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Sex differences in self-regulation: an evolutionary perspective
Bjorklund and Kipp (1996) provide an evolutionary framework predicting that there is a female advantage in inhibition and self-regulation due to differing selection pressures placed on males and females. The majority of the present review will summarize sex differences in self-regulation at the behavioral level. The neural and hormonal underpinnings of this potential sexual dimorphism will also be investigated and the results of the experiments summarized will be related to the hypothesis advanced by Bjorklund and Kipp (1996). Paradoxically, sex differences in self-regulation are more consistently reported in children prior to the onset of puberty. In adult cohorts, the results of studies examining sex differences in self-regulation are mixed. A few recent experiments suggesting that females are less impulsive than males only during fertile stages of the menstrual cycle will be reviewed. A brief discussion of an evolutionary framework proposing that it is adaptive for females to employ a self-regulatory behavioral strategy when fertile will follow.
Journal Article
Venomous Tongues
Sandy Bardsley examines the complex relationship between speech and gender in the fourteenth and fifteenth centuries and engages debates on the static nature of women's status after the Black Death. Focusing on England, Venomous Tongues uses a combination of legal, literary, and artistic sources to show how deviant speech was increasingly feminized in the later Middle Ages. Women of all social classes and marital statuses ran the risk of being charged as scolds, and local jurisdictions interpreted the label \"scold\" in a way that best fit their particular circumstances. Indeed, Bardsley demonstrates, this flexibility of definition helped to ensure the longevity of the term: women were punished as scolds as late as the early nineteenth century.The tongue, according to late medieval moralists, was a dangerous weapon that tempted people to sin. During the fourteenth and fifteenth centuries, clerics railed against blasphemers, liars, and slanderers, while village and town elites prosecuted those who abused officials or committed the newly devised offense of scolding. In courts, women in particular were prosecuted and punished for insulting others or talking too much in a public setting. In literature, both men and women were warned about women's propensity to gossip and quarrel, while characters such as Noah's Wife and the Wife of Bath demonstrate the development of a stereotypically garrulous woman. Visual representations, such as depictions of women gossiping in church, also reinforced the message that women's speech was likely to be disruptive and deviant.
eBook
Man and woman : an inside story
\"The saga of sex differences in brain and behavior begins with a tiny sperm swimming toward a huge egg, to contribute its tiny Y chromosome plus its copies of the other chromosomes. Genetic, anatomic and physiologic alterations in the male ensue, making his brain and behavior different in specific respects from his sister. Brain-wise, specific cell groups develop differently in males compared to females, in some cases right after birth and in other cases at puberty. But genetics and neuroanatomy do not dominate the scene. Prenatal stress, postnatal stress and lousy treatment at puberty all can affect males and females in different ways. The upshot of all these genetic and environmental factors produces small sex differences in certain abilities and huge sex differences in feelings, in pain and in suffering. Put this all together and the reader will see that biological and cultural influences on gender roles operate at so many different levels to influence behavioral mechanisms that gender role choices are flexible, reversible and non-dichotomous, especially in modern societies.\"--Book jacket.
Book
Sex differences in immune responses
Key Points
Sex is a biological variable that affects the functions of the immune system.
Sex differences occur in both innate and adaptive immune responses and are evolutionarily conserved across diverse species.
Sex differences in immune responses change throughout life and are influenced by both the age and reproductive status of an individual.
Sex chromosome genes and sex hormones, including oestrogens, progesterone and androgens, contribute to the differential regulation of immune responses between the sexes.
Environmental factors, including nutrition status and the composition of the microbiome, also alter the development and functioning of the immune system differently in males and females.
Sex differences in immune responses result in differential susceptibility of males and females to autoimmune diseases, malignancies and infectious diseases, as well as affecting the outcome of vaccination.
In this Review the authors discuss some of the key differences that exist between male and female immune functions. They explain how these differences lead to sex biases in susceptibility to infections, inflammatory diseases and cancer. Moreover, they highlight the urgent need for immunologists to consider these sex differences when designing experiments.
Males and females differ in their immunological responses to foreign and self-antigens and show distinctions in innate and adaptive immune responses. Certain immunological sex differences are present throughout life, whereas others are only apparent after puberty and before reproductive senescence, suggesting that both genes and hormones are involved. Furthermore, early environmental exposures influence the microbiome and have sex-dependent effects on immune function. Importantly, these sex-based immunological differences contribute to variations in the incidence of autoimmune diseases and malignancies, susceptibility to infectious diseases and responses to vaccines in males and females. Here, we discuss these differences and emphasize that sex is a biological variable that should be considered in immunological studies.
Journal Article
Sex differences in the brain : from genes to behavior
Sex is a fundamentally important biological variable. Recent years have seen significant progress in the integration of sex in many aspects of basic and clinical research, including analyses of sex differences in brain function. Significant advances in the technology available for studying the endocrine and nervous systems are now coupled with a more sophisticated awareness of the interconnections of these two communication systems of the body. A thorough understanding of the current knowledge, conceptual approaches, methodological capabilities, and challenges is a prerequisite to continued progress in research and therapeutics in this interdisciplinary area. This book provides scientists with the basic tools for investigating sex differences in brain and behavior, and insight into areas where important progress in understanding physiologically relevant sex differences has already been made. The book is arranged in three parts. The first part of the book introduces the study of sex differences in the brain, with an overview of how the brain, stress systems, and pharmacogenetics differ in males and females and how this information is important for the study of behavior and neurobiology of both genders. The second part presents examples of sex differences in neurobiology and behavior from both basic and clinical research perspectives, covering both humans and nonhuman animals. The final part discusses sex differences in the neurobiology of disease and neurological disorders.
eBook
A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK
Background
Colorectal cancer (CRC) is an illness strongly influenced by sex and gender, with mortality rates in males significantly higher than females. There is still a dearth of understanding on where sex differences exist along the pathway from presentation to survival. The aim of this review is to identify where actions are needed to improve outcomes for both sexes, and to narrow the gap for CRC.
Methods
A cross-sectional review of national data was undertaken to identify sex differences in incidence, screening uptake, route to diagnosis, cancer stage at diagnosis and survival, and their influence in the sex differences in mortality.
Results
Overall incidence is higher in men, with an earlier age distribution, however, important sex differences exist in anatomical site. There were relatively small differences in screening uptake, route to diagnosis, cancer staging at diagnosis and survival. Screening uptake is higher in women under 69 years. Women are more likely to present as emergency cases, with more men diagnosed through screening and two-week-wait. No sex differences are seen in diagnosis for more advanced disease. Overall, age-standardised 5-year survival is similar between the sexes.
Conclusions
As there are minimal sex differences in the data from routes to diagnosis to survival, the higher mortality of colorectal cancer in men appears to be a result of exogenous and/or endogenous factors pre-diagnosis that lead to higher incidence rates. There are however, sex and gender differences that suggest more targeted interventions may facilitate prevention and earlier diagnosis in both men and women.
Journal Article