Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
259,717
result(s) for
"RESEARCH CENTERS"
Sort by:
Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase ( SQLE ) Gene
and
are important causative agents of superficial mycoses, demonstrating emergent antifungal drug resistance. We studied the antifungal susceptibility profiles in Iranian isolates of these two species.
A total of 96
and 45
isolates were subjected to molecular typing by ribosomal ITS region. Antifungal susceptibility profiles for terbinafine, griseofulvin, clotrimazole, efinaconazole, luliconazole, amorolfine and ciclopirox were obtained by CLSI broth microdilution method. The squalene epoxidase (
) gene was subjected to sequencing for mutations, if any, in isolates exhibiting elevated MICs for terbinafine.
Luliconazole and efinaconazole showed the lowest MIC values against
and
isolates. There were five isolates with terbinafine MICs ≥32 µg/mL in our sample. They belonged to
type VIII and harbored two alternative
gene sequence variants, leading to Phe397Leu and Ala448Thr or Leu393Ser and Ala448Thr substitutions in the enzyme. All terbinafine resistant strains could be inhibited by luliconazole and efinaconazole.
This study documented a step in the global spread of resistance mechanisms in
. However, treatment alternatives for resistant isolates were available.
Journal Article
Institutional ethnography : a theory of practice for writing studies researchers
\"Reclaims ethnography as a rigorous writing studies research practice, particularly how \"work\" (a concept defined generously) is co-constituted within writing. The study of work and work processes reveals how institutional discourse, social relations, and norms of professional practice coordinate what people do across time\"--Provided by publisher.
Book
The partnership between the Alzheimer's Association, Alzheimer's Disease Research Centers (ADRCs), and the National Alzheimer's Coordinating Center (NACC) in advancing Alzheimer's disease research and care
Over the past four decades, the partnership between the Alzheimer's Association, Alzheimer's Disease Research Centers (ADRCs), and the National Alzheimer's Coordinating Center (NACC) has been instrumental in advancing research, data infrastructure, and community impact in Alzheimer's disease (AD) and related dementias (ADRD). Established in 1984, ADRCs now span 36 centers conducting cutting‐edge translational research, supported by NACC's comprehensive infrastructure that harmonizes, standardizes, and centralizes ADRC data. The Alzheimer's Association has actively amplified these efforts through major research funding, federal advocacy, data‐sharing platforms, and community engagement programs. The partnership between the Alzheimer's Association, ADRCs, and NACC has accelerated discoveries in AD/ADRD, influenced public policy, and enhanced translation of research into real‐world practice. Their sustained collaboration represents a powerful and scalable model for addressing the growing burden of AD/ADRD and advancing progress in prevention, diagnosis, and care. Highlights The four‐decade partnership between the Alzheimer's Association, ADRCs, and NACC has built a nationally coordinated research ecosystem that accelerates discovery in ADRD. Harmonized data infrastructure, major research funding, federal advocacy, and community engagement have strengthened scientific capacity across ADRCs and expanded access to high‐quality clinical, biomarker, and neuropathologic data. This collaborative model has advanced translational research, informed public policy, and established a scalable framework to drive future progress in prevention, diagnosis, and care for AD/ADRD.
Journal Article
Climbing atop the Shoulders of Giants: The Impact of Institutions on Cumulative Research
While cumulative knowledge production is central to growth, little empirical research investigates how institutions shape whether existing knowledge can be exploited to create new knowledge. This paper assesses the impact of a specific institution, a biological resource center, whose objective is to certify and disseminate knowledge. We disentangle the marginal impact of this institution on cumulative research from the impact of selection, in which the most important discoveries are endogenously linked to research-enhancing institutions. Exploiting exogenous shifts of biomaterials across institutional settings and employing a difference-in-differences approach, we find that effective institutions amplify the cumulative impact of individual scientific discoveries.
Journal Article
A cross‐consortium, stakeholder‐driven model for implementing a modern electronic data capture and submission system across the Alzheimer's Disease Research Centers Program
INTRODUCTION The National Alzheimer's Coordinating Center (NACC) and Alzheimer's Disease Research Center (ADRC) Program advances dementia research by collecting and sharing standardized, longitudinal data, including the Uniform Data Set with the global research community. To modernize workflow and accelerate the availability of analyzable data, we co‐developed a consortium‐wide Electronic Data Capture and Submission system. METHODS A cross‐disciplinary workgroup of ADRC and NACC members co‐developed the system using a stakeholder‐centered sociotechnical implementation model. Subgroups focused on requirements, development, and training. Surveys and pilot testing across centers guided design and priorities. RESULTS Research Electronic Data Capture was selected as the foundational platform. Deliverables included modular UDS version 4 instruments, embedded logic and automated quality checks, dynamic training resources, and an API‐based submission pipeline to NACC. The platform was adopted across all 36 ADRCs and surveys indicated high user satisfaction. DISCUSSION Beyond infrastructure, this initiative provides a scalable, stakeholder‐driven implementation model that supports higher‐quality, more timely multicenter data submission, accelerating biomarker validation, early detection studies, and precision‐medicine analyses. Highlights A cross‐disciplinary workgroup of ADRC and NACC members designed a stakeholder‐centric sociotechnical implementation model. The workgroup drove the adoption of a modernized data infrastructure across a national consortium. Deployed a modern electronic data capture and submission system for the ADRC program. Leveraged REDCap as a flexible, scalable tool for a large‐scale EDCS system.
Journal Article
Four decades of Alzheimer's disease discoveries, data, and research resources: The NIH Alzheimer's Disease Research Center Program
The Alzheimer's Disease Research Centers (ADRC) program, funded by the National Institute on Aging (NIA), is a national network for conducting cutting‐edge basic, clinical, and translational Alzheimer's disease (AD) and AD‐related dementias (ADRD) research. ADRCs collect clinical, biomarker, neuroimaging, and autopsy data on thousands of longitudinally followed research participants and the well‐characterized data and samples generated by the ADRCs are readily available to the research community. Beyond conducting research, the primary objectives of the ADRC program are to train the next generation of multidisciplinary AD/ADRD researchers and share information with the public, including the latest findings and opportunities to participate in clinical studies. This article provides an overview of the 40‐year history of the ADRC program, from its establishment by Congress in 1984 to now, highlighting the AD/ADRD scientific achievements enabled by the ADRCs, the data, samples, and resources that ADRCs provide, and future directions for the program. Highlights This article summarizes the history and infrastructure of the Alzheimer's Disease Research Center (ADRC) program. It describes ADRC contributions to the wider research field of neurodegenerative diseases. It highlights scientific achievements over the past 40 years that were enabled by the research, resources, and data contributions of ADRCs
Journal Article
Integrating real‐world data with gold‐standard longitudinal clinical and genomic data to advance precision medicine for the Alzheimer's Disease Research Center Program and beyond: a proof‐of‐concept data platform
INTRODUCTION Integrating real‐world data (RWD) with clinical research datasets creates more complete, context‐rich resources to drive discovery and enable precision medicine in Alzheimer's disease and related dementias. The National Alzheimer's Coordinating Center conducted a proof‐of‐concept (POC) project to link its longitudinal Uniform Data Set (UDS) with electronic health records (EHRs), Medicare claims, and genomic data. METHODS In partnership with three Alzheimer's Disease Research Centers (ADRCs), we developed scalable data pipelines and a governance framework to collect, harmonize, and securely share linked data through the National Institute on Aging's LINKAGE Program. RESULTS We linked UDS and EHR data for 2206 participants and added Medicare claims for 1522. Nearly 500 participants have 5 or more years of linked data, with genomic profiles available for 93%. DISCUSSION This POC demonstrates the feasibility of integrating clinical, genomic, and RWD across ADRCs, offering a scalable model for broader implementation. Highlights Linking real‐world and clinical research data can provide additional ADRD insights. Required governance and data security for multisite data integration is complex. This POC study linked real‐world and clinical data for > 2000 ADRC participants.
Journal Article
Retention of American Indian and Alaska Native participants in the National Alzheimer's Coordinating Center Uniform Data Set
The number of American Indian and Alaska Native (AI/AN) elders is expected to double by 2060. Thus it is imperative to retain AI/AN participants in longitudinal research studies to identify novel risk factors and potential targets for intervention for Alzheimer's disease and related dementias in these communities.
The National Alzheimer's Coordinating Center houses uniformly collected longitudinal data from the network of National Institute on Aging (NIA)-funded Alzheimer's Disease Research Centers (ADRCs). We used logistic regression to quantify participant retention at 43 ADRCs, comparing self-identified AI/AN participants to non-Hispanic White (NHW) participants, adjusting for potential confounding factors including baseline diagnosis, age, sex, education, and smoking.
The odds of AI/AN participant retention at the first follow-up visit were significantly lower than those for NHW participants (adjusted odds ratio [aOR]: 0.599; 95%: 0.46-0.78; p < 0.001).
These results suggest the need for improved strategies to retain AI/AN participants, perhaps including improved researcher-community relationships and community engagement and education.
American Indian and Alaska Native (AI/AN) research participants were retained to the first follow-up appointment at lower rates than non-Hispanic White (NHW) participants. AI/AN participants are retained at lower rates than NHW participants for long-term follow-up. The majority of AI/AN participants were not retained to the second follow-up visit.
Journal Article