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In this work, we present an ecofriendly, non-hazardous, green synthesis of zinc oxide nanoparticles (ZnO NPs) by leaf extract of Crotalaria verrucosa (C. verrucosa). Total phenolic content, total flavonoid and total protein contents of C. verrucosa were determined. Further, synthesized ZnO NPs was characterized by UV–visible spectroscopy (UV-vis), X-ray diffractometer (XRD), Fourier transform infra-red (FTIR) Spectra, transmission electron microscope (TEM), and Dynamic light scattering (DLS) analysis. UV-vis shows peak at 375 nm which is unique to ZnO NPs. XRD analysis demonstrates the hexagonal phase structures of ZnO NPs. FTIR spectra demonstrates the molecules and bondings associated with the synthesized ZnO NPs and assures the role of phytochemical compounds of C. verrucosa in reduction and capping of ZnO NPs. TEM image exhibits that the prepared ZnO NPs is hexagonal shaped and in size ranged between 16 to 38 nm which is confirmed by DLS. Thermo-gravimetric analysis (TGA) was performed to determine the thermal stability of biosynthesized nanoparticles during calcination. The prepared ZnO NPs showed significant antibacterial potentiality against Gram-positive (S. aureus) and Gram-negative (Proteus vulgaris, Klebsiella pneumoniae, and Escherichia coli) pathogenic bacteria and SEM image shows the generalized mechanism of action in bacterial cell after NPs internalization. In addition, NPs are also found to be effective against the studied cancer cell lines for which cytotoxicity was assessed using MTT assay and results demonstrate highest growth of inhibition at the concentration of 100 µg/mL with IC50 value at 7.07 µg/mL for HeLa and 6.30 µg/mL for DU145 cell lines, in contrast to positive control (C. verrucosa leaf extract) with IC50 of 22.30 µg/mL on HeLa cells and 15.72 µg/mL on DU145 cells. Also, DAPI staining was performed in order to determine the effect on nuclear material due to ZnO NPs treatment in the studied cell lines taking leaf extract as positive control and untreated negative control for comparison. Cell migration assay was evaluated to determine the direct influence of NPs on metastasis that is potential suppression capacity of NPs to tumor cell migration. Outcome of the synthesized ZnO NPs using C. verrucosa shows antimicrobial activity against studied microbes, also cytotoxicity, apoptotic mediated DNA damage and antiproliferative potentiality in the studied carcinoma cells and hence, can be further used in biomedical, pharmaceutical and food processing industries as an effective antimicrobial and anti-cancerous agent.

Cladosporium, a genus of ascomycete fungi in the Dematiaceae family, is primarily recognized as a widespread environmental saprotrophic fungus or plant endophyte. Further research has shown that the genus is distributed in various environments, particularly in marine ecosystems, such as coral reefs, mangroves and the polar region. Cladosporium, especially the marine-derived Cladosporium, is a highly resourceful group of fungi whose natural products have garnered attention due to their diverse chemical structures and biological activities, as well as their potential as sources of novel leads to compounds for drug production. This review covers the sources, distribution, bioactivities, biosynthesis and structural characteristics of compounds isolated from Cladosporium in the period between January 2000 and December 2022, and conducts a comparative analysis of the Cladosporium isolated compounds derived from marine and terrestrial sources. Our results reveal that 34% of Cladosporium-derived natural products are reported for the first time. And 71.79% of the first reported compounds were isolated from marine-derived Cladosporium. Cladosporium-derived compounds exhibit diverse skeletal chemical structures, concentrating in the categories of polyketides (48.47%), alkaloids (19.21%), steroids and terpenoids (17.03%). Over half of the natural products isolated from Cladosporium have been found to have various biological activities, including cytotoxic, antibacterial, antiviral, antifungal and enzyme-inhibitory activities. These findings testify to the tremendous potential of Cladosporium, especially the marine-derived Cladosporium, to yield novel bioactive natural products, providing a structural foundation for the development of new drugs.

The origin and basis of the notion of quantum contextuality is identified in the Copenhagen approach to quantum mechanics, where context is automatically invoked by its requirement that the experimental arrangement involved in any measurements or set of measurements be taken into account while, in general, the outcome of a measurement may depend on other measurements immediately preceding or jointly performed on the same system. For Bohr, the specification of the experimental situation of any measurement is essential to its significance in light of complementarity and the omnipresence of the quantum of action in physics; for Heisenberg, the incompatibility of pairs of sharp measurements belonging to different situations coheres with both the completeness of the quantum state as an objective physical description and the principle of indeterminacy. Here, context in the Copenhagen approach is taken to be the equivalence class of experimental arrangements corresponding to a set of compatible measurements of quantum observables in standard quantum mechanics; the associated form of contextuality in quantum mechanics arises via the non-commutativity in general of sharp observables, proven by von Neumann, that can appear, providing different contexts. This notion is related to theoretical situations explored later by Bell, by Kochen and Specker, and by others in relation to the classification of hidden-variables theories and elsewhere in physics. This article is part of the theme issue ‘Contextuality and probability in quantum mechanics and beyond’.

The aim of the study was to estimate future groundwater potential zones based on machine learning algorithms and climate change scenarios. Fourteen parameters (i.e., curvature, drainage density, slope, roughness, rainfall, temperature, relative humidity, lineament density, land use and land cover, general soil types, geology, geomorphology, topographic position index (TPI), topographic wetness index (TWI)) were used in developing machine learning algorithms. Three machine learning algorithms (i.e., artificial neural network (ANN), logistic model tree (LMT), and logistic regression (LR)) were applied to identify groundwater potential zones. The best-fit model was selected based on the ROC curve. Representative concentration pathways (RCP) of 2.5, 4.5, 6.0, and 8.5 climate scenarios of precipitation were used for modeling future climate change. Finally, future groundwater potential zones were identified for 2025, 2030, 2035, and 2040 based on the best machine learning model and future RCP models. According to findings, ANN shows better accuracy than the other two models (AUC: 0.875). The ANN model predicted that 23.10 percent of the land was in very high groundwater potential zones, whereas 33.50 percent was in extremely high groundwater potential zones. The study forecasts precipitation values under different climate change scenarios (RCP2.6, RCP4.5, RCP6, and RCP8.5) for 2025, 2030, 2035, and 2040 using an ANN model and shows spatial distribution maps for each scenario. Finally, sixteen scenarios were generated for future groundwater potential zones. Government officials may utilize the study’s results to inform evidence-based choices on water management and planning at the national level.

Advances in low-dimensions nanomaterials drug-carrier have rapidly translated into clinical practice. Interestingly, the two-dimensional (2D) nanomaterials of hexagonal boron nitride (h-BN), so-called \"white graphite\" are relatively less explored compared to the post popular 2D graphene oxide (GO). However, the unique properties of h-BN nanomaterials make them well suited for the delivery of chemotherapeutic in cancer treatment. Recent studies have shown that the h-BN is a potential candidate in biomedical sciences, both as nanocarriers and nano-transducers. In this review, we discuss the various physicochemical properties and important concepts involved in h-BN nanosheets as anticancer drug carriers.

Actinomycetes are currently one of the major sources of bioactive secondary metabolites used for medicine development. Accumulating evidence has shown that Nocardiopsis, a key class of actinomycetes, has the ability to produce novel bioactive natural products. This review covers the sources, distribution, bioactivities, biosynthesis, and structural characteristics of compounds isolated from Nocardiopsis in the period between March 2018 and 2021. Our results reveal that 67% of Nocardiopsis-derived natural products are reported for the first time, and 73% of them are isolated from marine Nocardiopsis. The chemical structures of the Nocardiopsis-derived compounds have diverse skeletons, concentrating on the categories of polyketides, peptides, terphenyls, and alkaloids. Almost 50% of the natural products isolated from Nocardiopsis have been discovered to display various bioactivities. These results fully demonstrate the great potential of the genus Nocardiopsis to produce novel bioactive secondary metabolites that may serve as a structural foundation for the development of novel drugs.

This study presents an integrated 3D structural modelling workflow as a quantitative framework for applying advanced geological understanding to the spatial distribution of discrete and continuous reservoir properties of the underexplored, structurally complex Nukhul Formation in the October Oil Field. The updated 3D structural model was constructed by integrating high-resolution seismic interpretation with multidisciplinary subsurface datasets, including electric logs, detailed stratigraphic correlations, petrophysical evaluation, and production performance data from drilled wells. The current study specifically evaluates the structural controls on reservoir distribution and trapping styles within the field by combining 3D seismic interpretation with well-log and core-derived information. The refined model reveals a fault architecture dominated by a NNW–SSE (Clysmic) trend, with major faults dipping south-southwest (SSW) and horizons oriented northeast (NE), as determined from dipmeter data and seismic interpretation. The Nukhul reservoir is defined by a three-way dip closure, bounded by fault-dependent seals, where sealing capacity is governed by fault throw that juxtaposes permeable sand layers against impermeable lithologies. This configuration effectively inhibits cross-fault hydrocarbon migration, preserving attic accumulations. By integrating geological, geophysical, and petrophysical datasets, the new model significantly improves the delineation of attic targets, fault-bounded compartments, and reservoir–seal juxtapositions. Consequently, it provides refined well-placement recommendations, including high-potential attic infill drilling locations. Furthermore, the model establishes a technically robust basis for reservoir management and depletion planning, aiming to maximize recovery while minimizing water-handling risks. These outcomes demonstrate the value of incorporating new seismic and well datasets into legacy models and highlight their potential for reducing uncertainty in structurally complex syn-rift settings. Beyond the October Field, the updated structural modelling approach has broader implications for syn-rift petroleum systems in the Gulf of Suez and analogous rift basins, offering a predictive tool for fault-seal analysis, volumetric assessment, reservoir performance evaluation, and optimized drilling strategies.

According to ecological psychology, animals perceive not just the qualities of things in their environment, but their affordances: in James Gibson’s words, ’what things furnish, for good or ill’. I propose a metaphysics for affordances that fits into a contemporary anti-Humean metaphysics of powers or potentialities. The goal is to connect two debates, one in the philosophy of perception and one in metaphysics, that stand to gain much from each other.

Chemical toxicity is part of everyday life in Puchuncaví. The most polluted industrial compound in Chile, Puchuncaví is home of fourteen industrial complexes, including the largest copper smelting plant in the country and four thermoelectric plants. Stories of biological mutation, corrosion and death among plants, humans, fishes and cattle are proliferate in Puchuncaví. Engaging with the growing interest in care and affective modes of attention within STS, this paper examines how ill, intoxicated or otherwise affected people in Puchuncaví act upon and know about their chronic sufferings. Drawing on ethnographic fieldwork, I focus on what I call ‘hypo-interventions’, or the minimal and unspectacular yet life-enabling practices of caring, cleaning and healing the ailments of their significant others, human and otherwise. By minutely engaging with somatic and affective alterations in the domestic spaces of the body, the home and the garden, Puchuncavinos render industrial harm visible and knowable, and hence a type of political action is invoked. While outside technical validation and alien to conventional politics, these actions have proved crucial for people in Puchuncaví striving to persevere in the face of industrial violence and institutional abandonment. I coin the term ‘intimate activism’ to describe the ethical and political affordances of the subdued doings and engagements deployed in Puchuncaví. Intimate activism, I claim, draws its political power on its capacity to create minimal conditions for ethical and material endurance.

In the Bantu language Kirundi (JD62), the verbal prefix oo- has traditionally been described as either conditional or potential. In this article, we show by means of a corpus-based analysis of its uses that it is first and foremost a modal prefix, and its conditional use is only a secondary development. Dans la langue bantoue kirundi (JD62), le préfixe verbal oo‑ a été décrit comme un marqueur soit du conditionnel, soit du potentiel. Dans cet article, nous montrons à partir d’une analyse de corpus qu’il est avant tout un préfixe modal et que son usage comme marque du conditionnel n’est qu’un développement secondaire