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Ronald Reagan, a former actor and one of America's most popular presidents, married not one but two Hollywood actresses. This book is three biographies in one, discovering fascinating connections among Jane Wyman (1917-2007), Ronald Reagan (1911-2004), and Nancy Davis (b. 1921). Jane Wyman, who married Reagan in 1940 and divorced him seven years later, knew an early life of privation. She gravitated to the movies and made her debut at fifteen as an unbilled member of the chorus, then toiled as an extra for four years until she finally received billing. She proved herself as a dramatic actress inThe Lost Weekend, and the following year, she was nominated for an Oscar for The Yearling and soon won for her performance inJohnny Belinda, in which she did not speak a single line. Other Oscar nominations followed, along with a Golden Globe for her portrayal of Angela Channing inFalcon Crest. Conversely, Nancy Davis led a relatively charmed life, the daughter of an actress and the stepdaughter of a neurosurgeon. Surrounded by her mother's friends--Walter Huston, Spencer Tracy, Katharine Hepburn, Lillian Gish, and Alla Nazimova, her godmother--Davis started in the theater, then moved on to Hollywood, where she enjoyed modest success, and finally began working in television. When she married Reagan in 1952, she unwittingly married into politics, eventually leaving acting to concentrate on being the wife of the governor of California, and then the wife of the president of the United States. In her way, Davis played her greatest role as Reagan's friend, confidante, and adviser in life and in politics. This book considers three actors who left an indelible mark on both popular and political culture for more than fifty years.

Washington Post opinions columnist Karen Tumulty's new book, “The Triumph of Nancy Reagan,” chronicles the first lady who shaped one of the most consequential presidencies of the 20th century. Join Washington Post opinions editor-at-large Michael Duffy in conversation with Tumulty.

First lady Nancy Reagan accompanied her husband; some 600 journalists covered the trip. In Beijing, one of my responsibilities was making sure that The Wall Street Journal got delivered to the doors at the Diaoyutai State Guest House every morning, a task totally dependent on the unreliable flight from Hong Kong carrying the newspapers. [...]we got a small taste of the reaction a month later when my husband and I stood in for the ambassador at a banquet that the mayor of Beijing was giving for teenage students from Greenwich, Connecticut on an art exchange program.

Here we highlight the Alzheimer's Association's role since its inception, as a strategic collaborator with National Institutes of Health–National Institute on Aging in the development of the modern era of the Alzheimer's Movement and in making Alzheimer's disease (AD) a national priority in the United States by developing several initiatives to advance knowledge about the cause, diagnosis, and treatment of dementia. Among these collaborative undertakings, the Alzheimer's Disease Neuroimaging Initiative (ADNI) is an exemplary case, launched with groundwork by the Neuroimaging Working Group sponsored by the Association's Ronald and Nancy Reagan Research Institute on AD. The unique contribution of the Association to the development of ADNI includes participation as a member of ADNI's Private Partner Scientific Board and involvement in developing an AD biomarker standardization and validation subproject, which has led to a conceptual shift in the field to define AD based on its underlying biology. Furthermore, the creation of Worldwide ADNI (WW‐ADNI) is highlighted, underscoring the global impact of these efforts. Highlights The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a keystone undertaking in the evolving landscape of Alzheimer's disease (AD) research, and is now in its fourth iteration. The Alzheimer's Association has partnered with ADNI since its inception. ADNI 4 and the Association continue to collaborate, ensuring representation within the study population.

It is well known that Alzheimer's disease (AD) is one of the most common progressive neurodegenerative diseases; it begins gradually, and therefore no effective medicine is administered in the beginning. Thus, early diagnosis and prevention of AD are crucial. The present study focused on comparing the plasma protein changes between patients with AD and their healthy counterparts, aiming to explore a specific protein panel as a potential biomarker for AD patients in Han Chinese. Hence, we recruited and collected plasma samples from 98 AD patients and 101 elderly healthy controls from Wuxi and Shanghai Mental Health Centers. Using a Luminex assay, we investigated the expression levels of fifty plasma proteins in these samples. Thirty-two out of 50 proteins were found to be significantly different between AD patients and healthy controls ( < 0.05). Furthermore, an eight-protein panel that included brain-derived neurotrophic factor (BDNF), angiotensinogen (AGT), insulin-like growth factor binding protein 2 (IGFBP-2), osteopontin (OPN), cathepsin D, serum amyloid P component (SAP), complement C4, and prealbumin (transthyretin, TTR) showed the highest determinative score for AD and healthy controls (all = 0.00). In conclusion, these findings suggest that a combination of eight plasma proteins can serve as a promising diagnostic biomarker for AD with high sensitivity and specificity in Han Chinese populations; the eight plasma proteins were proven important for AD diagnosis by further cross-validation studies within the AD cohort.

[...]you're a Disney cartoon.

On this edition of Meet the Press: Chris Dodd and Newt Gingrich debate troop withdrawal from Iraq; Douglas Brinkley, Michael Deaver, and Ed Meese discuss the newly released Reagan diaries.

In recent years, the figure of Pablo Escobar, the late Colombian drug trafficker, has been increasingly appropriated by public imagination through different media and by different audiences. Memes, sticker albums, shirts are but some of the ways in which Escobar has been reincarnated as a jest, as a brand, or as a revolutionary act. He has returned to take part in a Colombian as well as a global imaginary in a way unprecedented since his death in Medellín in 1993. This new Escobar transcend Colombia's borders. Today, landmarks such as the show Narcos (2015), a successful American production by Netflix, have established the image of the drug trafficker as a \"War on Drugs\" icon. Nevertheless, Escobar's mediatic and international turn appears within a narrative that has its own tradition and is based on a history that links drug production and drug trafficking to contemporary Latin America, and Colombia in particular. Trying to find the link between the local and the global use of Escobar's figure is fundamental to understanding the moral narrative of the War on Drugs, wherein drugs and the people-and things-who produce and commercialize them are portrayed as the public enemy.In this paper, I will trace the origins of Escobar's mediatic boom to the death of one the hippos kept in his personal zoo. The animal's death, sixteen years after Escobar's, put the spotlight back on the capo, providing a new scheme of discourse that enables the reinvention and renewed existence of his figure. I argue that looking at the narratives surrounding Escobar's rise and death through the hippo's death evinces both the narrative apparatus that frames the War on Drugs in Colombia and possible ways to disarticulate it. The War on Drugs narrative has made drug traffickers such as Escobar and the coca leaf, from which cocaine comes, into monstrous figures. Returning the figure of the monster to its animal condition, namely through the presence of the hippo, allows for a better understanding of how media and art play a central role in the politics of the war against drug trafficking. Using Escobar's figure, this paper traces how media and art have evolved to construct and deconstruct discourses on drug trafficking from Ronald and Nancy Reagan's \"just say no\" campaign to the most recent narco-series media boom.