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[...]zinc was identified as a potentially major modulating factor in Shankopathies, given its role in recruiting Shank2 and Shank3 at synapses, as well as having a key role in the gastro-intestinal tract, as reviewed by Hagmeyer et al.. Transcriptomic analyses allowed (Jin et al.) to identify brain region-specific modulation of gene expression in different Shank3 models, across age classes and between brain regions (prefrontal cortex, striatum, and hippocampus). [...]the involvement of the reward system was examined directly and indirectly.