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Neuroscience research has exploded, with more than fifty thousand neuroscientists applying increasingly advanced methods. A mountain of new facts and mechanisms has emerged. And yet a principled framework to organize this knowledge has been missing. In this book, Peter Sterling and Simon Laughlin, two leading neuroscientists, strive to fill this gap, outlining a set of organizing principles to explain the whys of neural design that allow the brain to compute so efficiently. Setting out to \"reverse engineer\" the brain -- disassembling it to understand it -- Sterling and Laughlin first consider why an animal should need a brain, tracing computational abilities from bacterium to protozoan to worm. They examine bigger brains and the advantages of \"anticipatory regulation\"; identify constraints on neural design and the need to \"nanofy\"; and demonstrate the routes to efficiency in an integrated molecular system, phototransduction. They show that the principles of neural design at finer scales and lower levels apply at larger scales and higher levels; describe neural wiring efficiency; and discuss learning as a principle of biological design that includes \"save only what is needed.\"Sterling and Laughlin avoid speculation about how the brainmightwork and endeavor to make sense of what is already known. Their distinctive contribution is to gather a coherent set of basic rules and exemplify them across spatial and functional scales.

The adult brain is not as hard-wired as traditionally thought. By modifying their small- or large-scale morphology, neurons can make new synaptic connections or break existing ones (structural plasticity). Structural changes accompany memory formation and learning, and are induced by neurogenesis, neurodegeneration and brain injury such as stroke. Exploring the role of structural plasticity in the brain can be greatly assisted by mathematical and computational models, as they enable us to bridge the gap between system-level dynamics and lower level cellular and molecular processes. In this title, the editors bring together contemporary modeling studies that investigate the implications of structural plasticity for brain function and pathology.

Drug Addiction Mechanisms in the Brain explores the fascinating world of drug substances and their effects on the brain. This book provides a comprehensive overview of the ten major substances that contribute to drug addiction Information about each substance is presented in a specific chapter, shedding light on their biochemical mechanisms and physiological effects. From the stimulating effects of cocaine to the sedative properties of heroin, and the hallucinogenic experiences induced by LSD, the book takes the reader through the intricate pathways of addiction. Other substances covered in the book include alcohol, nicotine, MDMA, METH, morphine, ketamine, and fentanyl. Readers will gain an understanding about neurochemical alterations in the brain Anyone looking for interesting knowledge about the addictive nature of common drugs and their complex interplay with the brain will find this book informative. Readership Researchers, healthcare professionals, counsellors and general readers.

The connection of the brain to the mind remains one of the most persistent mysteries in philosophy and neuroscience. Georg Northoff proposes a new approach to the so-called mind-body problem, drawing on an insight from physics: time structures all objects and events in the world, and all objects and events are in dynamic relationship. This also shapes the brain as it is part of the dynamic of the world as whole. In Neurowaves Northoff posits that the entire world is structured by waves of time and argues that the passing of these waves through our brains – neurowaves – produces mental experience. The brain's neural waves transform into mental waves; time and its dynamics are shared by brain and mind as their common currency. As in physics and biology, that radically changes our view. Copernicus showed how the earth moves and that its movements are just a tiny part of the universe's passage of time. Darwin showed that the human species is one among many species passing through evolution's timescales. Northoff calls for another Copernican revolution, replacing the mind-body problem with questions about the temporal-dynamic relationship between brain and world. Illustrated with vivid examples from different facets of the physical and biological world, Neurowaves provides captivating insights and an innovative, entertaining unravelling of the temporal connection of brain and mind.

Two leading neuroscientists introduce the concepts of \"cerebral plasticity\" and the \"regenerating brain,\" describing what we know now about the processes through which the brain constantly reconstructs itself and the potential benefits this knowledge could have in addressing concerns for neurological, cognitive, and emotional health. The authors begin with a survey of the fundamental scientific developments that led to our current understanding of the regenerative mind, elucidating the breakthrough neurobiological studies that paved the way for our present understanding of the brain's plasticity and regenerative capabilities. They then discuss the application of these findings to such issues as depression, dyslexia, schizophrenia, and cognitive therapy, incorporating the latest technologies in neuroimaging, optogenetics, and nanotechnology. Their work shows the brain is anything but a static organ, ceasing to grow as human beings become adults. Rather, the brain is dynamic, evolving organically in relation to physical, cultural, historical, and affective stimuli, a plasticity that provides early hope to survivors of trauma and degenerative disorders.

When leaded gasoline was first developed in the 1920s, medical experts were quick to warn of the public health catastrophes it would cause. Yet government regulators did not heed their advice, and for more than half a century, nearly all cars used leaded gasoline, which contributed to a nationwide epidemic of lead poisoning. By the 1970s, 99.8% of American children had significantly elevated levels of lead in their blood. Unleaded tells the story of how crusading scientists and activists convinced the U.S. government to ban lead additives in gasoline. It also reveals how, for nearly fifty years, scientific experts paid by the oil and mining industries abused their authority to convince the public that leaded gasoline was perfectly harmless.  Combining environmental history, sociology, and neuroscience, Carrie Nielsen explores how lead exposure affects the developing brains of children and is linked to social problems including academic failure, teen pregnancies, and violent crime. She also shows how, even after the nationwide outrage over Flint's polluted water, many poor and minority communities and communities of color across the United States still have dangerously high lead levels. Unleaded vividly depicts the importance of sound science and strong environmental regulations to protect our nation's most vulnerable populations.

Molecular Neuroendocrinology: From Genome to Physiology, provides researchers and students with a critical examination of the steps being taken to decipher genome complexity in the context of the expression, regulation and physiological functions of genes in neuroendocrine systems. The 19 chapters are divided into four sectors: A) describes and explores the genome, its evolution, expression and the mechanisms that contribute to protein, and hence biological, diversity. B) discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification. C) considers the molecular tools that today's neuroendocrinologists can use to study the regulation and function of neuroendocrine genes within the context of the intact organism. D) presents a range of case studies that exemplify the state-of-the-art application of genomic technologies in physiological and behavioural experiments that seek to better understand complex biological processes. • Written by a team of internationally renowned researchers • Both print and enhanced e-book versions are available • Illustrated in full colour throughout This is the third volume in a new Series  'Masterclass in Neuroendocrinology' , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA