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While urban preservation is almost as old as cities themselves, it has become increasingly controversial in modern cities. In this book, Yue Zhang presents a cross-national comparative analysis of the politics of urban preservation. Based on comprehensive archival research and more than two hundred in-depth interviews in Beijing, Chicago, and Paris, Zhang finds that urban preservation provides a tool for diverse political and social actors to frame their propositions and advance their favored courses of action. In cities from West to East, divergent political and economic interests have caused urban preservation to become contested. Exploring three of the world's great cities, Zhang deftly navigates readers through each case study, illustrating the complexities of the politics of urban preservation in each city. In Beijing, urban preservation was integral to promoting economic growth and enhancing the city's image during the lead-up to the 2008 Olympics; in Chicago, it is used to increase property values and revitalize neighborhoods; and in Paris, it offers a channel for national and municipal governments to compete for control over urban space. Although urban preservation serves various purposes in these cities, Zhang explains how different types of political fragmentation have affected the implementation of preservation initiatives in predictable ways, thus generating distinct patterns of urban preservation. A comparative urban politics study of unusual breadth, The Fragmented Politics of Urban Preservation gives us insight into the complex policy process of urban preservation through which political institutions are intertwined with interests and inclinations, fundamentally shaping the direction of urban development, the physical forms of cities, and the lives of citizens.

Fifty years ago, urban waterfronts were industrial, polluted, and diseased. Today, luxury homes and shops line riverbanks, harbors, and lakes across Europe and North America. The visual drama of physical reconstruction makes this transition look swift and decisive, but reimaging water is a slow process, punctuated by small cultural shifts and informal spatial seizures that change the meaning of wet urban spaces. InThe Politics of Urban Water, Kimberley Kinder explores how active residents in Amsterdam deployed their cityscape when rallying around these concerns, turning space into a vehicle for social reform. While market dynamics certainly contributed to the transformation of Amsterdam's shorelines, squatters, partiers, artists, historians, environmentalists, tourists, reporters, and government officials also played crucial roles in bringing waterscapes to life. Their interventions pulled water in new directions, connecting it to political discussions about affordable housing, cultural tolerance, climate change, and national identity. Over time, these political valences have become embedded in laws, norms, symbols, markets, and landscapes, bringing rich undercurrents of friction to urban shores. Amsterdam's development serves as both an inspiration and a cautionary tale for cities across Europe and North America where rapid new growth creates similar pressures and anxieties.

Once the cosmopolitan center of the Middle East, Beirut was devastated by the civil war that ran from 1975 to 1991, which dislocated many residents, disrupted normal municipal functions, and destroyed the vibrant downtown district. The aftermath of the war was an unstable situation Sawalha considers “a postwar state of emergency,” even as the state strove to restore normalcy. This ethnography centers on various groups’ responses to Beirut’s large, privatized urban-renewal project that unfolded during this turbulent moment. At the core of the study is the theme of remembering space. The official process of rebuilding the city as a node in the global economy collided with local day-to-day concerns, and all arguments invariably inspired narratives of what happened before and during the war. Sawalha explains how Beirutis invoked their past experiences of specific sites to vie for the power to shape those sites in the future. Rather than focus on a single site, the ethnography crosses multiple urban sites and social groups, to survey varied groups with interests in particular spaces. The book contextualizes these spatial conflicts within the discourses of the city’s historical accounts and the much-debated concept of heritage, voiced in academic writing, politics, and journalism. In the afterword, Sawalha links these conflicts to the social and political crises of early twenty-first-century Beirut.

The much-praised Cultural Quarters returns in a revised edition, offering new case studies and new chapters on the economics of cultural quarters and the importance of historical buildings. This definitive text provides a conceptual context for cultural quarters through a detailed discussion of urban design and planning.

In Brazil and throughout the African diaspora, black women, especially poor black women, are rarely considered leaders of social movements let alone political theorists. But in the northeastern city of Salvador, Brazil, it is these very women who determine how urban policies are established. Focusing on the Gamboa de Baixo neighborhood in Salvador's city center,Black Women against the Land Grabexplores how black women's views on development have radicalized local communities to demand justice and social change. InBlack Women against the Land Grab, Keisha-Khan Y. Perry describes the key role of local women activists in the citywide movement for land and housing rights. She reveals the importance of geographic location for understanding the gendered aspects of urban renewal and the formation of black women-led social movements. How have black women shaped the politics of urban redevelopment, Perry asks, and what does this kind of political intervention tell us about black women's agency? Her work uncovers the ways in which political labor at the neighborhood level is central to the mass mobilization of black people against institutional racism and for citizenship rights and resources in Brazil. Highlighting the political life of black communities, specifically those in urban contexts often represented as socially pathological and politically bankrupt,Black Women against the Land Graboffers a valuable corrective to how we think about politics and about black women, particularly poor black women, as a political force.

Why do autocrats build spectacular new capital cities? InThe Geopolitics of Spectacle, Natalie Koch considers how autocratic rulers use \"spectacular\" projects to shape state-society relations, but rather than focus on the standard approach-on the project itself-she considers the unspectacular \"others.\" The contrasting views of those from the poorest regions toward these new national capitals help her develop a geographic approach to spectacle. Koch uses Astana in Kazakhstan to exemplify her argument, comparing that spectacular city with others from resource-rich, nondemocratic nations in central Asia, the Arabian Peninsula, and Southeast Asia.The Geopolitics of Spectacledraws new political-geographic lessons and shows that these spectacles can be understood only from multiple viewpoints, sites, and temporalities. Koch explicitly theorizes spectacle geographically and in so doing extends the analysis of governmentality into new empirical and theoretical terrain. With cases ranging from Azerbaijan to Qatar and Myanmar, and an intriguing account of reactions to the new capital of Astana from the poverty-stricken Aral Sea region of Kazakhstan, Koch's book provides food for thought for readers in human geography, anthropology, sociology, urban studies, political science, international affairs, and post-Soviet and central Asian studies.

Aberrant activation of the Hedgehog signaling pathway has been implicated in the maintenance of leukemia stem cell populations in several model systems. PF‐04449913 (PF‐913) is a selective, small‐molecule inhibitor of Smoothened, a membrane protein that regulates the Hedgehog pathway. However, details of the proof‐of‐concept and mechanism of action of PF‐913 following administration to patients with acute myeloid leukemia (AML) are unclear. This study examined the role of the Hedgehog signaling pathway in AML cells, and evaluated the in vitro and in vivo effects of the Smoothened inhibitor PF‐913. In primary AML cells, activation of the Hedgehog signaling pathway was more pronounced in CD34+ cells than CD34− cells. In vitro treatment with PF‐913 induced a decrease in the quiescent cell population accompanied by minimal cell death. In vivo treatment with PF‐913 attenuated the leukemia‐initiation potential of AML cells in a serial transplantation mouse model, while limiting reduction of tumor burden in a primary xenotransplant system. Comprehensive gene set enrichment analysis revealed that PF‐913 modulated self‐renewal signatures and cell cycle progression. Furthermore, PF‐913 sensitized AML cells to cytosine arabinoside, and abrogated resistance to cytosine arabinoside in AML cells cocultured with HS‐5 stromal cells. These findings imply that pharmacologic inhibition of Hedgehog signaling attenuates the leukemia‐initiation potential, and also enhanced AML therapy by sensitizing dormant leukemia stem cells to chemotherapy and overcoming resistance in the bone marrow microenvironment.

For more than one hundred years, governments have grappled with the complex problem of how to revitalize distressed urban areas. In 1995, the original urban Empowerment Zones (Atlanta, Baltimore, Chicago, Detroit, New York, and Philadelphia) each received a $100 million federal block grant and access to a variety of market-oriented policy tools to support the implementation of a ten-year strategic plan to increase economic opportunities and promote sustainable community development in high-poverty neighborhoods. In Collaborative Governance for Urban Revitalization, Michael J. Rich and Robert P. Stoker confront the puzzle of why the outcomes achieved by the original Empowerment Zones varied so widely given that each city had the same set of federal policy tools and resources and comparable neighborhood characteristics. The authors' analysis, based on more than ten years of field research in Atlanta and Baltimore and extensive empirical analysis of EZ processes and outcomes in all six cities shows that revitalization outcomes are best explained by the quality of local governance. Good local governance makes positive contributions to revitalization efforts, while poor local governance retards progress. While policy design and contextual factors are important, how cities craft and carry out their strategies are critical determinants of successful revitalization. Rich and Stoker find that good governance is often founded on public-private cooperation, a stance that argues against both the strongest critics of neoliberalism (who see private enterprise as dangerous in principle) and the strongest opponents of liberalism (who would like to reduce the role of government).

In the 1980s, Egypt witnessed a growing revival of religiosity among large sectors of the population, including artists. Many pious stars retired from art, \"repented\" from \"sinful\" activities, and dedicated themselves to worship, preaching, and charity. Their public conversions were influential in spreading piety to the Egyptian upper class during the 1990s, which in turn enabled the development of pious markets for leisure and art, thus facilitating the return of artists as veiled actresses or religiously committed performers. Revisiting the story she began in\"A Trade like Any Other\": Female Singers and Dancers in Egypt, Karin van Nieuwkerk draws on extensive fieldwork among performers to offer a unique history of the religious revival in Egypt through the lens of the performing arts. She highlights the narratives of celebrities who retired in the 1980s and early 1990s, including their spiritual journeys and their influence on the \"pietization\" of their fans, among whom are the wealthy, relatively secular, strata of Egyptian society. Van Nieuwkerk then turns to the emergence of a polemic public sphere in which secularists and Islamists debated Islam, art, and gender in the 1990s. Finally, she analyzes the Islamist project of \"art with a mission\" and the development of Islamic aesthetics, questioning whether the outcome has been to Islamize popular art or rather to popularize Islam. The result is an intimate thirty-year history of two spheres that have tremendous importance for Egypt-art production and piety.

This article focuses on the impact of the simultaneous implementation of dual laws on urban renewal implementation. Especially when the two laws have different case success rates. We refer to the agent-based model used by Acevedo et al. (2003) for the Los Angeles City Development Study. We used the Geographic Information System (GIS) data to replace the virtual grid. We selected the data of Taipei City for simulation. Compare with the \"Urban Renewal Act\" and the \"Statute for Expediting Reconstruction of Urban Unsafe and Old Buildings\" that are currently being implemented simultaneously. Simulations and studies were conducted based on the case success rate and the gap between the two laws. The study results show that only by widening the gap between the two laws can the \"Urban Renewal Act\" be used at a higher rate. This means clearer enforcement scope and conditions should be set in both regulations to avoid direct conflict.