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This article explores the poetic metaphors and multi-signification in Chinua Achebe’s No Longer at Ease . The novel itself has been the focus of several readings, many of which pursue the humanistic and sociological orientations of the text as merely an instrument of communication about the post-independence sociopolitical and cultural realities of Achebe’s society. This manner of reading may be attributed to the birth of African literature and Afrocentrism, which many of the earlier writers, including Achebe, believe was a reaction to the poor Euro-American portrayal of Africa and Africans. But it forecloses the possibility of a grounded analytical methodology capable of opening up multiple possibilities of meanings in the text through the linguistic elements of literature. Relying on Paul Ricoeur’s depth semantic theory, this article explores the poetic metaphors of the text to unveil the multilayered meanings.

Coordinated rhythmic movements are ubiquitous in animal behavior. In many organisms, chains of neural oscillators underlie the generation of these rhythms. In C. elegans, locomotor wave generation has been poorly understood; in particular, it is unclear where in the circuit rhythms are generated, and whether there exists more than one such generator. We used optogenetic and ablation experiments to probe the nature of rhythm generation in the locomotor circuit. We found that multiple sections of forward locomotor circuitry are capable of independently generating rhythms. By perturbing different components of the motor circuit, we localize the source of secondary rhythms to cholinergic motor neurons in the midbody. Using rhythmic optogenetic perturbation, we demonstrate bidirectional entrainment of oscillations between different body regions. These results show that, as in many other vertebrates and invertebrates, the C. elegans motor circuit contains multiple oscillators that coordinate activity to generate behavior.

Background The receptor-like kinase FEROINA (FER) plays a crucial role in controlling plant vegetative growth partially by sensing the rapid alkalinization factor (RALF) peptide. However, the role of RALF1-FER in the vegetative-reproductive growth transition remains unknown. Here, we analyze the mechanism through which FER affects the flowering time in Arabidopsis. Results We found that the FER mRNA levels exhibit an oscillating pattern with a diurnal rhythm and that the clock oscillator CIRCADIAN CLOCK-ASSOCIATED1 ( CCA1 ) up-regulates the expression of FER by associating with its chromatin. In addition, FER expression is regulated by clock genes, and FER also modulates the expression patterns of clock genes. Consistent with its gene expression pattern, FER positively regulates flowering by modulating the transcript accumulation and mRNA alternative splicing of certain flowering-related genes, including FLOWERING LOCUS C (FLC) and its homolog MADS AFFECTING FLOWERING (MAF) . However, the RALF1 ligand negatively regulates flowering compared with FER. Conclusions We found that FER, which is up-regulated by CCA1, controls the flowering time by regulating the transcript accumulation and mRNA alternative splicing (AS) of some important flowering genes, and these findings link FER to the floral transition.

Atrial fibrillation (AF) is the most common form of cardiac arrhythmia and significantly increases the risks of morbidity, mortality and health care expenditure; however, treatment for AF remains unsatisfactory due to the complicated and incompletely understood underlying mechanisms. In the present study, weighted gene co-expression network analysis (WGCNA) was conducted to identify key modules and hub genes to determine their potential associations with AF. WGCNA was performed in an AF dataset GSE79768 obtained from the Gene Expression Omnibus, which contained data from paired left and right atria in cardiac patients with persistent AF or sinus rhythm. Differentially expressed gene (DEG) analysis was used to supplement and validate the results of WGCNA. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were also performed. Green and magenta modules were identified as the most critical modules associated with AF, from which 6 hub genes, acetyl-CoA Acetyltransferase 1, death domain-containing protein CRADD, gypsy retrotransposon integrase 1, FTX transcript, XIST regulator, transcription elongation factor A like 2 and minichromosome maintenance complex component 3 associated protein, were hypothesized to serve key roles in the pathophysiology of AF due to their increased intramodular connectivity. Functional enrichment analysis results demonstrated that the green module was associated with energy metabolism, and the magenta module may be associated with the Hippo pathway and contain multiple interactive pathways associated with apoptosis and inflammation. In addition, the blue module was identified to be an important regulatory module in AF with a higher specificity for the left atria, the genes of which were primarily correlated with complement, coagulation and extracellular matrix formation. These results suggest that may improve understanding of the underlying mechanisms of AF, and assist in identifying biomarkers and potential therapeutic targets for treating patients with AF.

In her excellent volume Open Socrates: The Case for a Philosophical Life, Agnes Callard juxtaposes Socrates’s conclusion that the meaningfulness of life is a function of consistent critical inquiry into existence with Leo Tolstoy’s contrary insistence that existential meaning ensues from living life without constant interruptions of self-reflection. These two perspectives functionally identify the tension between whether individuals may linguistically express opinions on truth and meaning or must negotiate in some manner with an inescapable silence regarding how best to comprehend and communicate discrete interpretations of the significance and veracity of lived experience. This present article investigates that tension and how it depends on the poetic and apophatic characteristics of language to both Say and Unsay how meaning and truth may be conceived. Salient positions from Ludwig Wittgenstein and William Franke provide introductory material to set the context for a closer examination of the complementary hermeneutics of the French philosopher Paul Ricoeur and the American poet Wallace Stevens. Both thinkers concur that properly analyzing meaning and truth requires a reliance on the creative imagination with its privileging of poetic language and its dependence on the humility of an incredulous faith in approximating an operative asymptotic approach to existential meaning.

Classical Arabic poetry played a powerful social role in Arab society, particularly during the Jāhiliyya (pre-Islamic) period, due to its high level of eloquence (faṣāḥa) and balāgha. Within this poetic tradition—shaped around themes such as heroism (ḥamāsah), boasting (fakhr), satire (hijā’), and love (tashbīb)—‘aṣabiyya occupied a central position as a means of constructing and preserving tribal identity through language. Poets exalted their own tribes and disparaged rival ones by employing persuasive and emotionally charged expression. With the revelation of the Qur’an in 610 CE, this literary and cultural heritage, grounded in aesthetic and expressive power, was reconfigured within a new religious framework. The Qur’an’s challenge-oriented discourse entered into direct interaction with existing poetic sensibilities. Against this background, the present study examines the transformation of ‘aṣabiyya in classical Arabic poetry during the early Islamic period. It offers a comparative analysis of lineage-centered ‘aṣabiyya in Jāhiliyya poetry and the emergence of an ummah-centered discourse of unity in Islamic poetry, drawing on poems by different poets from both periods. Using content analysis, rhetorical text analysis, and inductive methods, the study demonstrates that the Qur’an’s influence on Arabic poetry was neither uniform nor one-dimensional but significantly shaped poetic themes and authorial attitudes. By focusing on ‘aṣabiyya, the article aims to contribute to a renewed understanding of the Qur’an–poetry relationship in early Islam.

This paper reconfigures the theme of divine encounters in the literature by examining the intersection of pantheism, vitalism, and ecological imagination, with a particular focus on Percy Bysshe Shelley. Far from depicting the divine as transcendent, Shelley envisions it as an immanent force permeating nature, matter, and life itself. In poems such as “Queen Mab”, “Mont Blanc”, “Hymn to Intellectual Beauty”, “Ode to the West Wind”, or “The Cloud” Shelley translates vitalist science into poetic vision, challenging orthodox religious beliefs and contemplating the divine as inherent in natural processes. The study also situates Shelley’s thought within a broader genealogy that extends through John Ruskin’s vitalist aesthetics, Henri Bergson’s élan vital, and into contemporary posthumanist philosophy, neomaterialism and ecocriticism, along with scholars who have contributed to reviving and transforming vitalist traditions, reframing human-nonhuman relations in the Anthropocene. The paper shows the importance of the Romantic period in the development of vitalist approaches in various fields of knowledge, anticipating ecological concerns. The study is framed as a genealogical and epistemological problem attempting to articulate connections while situating poetic practice as a privileged site where vitalism is negotiated.