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"Racial Differences"
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The Bio‐Hermes Study: Biomarker database developed to investigate blood‐based and digital biomarkers in community‐based, diverse populations clinically screened for Alzheimer's disease
by
Kerwin, Diana R.
,
Dwyer, John
,
West, Tim
in
Age differences
,
Alzheimer's disease
,
Alzheimer's disease blood‐based biomarkers
2024
INTRODUCTION Alzheimer's disease (AD) trial participants are often screened for eligibility by brain amyloid positron emission tomography/cerebrospinal fluid (PET/CSF), which is inefficient as many are not amyloid positive. Use of blood‐based biomarkers may reduce screen failures. METHODS We recruited 755 non‐Hispanic White, 115 Hispanic, 112 non‐Hispanic Black, and 19 other minority participants across groups of cognitively normal (n = 417), mild cognitive impairment (n = 312), or mild AD (n = 272) participants. Plasma amyloid beta (Aβ)40, Aβ42, Aβ42/Aβ40, total tau, phosphorylated tau (p‐tau)181, and p‐tau217 were measured; amyloid PET/CSF (n = 956) determined amyloid positivity. Clinical, blood biomarker, and ethnicity/race differences associated with amyloid status were evaluated. RESULTS Greater impairment, older age, and carrying an apolipoprotein E (apoE) ε4 allele were associated with greater amyloid burden. Areas under the receiver operating characteristic curve for amyloid status of plasma Aβ42/Aβ40, p‐tau181, and p‐tau217 with amyloid positivity were ≥ 0.7117 for all ethnoracial groups (p‐tau217, ≥0.8128). Age and apoE ε4 adjustments and imputation of biomarker values outside limit of quantitation provided small improvement in predictive power. DISCUSSION Blood‐based biomarkers are highly associated with amyloid PET/CSF results in diverse populations enrolled at clinical trial sites. Highlights Amyloid beta (Aβ)42/Aβ40, phosphorylated tau (p‐tau)181, and p‐tau 217 blood‐based biomarkers predicted brain amyloid positivity. P‐tau 217 was the strongest predictor of brain amyloid positivity. Biomarkers from diverse ethnic, racial, and clinical cohorts predicted brain amyloid positivity. Community‐based populations have similar Alzheimer's disease (AD) biomarker levels as other populations. A prescreen process with blood‐based assays may reduce the number of AD trial screen failures.
Journal Article
Racial differences in whole-body sagittal alignment between Asians and Caucasians based on international multicenter data
by
Kanemura, Tokumi
,
Okamoto, Masashi
,
Ouchida, Jun
in
Comparative analysis
,
Correlation analysis
,
Race
2023
PurposeTo examine inherent differences adjusted for age and clinical score in whole-body sagittal (WBS) alignment involving the lower extremities between Asians and Caucasians, and to determine the relationship between age and WBS parameters by race and sex.MethodsA total of 317 individuals consisting of 206 Asians and 111 Caucasians participated. WBS parameters including C2-7 lordotic angle, lower lumbar lordosis (lower LL, L4-S), pelvic incidence (PI), pelvic thickness, knee flexion (KF), sagittal vertical axis (SVA), and T1 pelvic angle (TPA) were evaluated radiologically. Propensity score-matching adjustments for age and the Oswestry Disability Index scores for comparative analysis between the two race cohorts and correlation analysis between age and WBS parameters for all subjects by race and sex were conducted.ResultsThe comparative analysis included 136 subjects (age: Asians 41.1 ± 13.5, Caucasians 42.3 ± 16.2 years, p = 0.936). Racial differences in WBS parameters were observed in C2-7 lordotic angle (−1.8 ± 12.3 vs. 6.3 ± 12.2 degrees, p = 0.001), and lower LL (34.0 ± 6.6 vs. 38.0 ± 6.1 degrees, p < .001). In correlation analysis with age, moderate or more significant correlations with age were found in KF for all groups, and in SVA and TPA for females of both racial groups. Age-related changes in pelvic parameters of PI and pelvic thickness were more significant in Caucasian females.ConclusionAnalysis of the correlation between age and WBS parameters suggested that age-related WBS changes vary between races and should be considered during corrective spinal surgery.
Journal Article
Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer
by
Zhang, Zuo-Feng
,
Vaughan, Thomas L.
,
Smith, Elaine
in
Alcohol Drinking - epidemiology
,
Alcohol use
,
Biomedical and Life Sciences
2018
There have been few published studies on differences between Blacks and Whites in the estimated effects of alcohol and tobacco use on the incidence of head and neck cancer (HNC) in the United States. Previous studies have been limited by small numbers of Blacks. Using pooled data from 13 US case–control studies of oral, pharyngeal, and laryngeal cancers in the International Head and Neck Cancer Epidemiology Consortium, this study comprised a large number of Black HNC cases (n = 975). Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) for several tobacco and alcohol consumption characteristics. Blacks were found to have consistently stronger associations than Whites for the majority of tobacco consumption variables. For example, compared to never smokers, Blacks who smoked cigarettes for > 30 years had an OR 4.53 (95% CI 3.22–6.39), which was larger than that observed in Whites (OR 3.01, 95% CI 2.73–3.33; p
interaction < 0.0001). The ORs for alcohol use were also larger among Blacks compared to Whites. Exclusion of oropharyngeal cases attenuated the racial differences in tobacco use associations but not alcohol use associations. These findings suggest modest racial differences exist in the association of HNC risk with tobacco and alcohol consumption.
Journal Article
Racial difference in receiving computed tomography for head injury patients in emergency departments
2024
Prior studies have suggested potential racial differences in receiving imaging tests in emergency departments (EDs), but the results remain inconclusive. In addition, most prior studies may only have limited racial groups for minority patients. This study aimed to investigate racial differences in head computed tomography (CT) administration rates in EDs among patients with head injuries.
Patients with head injuries who visited EDs were examined. The primary outcome was patients receiving head CT during ED visits, and the primary exposure was patient race/ethnicity, including Asian, Hispanic, Non-Hispanic Black (Black), and Non-Hispanic White (White). Multivariable logistic regression analyses were performed using the National Hospital Ambulatory Medical Care Survey database, adjusting for patients and hospital characteristics.
Among 6130 patients, 51.9% received a head CT scan. Asian head injury patients were more likely to receive head CT than White patients (59.1% versus 54.0%, difference 5.1%, p < 0.001). This difference persisted in adjusted results (odds ratio, 1.52; 95% CI, 1.06–2.16, p = 0.022). In contrast, Black and Hispanic patients have no significant difference in receiving head CT than White patients after the adjustment.
Asian head injury patients were more likely to receive head CT than White patients. This difference may be attributed to the limited English proficiency among Asian individuals and the fact that there is a wide variety of different languages spoken by Asian patients. Future studies should examine rates of receiving other diagnostic imaging modalities among different racial groups and possible interventions to address this difference.
•Asian head injury patients were more likely to receive head CT than White patients.•This may be due to communication barriers between physicians and Asian patients.•Number of languages spoken by Asians may cause difficulty in finding translators.•Future studies should focus on the effect of improving communication services.
Journal Article
Racial Differences in Blood Pressure and Autonomic Recovery Following Acute Supramaximal Exercise in Women
by
Camhi, Sarah M.
,
Merchant, Noelle
,
Bajdek, Nicole
in
Aerobics
,
Arterial Pressure
,
Black people
2023
Despite the growing popularity of high-intensity anaerobic exercise, little is known about the acute effects of this form of exercise on cardiovascular hemodynamics or autonomic modulation, which might provide insight into the individual assessment of responses to training load. The purpose of this study was to compare blood pressure and autonomic recovery following repeated bouts of acute supramaximal exercise in Black and White women. A convenience sample of twelve White and eight Black young, healthy women were recruited for this study and completed two consecutive bouts of supramaximal exercise on the cycle ergometer with 30 min of recovery in between. Brachial and central aortic blood pressures were assessed by tonometry (SphygmoCor Xcel) at rest and 15-min and 30-min following each exercise bout. Central aortic blood pressure was estimated using brachial pressure waveforms and customized software. Autonomic modulation was measured in a subset of ten participants by heart-rate variability and baroreflex sensitivity. Brachial mean arterial pressure and diastolic blood pressure were significantly higher in Blacks compared to Whites across time (race effect, p = 0.043 and p = 0.049, respectively). Very-low-frequency and low-frequency bands of heart rate variability, which are associated with sympathovagal balance and vasomotor tone, were 22.5% and 24.9% lower, respectively, in Blacks compared to Whites (race effect, p = 0.045 and p = 0.006, respectively). In conclusion, the preliminary findings of racial differences in blood pressure and autonomic recovery following supramaximal exercise warrant further investigations of tailored exercise prescriptions for Blacks and Whites.
Journal Article
Differences Between Latinx and White Students in College-Going Behaviors
2022
Though Latinx students are going to college at an increasing rate, these students are still more likely to attend community college and less prestigious 4-year institutions than other groups. In an effort to understand this pattern, our study investigates how Latinx students prepare for college while in high school. We use nationally representative data to predict how Latinx students differ from White students when engaging in college-going behaviors. We find that, net of controls, Latinx students are less likely to take college entrance exams but submit more applications to college. We also find that increases in parental SES are associated with increases in college-going behaviors for White students, while Latinx students are consistent in engaging in college-going behaviors across parental SES. An increase in the number of friends planning to attend 4-year college is associated with greater engagement in some college-going behaviors for Latinx students, though less so than for White students. These results have implications for how researchers conceptualize the Latinx–White college enrollment gap.
Journal Article
A Census Tract–Level Examination of Differences in Social Determinants of Health Among People With HIV, by Race/Ethnicity and Geography, United States and Puerto Rico, 2017
by
Gant, Zanetta
,
Nwangwu-Ike, Ndidi
,
Lyons, Shacara Johnson
in
Adult
,
Adults
,
Black white differences
2022
Objective
Social and structural factors, referred to as social determinants of health (SDH), create pathways or barriers to equitable sexual health, and information on these factors can provide critical insight into rates of diseases such as HIV. Our objectives were to describe and identify differences, by race/ethnicity and geography, in SDH among adults with HIV.
Methods
We conducted an ecological study to explore SDH among people with HIV diagnosed in 2017, by race/ethnicity and geography, at the census-tract level in the United States and Puerto Rico. We defined the least favorable SDH as the following: low income (<$40 000 in median annual household income), low levels of education (≥18% of residents have
Journal Article
Double Jeopardy? The Interaction of Gender and Race on Earnings in the United States
2008
There are sizeable earnings differentials by gender and race in the U.S. labor market, with women earning less than men and most racial/ethnic minority groups earning less than whites. It has been proposed in the previous literature that the effects of gender and race on earnings are additive, so that minority women suffer the full disadvantage of each status. We test this proposition for a broad range of minority groups in the United States. We find that women of all minority groups suffer a smaller gender penalty than white women (relative to same-race men). Exploring the potential role of racial variation in gender role specialization in producing such differentials, we find some empirical evidence suggesting that white families specialize more than families of most other races.
Journal Article
Racial Differences in the Oral Microbiome: Data from Low-Income Populations of African Ancestry and European Ancestry
2019
In this systemic investigation of racial differences in the oral microbiome using a large data set, we disclosed the significant differences in the oral microbial richness/evenness, as well as in the overall microbial composition, between African-Americans and European-Americans. We also found multiple oral bacterial taxa, including several preidentified oral pathogens, showing a significant different abundance or prevalence between African-Americans and European-Americans. Furthermore, these taxa were consistently found to be associated with the percentage of genetic African ancestry. Our findings warrant further research to understand how the racial difference in the oral microbiome influences the health disparity. Increasing evidence indicates the significant racial difference in gut, vaginal, and skin microbiomes. However, little is known regarding the racial difference in the oral microbiome. In this study, deep sequencing of 16S rRNA genes was utilized to assess the oral microbiome in mouth rinse samples of 1,058 African-Americans (AAs) and 558 European-Americans (EAs) from the Southern Community Cohort Study. Generally, AAs had a higher species richness than EAs, with P = 5.28 × 10 −14 (Wilcoxon rank sum test) for Faith’s phylogenetic diversity index. A significant difference in overall microbiome composition was observed between AAs and EAs, with P = 5.94 × 10 −4 (MiRKAT) for the weighted UniFrac distance matrix. We also found 32 bacterial taxa showing a significant differential abundance or prevalence between the two racial groups at a Bonferroni-corrected P < 0.05 in linear or logistic regression analyses. Generally, AAs showed a higher abundance of Bacteroidetes and a lower abundance of Actinobacteria and Firmicutes . Interestingly, four periodontal pathogens, Porphyromonas gingivalis , Prevotella intermedia , Treponema denticola , and Filifactor alocis , were more prevalent among AAs than among EAs, with Bonferroni-corrected P values of 5.23 × 10 −6 , 4.47 × 10 −6 , 1.08 × 10 −3 , and 4.49 × 10 −5 , respectively. In addition, all of these 32 taxa were significantly correlated with the percentage of genetic African ancestry. These findings call for research to understand how the racial difference in oral microbiome influences the health disparity. IMPORTANCE In this systemic investigation of racial differences in the oral microbiome using a large data set, we disclosed the significant differences in the oral microbial richness/evenness, as well as in the overall microbial composition, between African-Americans and European-Americans. We also found multiple oral bacterial taxa, including several preidentified oral pathogens, showing a significant different abundance or prevalence between African-Americans and European-Americans. Furthermore, these taxa were consistently found to be associated with the percentage of genetic African ancestry. Our findings warrant further research to understand how the racial difference in the oral microbiome influences the health disparity.
Journal Article
Let’s “Talk” about the police: The role of race and police legitimacy attitudes in the legal socialization of youth
by
April, Keisha
,
Cole, Lindsey M.
,
Goldstein, Naomi E. S.
in
Attitudes
,
Behavioral Science and Psychology
,
Legitimacy
2023
Anecdotal evidence suggests Black caregivers tend to engage in a sociocultural practice called “the Talk,” in which they equip youth with knowledge to facilitate successful navigation of police encounters. Yet, little empirical research exists examining this practice and the factors that may influence the transmission of messages from parents to youth. This study examined the types of messages parents deem important for children to understand about police, whether racial differences exist, and whether parents’ police legitimacy attitudes play a role in perceived importance. Exploratory factor analysis of survey responses from 1,056 parents identified four constructs inherent in The Talk: messages about Police Role, Compliance, Police Behaviors and Safety Behaviors. Using survey data from 948 Black and White parents, multiple regression analyses revealed that parent race was significantly related to the importance parents placed on communicating specific types of messages about the police and that legitimacy attitudes moderated these relationships. Consistent with prior findings of racial differences in legitimacy attitudes, Black parents reported less trust in the police than White parents. Black parents also placed less importance on communicating positive socialization messages about police and greater importance on communicating messages related to compliance, expectations of negative police behaviors, and maintaining personal safety during police encounters. Although legitimacy attitudes significantly moderated the relationship between parent race and message content, Black parents’ legitimacy attitudes were a weaker driver of parents’ messages than White parents’ attitudes, suggesting that additional factors (e.g., expectations of differential treatment) may motivate Black parents’ socialization practices.
Journal Article
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