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Bit-related trauma is a welfare issue in equestrian sports; therefore, a proper understanding of how the bit behaves inside the mouth is of importance. The objective of this study is to investigate the influence of bit design (snaffle bits/single/double-jointed; ring/eggbutt and curb bits), size, rein tension, and rein angle on the intra-oral movement of the bit in ex vivo specimens. The lateral and posterior movement of different bits was measured on cadaver heads under different circumstances. This ex vivo model, while not fully replicating natural conditions, provided insight into potential bit-related movements. Lateral displacement of the snaffle bit was significantly greater with higher unilateral rein tension. Bits that were too wide exhibited significantly more lateral and posterior displacement under unilateral rein tension. Posterior displacement increased with both unilateral and bilateral rein tensions. Using a bit that is too wide, using reins at a 20° angle, and applying 4 kg of rein tension were identified as risk factors for contact with the mesial gingival tissues of the mandibular 06s. Similar patterns were observed with curb bits, although bit movement was more restricted, and no contact with the mesial gingival tissues of the mandibular 06s was noted. This study demonstrated that bit design, bit size, rein angle, and rein tension all influence bit movement in the horse’s mouth.

Recent years have witnessed noticeable advances in evaluating the behavior and contribution of fiber-reinforced polymer (FRP) bars in concrete columns under concentric loading. In contrast, there is a scarcity of investigation available in the literature on full-scale concrete columns reinforced with FRP bars and ties under combined axial and flexural loads. This paper reports experimental data on the behavior of square concrete columns reinforced with deformed and/or sand-coated glass FRP (GFRP) bars and ties. A total of 12 full-scale concrete columns 16 x 16 in. (405 x 405 mm) in cross section and 80 in. (2000 mm) in height were constructed and tested up to failure. The columns were loaded under four different levels of eccentricities to develop axial load-moment (P-M) interaction diagrams. The influence of different GFRP bars of comparable quality on the performance of the columns and their P-M interaction diagrams were assessed. In addition, columns reinforced with conventional steel bars and ties were introduced into the test matrix as references. The load-strain behavior for the concrete, bars, and ties; load-deformation curves (axial and lateral); and experimental P-M interaction diagrams are presented herein. The impact of the compressive behavior of longitudinal GFRP bars versus steel bars was assessed. The test results indicate that the specimens reinforced with two comparable types of GFRP bars (deformed and/or sand-coated) under different levels of eccentricity behaved similarly to their steel reinforced concrete counterparts. Design strain limits were proposed to define the failure-mode mechanisms of the GFRP specimens on the P-M interaction diagram. Keywords: column; compression; eccentric; failure mode; glass fiber-reinforced polymer reinforcement; P-M interaction diagram.

This experimental study investigates the influence of flexural cracks and punching shear failure inclination on double-headed stud anchorage within the critical perimeter. The research also explored the technical feasibility of using synthetic coarse aggregates from bauxite residue as a sustainable alternative in structural concrete production. The results showed that the overall structural integrity is impaired at 40 to 50% due to flexural cracks at the critical perimeter of 2d (30 degrees); however, the perimeter of 1.2d (45 degrees) enhanced the shear reinforcement activation and shear strength up 15%, providing a balanced failure within the strengthening zone. Thus, a concrete anchoring capacity (CAC) method was proposed to calculate the contribution of doubleheaded studs in serviceability and ultimate limit states. In addition, synthetic aggregates performed similarly to natural aggregates, offering environmental benefits such as reducing the carbon footprint and production stages. Keywords: anchorage; bauxite; concrete anchoring capacity (CAC); double-headed stud; flexural cracks; pullout strength; punching; shear reinforcement; sustainability; synthetic aggregate.

Information describing forces applied to the horse are needed to inform regulatory decisions regarding equine health and wellbeing. This study compares forces exerted beneath the noseband and headpiece of a snaffle bridle (SB) and a double bridle (DB). Horses were fitted with the same type of SB and DB. Forces were measured by pressure mats under the noseband (nasal/mandibular) and headpiece (occipital) of the bridle and by force sensors inserted bilaterally between the bit(s) and reins. The noseband was adjusted to 2 finger-equivalents using a tightness gauge. Data were recorded for eleven high-level dressage horses ridden in SB and DB in random order at collected walk, trot (sitting), and canter. The noseband pressures were similar between bridle types. Minimal, maximal, and mean occipital force and pressure were significantly higher for DB at walk, trot, and canter (all p ≤ 0.01), except minimal force for collected canter (p = 0.04). The rein tension for the bridoon bit alone and for the combined bridoon and curb bits was significantly lower than for the snaffle bit. Similar forces occur when ridden in SB and DB except that occipital force and pressure are higher due to the greater weight of the DB, and rein tension is lower for the DB.

The aim of this review is to provide a review of the immune system in fish, including the ontogeny, mechanisms of unspecific and acquired immunity and the action of some immunomodulators. Fish rely on their innate immune system for an extended period of time, beginning at the early stages of embryogenesis. The components of the innate immune response are divided into physical, cellular and humoral factors and include humoral and cellular receptor molecules that are soluble in plasma and other body fluids. The lymphoid organs found in fish include the thymus, spleen and kidney. Immunoglobulins are the principal components of the immune response against pathogenic organisms. Immunomodulatory products, including nucleotides, glucans and probiotics, are increasingly used in aquaculture production. The use of these products reduces the need for therapeutic treatments, enhances the effects of vaccines and, in turn, improves the indicators of production.

Background and Hypothesis Cardiovascular diseases are a leading cause of morbidity and mortality in patients with Chronic Kidney Disease (CKD). Acute Kidney Injury (AKI) has been increasingly recognized as a potential exacerbating factor for cardiovascular events in these patients. The CKD-REIN study aims to explore the relationship between AKI and the risk of Major Adverse Cardiovascular Events (MACE) in a cohort of CKD patients. We hypothesize that AKI is a significant and independent predictor of MACE in patients with CKD, and that the severity of AKI correlates with the risk of subsequent cardiovascular events. Methods This prospective cohort study included 3033 adult CKD patients from 40 outpatient nephrology clinics in France. Patients were followed for a median of 5.2 years. AKI episodes were identified and staged based on the KDIGO-AKI criteria. Cardiovascular events, including myocardial infarction, stroke, heart failure hospitalization, and cardiovascular death, were systematically recorded. The association between AKI and MACE was analyzed using a multivariable Cox model, adjusting for confounders such as demographic characteristics, medical history, and baseline kidney function. Results During the follow-up, 530 patients experienced at least one episode of AKI. The cumulative incidence of MACE at 1 year post-AKI was 8.1%. Patients with AKI had a significantly increased risk of MACE, with an adjusted Hazard Ratio (HR) of 5.78 (P < 0.001). The risk was consistent across different MACE components and was independent of age, sex, CKD stage, or comorbidities. The risk of MACE was higher for more severe AKI stages and for AKI events requiring hospitalization or associated with incomplete renal recovery. Conclusion The findings of this study confirm that AKI is a significant independent predictor of MACE in CKD patients, demonstrating a strong severity-response relationship. These results underscore the importance of vigilant cardiovascular monitoring and preventive strategies in CKD patients following AKI episodes. Understanding the mechanisms linking AKI to cardiovascular outcomes is crucial for developing targeted interventions to mitigate these risks.

In patients with tuberous sclerosis complex (TSC), renal complications are not limited to bleeding angiomyolipoma (AML); although rare, end-stage renal disease (ESRD) may occur. New treatments (e.g., mammalian target of rapamycin (m-Tor) inhibitors) for AML might influence the epidemiology of ESRD in patients with TSC. In France, 99 patients with TSC from the Renal Epidemiology and Information Network (REIN) registry and having undergone renal replacement therapy (RRT) between 2002 and 2016 were included in the present study. Additional data were collected from the patients’ medical charts. The mean ± standard deviation age at RRT initiation was 48.4 ± 16.4 and 73.8% had a neurologic impairment. Fifty-four patients underwent kidney transplantation after an average of 23 ± 12.3 months on dialysis. Among the 61 patients with additional data the most common renal lesion was AML: 26.2% of the patients had isolated AML, and 26.2% had AML and renal cysts, 65.6% of patients had undergone nephrectomy, and 16.4% had undergone at least one embolization. None of the patients had been treated with an m-Tor inhibitor before dialysis. The graft survival rate was 92.5% at 5 years and 70.2% at 10 years. The present cohort study is the first to have assessed TSC patients on RRT from a national registry. Nephrectomy or embolization due to AML was the leading cause of ESRD in our cohort. By reducing the size of the AML, m-tor inhibitors might lower the risk of complications and thus reduce the number of patients with TSC requiring RRT.

Background and Objectives: Vaginal uterine manipulators facilitate laparoscopic hysterectomy but are limited by cost and anatomical constraints. The Boztosun method offers a cost-effective intra-abdominal alternative. This study evaluated the clinical performance and safety of this technique. Materials and Methods: This single-center, retrospective descriptive study analyzed 40 patients who underwent laparoscopic hysterectomy using the Boztosun method at Akdeniz University Hospital between October 2021 and June 2022. Clinical characteristics and perioperative outcomes were assessed. Results: The mean operative time was 78.5 ± 20.6 min, and the mean colpotomy time was 8.05 ± 3.57 min. Conversion to laparotomy occurred in 3 patients (7.5%), primarily due to extensive adhesions or large uterine size. No intraoperative complications, organ injuries, or blood transfusions were recorded. All patients were discharged within two days. Patients with prior abdominal surgery had significantly longer operative and colpotomy times (p < 0.05). Conclusions: The Boztosun method is a safe, efficient, and low-cost alternative to vaginal manipulators in laparoscopic hysterectomy. It may be particularly useful in resource-limited settings or when vaginal manipulation is not feasible.

Auxiliary reins are commonly used for the training of riders and horses as well as in daily training. They are often criticized when used incorrectly, as they will not help and can harm the horse by causing overwork, accidents, and injuries, which harm the horse in the long term. They also often conceal causal rider problems while trying to achieve quick success. The aim of this paper was to investigate, with an online horse-owner questionnaire, which and how often auxiliary reins were used and whether they were used appropriately. Only participants who were currently using auxiliary reins were selected. Consequently, 823 participants were questioned, of which 362 were currently using auxiliary reins at least every two weeks. Auxiliary reins were mainly used according to their discipline: the running side rein was the most popular when working from the ground and the sliding ring martingale was the most popular for ridden equestrian activities. Most of the test subjects only attached the auxiliary reins after the warm-up phase, but half of the participants did not change them during the entire training session. Most participants (75%) could at least identify what the correct head position of the horse should look like. However, there were still too many (50%) who adjusted their horse too tightly and did not change anything at that time despite the related breathing problems. The study found that most participants used the reins responsibly, but there is still a need for clarification and information relating to the functions of the different auxiliary reins among horse owners.

Bit pressure and rein tension-induced mouth pain in horses have recently become a significant welfare concern, fueling debates within the equestrian community and beyond. Evidence indicates that bits can cause pain-related behaviors and even oral lesions. Although studying pressure-induced pain in animals is challenging, the similarities in the physiology of pain processing (nociception) across mammals suggest that it is reasonable to assume that pain perception in humans and horses is principally comparable. Therefore, we compared human pressure pain detection thresholds (PPDTs) to reported rein pressures in equestrian sports as reported in the scientific literature. Reported rein tensions (kPa) range from a minimum of 91.2–107.87 to a maximum of 1314.09–4285.51, while human PPDTs (in kPa) are 232.4 for the face, 445.3 for the hand, and 535.5 for the foot. These comparisons reveal that only the lowest reported bit pressures would be pain-free for humans. Average to maximum pressures would cause strong to severe pain sensations in humans. Furthermore, data on pressure pain-induced stimulus response functions suggest that bit pressures commonly encountered in equestrian sports could cause lesions in humans, making them unacceptable in human experimentation. In conclusion, bit pressures as reported in the scientific literature would cause significant pain if applied to humans, raising welfare concerns for horses.