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TEPC is the preferred device for measuring microdoses due to its excellent organizational equivalence and high energy response. The most important factor affecting its energy response is the electric field distribution in the avalanche region. This paper uses finite element analysis to examine the electric field distribution of a spherical structure with a sensitive area diameter of 2 cm and a cylindrical structure with a sensitive area of 2 cm × 2 cm. While the spherical structure exhibits better isotropy, it has significant distortions in the electric field at the anode wire end, making compensation optimization complex and hindering miniaturization. Cylindrical structures can compensate for the electric field by adding insulators at the anode wire end. When the insulator diameter is 3mm, the optimal protrusion length into the chamber is also 3mm. This lays the foundation for the miniaturization of TEPCs in subsequent research.

A novel and rapid method to determine 90 Sr activity in seawater by proportional counter has been developed. Precipitation of 90 Sr and radiochemical separation were investigated. 90 Sr was precipitated in the form of oxalate to remove the dominant salts present in seawater and then radiochemical separation was performed by using Sr-resin. The chemical recovery of 90 Sr (75–95%) was determined gravimetrically using a stable primary Sr 2+ solution. The minimum detectable activity (MDA) of 90 Sr was determined to be 0.025 Bq L −1 for 1 L seawater sample for 2 h counting time using ultra-low background proportional counters. The validation of the method has been performed by using the samples from the IAEA-RML-2021 and IAEA-RML-2019 proficiency tests organized by International Atomic Energy Agency (IAEA).ı

Boron neutron capture therapy (BNCT) is an emerging radiation treatment modality, exhibiting the potential to selectively destroy cancer cells. Currently, BNCT is conducted using a nuclear reactor. However, the future trend is to move toward an accelerator-based system for use in hospital environments. A typical BNCT radiation field has several different types of radiation. The beam quality should be quantified to accurately determine the dose to be delivered to the target. This study utilized a tissue equivalent proportional counter (TEPC) to measure microdosimetric and macrodosimetric quantities of an accelerator-based neutron source. The micro- and macro-dosimetric quantities measured with the TEPC were compared with those obtained via the the particle and heavy ion transport code system (PHITS) Monte Carlo simulation. The absorbed dose from events >20 keV/μm measured free in air for a 1-h irradiation was calculated as 1.31 ± 0.02 Gy. The simulated result was 1.41 ± 0.07 Gy. The measured and calculated values exhibit good agreement. The relative biological effectiveness (RBE) that was evaluated from the measured microdosimetric spectrum was calculated as 3.7 ± 0.02, similar to the simulated value of 3.8 ± 0.1. These results showed the PHITS Monte Carlo simulation can simulate both micro- and macro-dosimetric quantities accurately. The RBE was calculated using a single-response function, and the results were compared with those of several other institutes that used a similar method. However, care must be taken when using such a single-response function for clinical application, as it is only valid for low doses. For clinical dose ranges (i.e., high doses), multievent distribution inside the target needs to be considered.

A microdosimetric characterization of the 62 MeV proton beam line of CATANA has been performed all along the Spread Out Bragg Peak with three different detectors. Two silicon detectors and a Tissue Equivalent Proportional Counter measured at approximately the same depths of the SOBP. The TEPC is a new miniaturized gas counter developed at the Legnaro National Laboratories of INFN, modified to work without gas flow. The first silicon detector has been developed at the Politecnico of Milano and it is a monolithic telescope composed by a matrix of 2 µm thick cylindrical diodes with a diameter 9 µm. that compose the ΔE layer. The E and ΔE layers are fabricated on a single substrate of silicon. The third detector is the MicroPlus probe developed at the CMRP - University of Wollongong, it is an array of 3D sensitive volumes each with dimension 30x30 µm and 10 µm thick fabricated on SOI. Measurements performed with the three detectors are presented and discussed.

It is recognized today that the observable radiobiological effects of ionizing radiations are strongly correlated to the clustering of damages in micrometer- and nanometer-sized subcellular structures, hence to the particle track structure. The characteristic properties of track structure are directly measurable nowadays with bulky experimental apparatuses, which cannot be easily operated in a clinical environment. It is therefore interesting to investigate the feasibility of new portable detectors able to characterize the real therapeutic beams. With this in mind, a novel avalanche-confinement Tissue Equivalent Proportional Counter (TEPC) was constructed for simulating nanometric sites down to 25 nm. Experimental cluster size distributions measured with this TEPC were compared with Monte Carlo simulations of the same experiment and with cluster size distributions measured with the Startrack nanodosimeter.

Our cell survival data showed the obvious dependence of RBE on photon energy: The RBE value for 200 kV X-rays was approximately 10% greater than those for mega-voltage photon beams. In radiation therapy using mega-voltage photon beams, the photon energy distribution outside the field is different with that in the radiation field because of a large number of low energy scattering photons. Hence, the RBE values outside the field become greater. To evaluate the increase in RBE, the method of deriving the RBE using the Microdosimetric Kinetic model (MK model) was proposed in this study. The MK model has two kinds of the parameters, tissue-specific parameters and the dose-mean lineal energy derived from the lineal energy distributions measured with a Tissue-Equivalent Proportional Counter (TEPC). The lineal energy distributions with the same geometries of the cell irradiations for 200 kV X-rays, 60Co γ-rays, and 6 MV X-rays were obtained with the TEPC and Monte Carlo code GEANT4. The measured lineal energy distribution for 200 kV X-rays was quite different from those for mega-voltage photon beams. The dose-mean lineal energy of 200 kV X-rays showed the greatest value, 4.51 keV/μm, comparing with 2.34 and 2.36 keV/μm for 60Co γ-rays and 6 MV X-rays, respectively. By using the results of the TEPC and cell irradiations, the tissue-specific parameters in the MK model were determined. As a result, the RBE of the photon beams (yD: 2～5 keV/μm) in arbitrary conditions can be derived by the measurements only or the calculations only of the dose-mean lineal energy.

The tissue equivalent proportional counter (TEPC) is the most accurate device for measuring the microdosimetric properties of a particle beam, nevertheless no detailed information on the track structure of the impinging particles can be obtained, since the lower operation limit of common TEPCs is about 0.3 μm. On the other hand, the pattern of particle interactions is measured by track-nanodosimetry, which derives the single-event distribution of ionization cluster size at the nanometric scale. Anyway, only three nanodosimeters are available worldwide. A feasibility study for extending the performances of TEPC down to the nanometric region was performed and a novel avalanche-confinement TEPC was designed and constructed. This detector is constituted by a cylindrical chamber, based on a three-electrode structure, connected to a vacuum and gas flow system to ensure a continuous replacement of the tissue equivalent gas, thus allowing to simulate different biological site sizes in the range 300-25 nm. This TEPC can be calibrated by exploiting a built-in alpha source and a miniaturized solid-state detector as a trigger. Irradiations with photons, fast neutrons and two hadron beams demonstrated the good performances of the device. A satisfactory agreement with FLUKA simulations was obtained.

The tissue equivalent proportional counter (TEPC) is the most accurate device for measuring microdosimetric properties of particle beams. Since microdosimetric quantities span over several decades, the electronic and acquisition chain should meet specific requirements. In order to cover the wide dynamic range of the signals generated by the TEPC, the output signal from the preamplifier is fed in parallel to three linear amplifiers which shape and amplify the signal with different gains. Very low-energy deposition events are filtered in the high-gain stage, and high-energy deposition events are processed in the low-gain stage. A new system with high acquisition performance and compact hardware was developed for this purpose. The analog-to-digital conversion is performed by a commercial acquisition system that includes a FPGA. Thanks to the FPGA a parallel high-speed acquisition on three channels can be performed. The software merges signals together from the three electronic chains and computes a real time microdosimetric spectrum giving a prompt information about the irradiation field. This acquisition system, which performs analog-to-digital conversion and signal processing at a sampling rate up to 15 MS/s, was tested by irradiating a TEPC with an Am-Be fast neutron field, an intense quasi-monoenergetic neutron beam and a 62 MeV/u helium ion beam.

The authors attempt to establish the relative biological effectiveness (RBE) calculation for designing therapeutic proton beams on the basis of microdosimetry. The tissue-equivalent proportional counter (TEPC) was used to measure microdosimetric lineal energy spectra for proton beams at various depths in a water phantom. An RBE-weighted absorbed dose is defined as an absorbed dose multiplied by an RBE for cell death of human salivary gland (HSG) tumor cells in this study. The RBE values were calculated by a modified microdosimetric kinetic model using the biological parameters for HSG tumor cells. The calculated RBE distributions showed a gradual increase to about 1cm short of a beam range and a steep increase around the beam range for both the mono-energetic and spread-out Bragg peak (SOBP) proton beams. The calculated RBE values were partially compared with a biological experiment in which the HSG tumor cells were irradiated by the SOBP beam except around the distal end. The RBE-weighted absorbed dose distribution for the SOBP beam was derived from the measured spectra for the mono-energetic beam by a mixing calculation, and it was confirmed that it agreed well with that directly derived from the microdosimetric spectra measured in the SOBP beam. The absorbed dose distributions to planarize the RBE-weighted absorbed dose were calculated in consideration of the RBE dependence on the prescribed absorbed dose and cellular radio-sensitivity. The results show that the microdosimetric measurement for the mono-energetic proton beam is also useful for designing RBE-weighted absorbed dose distributions for range-modulated proton beams.

Cosmic Ray Laboratory – TIFR, Ooty, India is operating the largest tracking muon telescope as a component of the GRAPES-3 (Gamma Ray Astronomy PeV EnergieS at phase – 3) experiment. The basic building blocks of the telescope are proportional counters (PRCs), a large number of which are fabricated in-house for the planned expansion of the existing muon telescope to double its area and enhance the solid angle coverage from 2.3 sr to 3.7 sr as well as achieving higher sensitivity for studying space weather and atmospheric phenomena, cosmic ray composition, etc. The existing muon telescope consists of 3712 PRCs, and after the planned expansion which requires an additional 3776 PRCs, the area of the telescope will increase from the present 560 m 2 to 1130 m 2 . Each of the PRCs will need to be individually equipped with front-end electronics for processing the output signals. The output pulses from PRCs are extremely feeble, and their charges are in the order of ∼ 100 pC. The tiny signal has to be isolated from potential sources of noise before its processing. High-performance, ultra-low noise, and cost-effective electronics are designed, developed, and mass-produced in-house for about 8000 channels of PRCs. The quality of data is improved significantly by interfacing the new electronics with PRCs of the existing muon telescope due to improved signal-to-noise (S/N) ratio, and the data acquisition is made effective as a result of multifold improvement achieved by avoiding undesired interruptions in the data.