to collect the current knowledge of CVD, including its epidemiology, etiology, and risk factors, but emphasizing the pathophysiology and medical care of these patients, including clinical manifestations, diagnosis, and treatments. Furthermore, future directions will also be covered in this work in order to provide potential fields to explore in the context of CVD.
Journal Article