Explore the vast range of titles available.

Finding sustainable approaches to achieve independence from terrestrial resources is of pivotal importance for the future of space exploration. This is relevant not only to establish viable space exploration beyond low Earth–orbit, but also for ethical considerations associated with the generation of space waste and the preservation of extra-terrestrial environments. Here we propose and highlight a series of microbial biotechnologies uniquely suited to establish sustainable processes for in situ resource utilization and loop-closure. Microbial biotechnologies research and development for space sustainability will be translatable to Earth applications, tackling terrestrial environmental issues, thereby supporting the United Nations Sustainable Development Goals. Establishing sustainable approaches for human space exploration is key to achieve independency from terrestrial resources, as well as for ethical considerations. Here the authors highlight microbial biotechnologies that will support sustainable processes for space-based in situ resource utilization and loop-closure, and may be translatable to Earth applications.

Given the severity and scope of the current COVID-19 pandemic, it is critical to determine predictive features of COVID-19 mortality and medical resource usage to effectively inform health, risk-based physical distancing, and work accommodation policies. Non-clinical sociodemographic features are important explanatory variables of COVID-19 outcomes, revealing existing disparities in large health care systems. We use nation-wide multicenter data of COVID-19 patients in Brazil to predict mortality and ventilator usage. The dataset contains hospitalized patients who tested positive for COVID-19 and had either recovered or were deceased between March 1 and June 30, 2020. A total of 113,214 patients with 50,387 deceased, were included. Both interpretable (sparse versions of Logistic Regression and Support Vector Machines) and state-of-the-art non-interpretable (Gradient Boosted Decision Trees and Random Forest) classification methods are employed. Death from COVID-19 was strongly associated with demographics, socioeconomic factors, and comorbidities. Variables highly predictive of mortality included geographic location of the hospital (OR = 2.2 for Northeast region, OR = 2.1 for North region); renal (OR = 2.0) and liver (OR = 1.7) chronic disease; immunosuppression (OR = 1.7); obesity (OR = 1.7); neurological (OR = 1.6), cardiovascular (OR = 1.5), and hematologic (OR = 1.2) disease; diabetes (OR = 1.4); chronic pneumopathy (OR = 1.4); immunosuppression (OR = 1.3); respiratory symptoms, ranging from respiratory discomfort (OR = 1.4) and dyspnea (OR = 1.3) to oxygen saturation less than 95% (OR = 1.7); hospitalization in a public hospital (OR = 1.2); and self-reported patient illiteracy (OR = 1.1). Validation accuracies (AUC) for predicting mortality and ventilation need reach 79% and 70%, respectively, when using only pre-admission variables. Models that use post-admission disease progression information reach accuracies (AUC) of 86% and 87% for predicting mortality and ventilation use, respectively. The results highlight the predictive power of socioeconomic information in assessing COVID-19 mortality and medical resource allocation, and shed light on existing disparities in the Brazilian health care system during the COVID-19 pandemic.

MOXIE is a technology demonstration that addresses the Mars 2020 (Perseverance) objective of preparing for future human exploration by demonstrating In Situ Resource Utilization (ISRU) in the form of dissociating atmospheric CO 2 into O 2 . The primary goals of the MOXIE project are to verify and validate the technology of Mars ISRU as a springboard for the future, and to establish achievable performance requirements and design approaches that will lead to a full-scale ISRU system based on MOXIE technology. MOXIE has three top-level requirements: to be capable of producing at least 6 g/hr of oxygen in the context of the Mars 2020 mission (assuming atmospheric intake at 5 Torr, typical of Jezero Crater, and 0 ∘ C , typical of the rover interior); to produce oxygen with > 98 % purity; and to meet these first two requirements for at least 10 operational cycles after delivery. Since MOXIE is expected to operate in all seasons and at all times of day and night on Mars, these requirements are intended to be satisfied under worst-case environmental conditions, including during a dust storm, if possible.

Mars colonization demands technological advances to enable the return of humans to Earth. Shipping the propellant and oxygen for a return journey is not viable. Considering the gravitational and atmospheric differences between Mars and Earth, we propose bioproduction of a Mars-specific rocket propellant, 2,3-butanediol (2,3-BDO), from CO 2 , sunlight and water on Mars via a biotechnology-enabled in situ resource utilization (bio-ISRU) strategy. Photosynthetic cyanobacteria convert Martian CO 2 into sugars that are upgraded by engineered Escherichia coli into 2,3-BDO. A state-of-the-art bio-ISRU for 2,3-BDO production uses 32% less power and requires a 2.8-fold higher payload mass than proposed chemical ISRU strategies, and generates 44 tons of excess oxygen to support colonization. Attainable, model-guided biological and materials optimizations result in an optimized bio-ISRU that uses 59% less power and has a 13% lower payload mass, while still generating 20 tons excess oxygen. Addressing the identified challenges will advance prospects for interplanetary space travel. Returning from Mars to Earth requires propellant. The authors propose a biotechnology-enabled in situ resource utilization (bioISRU) process to produce a Mars specific rocket propellant, 2,3-butanediol, using cyanobacteria and engineered E. coli , with lower payload mass and energy usage compared to chemical ISRU strategies.

Roof water inrush at the mine face and shortages of water resources are both problems in the karst mining area in southwestern China. In this study, field measurements, similar simulations, and theoretical analysis were conducted, a physical model of upward and downward mining in a test mine was constructed, and the dynamic evolution of water inrush and the mechanism of water inrush in karst roofs under different mining sequences were analysed. As a result, the problem of water inrush at the mine face was solved, and a method to utilize the karst groundwater water resources was proposed. The research showed that after downward mining, the maximum development height of the water-conducting fracture in coal seam 4 was 43.1 m, and the fracture mining ratio was 14.4. A water-inrush pathway formed at the connection between the mining-induced fractures and the roof karst aquifers, and the safe mining of coal seams 4 and 9 were threatened by water inrush from the goaf. So, the feasibility of upward mining was determined by the ratio test and \"three zones\" discrimination methods, and the evolution of water-inrush pathways during upward and downward-inclined mining were compared. Upward-inclined mining was proposed to control roof water inrush. Moreover, the quality of the water flowing into the goaf was compared with the Chinese standards for water use, and the water in the goaf of the lower coal group was suitable for water resource utilization. This research provides a basis for preventing and controlling roof water inrush disasters and for appropriate utilization of water resources in these mining areas.

Background Rational medicine use is essential to optimize quality of healthcare delivery and resource utilization. We aim to conduct a systematic review of changes in prescribing patterns in the WHO African region and comparison with WHO indicators in two time periods 1995–2005 and 2006–2015. Methods Systematic searches were conducted in PubMed, Scopus, Web of science, Africa-Wide Nipad, Africa Journals Online (AJOL), Google scholar and International Network for Rational Use of Drugs (INRUD) Bibliography databases to identify primary studies reporting prescribing indicators at primary healthcare centres (PHCs) in Africa. This was supplemented by a manual search of retrieved references. We assessed the quality of studies using a 14-point scoring system modified from the Downs and Black checklist with inclusions of recommendations in the WHO guidelines. Results Forty-three studies conducted in 11 African countries were included in the overall analysis. These studies presented prescribing indicators based on a total 141,323 patient encounters across 572 primary care facilities. The results of prescribing indicators were determined as follows; average number of medicines prescribed per patient encounter = 3.1 (IQR 2.3–4.8), percentage of medicines prescribed by generic name =68.0 % (IQR 55.4–80.3), Percentage of encounters with antibiotic prescribed =46.8 % (IQR 33.7–62.8), percentage of encounters with injection prescribed =25.0 % (IQR 18.7–39.5) and the percentage of medicines prescribed from essential medicines list =88.0 % (IQR 76.3–94.1). Prescribing indicators were generally worse in private compared with public facilities. Analysis of prescribing across two time points 1995–2005 and 2006–2015 showed no consistent trends. Conclusions Prescribing indicators for the African region deviate significantly from the WHO reference targets. Increased collaborative efforts are urgently needed to improve medicine prescribing practices in Africa with the aim of enhancing the optimal utilization of scarce resources and averting negative health consequences.

Human deep space exploration is presented with multiple challenges, such as the reliable, efficient and sustainable operation of life support systems. The production and recycling of oxygen, carbon dioxide (CO 2 ) and fuels are hereby key, as a resource resupply will not be possible. Photoelectrochemical (PEC) devices are investigated for the light-assisted production of hydrogen and carbon-based fuels from CO 2 within the green energy transition on Earth. Their monolithic design and the sole reliance on solar energy makes them attractive for applications in space. Here, we establish the framework to evaluate PEC device performances on Moon and Mars. We present a refined Martian solar irradiance spectrum and establish the thermodynamic and realistic efficiency limits of solar-driven lunar water-splitting and Martian carbon dioxide reduction (CO 2 R) devices. Finally, we discuss the technological viability of PEC devices in space by assessing the performance combined with solar concentrator devices and explore their fabrication via in-situ resource utilization. Long-term space missions to the Moon and Mars rely on sunlight as an energy source. Here, authors assess the performance of monolithic photoelectrochemical devices for light-assisted O 2 and fuel production on the Moon and Mars as potential complementary technologies to existing life support systems.

As we aim to expand human presence in space, we need to find viable approaches to achieve independence from terrestrial resources. Space biomining of the Moon, Mars and asteroids has been indicated as one of the promising approaches to achieve in-situ resource utilization by the main space agencies. Structural and expensive metals, essential mineral nutrients, water, oxygen and volatiles could be potentially extracted from extraterrestrial regolith and rocks using microbial-based biotechnologies. The use of bioleaching microorganisms could also be applied to space bioremediation, recycling of waste and to reinforce regenerative life support systems. However, the science around space biomining is still young. Relevant differences between terrestrial and extraterrestrial conditions exist, including the rock types and ores available for mining, and a direct application of established terrestrial biomining techniques may not be a possibility. It is, therefore, necessary to invest in terrestrial and space-based research of specific methods for space applications to learn the effects of space conditions on biomining and bioremediation, expand our knowledge on organotrophic and community-based bioleaching mechanisms, as well as on anaerobic biomining, and investigate the use of synthetic biology to overcome limitations posed by the space environments.

Sustainable water management is a critical challenge in space exploration, where the limited availability of resources requires innovative approaches to ensure astronauts' survival on long‐duration missions. This narrative review explores the key technologies and methods involved in water recycling, in situ resource utilization (ISRU), and bioregenerative life support systems (BLSS) essential for supporting human life in space. The Environmental Control and Life Support System (ECLSS) aboard the International Space Station has demonstrated significant progress in recycling water from urine, sweat, and humidity, achieving up to 93% recovery. However, challenges remain in reducing energy consumption, improving system durability, and ensuring water quality. ISRU technologies, particularly those aimed at extracting water ice from lunar and Martian environments, offer promising solutions for future missions, but they must overcome scalability and logistical hurdles. This review also highlights the potential of nanotechnology and AI‐driven autonomous systems in enhancing water purification and management. Nanomaterials like graphene oxide membranes could revolutionize filtration efficiency, while AI could optimize real‐time water quality monitoring and recycling processes. As space agencies push toward establishing colonies on the Moon and Mars, the development of sustainable, closed‐loop water systems will be pivotal to the success of these missions. Continued research and innovation are essential to ensuring water resources are efficiently managed for long‐term human presence in space.

NASA’s current mandate is to land humans on Mars by 2033. Here, we demonstrate an approach to produce ultrapure H₂ and O₂ from liquid-phase Martian regolithic brine at ∼−36 °C. Utilizing a Pb₂Ru₂O7–δ pyrochlore O₂-evolution electrocatalyst and a Pt/C H₂-evolution electrocatalyst, we demonstrate a brine electrolyzer with >25× the O₂ production rate of the Mars Oxygen In Situ Resource Utilization Experiment (MOXIE) from NASA’s Mars 2020 mission for the same input power under Martian terrestrial conditions. Given the Phoenix lander’s observation of an active water cycle on Mars and the extensive presence of perchlorate salts that depress water’s freezing point to ∼−60 °C, our approach provides a unique pathway to life-support and fuel production for future human missions to Mars.