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CD30 induces Reed‐Sternberg cell‐like morphology and chromosomal instability in classic Hodgkin lymphoma cell lines
Classic Hodgkin lymphoma (cHL) is characterized by multinucleated cells called Reed‐Sternberg (RS) cells and genetic complexity. Although CD30 also characterizes cHL cells, its biological roles are not fully understood. In this report, we examined the link between CD30 and these characteristics of cHL cells. CD30 stimulation increased multinucleated cells resembling RS cells. We found chromatin bridges, a cause of mitotic errors, among the nuclei of multinucleated cells. CD30 stimulation induced DNA double‐strand breaks (DSBs) and chromosomal imbalances. RNA sequencing showed significant changes in the gene expression by CD30 stimulation. We found that CD30 stimulation increased intracellular reactive oxygen species (ROS), which induced DSBs and multinucleated cells with chromatin bridges. The PI3K pathway was responsible for CD30‐mediated generation of multinucleated cells by ROS. These results suggest that CD30 involves generation of RS cell‐like multinucleated cells and chromosomal instability through induction of DSBs by ROS, which subsequently induces chromatin bridges and mitotic error. The results link CD30 not only to the morphological features of cHL cells, but also to the genetic complexity, both of which are characteristic of cHL cells. CD30 involves generation of Reed‐Sternberg cell‐like multinucleated cells and chromosomal instability via induction of DNA double‐strand breaks by reactive oxygen species. The results link CD30 not only to the morphological feature, but also to the genetic complexity, both of which are characteristic of classic Hodgkin lymphoma cells.
Journal Article
The art of the straight line : my Tai chi
\"Lou Reed was a musician, singer, songwriter, poet, and founding member of the legendary rock band the Velvet Underground. He collaborated with many artists, from Andy Warhol and John Cale to Robert Wilson and Metallica. Reed had a groundbreaking solo career that spanned five decades until his death in 2013. Reed was also an accomplished martial artist whose practice began in the 1980s. He studied with Chen Tai Chi pioneer Master Ren GuangYi. This book is a comprehensive collection of Reed's writings on Tai Chi. It includes conversations with Reed's fellow musicians, artists, friends, and Tai Chi practitioners, including Julian Schnabel, A. M. Homes, Hal Willner, Mingyur Rinpoche, Eddie Stern, Tony Visconti, and Iggy Pop. The Art of the Straight Line features Reed's unpublished writings on the technique, practice, and purpose of martial arts, as well as essays, observations, and riffs on meditation and life\"--Inside front jacket flap.
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Genetic and ecological characterization of the giant reed
Arundo donax (giant reed) is currently found in all tropical-subtropical and warm-temperate areas of the world. In Mexico, A. donax is a common introduced species, growing in a variety of climates and habitats. We used Inter Simple Sequence Repeats (ISSRs) markers to analyze 20 populations across different geographic regions of Mexico to estimate the geographic structure of its genetic variation, the levels of clonal diversity, and their predominant reproductive mode (clonal vs. sexual), and to explore environmental factors that may be related to genetic differentiation. In addition, we used bioclimatic variables to perform multivariate statistical analyses. We detected a total of 77 different genotypes, finding that all the analyzed populations are multiclonal (including from 3 to 9 different genotypes). The data suggest that sporadic sexual reproduction takes place in some populations. We found four main genetic groups and low levels of gene flow among clusters. Ecological characterization analyses indicate that the distribution and abundance of genotypes is structured and influenced by environmental factors, supporting the existence of three main ecological-genetic groups in Mexico (Central Highlands, Coasts, and North).
Journal Article