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Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties mediated by 5-HT2A receptor signaling, supporting their evaluation as a therapeutic for neuroinflammation associated with neurodegenerative disease.ObjectiveThis study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of orally repeated administration of 5 μg, 10 μg, and 20 μg LSD in older healthy individuals. In the current paper, we present safety, tolerability, pharmacokinetics, and pharmacodynamic measures that relate to safety, tolerability, and dose response.MethodsThis was a phase 1 double-blind, placebo-controlled, randomized study. Volunteers were randomly assigned to 1 of 4 dose groups (5 μg, 10 μg, 20 μg LSD, and placebo), and received their assigned dose on six occasions (i.e., every 4 days).ResultsForty-eight older healthy volunteers (mean age = 62.9 years) received placebo (n = 12), 5 μg (n = 12), 10 μg (n = 12), or 20 μg (n = 12) LSD. LSD plasma levels were undetectable for the 5 μg group and peak blood plasma levels for the 10 μg and 20 μg groups occurred at 30 min. LSD was well tolerated, and the frequency of adverse events was no higher than for placebo. Assessments of cognition, balance, and proprioception revealed no impairment.ConclusionsOur results suggest safety and tolerability of orally administered 5 μg, 10 μg, and 20 μg LSD every fourth day over a 21-day period and support further clinical development of LSD for the treatment and prevention of Alzheimer’s disease (AD).

The study investigated the effects of FIFA 11+ and HarmoKnee, both being popular warm-up programs, on proprioception, and on the static and dynamic balance of professional male soccer players. Under 21 year-old soccer players (n = 36) were divided randomly into 11+, HarmoKnee and control groups. The programs were performed for 2 months (24 sessions). Proprioception was measured bilaterally at 30°, 45° and 60° knee flexion using the Biodex Isokinetic Dynamometer. Static and dynamic balances were evaluated using the stork stand test and Star Excursion Balance Test (SEBT), respectively. The proprioception error of dominant leg significantly decreased from pre- to post-test by 2.8% and 1.7% in the 11+ group at 45° and 60° knee flexion, compared to 3% and 2.1% in the HarmoKnee group. The largest joint positioning error was in the non-dominant leg at 30° knee flexion (mean error value = 5.047), (p<0.05). The static balance with the eyes opened increased in the 11+ by 10.9% and in the HarmoKnee by 6.1% (p<0.05). The static balance with eyes closed significantly increased in the 11+ by 12.4% and in the HarmoKnee by 17.6%. The results indicated that static balance was significantly higher in eyes opened compared to eyes closed (p = 0.000). Significant improvements in SEBT in the 11+ (12.4%) and HarmoKnee (17.6%) groups were also found. Both the 11+ and HarmoKnee programs were proven to be useful warm-up protocols in improving proprioception at 45° and 60° knee flexion as well as static and dynamic balance in professional male soccer players. Data from this research may be helpful in encouraging coaches or trainers to implement the two warm-up programs in their soccer teams.

Could it be possible that, in the not-so-distant future, we will be able to reshape the human body so as to have extra limbs? A third arm helping us out with the weekly shopping in the local grocery store, or an extra artificial limb assisting a paralysed person? Here we report a perceptual illusion in which a rubber right hand, placed beside the real hand in full view of the participant, is perceived as a supernumerary limb belonging to the participant's own body. This effect was supported by questionnaire data in conjunction with physiological evidence obtained from skin conductance responses when physically threatening either the rubber hand or the real one. In four well-controlled experiments, we demonstrate the minimal required conditions for the elicitation of this \"supernumerary hand illusion\". In the fifth, and final experiment, we show that the illusion reported here is qualitatively different from the traditional rubber hand illusion as it is characterised by less disownership of the real hand and a stronger feeling of having two right hands. These results suggest that the artificial hand 'borrows' some of the multisensory processes that represent the real hand, leading to duplication of touch and ownership of two right arms. This work represents a major advance because it challenges the traditional view of the gross morphology of the human body as a fundamental constraint on what we can come to experience as our physical self, by showing that the body representation can easily be updated to incorporate an additional limb.

While the FIFA 11 + Referees program (the 11 + Referees) is the only structured injury prevention program for referees, its effects on injury-related risk factors among referees remain underexplored. This study investigated the effects of the 11 + Referees on knee joint proprioception and dynamic balance. Thirty four female referees from the Tehran Premier Futsal League voluntarily participated and were randomly assigned to either a control group ( n  = 17) or the 11 + Referees group ( n  = 17). All participants underwent a baseline assessment including knee joint proprioception at angular velocities of 15°/s, 45°/s, and 60°/s, and position sense, as well as dynamic balance. Subsequently, the intervention group performed the 11 + Referees program three times weekly for 8 weeks, while the control group performed general warm-ups. Post-intervention, the same test battery was administered, and changes were analyzed to identify the program’s effects on the measures understudied. Significant improvements were observed in knee joint proprioception at 15°/s (F = 18.19, p  < 0.001, η²=0.44), 45°/s (F = 4.07, p  = 0.056, ηp²=0.15), and 60°/s (F = 6.63, p  = 0.017, η²=0.22) in the intervention group. However, dynamic balance did not show significant improvement (F = 0.79, p  = 0.38, η²=0.033). In conclusion, an eight-week application of the 11 + Referees enhanced knee joint proprioception in female referees with large effect sizes, but had no significant effect on dynamic balance. Improvements in proprioception may be attributed to neuromuscular adaptations resulting from regular program use. The absence of balance improvement could be due to the short intervention period and the hard futsal court surface, which may limit the effectiveness of certain balance exercises. Future studies should explore the program's effects on other injury risk factors and injury rates.

Fatigue is a major cause of exercise-induced muscle damage (EIMD). Compression garments (CGs) can aid post-exercise recovery, therefore, this study explored the effects of CGs on muscular efficacy, proprioception, and recovery after exercise-induced muscle fatigue in people who exercise regularly. Twelve healthy participants who exercised regularly were enrolled in this study. Each participant completed an exercise-induced muscle fatigue test while wearing a randomly assigned lower-body CG or sports pants (SP); after at least 7 days, the participant repeated the test while wearing the other garment. The dependent variables were muscle efficacy, proprioception (displacements of center of pressure/COP, and absolute error), and fatigue recovery (muscle oxygen saturation/SmO 2 , deoxygenation and reoxygenation rate, and subjective muscle soreness). A two-way repeated measure analysis of variance was conducted to determine the effect of garment type. The results indicated that relative to SP use, CG use can promote muscle efficacy, proprioception in ML displacement of COP, and fatigue recovery. Higher deoxygenation and reoxygenation rates were observed with CG use than with SP use. For CG use, SmO 2 quickly returned to baseline value after 10 min of rest and was maintained at a high level until after 1 h of rest, whereas for SP use, SmO 2 increased with time after fatigue onset. ML displacement of COP quickly returned to baseline value after 10 min of rest and subsequently decreased until after 1 hour of rest. Relative to SP use, CG use was associated with a significantly lower ML displacement after 20 min of rest. In conclusion, proprioception and SmO 2 recovery was achieved after 10 min of rest; however, at least 24 h may be required for recovery pertaining to muscle efficacy and soreness regardless of CG or SP use.

Limited ankle dorsiflexion range of motion is one of the most important risk factors for lower limb injury, which changes the biomechanics and the neuromuscular control of the lower limb muscles. This study aims to test the effectiveness of a comprehensive corrective exercise program (CCEP) on the range of motion, proprioception, dynamic balance, and muscle activation in female athletes with limited weight-bearing lunge ankle dorsiflexion range of motion. 30 female athletes aged 15 to 25 years with dorsiflexion under 34° were randomized to two groups. The intervention group (n = 15) received eight weeks of CCEP including soft tissue mobilization, joint mobilization, stretching, and strengthening, and the control (n = 15) group did not receive any intervention. range of motion, proprioception, dynamic balance, and muscle activation were assessed before and after the intervention. The training group showed clinically acceptable and statistically significant changes in ankle dorsiflexion range of motion (ES = 0.714), balance (ES = 0.423), and proprioception (ES = 0.253; P < 0.05). There were significant changes in the activity of the tibialis anterior and soleus muscles in the dynamic overhead squat test (descending and ascending phases) and the activity of the medial gastrocnemius in the descending phase decreased significantly (P < 0.05). No significant change was observed in the activity of the peroneus longus muscle (P > 0.05). The findings show that CCEP appears to be beneficial in increasing dorsiflexion range of motion, proprioception, balance, and decreasing ankle muscle activity among individuals with limited ankle dorsiflexion. Improving the dorsiflexion range of motion may be promising for reducing ankle sprain injury.

Neurofeedback of self-regulated brain activity in circumscribed cortical regions is used as a novel strategy to facilitate functional restoration following stroke. Basic knowledge about its impact on motor system oscillations and functional connectivity is however scarce. Specifically, a direct comparison between different feedback modalities and their neural signatures is missing. We assessed a neurofeedback training intervention of modulating β-activity in circumscribed sensorimotor regions by kinesthetic motor imagery (MI). Right-handed healthy participants received two different feedback modalities contingent to their MI-associated brain activity in a cross-over design: (I) visual feedback with a brain–computer interface (BCI) and (II) proprioceptive feedback with a brain–robot interface (BRI) orthosis attached to the right hand. High-density electroencephalography was used to examine the reactivity of the cortical motor system during the training session of each task by studying both local oscillatory power entrainment and distributed functional connectivity. Both feedback modalities activated a distributed functional connectivity network of coherent oscillations. A significantly higher skill and lower variability of self-controlled sensorimotor β-band modulation could, however, be achieved in the BRI condition. This gain in controlling regional motor oscillations was accompanied by functional coupling of remote β-band and θ-band activity in bilateral fronto-central regions and left parieto-occipital regions, respectively. The functional coupling of coherent θ-band oscillations correlated moreover with the skill of regional β-modulation thus revealing a motor learning related network. Our findings indicate that proprioceptive feedback is more suitable than visual feedback to entrain the motor network architecture during the interplay between motor imagery and feedback processing thus resulting in better volitional control of regional brain activity. [Display omitted] •Proprioceptive input is superior to visual input to entrain the motor network during neurofeedback.•Proprioceptive feedback increases self-control of regional β-band modulation.•Proprioceptive feedback entrains motor functional connectivity in the θ- and β-band.•Large-scale functional connectivity in θ-band correlates with regional β-band control.

Balance and proprioception are crucial in children, especially in sports. The ankle joint plays a key role in postural control, and triceps surae retraction is common in active children. This study aimed to analyze the effects of stretching exercises versus heel cups on postural control in children aged 8 to 12 with triceps surae retraction. A six-month randomized controlled trial was conducted with 150 children assigned to either stretching exercises ( n  = 76) or heel cups ( n  = 74). The study was registered at ClinicalTrials.gov under the identification number NCT05902949 (first posted on 06/15/23). The area of oscillation was measured using the Gyko system under four conditions: eyes open/closed and firm ground/foam. A linear mixed regression model was applied to analyze the effects of the treatments, adjusting for sex, age, and physical activity. Stretching exercises were associated with significant reductions around oscillation across all conditions ( p  < 0.001 at six months). In contrast, heel cups were linked to significant increases around oscillation in all conditions ( p  < 0.001 at six months), indicating a negative effect on balance. Additionally, higher levels of physical activity and female sex were associated with better postural control ( p  < 0.001). In conclusion, stretching exercises significantly improved postural control in children with triceps surae retraction, whereas heel cups worsened this essential motor-performance ability. Further research is needed, but these findings support the incorporation of stretching exercises and regular physical activity in the management of these patients. Clinical trial registration number : NCT05902949.

This study investigates the efficacy of proprioceptive and motor balance training using quick reflexes in improving jumping and shooting performance, neuroplasticity, and kinematic variables among basketball players. A total of 32 participants were divided into two equal groups: an experimental group of 16 players with an average age of 18.84 years and a control group of 16 players with an average age of 19.03 years. The experimental group underwent training involving proprioceptive and motor balance exercises with blink reflex stimulation, while the control group followed standard training routines. Post-intervention assessment revealed significant neurological plasticity and improvements in the key variables related to jump shooting performance in the experimental group compared to the control group ( p  < 0.001). This shows that proprioceptive and motor balance training with saccade stimulation enhances jump shooting skills and kinematic attributes related to shooting in basketball players. This adds to the emerging evidence on the diverse alternative training strategies that can improve athletic performance, thus providing important historical context for future studies as well as practical applications in sports training.

This study presents a novel training technique, visual + electrotactile proprioception training (visual + EP training), which provides additional proprioceptive information via tactile channel during motor training to enhance the training effectiveness. In this study, electrotactile proprioception delivers finger aperture distance information in real-time, by mapping frequency of electrical stimulation to finger aperture distance. To test the effect of visual + EP training, twenty-four healthy subjects participated in the experiment of matching finger aperture distance with distance displayed on screen. Subjects were divided to three groups: the first group received visual training and the other two groups received visual + EP training with or without a post-training test with electrotactile proprioception. Finger aperture control error was measured before and after the training (baseline, 15-min post, 24-h post). Experimental data suggest that both training methods decreased finger aperture control error at 15-min post-training. However, at 24-h post-training, the training effect was fully retained only for the subjects who received visual + EP training, while it washed out for the subjects with visual training. Distribution analyses based on Bayesian inference suggest that the most likely mechanism of this long-term retention is proprioceptive recalibration. Such applications of artificially administered sense have the potential to improve motor control accuracy in a variety of applications.