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This study aimed at examining the reliability and validity of the Adverse Competition-related Cognitions Questionnaire (ACCQ) in an English-speaking sample of athletes. The ACCQ is a performance-focused measure that captures six different areas of adverse competition-related cognitions– athletic comparison, coach devaluation, devaluation of one’s own performance, appreciation by coach and family, inner resistance against competitions, and general exhaustion. Data from 278 athletes ( M age = 27.64, age range = 16–68 years) from different sports were collected and subjected to confirmatory factor analysis, which confirmed the 6-factor solution of the translated ACCQ (CFI = 0.915; RMSEA = 0.056). In addition, the different subscales of the ACCQ showed sufficient internal consistency (Cronbach’s alpha > 0.60). Furthermore, we examined the relationships with cognitive interference, satisfaction in three different domains (i.e., general in life, sporting development, and athletic performance) and athletes’ subjective performance evaluations (i.e., performance and peak performance in the previous season and confidence in achieving their goals in the upcoming season). Results indicated positive correlations with athletes’ cognitive interference (i.e., construct validity in terms of a nomological network), low negative relations with athletes’ satisfaction in the three different domains and with the three parameters of subjective performance evaluation (i.e., concurrent validity). Implications of these findings and perspectives for future research are discussed.

In youth, ADHD is more commonly diagnosed in males than females, but higher male-to-female ratios are found in clinical versus population-based samples, suggesting a sex bias in the process of receiving a clinical diagnosis of ADHD. This study investigated sex differences in the severity and presentation of ADHD symptoms, conduct problems, and learning problems in males and females with and without clinically diagnosed ADHD. We then investigated whether the predictive associations of these symptom domains on being diagnosed and treated for ADHD differed in males and females. Parents of 19,804 twins (50.64% male) from the Swedish population completed dimensional assessments of ADHD symptoms and co-occurring traits (conduct and learning problems) when children were aged 9 years. Children from this population sample were linked to Patient Register data on clinical ADHD diagnosis and medication prescriptions. At the population level, males had higher scores for all symptom domains (inattention, hyperactivity/impulsivity, conduct, and learning problems) compared to females, but similar severity was seen in clinically diagnosed males and females. Symptom severity for all domains increased the likelihood of receiving an ADHD diagnosis in both males and females. Prediction analyses revealed significant sex-by-symptom interactions on diagnostic and treatment status for hyperactivity/impulsivity and conduct problems. In females, these behaviours were stronger predictors of clinical diagnosis (hyperactivity/impulsivity: OR 1.08, 95% CI 1.01, 1.15; conduct: OR 1.43, 95% CI 1.09, 1.87), and prescription of pharmacological treatment (hyperactivity/impulsivity: OR 1.24, 95% CI 1.02, 1.50; conduct: OR 2.20, 95% CI 1.05, 4.63). Females with ADHD may be more easily missed in the ADHD diagnostic process and less likely to be prescribed medication unless they have prominent externalising problems.

Background Although regular participation in physical activity (PA) has health benefits across the life span, the proportion of people doing sufficient activity for these benefits decreases with age. The aim of this study was to identify motivating factors and context preferences for PA in people in their sixties, and to examine gender differences in these factors. Methods Data were used from people aged 60–67 years who responded to a mail survey in Brisbane, Australia, in 2009. Respondents indicated their agreement/disagreement with seven PA motivators and 14 PA context preferences. Data were analyzed using multi-level multinomial logistic regression, adjusted for sociodemographic and health variables, and PA level. Results Of the 1845 respondents, 59% was female. Based on self-reported PA, one in three respondents (35%) did not meet the PA guidelines of at least 150 min of moderate intensity PA per week. The three leading motivating factors for both women and men were to prevent health problems, to feel good and to lose weight. Women were more likely than men to be motivated by improving appearance (OR 2.93, 95%CI 2.07–4.15), spending time with others (1.76, 1.31–2.37), meeting friends (1.76, 1.31–2.36) or losing weight (1.74, 1.12–2.71). The three leading context preferences for both women and men were for activities close to home, at low cost and that could be done alone. Women were more likely than men to prefer activities that are with people of the same sex (OR 4.67, 95%CI 3.14–6.94), supervised (2.79, 1.94–4.02), with people the same age (2.00, 1.43–2.78) and at a fixed time (1.42, 1.06–1.91). Women were less likely than men to prefer activities that are competitive (OR 0.32, 95%CI 0.22–0.46), are vigorous (0.33, 0.24–0.47), require skill and practice (0.40, 0.29–0.55) and done outdoors (0.51, 0.30–0.86). Conclusion Although there was overlap in motivating factors and context preferences for PA in women and men aged 60–67 years, there were also marked gender differences. These results suggest that PA options for people in their sixties should be tailored to meet gender specific interests in order to promote PA participation in this rapidly growing population group.

Retrotransposable elements (RTEs) have been implicated in the pathogenesis of several age‐associated diseases. Although model systems indicate that age‐ and sex‐dependent loss of heterochromatin increases RTE expression, data from large human studies are lacking. Here we assessed the expression levels of 795 blood RTE subfamilies in 2467 participants of the population‐based Rhineland Study. We found that the expression of more than 98% of RTE subfamilies increased with both chronological and biological age. Moreover, the expression of heterochromatin regulators involved in RTE silencing was negatively related to the expression of 690 RTE subfamilies. Finally, we observed sex differences in 42 RTE subfamilies, with higher expression in men. The genes mapped to sex‐related RTEs were enriched in immune response‐related pathways. Importantly, we validated our key findings in an independent population‐based cohort. Our findings indicate that RTEs and their repressors are markers of aging and that their dysregulation is linked to inflammation, especially in men. Retrotransposable element (RTE) expression increases with chronological and biological age and is negatively associated with heterochromatin regulators. Moreover, RTE expression shows sex‐specific differences, with higher levels in men and enrichment for immune‐related pathways. Our findings highlight RTEs as aging markers and suggest their dysregulation contributes to inflammation, particularly in men.

Background Using the published survival statistics from cancer registration or population‐based studies, we aimed to describe the global pattern and trend of lung cancer survival. Methods By searching SinoMed, PubMed, Web of Science, EMBASE, and SEER, all survival analyses from cancer registration or population‐based studies of lung cancer were collected by the end of November 2022. The survival rates were extracted by sex, period, and country. The observed, relative, and net survival rates of lung cancer were applied to describe the pattern and time changes from the late 1990s to the early 21st century. Results Age‐standardized 5‐year relative/net survival rate of lung cancer was typically low, with 10%–20% for most regions. The highest age‐standardized relative/net survival rate was observed in Japan (32.9%, 2010–2014), and the lowest was in India (3.7%, 2010–2014). In most countries, the five‐year age‐standardized relative/net survival rates of lung cancer were higher in females and younger people. The patients with adenocarcinoma had a better prognosis than other groups. In China, the highest 5‐year overall relative/net survival rates were 27.90% and 31.62% in men and women in Jiangyin (2012–2013). Conclusion Over the past decades, the prognosis of lung cancer has gradually improved, but significant variations were also observed globally. Worldwide, a better prognosis of lung cancer can be observed in females and younger patients. It is essential to compare and evaluate the histological or stage‐specific survival rates of lung cancer between different regions in the future. This study collected globally published data on observed and relative survival rates of lung cancer from population‐based cancer registration. Over the past decades, the prognosis of lung cancer has gradually improved. However, region, period, sex, and age might affect the survival rate of lung cancer patients. The observed and relative survival rate of lung cancer patients varies greatly among different histological types and stages.

Abstract A sex- and gender-informed perspective increases rigor, promotes discovery, and expands the relevance of biomedical research. In the current era of accountability to present data for males and females, thoughtful and deliberate methodology can improve study design and inference in sex and gender differences research. We address issues of motivation, subject selection, sample size, data collection, analysis, and interpretation, considering implications for basic, clinical, and population research. In particular, we focus on methods to test sex/gender differences as effect modification or interaction, and discuss why some inferences from sex-stratified data should be viewed with caution. Without careful methodology, the pursuit of sex difference research, despite a mandate from funding agencies, will result in a literature of contradiction. However, given the historic lack of attention to sex differences, the absence of evidence for sex differences is not necessarily evidence of the absence of sex differences. Thoughtfully conceived and conducted sex and gender differences research is needed to drive scientific and therapeutic discovery for all sexes and genders. A review of study motivation, subject selection, sample size, data collection, analysis, and interpretation in sex and gender differences research for basic, clinical, and population studies is provided.

This review will describe the global patterns and trends of colorectal cancer survival, using data from the population-based studies or cancer registration. We performed a systematic search of China National Knowledge Infrastructure (CNKI), Wanfang Data, PubMed, Web of Science, EMBASE, and SEER and collected all population-based survival studies of colorectal cancer (up to June 2020). Estimates of observed and relative survival rates of colorectal cancer by sex, period, and country were extracted from original studies to describe the temporal patterns and trends from the late 1990s to the early 21st century. Globally, 5-year observed survival rates were higher in Seoul, Republic of Korea (1993–1997; 56.8% and 54.3% for colon and rectum cancers, respectively), Zhejiang province (2005–2010; 52.9% for colon cancer), Tianjin (1991–1999; 52.5% for colon cancer), Shanghai (2002–2006; 50.0% for rectum cancer) of China, and in Japan (1993–1996, 59.6% for colorectal cancer). Five-year relative survival rates of colorectal cancer in the Republic of Korea (2010–2014), Queensland, Australia (2005–2012), and the USA (2005–2009) ranked at relatively higher positions compared to other countries. In general, colorectal cancer survival rates are improving over time worldwide. Sex disparities in survival rates were also observed in the colon, rectum, and colorectal cancers in most countries or regions. The poorest age-specific 5-year relative survival rate was observed in patients > 75 years of age. In conclusion, over the past 3 decades, colorectal cancer survival has gradually improved. Geographic variations, sex differences, and age gradients were also observed globally in colorectal cancer survival. Further studies are therefore warranted to investigate the prognostic factors of colorectal cancer.

BackgroundThis study explored the global burden of esophageal cancer mortality and temporal trends, with a focus on premature populations aged 30-69 years.MethodsEsophageal cancer mortality data for premature populations was extracted from the World Health Organisation’s Global Cancer Observatory (GLOBOCAN) database. The age-standardised mortality rate (ASR) was used to demonstrate the cancer mortality burden. The average annual percentage change (AAPC) and 95% confidence intervals (CI) were calculated using the joinpoint regression model to assess temporal trends.ResultsIn 2022, the global ASR of esophageal cancer for the premature population was 6.8 per 100,000 persons. The ASR was considerably higher in males than females (10.4 vs. 3.4). Medium HDI regions had the highest ASR of 9.7, compared to low, high and very high human development regions (7.1, 6.7 and 3.9, respectively). Temporal trend analysis revealed an overall decline in esophageal cancer mortality in premature populations across most countries. However, some countries demonstrated a clear increase, such as Iran (AAPC: 22.19, 95% CI: 11.08 to 34.42, p<0.001), Antigua and Barbuda (AAPC: 17.43, 95% CI: 14.04 to 20.92, p<0.001), and Greece (AAPC: 16.46, 95% CI: 6.70 to 27.11, p=0.001). While premature male deaths showed a mixed trend, premature female deaths underwent a drastic decline. In the older population, Iran (AAPC: 35.10, 95% CI: 11.15 to 35.10, p<0.001) displayed the most significant increase in esophageal cancer mortality, whereas Greece (AAPC: 49.21, 95% CI: 4.80 to 49.21) showed the greatest increase in the younger population.ConclusionsEsophageal cancer mortality in premature populations has declined globally in the past decade, particularly among females. However, significant regional variations were observed, with certain populations experiencing increasing trends in esophageal cancer mortality in premature populations.

The prevalence of mental disorders among Black, Latino, and Asian adults is lower than among Whites. Factors that explain these differences are largely unknown. We examined whether racial/ethnic differences in exposure to traumatic events (TEs) or vulnerability to trauma-related psychopathology explained the lower rates of psychopathology among racial/ethnic minorities. We estimated the prevalence of TE exposure and associations with onset of DSM-IV depression, anxiety and substance disorders and with lifetime post-traumatic stress disorder (PTSD) in the Collaborative Psychiatric Epidemiology Surveys, a national sample (N = 13 775) with substantial proportions of Black (35.9%), Latino (18.9%), and Asian Americans (14.9%). TE exposure varied across racial/ethnic groups. Asians were most likely to experience organized violence - particularly being a refugee - but had the lowest exposure to all other TEs. Blacks had the greatest exposure to participation in organized violence, sexual violence, and other TEs, Latinos had the highest exposure to physical violence, and Whites were most likely to experience accidents/injuries. Racial/ethnic minorities had lower odds ratios of depression, anxiety, and substance disorder onset relative to Whites. Neither variation in TE exposure nor vulnerability to psychopathology following TEs across racial/ethnic groups explained these differences. Vulnerability to PTSD did vary across groups, however, such that Asians were less likely and Blacks more likely to develop PTSD following TEs than Whites. Lower prevalence of mental disorders among racial/ethnic minorities does not appear to reflect reduced vulnerability to TEs, with the exception of PTSD among Asians. This highlights the importance of investigating other potential mechanisms underlying racial/ethnic differences in psychopathology.

Background The aim of this work was to study potential gender differences in perceived food healthiness and food avoidance in a population-representative sample of the Swedish adult population. Methods A questionnaire regarding diet and health was posted to 2000 randomly selected residents in Sweden, aged 20–65 years. Questions were posed regarding which foods or food components the participants avoided due to perceived unhealthiness and how healthy they believed the food items to be. The pre-specified food components included sugar, carbohydrate, gluten, lactose, dairy, fat, saturated fat, red meat, white flour, salt, alcohol and food additives (specifically glutamate, sweetening, preservative and coloring agents). Chi square tests were used to study differences in perceived food healthiness and food avoidance depending on gender. Results Around 50% reported avoidance of sugar (51.6%) and sweeting agents (45.2%), whereas fewer reported avoidance of saturated fat (16.8%) and salt (10.6%). Women were more likely than men to avoid gluten (AOR [95% CI] 2.84 [1.33–6.05]), red meat (3.29 [1.86–5.80]), white flour (2.64 [1.65–4.21]), preservatives (1.7 [1.07–2.70]) and coloring agents (2.10 [1.29–3.41]) due to perceived unhealthiness. Gender differences were also apparent in perceived healthiness of sugar, gluten, dairy, red meat, white flour, alcohol and food additives, where women tended to be more negative than men in their attitudes. Women more often said to read new findings in media about diet (16% vs 9%, p  = 0.029) and prioritize a healthy lifestyle (35% vs 25%, p  = 0.015). More than a third of both women and men reported worrying over the healthiness of their diet, and a higher proportion of women than men (18% vs 11%, p  = 0.015) agreed with the statement that they were often anxious over having an unhealthy diet. Conclusions Women in this population-based study of residents in Sweden were more likely than men to avoid eating gluten, red meat, white flour and food additives due to perceived unhealthiness, and reported more diet and health related anxiety. Future research to identify effective ways of promoting healthy eating for both women and men, while minimizing diet-health related anxiety, is highly warranted.