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As an endocrine disruptor chemical, pesticide exposure may affect the regulation of growth hormones such as insulin-like growth factor-1 (IGF-1). A few current studies to date have noted that long-term pesticide exposure disrupted IGF-1, a potential risk of stunting in children. This study aims to evaluate studies to date of the effect of pesticide exposure on stunting incidence. This systematic review and meta-analysis adhered to the PRISMA (Pre-ferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. The PubMed and EBSCO databases were searched for relevant articles without publication restrictions. This review aimed to include reviews, randomized controlled trials (RCT), and cohort, case-control, and cross-sectional studies, which provide actual exposure types of pesticides with stunting measurement by height-age z score. A screening, extraction, and synthesis were conducted, leading to a consensus for reaching mutual agreement. The analysis was performed using Microsoft Excel 2017 for the screening and extraction, Revman version 5.4 software for the meta-analysis, and OpenMEE software for the meta-regression. Of the 13 studies subjected to the qualitative analysis, 6 were eligible for inclusion in the meta-analysis: 2 reviews, 2 RCTs, 2 cohorts, 2 case-control, and 5 cross-sectional studies. Exposure to organophosphate and pyrethroid pesticides was not associated with stunting (P=0.78; odds ratio [OR], 1.11; 95% confidence interval [CI], 0.65–1.88). Heterogeneity existed for 79% of the meta-analysis (P≤0.000; z=-5.37; 95% CI, -0.034 to -0.016), and the meta-regression identified age as the causative covariate. Pesticide exposure, regardless of type, is not associated with stunting in children.

Background The thermophile Geobacillus thermoglucosidasius has considerable attraction as a chassis for the production of chemicals and fuels. It utilises a wide range of sugars and oligosaccharides typical of those derived from lignocellulose and grows at elevated temperatures. The latter improves the rate of feed conversion, reduces fermentation cooling costs and minimises the risks of contamination. Full exploitation of its potential has been hindered by a dearth of effective gene tools. Results Here we designed and tested a collection of vectors (pMTL60000 series) in G. thermoglucosidasius NCIMB 11955 equivalent to the widely used clostridial pMTL80000 modular plasmid series. By combining a temperature-sensitive replicon and a heterologous pyrE gene from Geobacillus kaustophilus as a counter-selection marker, a highly effective and rapid gene knock-out/knock-in system was established. Its use required the initial creation of uracil auxotroph through deletion of pyrE using allele-coupled exchange (ACE) and selection for resistance to 5-fluoroorotic acid. The turnaround time for the construction of further mutants in this pyrE minus strain was typically 5 days. Following the creation of the desired mutant, the pyrE allele was restored to wild type, within 3 days, using ACE and selection for uracil prototrophy. Concomitant with this process, cargo DNA (pheB) could be readily integrated at the pyrE locus. The system's utility was demonstrated through the generation in just 30 days of three independently engineered strains equivalent to a previously constructed ethanol production strain, TM242. This involved the creation of two in-frame deletions (ldh and pfl) and the replacement of a promoter region of a third gene (pdh) with an up-regulated variant. In no case did the production of ethanol match that of TM242. Genome sequencing of the parental strain, TM242, and constructed mutant derivatives suggested that NCIMB 11955 is prone to the emergence of random mutations which can dramatically affect phenotype. Conclusions The procedures and principles developed for clostridia, based on the use of pyrE alleles and ACE, may be readily deployed in G. thermoglucosidasius. Marker-less, in-frame deletion mutants can be rapidly generated in 5 days. However, ancillary mutations frequently arise, which can influence phenotype. This observation emphasises the need for improved screening and selection procedures at each step of the engineering processes, based on the generation of multiple, independent strains and whole-genome sequencing.

Is \"space\" a thing, a container, an abstraction, a metaphor, or a social construct? This much is certain: space is part and parcel of the theater, of what it is and how it works. InThe Play of Space, noted classicist-director Rush Rehm offers a strikingly original approach to the spatial parameters of Greek tragedy as performed in the open-air theater of Dionysus. Emphasizing the interplay between natural place and fictional setting, between the world visible to the audience and that evoked by individual tragedies, Rehm argues for an ecology of the ancient theater, one that \"nests\" fifth-century theatrical space within other significant social, political, and religious spaces of Athens. Drawing on the work of James J. Gibson, Kurt Lewin, and Michel Foucault, Rehm crosses a range of disciplines--classics, theater studies, cognitive psychology, archaeology and architectural history, cultural studies, and performance theory--to analyze the phenomenology of space and its transformations in the plays of Aeschylus, Sophocles, and Euripides. His discussion of Athenian theatrical and spatial practice challenges the contemporary view that space represents a \"text\" to be read, or constitutes a site of structural dualities (e.g., outside-inside, public-private, nature-culture). Chapters on specific tragedies explore the spatial dynamics of homecoming (\"space for returns\"); the opposed constraints of exile (\"eremetic space\" devoid of normal community); the power of bodies in extremis to transform their theatrical environment (\"space and the body\"); the portrayal of characters on the margin (\"space and the other\"); and the tragic interactions of space and temporality (\"space, time, and memory\"). An appendix surveys pre-Socratic thought on space and motion, related ideas of Plato and Aristotle, and, as pertinent, later views on space developed by Newton, Leibniz, Descartes, Kant, and Einstein. Eloquently written and with Greek texts deftly translated, this book yields rich new insights into our oldest surviving drama.

Geophysical modelling performs to obtain subsurface structures in agreement with measured data. Freeware algorithms for geoelectrical data inversion have not been widely used in geophysical communities; however, different open-source modelling/inversion algorithms were developed in recent years. In this study, we review the structures and applications of openly Python-based inversion packages, such as pyGIMLi (Python Library for Inversion and Modelling in Geophysics), BERT (Boundless Electrical Resistivity Tomography), ResIPy (Resistivity and Induced Polarization with Python), pyres (Python wrapper for electrical resistivity modelling), and SimPEG (Simulation and Parameter Estimation in Geophysics). In addition, we examine the recovering ability of pyGIMLi, BERT, ResIPy, and SimPEG freeware through inversion of the same synthetic model forward responses. A versatile pyGIMLi freeware is highly suitable for various geophysical data inversion. The SimPEG framework is developed to allow the user to explore, experiment with, and iterate over multiple approaches to the inverse problem. In contrast, BERT, pyres, and ResIPy are exclusively designed for geoelectric data inversion. BERT and pyGIMLi codes can be easily modified for the intended applications. Both pyres and ResIPy use the same mesh designs and inversion algorithms, but pyres uses scripting language, while ResIPy uses a graphical user interface (GUI) that removes the need for text inputs. Our numerical modelling shows that all the tested inversion freeware could be effective for relatively larger targets. pyGIMLi and BERT could also obtain reasonable model resolutions and anomaly accuracies for small-sized subsurface structures. Based on the heterogeneous layered model and experimental target scenario results, the geoelectrical data inversion could be more effective in pyGIMLi, BERT, and SimPEG freeware packages. Moreover, this study can provide insight into implementing suitable inversion freeware for reproducible geophysical research, mainly for geoelectrical modelling.

This paper analyzes the results of studies carried out at the National Research Center “Kurchatov Institute”, Moscow, using the methods of neutron and X-ray synchrotron tomography from the point of view of the preservation state of metal objects. Objects damaged by corrosion and exposure to fire were the focus of this study. To identify regions of metal preservation, the diffraction contrast on grains of metal, observed in tomographic projections, was used. The simultaneous use of neutron and synchrotron imaging is shown to be a powerful tool for identification of the constituents of an object.

The ‘terre di rogo’ (pyre debris) are black-coloured layers resulting from the crematory pyres, placed inside graves within the ritual of secondary deposition and containing different materials, including cremation slags. The characterisation of the slags, until now rarely conducted by chemical techniques, can provide useful data to explain more precisely the protocol of the funeral ritual and to better understand the effects of fire during cremation for the accumulation of pyre debris. In this study, a fast screening method using ATR-mode infrared spectroscopy is proposed, which may highlight the need for further investigations with SEM and XRD. The protocol was tested on the black and irregularly shaped cremation slags from the pyre debris of two Iron Age cremation necropolises in Padua (northern Italy). The results of the analysis identified several types of cremation slags within each individual pyre ground and the presence of bone fragments exposed to different intensities of combustion during cremation.

This study investigates the air pollution-induced mortality rate during the second wave of COVID-19, which claimed several thousand lives in the capital city of India, New Delhi, even during a lockdown period. Delhi is a hotspot of unhealthy air quality. During the second wave of COVID-19 in 2021, surface ozone levels were observed to be higher, which had a direct impact on lung function, thereby making people more susceptible to COVID-19. The correlation coefficient between surface ozone concentration and mortality has been observed to be 0.74 at a 95% confidence level. This work focuses on the plausible impact and feedback of poor air quality induced by the burning of open-air funeral pyres due to the increased COVID-19 mortality rate in New Delhi, estimated by using an epidemiological model (AirQ+) of the World Health Organization. The mortality rate estimated quantitatively with the aid of AirQ+ is 1.27 excess deaths per 100,000 population due to surface ozone from pyre burning. The findings suggest transformational system goals before the resurgence of a subsequent wave.

Using data from several well-preserved pyres, which are rarely found well preserved in the southwestern United States and northern Mexico, we examine cremation customs and their associated pyrotechnologies at the site of Cerro de Trincheras in northern Sonora, Mexico, from AD 1300 to 1450/1500. We explore variations in pyre construction and use, thermal alterations of the deceased, the deceased individuals’ biological profiles, the performance of mortuary rituals, and the sensorial experiences of both the mourners and the wider Cerro de Trincheras community. The residents of the site were masters of the pyrotechnologies associated with cremations, making efficient pyres for the deceased and maximizing their resources. The group also created transformative funeral rituals that may have facilitated and mediated a wide range of emotional responses toward their deceased.

Three cases of cremation on open-air pyres are described. One was classified as a suicide and two as homicides. Fire duration was estimated at approximately 1h, close to 2h and more than 3h, respectively. The position of the remains, the colour alteration of bone and the burned bone fractures biomechanics are discussed. Knowledge of normal burn patterns in fire and detection of perimortem lesions are essential. These three cases highlight the specific thermal alterations and burning processes in accordance with fire duration. In each case, careful investigation yielded clues as to the manner of death. Close cooperation between law enforcement and forensic pathology investigators is required in order to correctly identify the circumstances of death.