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What will I be from A to Z
It's never too early for children to wonder, \"What will I be when I grow up?\" Written to inspire the next generations of diverse dreamers, What Will I Be from A to Z empowers children to envision themselves in a variety of STEM fields, from astronauts to zoologists. With simple, rhyming text and colorful illustrations, the dream team behind A Steminist Force invited every child to dream big and follow their passions.
CHILDBOOK
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly in the white matter. These were associated with white matter PVS already in young adults (
N
= 1,748; 22.1 ± 2.3 yr) and were enriched in early-onset leukodystrophy genes and genes expressed in fetal brain endothelial cells, suggesting early-life mechanisms. In total, 53% of white matter PVS risk loci showed nominally significant associations (27% after multiple-testing correction) in a Japanese population-based cohort (
N
= 2,862; 68.3 ± 5.3 yr). Mendelian randomization supported causal associations of high blood pressure with basal ganglia and hippocampal PVS, and of basal ganglia PVS and hippocampal PVS with stroke, accounting for blood pressure. Our findings provide insight into the biology of PVS and cerebral small vessel disease, pointing to pathways involving extracellular matrix, membrane transport and developmental processes, and the potential for genetically informed prioritization of drug targets.
Genomic analyses of large population-based cohorts uncover the genetic determinants of perivascular space burden, an MRI marker of cerebral small vessel disease, across the lifespan, and reveal potential pathways implicated in the etiology of stroke and dementia.
Journal Article
Dream jobs in science
\"A career in science can involve traveling around the world and maybe even leaving it! From tracking violent storms or studying penguins in the Antarctic to repairing the International Space Station or searching for new planets, this fascinating book shows that a career in science can lead to thrilling and limitless possibilities.\"--Provided by publisher.
BOOK
A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population
There is a strong association between genetic polymorphisms and the acenocoumarol dosage requirements. Genotyping the polymorphisms involved in the pharmacokinetics and pharmacodynamics of acenocoumarol before starting anticoagulant therapy would result in a better quality of life and a more efficient use of healthcare resources. The objective of this study is to develop a new algorithm that includes clinical and genetic variables to predict the most appropriate acenocoumarol dosage for stable anticoagulation in a wide range of patients. We recruited 685 patients from 2 Spanish hospitals and 1 primary healthcare center. We randomly chose 80% of the patients (n = 556), considering an equitable distribution of genotypes to form the generation cohort. The remaining 20% (n = 129) formed the validation cohort. Multiple linear regression was used to generate the algorithm using the acenocoumarol stable dosage as the dependent variable and the clinical and genotypic variables as the independent variables. The variables included in the algorithm were age, weight, amiodarone use, enzyme inducer status, international normalized ratio target range and the presence of CYP2C9*2 (rs1799853), CYP2C9*3 (rs1057910), VKORC1 (rs9923231) and CYP4F2 (rs2108622). The coefficient of determination (R2) explained by the algorithm was 52.8% in the generation cohort and 64% in the validation cohort. The following R2 values were evaluated by pathology: atrial fibrillation, 57.4%; valve replacement, 56.3%; and venous thromboembolic disease, 51.5%. When the patients were classified into 3 dosage groups according to the stable dosage (<11 mg/week, 11-21 mg/week, >21 mg/week), the percentage of correctly classified patients was higher in the intermediate group, whereas differences between pharmacogenetic and clinical algorithms increased in the extreme dosage groups. Our algorithm could improve acenocoumarol dosage selection for patients who will begin treatment with this drug, especially in extreme-dosage patients. The predictability of the pharmacogenetic algorithm did not vary significantly between diseases.
Journal Article
Taxonomic Tapestries
This volume explores the complexity, diversity and interwoven nature of taxonomic pursuits within the context of explorations of humans and related species. It also pays tribute to Professor Colin Groves, whose work has had an enormous impact on this field. Recent research into that somewhat unique species we call humankind, through the theoretical and conceptual approaches afforded by the discipline of biological anthropology, is showcased. The focus is on the evolution of the human species, the behaviour of primates and other species, and how humans affect the distribution and abundance of other species through anthropogenic impact. Weaving together these three key themes, through the considerable influence of Colin Groves, provides glimpses of how changes in taxonomic theory and methodology, including our fluctuating understanding of speciation, have recrafted the way in which we view animal behaviour, human evolution and conservation studies.
eBook
When Grandma gives you a lemon tree
When Grandma gives you a lemon tree, definitely don't make a face! Care for the tree, and you might be surprised at how new things, and new ideas, bloom. When life gives you lemons, make lemonade. In this imaginative take on that popular saying, a child is surprised (and disappointed) to receive a lemon tree from Grandma for her birthday. After all, she DID ask for a new gadget! But when she follows the narrator's careful--and funny--instructions, she discovers that the tree might be exactly what she wanted after all. This clever story, complete with a recipe for lemonade, celebrates the pleasures of patience, hard work, nature, community ... and putting down the electronic devices just for a while.
Book
International survey on skin patch test procedures, attitudes and interpretation
Background Skin patch test is the gold standard method in diagnosing contact allergy. Although used for more than 100 years, the patch test procedure is performed with variability around the world. A number of factors can influence the test results, namely the quality of reagents used, the timing of the application, the patch test series (allergens/haptens) that have been used for testing, the appropriate interpretation of the skin reactions or the evaluation of the patient’s benefit.
Methods We performed an Internet –based survey with 38 questions covering the educational background of respondents, patch test methods and interpretation. The questionnaire was distributed among all representatives of national member societies of the World Allergy Organization (WAO), and the WAO Junior Members Group.
Results One hundred sixty-nine completed surveys were received from 47 countries. The majority of participants had more than 5 years of clinical practice (61 %) and routinely carried out patch tests (70 %). Both allergists and dermatologists were responsible for carrying out the patch tests. We could observe the use of many different guidelines regardless the geographical distribution. The use of home-made preparations was indicated by 47 % of participants and 73 % of the respondents performed 2 or 3 readings. Most of the responders indicated having patients with adverse reactions, including erythroderma (12 %); however, only 30 % of members completed a consent form before conducting the patch test.
Discussion The heterogeneity of patch test practices may be influenced by the level of awareness of clinical guidelines, different training backgrounds, accessibility to various types of devices, the patch test series (allergens/haptens) used for testing, type of clinical practice (public or private practice, clinical or research-based institution), infrastructure availability, financial/commercial implications and regulations among others.
Conclusion There is a lack of a worldwide homogeneity of patch test procedures, and this raises concerns about the need for standardization and harmonization of this important diagnostic procedure.
Journal Article
Race/Ethnicity and Education Effects on Employment in High Technology Industries and Occupations in the US, 1992–2002
High technology industries employ higher than average numbers of scientists and engineers when compared to the employment of the same group among all industries. Since these jobs require high levels of skills to undertake creative, cutting edge activities, it is anticipated that employment in these industries will be largely based on the levels of human capital of individuals or merit. This study compares how changes in levels of educational attainment affect employment in science and engineering jobs in high technology industries with those outside for four racial and ethnic groups. Although blacks and Hispanics are under-represented in science and engineering occupations, the study finds that the effects of education vary with the level of education, race/ethnicity, and the industry/occupational group under consideration in ways that suggest that the race/ethnicity of an individual still plays an important role in determining employment.
Journal Article