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\"A spectacular retrospective of the profoundly influential photographer Rankin's extraordinary thirty-year career on the cutting edge of fashion and pop culture. A photographer who defined the aesthetics and attitudes of the 1990s and 2000s, Rankin's influence continues to be seen everywhere, from fashion editorials to cinematography, graphic design, and music videos for artists from Iggy Azalea to Miley Cyrus. Edited by the photographer himself, and drawing from thirty years of work, this is the first retrospective of Rankin's full career. From early provocative portraiture in the late 1980s, through his founding with Jefferson Hack of the fashion bibles of the 1990s and 2000s, Dazed & Confused and AnOther Magazine, to his pioneering of independent television and film through Hunger and his iconic monographs on Heidi Klum and Rosie Huntington-Whiteley, Rankin's work has defined the face of popular culture for generations. Presented in reverse chronology, with a nod to a continuing spirit of contradiction, Unfashionable moves from Rankin's most iconic portraiture and documentary work through his nudes, his groundbreaking fashion work, and back to his earliest Polaroids. With contributions from Rankin and several of his influences, peers, subjects, and admirers, this is the definitive look at one of the most profound influences on fashion and photography working today\"--Publisher's description.

Let π be a HeckeMaass cusp form for SL(3,Z) and f be a holomorphic (or Maass) Hecke cusp form for SL(2,Z). In this paper we prove the subconvex boundL(1/2+it,π×f)≪π,f,ε​(1+∣t∣)3/2−1/51+ε.

Let π be a Hecke–Maass cusp form for SL(3,Z) and f be a holomorphic cusp form for SL(2,Z) of weight k or a Hecke–Maass cusp form corresponding to the Laplacian eigenvalue 1/4+k2, k≥1, for SL(2,Z). In this paper, we prove the following subconvexity bound:L(1/2,π×f)≪π,ε​k3/2−1/51+ε.

Abstract BACKGROUND Predicting outcome after aneurysmal subarachnoid hemorrhage (aSAH) is known to be challenging and complex. Machine learning approaches, of which feedforward artificial neural networks (ffANNs) are the most widely used, could contribute to the patient-specific outcome prediction. OBJECTIVE To investigate the prediction capacity of an ffANN for the patient-specific clinical outcome and the occurrence of delayed cerebral ischemia (DCI) and compare those results with the predictions of 2 internationally used scoring systems. METHODS A prospective database was used to predict (1) death during hospitalization (ie, mortality) (n = 451), (2) unfavorable modified Rankin Scale (mRS) at 6 mo (n = 413), and (3) the occurrence of DCI (n = 362). Additionally, the predictive capacities of the ffANN were compared to those of Subarachnoid Haemorrhage International Trialists (SAHIT) and VASOGRADE to predict clinical outcome and occurrence of DCI. RESULTS The area under the curve (AUC) of the ffANN showed to be 88%, 85%, and 72% for predicting mortality, an unfavorable mRS, and the occurrence of DCI, respectively. Sensitivity/specificity rates of the ffANN for mortality, unfavorable mRS, and the occurrence of DCI were 82%/80%, 94%/80%, and 74%/68%. The ffANN and SAHIT calculator showed similar AUCs for predicting personalized outcome. The presented ffANN and VASOGRADE were found to perform equally with regard to personalized prediction of occurrence of DCI. CONCLUSION The presented ffANN showed equal performance when compared with VASOGRADE and SAHIT scoring systems while using less individual cases. The web interface launched simultaneously with the publication of this manuscript allows for usage of the ffANN-based prediction tool for individual data (https://nutshell-tool.com/).

Prediction of neurological outcome after cardiac arrest is a major challenge. The aim of this study was to assess whether quantitative whole-brain white matter fractional anisotropy (WWM-FA) measured by diffusion tensor imaging between day 7 and day 28 after cardiac arrest can predict long-term neurological outcome. This prospective, observational, cohort study (part of the MRI-COMA study) was done in 14 centres in France, Italy, and Belgium. We enrolled patients aged 18 years or older who had been unconscious for at least 7 days after cardiac arrest into the derivation cohort. The following year, we recruited the validation cohort on the same basis. We also recruited a minimum of five healthy volunteers at each centre for the normalisation procedure. WWM-FA values were compared with standard criteria for unfavourable outcome, conventional MRI sequences (fluid-attenuated inversion recovery and diffusion-weighted imaging), and proton magnetic resonance spectroscopy. The primary outcome was the best achieved Glasgow-Pittsburgh Cerebral Performance Categories (CPC) at 6 months, dichotomised as favourable (CPC 1–2) and unfavourable outcome (CPC 3–5). Prognostication performance was assessed by the area under the receiver operating characteristic (ROC) curves and compared between groups. This study was registered with ClinicalTrials.gov, number NCT00577954. Between Oct 1, 2006, and June 30, 2014, 185 patients were enrolled in the derivation cohort, of whom 150 had an interpretable multimodal MRI and were included in the analysis. 33 (22%) patients had a favourable neurological outcome at 6 months. Prognostic accuracy, as quantified by the area under the ROC curve, was significantly higher with the normalised WWM-FA value (area under the ROC curve 0·95, 95% CI 0·91–0·98) than with the standard criteria for unfavourable outcome or other MRI sequences. In a subsequent validation cohort of 50 patients (enrolled between April 1, 2015, and March 31, 2016), a normalised WWM-FA value lower than 0·91, set from the derivation cohort, had a negative predictive value of 71·4% (95% CI 41·9–91·6) and a positive predictive value of 100% (90·0–100), with 89·7% sensitivity (75·8–97·1) and 100% specificity (69·1–100) for the prediction of unfavourable outcome. In patients who are unconscious 7 days after cardiac arrest, the normalised WWM-FA value, measured by diffusion tensor imaging, could be used to accurately predict neurological outcome at 6 months. This evidence requires confirmation from future large-scale trials with a strict protocol of withdrawal or limitation-of-care decisions and time window for MRI. French Ministry of Health, French National Agency for Research, Italian Ministry of Health, and Regione Lombardia.

Over any fixed totally real number field with narrow class number one, we prove that the Rankin–Cohen bracket of two Hecke eigenforms for the Hilbert modular group can only be a Hecke eigenform for dimension reasons, except for a couple of cases where the Rankin–Selberg method does not apply. We shall also prove a conjecture of Freitag on the volume of Hilbert modular groups, and assuming a conjecture of Freitag on the dimension of the cuspform space, we obtain a finiteness result on eigenform product identities.

Transient modeling of an innovative dual-loop Rankin–organic Rankin (RC–ORC) heat recovery and power generation system integrated with a gas engine is performed here. The transient behavior of dual-loop cycles is not investigated so far, and hence the present work is an essential tool for predicting and controlling the performance of the RC–ORC dual-loop cycle during the start-up and the gas engine load change conditions. Transient energy conservation equations for heat exchangers are solved in discretized form. Quasi-dynamic equations are also considered for pumps, steam turbines, and expanders by the use of existing empirical relations. The model is developed in MATLAB software and validated using available data. Variations with time of operational parameters are presented and analyzed for both loops of RC and ORC. The results for the start-up period show a relatively sharp increase in parameters in time interval 500–1200 s. RC evaporator working fluid outlet temperature changes from 159 to 254 °C, RC net power output changes from 147 to 308 kW, and ORC net power output changes from 165 to 300 kW. Furthermore, RC and ORC working fluid mass flow rates changes from 0.25 to 0.50 kg s −1 and from 2.2 to 4.65 kg s −1 respectively. Moreover, results show that the turbine reached the steady state condition faster (1200 s) than that for evaporator (1750 s), RC loop reached steady state condition later than ORC loop (1750 s in comparison with 1300 s), and a single-loop ORC cycle reached steady state condition faster than RC–ORC dual-loop cycle (820 s in comparison with 1750 s).

Background The modified Rankin Scale (mRS) is a key global outcome measure after stroke internationally. The latest English version of the simplified modified Rankin scale questionnaire (smRSq)(2011) is a reliable and valid tool in scoring the mRS after stroke. In order to use this tool in Chinese patients, we translated it into Chinese and tested its clinimetric properties. Methods The English version smRSq (2011) was translated into Chinese by a standard process. We recruited 300 consecutive hospitalized ischemic stroke patients in the department of neurology, Beijing Chaoyang Hospital. Six randomly paired raters scored the conventional mRS, the novel Chinese version smRSq (2011), the National Institutes of Health Stroke Scale (NIHSS), and the Barthel index (BI) in-person. Inter-rater reliability and validity were assessed. Results Among the 300 ischemic stroke patients, mean age was 64.9 ± 12.1 years, and 220 (73%) were male. For inter-rater reliability of the smRSq (2011), the percent agreement among the paired raters was 87%, the kappa (κ) was 0.84 (95% CI, 0.79–0.88), and the weighted kappa (κ w ) was 0.96 (95% CI, 0.95–0.98). The percent agreement between the smRSq (2011) scores and the conventional mRS scores was 55%, κ = 0.47 (95% CI, 0.40–0.54), and κ w  = 0.91 (95% CI, 0.89–0.93). In construct validity testing, the Spearman’s correlation coefficients comparing the smRSq (2011) scores with the NIHSS and the BI scores were 0.83 ( P  < 0.001) and − 0.86 ( P  < 0.001), respectively. Conclusions Our results show good to excellent clinimetric properties of the novel Chinese version smRSq (2011) in scoring the mRS in Chinese stroke patients. Further validation in other clinical settings, including in communities and by remote methods in China is warranted.

Traumatic brain injury (TBI) remains a main public health problem being associated with high mortality and morbidity. The functional outcome of TBI remains unfavorable despite several surgical and medical therapies. Cerebrolysin is a neuropeptide with potential neuroregenerative entities. The aim of the current systematic review and meta-analysis was to investigate the effects of cerebrolysin on functional outcome in patients with moderate and severe TBI. Online databases used included Medline, Scopus, EMBASE, Google Scholar, Web of Science, and Cochrane Library. All the relevant studies with randomized clinical trial and cohort design evaluating the effects of intravenous cerebrolysin vs placebo on functional outcome of patients with TBI within the English literature up to October 2018 were included. The articles were reviewed by two independent authors and the data were extracted to a data sheet. and Cochran's -statistics were used to assess heterogeneity. Based on the presence of significant heterogeneity across included studies, data were pooled using random-effects model with Dersimonian-Laird method and presented as standardized mean differences (SMDs) and corresponding 95% CI. Five articles (5,685 participants) were included in the current meta-analysis. The overall pooled findings using random-effects models among patients with TBI indicated that intravenous administration of cerebrolysin significantly increased Glasgow Outcome Scale score (SMD =0.30; 95% CI: 0.18 to 0.42; <0.001; : 87.8%) and decreased modified Rankin Scale score (SMD =-0.29; 95% CI: -0.42 to 0.16; =0.05; : 89.6%). The results are mainly based on cohort studies and there is a lack of clinical trials in the literature. There is also heterogeneity among the studies regarding the dosage and duration of administration and the measurement of functional outcome. The results of the current study revealed that intravenous administration of cerebrolysin is associated with improved functional outcome in patients with TBI measured by the Glasgow Outcome Scale and the modified Rankin Scale scores.