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Poppy
Few weeds have been more successful throughout history than the poppy. Hated by farmers for its stubbornness, the poppy has been a favorite of artists and poets, due to its distinct and brilliant color, and it has functioned symbolically as everything from a war memorial to an emblem of the exotic cultures of the East. In this book, Andrew Lack explores all the aspects of one of our most familiar flowers, combining biology, history, and culture to paint a bright portrait of this fascinating plant. Lack looks deep into the past of the poppy's ancient history-before it seemed to inhabit only ditches and cornfields-and examines the biology that gives it its unique coloring. He analyzes the poppy's many members of this beautiful family, including the opium poppy, which is the source of one of the world's oldest-and most ravaging-narcotics. He describes how the poppy came to be associated with war and remembrance, and he looks at how they have been used to commemorate everything from weddings to funerals. Beautifully illustrated, the book will appeal to gardeners or anyone fascinated by the way plants have so powerfully figured in human culture and traditions.
eBook
Comparison of direct analysis in real-time mass spectrometry, atmospheric solids analysis probe–mass spectrometry, and ion mobility spectrometry for ensuring food safety by rapid screening of poppy seeds
The opium poppy (Papaver somniferum) is a global commercial crop that has been historically valued for both medicinal and culinary purposes. Naturally occurring opium alkaloids including morphine, codeine, thebaine, noscapine, and papaverine are found primarily in the latex produced by the plant. If the plant is allowed to fully mature, poppy seeds that do not contain the opium alkaloids will form within the pods and may be used in the food industry. It is possible for the seeds to become contaminated with alkaloids by the latex during harvesting, posing a potential health risk for consumers. In the USA, there have been more than 600 reported adverse events including 19 fatalities that may be linked to the consumption of a contaminated poppy-containing product such as home-brewed poppy seed tea. Unwashed poppy seeds and pods may be purchased over the Internet and shipped worldwide. The Forensic Chemistry Center, US Food and Drug Administration (FDA) has evaluated several mass spectrometers (MS) capable of rapid screening to be used for high-throughput analysis of samples such as poppy seeds. These include a direct analysis in real-time (DART) ambient ionization source coupled to a single-quadrupole MS, an atmospheric solids analysis probe (ASAP) ionization source coupled to the same MS, and ion mobility spectrometers (IMS). These instruments have been used to analyze 17 poppy seed samples for the presence of alkaloids, and the results were compared to data obtained using liquid chromatography with mass spectral detection (LC–MS/MS). Results from the 17 poppy seed samples indicate that the DART-MS, ASAP-MS, and IMS devices detect many of the same alkaloids confirmed during the LC–MS/MS analyses, although both the false-positive and false-negative rates are higher, possibly due to the non-homogeneity of the samples and the lack of chromatographic separation.
Journal Article
Poppies : blood swept lands and seas of red
The major art installation Blood Swept Lands and Seas of Red at the Tower of London marked one hundred years since the first full day of Britain's involvement in the First World War. Created by artists Paul Cummins and Tom Piper, 888,246 ceramic poppies progressively filled the Tower's famous moat between 17 July and 11 November 2014. Each poppy represented a British military fatality during the war. The poppies encircled the iconic landmark, creating a spectacular display visible from all around the Tower, which attracted more than 5 million visitors. The scale of the installation was intended to reflect the magnitude of such an important centenary and create a powerful visual commemoration. Featuring forewords by Paul Cummins and Tom Piper and stunning photography of the installation, The Poppies: Blood Red Lands and Seas of Red is the only official publication to mark this landmark event. As thousands of the poppies used in the installation tour the country during the remainder of the First World War Centenary, this publication will undoubtedly prove popular with visitors to both the Tower and the new venues alike.
BOOK
Complete biosynthesis of opioids in yeast
Opioids are the primary drugs used in Western medicine for pain management and palliative care. Farming of opium poppies remains the sole source of these essential medicines, despite diverse market demands and uncertainty in crop yields due to weather, climate change, and pests. We engineered yeast to produce the selected opioid compounds thebaine and hydrocodone starting from sugar. All work was conducted in a laboratory that is permitted and secured for work with controlled substances. We combined enzyme discovery, enzyme engineering, and pathway and strain optimization to realize full opiate biosynthesis in yeast. The resulting opioid biosynthesis strains required the expression of 21 (thebaine) and 23 (hydrocodone) enzyme activities from plants, mammals, bacteria, and yeast itself. This is a proof of principle, and major hurdles remain before optimization and scale-up could be achieved. Open discussions of options for governing this technology are also needed in order to responsibly realize alternative supplies for these medically relevant compounds.
Journal Article
Corn poppy, Papaver rhoeas L.: a critical review of its botany, phytochemistry and pharmacology
Papaver rhoeas
L. (Papaveraceae), commonly known as corn poppy, is a cosmopolitan weed and edible plant capable of possessing biological properties, thus positive correlating with human health. The plant is also known as field poppy, flanders poppy or shirley poppy. It can be consumed raw or cooked, and has been traditionally used to treat nervousness, insomnia, digestive and respiratory disorders, baldness, eye infections, as well as measles treatment. This paper is aimed to contribute to the knowledge of corn poppy by providing a critical review of the botanic characteristics, the traditional uses, the plant chemistry and pharmacology.
Journal Article
Pattern-triggered immunity in blue and white seed cultivars of Papaver somniferum
Abstract
Papaver somniferum (poppy) is a traditional ingredient in Central and Eastern European cuisine and an important oilseed crop of the region. Since the main threat to stable poppy yield is pathogen infection, a detailed understanding of its defence mechanism is essential. The first robust layer of plant immunity, which plays a crucial role in combating pathogens, is pattern-triggered immunity (PTI). Here, we provide the first comprehensive insights into PTI in poppy. We selected four poppy varieties used in the food industry and investigated their response to various previously described peptide elicitors. Among all tested peptides, flg22 induced the most robust reactive oxygen species (ROS) burst, as well as triggering putative mitogen-activated protein kinase phosphorylation and seedling growth inhibition in all selected cultivars. We identified PsWRKY22 and PsPR2 as candidate marker genes suitable for monitoring poppy PTI responses. The tested poppy cultivars have low levels of salicylic acid. Callose accumulation was triggered by wounding but not by flg22. When studying PTI in plants, wounding is a challenge that needs to be considered, as it can obscure potential PTI responses. Our findings highlight conserved aspects of poppy immunity and the challenges of studying its PTI. The established pipeline facilitates improving our understanding of poppy immunity and has the potential for widespread application in breeding and improving selection for broad-spectrum disease resistance provided by enhanced PTI.
This study reveals how poppy plants activate immune defences against pathogens, focusing on pattern-triggered immunity (PTI). By testing four food-grade poppy varieties on the response to known immune-triggering peptides, we found that the peptide flg22 consistently activated robust immune responses, including oxidative bursts and growth inhibition. We identified two poppy genes, PsWRKY22 and PsPR2, as reliable markers of PTI. Interestingly, poppy plants showed low levels of salicylic acid and did not accumulate callose in response to flg22, highlighting unique aspects of poppy immunity. The findings offer a valuable framework for breeding poppy varieties with improved disease resistance.
Journal Article
Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein
Morphinan alkaloids from the opium poppy are used for pain relief. The direction of metabolites to morphinan biosynthesis requires isomerization of (S)- to (R)-reticuline. Characterization of high-reticuline poppy mutants revealed a genetic locus, designated STORR [(S)- to (R)-reticuline] that encodes both cytochrome P450 and oxidoreductase modules, the latter belonging to the aldo-keto reductase family. Metabolite analysis of mutant alleles and heterologous expression demonstrate that the P450 module is responsible for the conversion of (S)-reticuline to 1,2-dehydroreticuline, whereas the oxidoreductase module converts 1,2-dehydroreticuline to (R)-reticuline rather than functioning as a P450 redox partner. Proteomic analysis confirmed that these two modules are contained on a single polypeptide in vivo. This modular assembly implies a selection pressure favoring substrate channeling. The fusion protein STORR may enable microbial-based morphinan production.
Journal Article
Design and Optimisation of Sustainable Sample Treatments Based on Ultrasound-Assisted Extraction and Strong Cation-Exchange Purification with Functionalised SBA-15 for Opium Alkaloids in Ground Poppy Seeds
An analysis methodology was optimised and validated for the quantification of opium alkaloids (OAs) in ground poppy seeds. This involved ultrasound-assisted extraction (UAE) and solid-phase extraction (SPE) purification before analysis using a high-performance liquid chromatography mass spectrometry detector (HPLC-MS/MS). UAE was optimised through the design of experiments with three factors and a three-level full factorial design. For SPE optimisation, a commercial material was compared with a previously synthesised material of SBA-15 silica functionalised with sulfonic groups (SBA-15-SO3−). The synthesised material demonstrated superior efficiency with only 25 mg and proved to be reusable for up to four cycles. The methodology was properly validated in terms of linearity, limits of detection and quantification, and selectivity. Matrix effects were negligible; adequate recovery values (85–100%) and inter-day and intra-day precision (≤15%) were obtained. The greenness of the method was evaluated with the AGREEprep metric scale, being more environmentally friendly compared to OA analysis methods. Finally, the method was applied to different samples of ground poppy seeds and revealed a concentration of 140 mg/kg of morphine equivalents in one of the samples, surpassing the legislatively established limits by sevenfold. This highlights the need to analyse these types of samples to mitigate potential public health issues.
Journal Article