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Evidence for the earliest stone tools produced by human ancestors (from ∼2.6 million years ago) has hitherto come from East Africa. Sahnouni et al. report the discovery of Oldowan stone artifacts and associated cutmarks on fossil bones excavated in Algeria, with the earliest dated to 2.4 million years ago. Thus, hominins inhabited the Mediterranean fringe in North Africa earlier than commonly believed. Furthermore, either stone tool manufacture and use dispersed early from East Africa or stone tool manufacture and use originated in both North and East Africa. Science , this issue p. 1297 Stone tools and cutmarked bones indicate an early presence of human ancestors in North Africa. East Africa has provided the earliest known evidence for Oldowan stone artifacts and hominin-induced stone tool cutmarks dated to ~2.6 million years (Ma) ago. The ~1.8-million-year-old stone artifacts from Ain Hanech (Algeria) were considered to represent the oldest archaeological materials in North Africa. Here we report older stone artifacts and cutmarked bones excavated from two nearby deposits at Ain Boucherit estimated to ~1.9 Ma ago, and the older to ~2.4 Ma ago. Hence, the Ain Boucherit evidence shows that ancestral hominins inhabited the Mediterranean fringe in northern Africa much earlier than previously thought. The evidence strongly argues for early dispersal of stone tool manufacture and use from East Africa or a possible multiple-origin scenario of stone technology in both East and North Africa.

National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to health care only focused on high-income countries and faced several methodological challenges. In the present analysis, we use the highly standardised cause of death and risk factor estimates generated through the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to improve and expand the quantification of personal health-care access and quality for 195 countries and territories from 1990 to 2015. We mapped the most widely used list of causes amenable to personal health care developed by Nolte and McKee to 32 GBD causes. We accounted for variations in cause of death certification and misclassifications through the extensive data standardisation processes and redistribution algorithms developed for GBD. To isolate the effects of personal health-care access and quality, we risk-standardised cause-specific mortality rates for each geography-year by removing the joint effects of local environmental and behavioural risks, and adding back the global levels of risk exposure as estimated for GBD 2015. We employed principal component analysis to create a single, interpretable summary measure–the Healthcare Quality and Access (HAQ) Index–on a scale of 0 to 100. The HAQ Index showed strong convergence validity as compared with other health-system indicators, including health expenditure per capita (r=0·88), an index of 11 universal health coverage interventions (r=0·83), and human resources for health per 1000 (r=0·77). We used free disposal hull analysis with bootstrapping to produce a frontier based on the relationship between the HAQ Index and the Socio-demographic Index (SDI), a measure of overall development consisting of income per capita, average years of education, and total fertility rates. This frontier allowed us to better quantify the maximum levels of personal health-care access and quality achieved across the development spectrum, and pinpoint geographies where gaps between observed and potential levels have narrowed or widened over time. Between 1990 and 2015, nearly all countries and territories saw their HAQ Index values improve; nonetheless, the difference between the highest and lowest observed HAQ Index was larger in 2015 than in 1990, ranging from 28·6 to 94·6. Of 195 geographies, 167 had statistically significant increases in HAQ Index levels since 1990, with South Korea, Turkey, Peru, China, and the Maldives recording among the largest gains by 2015. Performance on the HAQ Index and individual causes showed distinct patterns by region and level of development, yet substantial heterogeneities emerged for several causes, including cancers in highest-SDI countries; chronic kidney disease, diabetes, diarrhoeal diseases, and lower respiratory infections among middle-SDI countries; and measles and tetanus among lowest-SDI countries. While the global HAQ Index average rose from 40·7 (95% uncertainty interval, 39·0–42·8) in 1990 to 53·7 (52·2–55·4) in 2015, far less progress occurred in narrowing the gap between observed HAQ Index values and maximum levels achieved; at the global level, the difference between the observed and frontier HAQ Index only decreased from 21·2 in 1990 to 20·1 in 2015. If every country and territory had achieved the highest observed HAQ Index by their corresponding level of SDI, the global average would have been 73·8 in 2015. Several countries, particularly in eastern and western sub-Saharan Africa, reached HAQ Index values similar to or beyond their development levels, whereas others, namely in southern sub-Saharan Africa, the Middle East, and south Asia, lagged behind what geographies of similar development attained between 1990 and 2015. This novel extension of the GBD Study shows the untapped potential for personal health-care access and quality improvement across the development spectrum. Amid substantive advances in personal health care at the national level, heterogeneous patterns for individual causes in given countries or territories suggest that few places have consistently achieved optimal health-care access and quality across health-system functions and therapeutic areas. This is especially evident in middle-SDI countries, many of which have recently undergone or are currently experiencing epidemiological transitions. The HAQ Index, if paired with other measures of health-system characteristics such as intervention coverage, could provide a robust avenue for tracking progress on universal health coverage and identifying local priorities for strengthening personal health-care quality and access throughout the world. Bill & Melinda Gates Foundation.

Heavy metal pollution is a challenging concern that threatens the soil environment and human health worldwide. The purpose of this work is to assess the heavy metals (Cr, Cu, Zn, and Pb) pollution in the urban and peri-urban soils in and around Setif city, eastern Algeria. The work combines chemical analysis of thirty-six soil samples, statistical valuation and interpretation of chemical data and pollution indices (geoaccumulation index, pollution index, and integrated pollution index) with thematic mapping. The average concentrations (in mg/kg) of Cd, Cr, Cu, Pb, and Zn were found < 0.02, 43.35, 43.75, 331.20, and 78.26 mg/kg, respectively. Compared with the French regulatory limits (AFNOR U44-041), Cd, Cr, and Cu still non-hazardous at Setif city scale; however, Zn and Pb concentrations are two to three times higher than the background values referred to the Chinese B n standard (GB15618-1995). The pollution indices indicate that Pb and Zn represent the highest threats among the studied pollutants and polluted wide areas of anthropogenic activities located respectively in the oldest district of the city, near the industrial zone and near uncontrolled landfill of domestic and industrial waste. Cu, Pb, and Zn originate seemly from vehicle emission, particles of brakes and tires, and industrial emissions. However, Cr distribution is uncorrelatable with anthropogenic sources. The Cr with an average concentration less than the background value derives seemly from animal feces and organic fertilizers. The integrated pollution index shows that the accumulation of heavy metals in the soils of Setif city from anthropogenic sources reached alarming levels that can disperse into the environment and threaten the human health. The urbanization and industrial development of Setif city are expected to grow and a subsequent heavy metal pollution will be rising prior issue. Corrective measures should be endeavored by the local authorities to mitigate the current environmental situation and a sustainable development plan for the city should be anticipated to guarantee optimal future environmental conditions.

This article aims to investigate the complex relationship between a local population and its natural and urban environment. The study area, which was previously dominated by cereal cultivation, is currently facing profitability challenges due to climate change, water scarcity, rapid urban expansion, and the overexploitation of aquifers, influenced by changes in agricultural practices, which are disrupting the local ecosystem. This study relies on three interconnected indicators, population growth, climate change effects on agriculture, and the NDVI (Normalized Difference Vegetation Index), and reveals the impact of these factors on agricultural practices. Google Earth Engine was employed to determine the urbanization and greenness indices using scripts. The significant findings of this study demonstrate the remarkable demographic growth of 49.96% during the study period (2000–2020). Furthermore, this growth has led to a new trend towards intensive farming, with a substantial increase in irrigated lands by 44.19% and a multiplication of protected crop lands by 20 times, rising from 19.88 to 405.89 hectares. Additionally, horticultural production surged by 212.4% during the same period. Moreover, groundwater levels shifted from less than 50 m in the northern regions to less than 150 and 300 m in the southern part of the study area. The water potential in the study zone cannot meet the demands of the new agricultural orientation, which tends to deplete local groundwater, potentially causing recurrent shortages of agricultural products. This study underscores the importance of incorporating agricultural production into future urban planning and development programs to maintain a renewed balance between built environments and agriculture in peri-urban areas.

The objective of this paper is to proceed to the analysis and then to obtain a new classification and spatialization of the tourist potential of a specific territory, for the purpose of a tourism development of its resources. Besides, such analysis sheds light on the assets and constraints of the territory itself by using geographical and technical documents, in respect such as national, regional and local tourism development plans. More to the point, results show that the territory of the province of Setif is of specific aptitudes for a consequent attractiveness and a complementarity of interesting natural and cultural resources, as well. Nevertheless, the study reveals numerous limitations such as the inadequate classification of the tourist potential, which is confirmed by the vague and generalised vision of the State throughout the region. In virtue of which, based on the obtained results, a new taxonomy of the tourism potential has been proposed for the purpose of helping the operators and actors involved in a participatory approach for a wider tourism development of the province of Setif.

Spondylodiscitis is a serious and suggestive complication of brucellosis. Few studies have been devoted to it in Algeria, although the infection remains a public health problem. The aim of this study was to report the epidemiological and clinical aspects of brucellosis spondylodiscitis and to identify the neurological complications. This is a descriptive analysis of a cohort of adult patients with spondylodiscitis, based on data collected from patient records recruited between January 2016 and December 2022. Thirteen females and 24 males with a mean age of 48 ± 15 years [21 to 71 years] were included in the study. Diagnosis was made on average 120 days ± 100 [30-360] after the onset of clinical symptoms. Commonly reported symptoms were: back pain (100%), fever (46%), sweating (70%), asthenia (84%), chills (22%), and weight loss (27%). Neurological complications were numerous and sometimes varied in the same patient: one case of paraplegia, three cases of paraparesis, six cases of sensory disturbances, and one case of sphincter disorders. Involvement of the lumbar spine was predominant, observed in 22 patients, including 15 at the L4-L5 level.In addition to discovertebral lesions, imaging revealed 27 cases of epiduritis, 13 cases of spinal cord compression, 25 cases of radicular compression, and pre- or para-vertebral and psoas abscesses.Two treatment regimens were used: doxycycline-cotrimoxazole-gentamycin (22 cases) and doxycycline-rifampicin-gentamycin (15 cases). At the end of the one-year post-therapeutic follow-up, we observed one relapse, sequelae of paraparesis, and sequelae of spinal pain in 12 patients. This study has allowed us to observe prognostic elements. Early spinal imaging is essential to combat the excessive delay in diagnosis in our patients. There is no clear consensus in the scientific literature regarding neurological complications, such as epiduritis, and optimal treatment. The results of our study may contribute to the development of more personalized management algorithms.

A cross-sectional study was conducted to determine the seroprevalence and the risk factors associated with C. burnetii infection in cattle in the state of Setif in northeastern Algeria from March 2016 to April 2018. A total of 678 cows animals aged at least 24 months and belonging to 90 herds were randomly selected. A serum sample from each cow was tested for antibodies against C. burnetii using an indirect enzyme-linked immunosorbent assay (ELISA). A structured questionnaire focusing on risk factors for C. burnetii infection was administered to farm owners involved in the study. The individual animal prevalence was 11.36% (77/678) (95%CI 8.97–13.75%), the herd prevalence was 45.56% (41/90) (95%CI 35.27–55.84%), and the within-herd prevalence ranged from 9.09 to 57.14% (mean 23.71%; Q1 11.11%, Q2 or median 20%, Q3 30%). Multivariable logistic regression analysis revealed that contact with other herds (odds ratio (OR) 1.95, 95 CI 1.12–3.42) and purchased animals (OR 2.05, 95 CI 1.14–3.68) was identified as risk factors for seropositivity to C. burnetii, while the use of disinfectants (OR 0.32, 95 CI 0.14–0.72) was identified as protective factor. The results from the present study indicate that C. burnetii is circulating into cattle herds in the region of Setif in Northeastern of Algeria. It is recommended to implement good hygienic practices and measures of biosecurity to reduce the spread of infection between cattle herds and possible exposure of humans.

In the last decade, North Africa has witnessed significant population growth, particularly those bordering the Mediterranean Sea. This led to increased demand for groundwater, which is an essential source for various water uses such as drinking water supplies and irrigation. Generally, human activities play a crucial role in the different quantitative and qualitative changes in groundwater. Now, climate changes such as a decrease in precipitation have also led to a shortage of water resources and a decline in the groundwater table. This paper presents the impact of climate changes on groundwater resources in the Ain Azel region, Setif, northeastern Algeria. The analysis of long-term spatiotemporal variability in rainfall over 63 years (1958–2021) revealed a significant decline in groundwater recharge, especially after 2013. In contrast, the Pettitt and Mann–Kendall tests show increased temperatures with breaks between 1984 and 1986. A piezometric analysis of the alluvial aquifer demonstrated a significant decline in groundwater levels in the last 20 years. Hydrochemical analysis showed that groundwater in the region is dominated by Ca–Mg–Cl water type, which indicates the presence of water salinity phenomenon. Water Quality Index (WQI) analysis showed the deterioration of groundwater in the area, which may be caused by several factors: brine intrusion from the Salt Lake (Sebkha) in the north; the dissolution of evaporites (Triassic) and/or anthropogenic sources of agricultural and industrial origin. Our findings provide an overview summarizing the state of groundwater, which will help improve groundwater resource management in the region in the coming years.

Setif city covers an area of 6550 km 2 ; it is located about 300 km southeast of Algiers and 100 km to the south of the Mediterranean sea. The aim of our study is to know the tectonic mechanisms responsible for the emergencies and to highlight their chemical characteristics of water springs in Setif. Wherein thermalism is characterized by the presence of a number of thermal springs, the latest are usually related to recent large fractures deeply affecting the sedimentary formations and sometimes even crystallin basement. These fractures are often injected by Triassic evaporates; their directions are NNW–SSE, NW–SE, and NE–SW and limiting great structural units. Four groundwater facies were identified: the high percentage of sources, staking major accidents related to limestone mountains or to the basement, shows a calcium or sodium sulfate facies; and the sources are often hot (meso or hyperthermal). A second group, related to terrigenous saliferous formations, shows a sodium bicarbonate or sodium chloride facies. The geothermic interpretation allows us to conclude that the reservoir supplies the two aquifer systems of the thermal complex, and is stored in fissured Jurassic limestone, where water storage and circulation is beyond 2600 m deep.