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The cGAS–STING pathway as a therapeutic target in inflammatory diseases
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage. Underlying this broad involvement of the cGAS–STING pathway is its capacity to sense and regulate the cellular response towards microbial and host-derived DNAs, which serve as ubiquitous danger-associated molecules. Insights into the structural and molecular biology of the cGAS–STING pathway have enabled the development of selective small-molecule inhibitors with the potential to target the cGAS–STING axis in a number of inflammatory diseases in humans. Here, we outline the principal elements of the cGAS–STING signalling cascade and discuss the general mechanisms underlying the association of cGAS–STING activity with various autoinflammatory, autoimmune and degenerative diseases. Finally, we outline the chemical nature of recently developed cGAS and STING antagonists and summarize their potential clinical applications.The cGAS–STING pathway drives innate immune activation in response to cytosolic DNA. This is important for immunity to bacteria and viruses, but aberrant cGAS–STING activity is also linked to inflammatory disease. Here, Ablasser and colleagues discuss how cGAS–STING signalling contributes to various autoimmune, inflammatory and degenerative diseases and describe the novel therapeutics targeting this pathway.
Journal Article
A wavelet tour of signal processing : the sparse way
Mallat's book is the undisputed reference in this field - it is the only one that covers the essential material in such breadth and depth.- Laurent Demanet, Stanford UniversityThe new edition of this classic book gives all the major concepts, techniques and applications of sparse representation, reflecting the key role the subject plays in.
eBook
ERK signalling: a master regulator of cell behaviour, life and fate
The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream components of a phosphorelay pathway that conveys growth and mitogenic signals largely channelled by the small RAS GTPases. By phosphorylating widely diverse substrates, ERK proteins govern a variety of evolutionarily conserved cellular processes in metazoans, the dysregulation of which contributes to the cause of distinct human diseases. The mechanisms underlying the regulation of ERK1 and ERK2, their mode of action and their impact on the development and homeostasis of various organisms have been the focus of much attention for nearly three decades. In this Review, we discuss the current understanding of this important class of kinases. We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2. We then systematically discuss how ERK signalling regulates six fundamental cellular processes in response to extracellular cues. These processes are cell proliferation, cell survival, cell growth, cell metabolism, cell migration and cell differentiation.Extracellular signal-regulated kinase 1 (ERK1) and ERK2 relay cell growth and mitogenic signals to multiple substrates, and thus control essential physiological processes. This Review discusses the regulation of ERKs, and their control of cell proliferation, cell survival, cell growth, cell metabolism, cell migration and cell differentiation.
Journal Article
Compressed Sensing
Compressed sensing is an exciting, rapidly growing field, attracting considerable attention in electrical engineering, applied mathematics, statistics and computer science. This book provides the first detailed introduction to the subject, highlighting recent theoretical advances and a range of applications, as well as outlining numerous remaining research challenges. After a thorough review of the basic theory, many cutting-edge techniques are presented, including advanced signal modeling, sub-Nyquist sampling of analog signals, non-asymptotic analysis of random matrices, adaptive sensing, greedy algorithms and use of graphical models. All chapters are written by leading researchers in the field, and consistent style and notation are utilized throughout. Key background information and clear definitions make this an ideal resource for researchers, graduate students and practitioners wanting to join this exciting research area. It can also serve as a supplementary textbook for courses on computer vision, coding theory, signal processing, image processing and algorithms for efficient data processing.
eBook
Elementary signal detection theory
Signal detection theory describes how an observer makes decisions about weak, uncertain, or ambiguous events or signals. It is widely applied in psychology, medicine, and other related fields. This book describes the theory, explains its mathematical basis, and shows how to separate the observer's sensitivity to a signal from his or her tendency to say “yes” or “no.” Both detection of an event and discrimination between two events are treated. Chapters 1-4 describe the basic form of the signal-detection model and how to use it; Chapters 5-7 extend the model to different procedures such as identification of a signal; Chapters 8-10 expand it to other methods and distributions; and Chapter 11 describes the statistical treatment of detection data.
eBook