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Maggie and Oliver, or, A bone of one's own
A dog whose beloved owner has died and an orphaned ten-year-old girl find each other while enduring poverty and homelessness in early-twentieth-century Boston.
Book
A Shattered Nation
Historians often assert that Confederate nationalism had its origins in pre-Civil War sectional conflict with the North, reached its apex at the start of the war, and then dropped off quickly after the end of hostilities. Anne Sarah Rubin argues instead that white Southerners did not actually begin to formulate a national identity until it became evident that the Confederacy was destined to fight a lengthy war against the Union. She also demonstrates that an attachment to a symbolic or sentimental Confederacy existed independent of the political Confederacy and was therefore able to persist well after the collapse of the Confederate state. White Southerners redefined symbols and figures of the failed state as emotional touchstones and political rallying points in the struggle to retain local (and racial) control, even as former Confederates took the loyalty oath and applied for pardons in droves.Exploring the creation, maintenance, and transformation of Confederate identity during the tumultuous years of the Civil War and Reconstruction, Rubin sheds new light on the ways in which Confederates felt connected to their national creation and provides a provocative example of what happens when a nation disintegrates and leaves its people behind to forge a new identity.
eBook
Ditch of dreams : the Cross Florida Barge Canal and the struggle for Florida's future
\"Traces the long standing effort to build a canal across Florida. The book reveals much about competing visions of progress, economic growth, and environmental preservation in the fragile ecosystem of Florida, as well as the 'ins and outs, ' of politics, influence, and power in the Sunshine State. The history of the canal is not just a story of Florida's past, but a compelling lesson for its future.\"-- Provided by publisher.
Book
Paths Out of Dixie: The Democratization of Authoritarian Enclaves in America's Deep South, 1944-1972
The transformation of the American South--from authoritarian to democratic rule--is the most important political development since World War II. It has re-sorted voters into parties, remapped presidential elections, and helped polarize Congress. Most important, it is the final step in America's democratization.Paths Out of Dixieilluminates this sea change by analyzing the democratization experiences of Georgia, Mississippi, and South Carolina.
Robert Mickey argues that Southern states, from the 1890s until the early 1970s, constituted pockets of authoritarian rule trapped within and sustained by a federal democracy. These enclaves--devoted to cheap agricultural labor and white supremacy--were established by conservative Democrats to protect their careers and clients. From the abolition of the whites-only Democratic primary in 1944 until the national party reforms of the early 1970s, enclaves were battered and destroyed by a series of democratization pressures from inside and outside their borders. Drawing on archival research, Mickey traces how Deep South rulers--dissimilar in their internal conflict and political institutions--varied in their responses to these challenges. Ultimately, enclaves differed in their degree of violence, incorporation of African Americans, and reconciliation of Democrats with the national party. These diverse paths generated political and economic legacies that continue to reverberate today.
Focusing on enclave rulers, their governance challenges, and the monumental achievements of their adversaries,Paths Out of Dixieshows how the struggles of the recent past have reshaped the South and, in so doing, America's political development.
eBook
The art and life of Fukuda Kodōjin : Japan's great poet and landscape artist
\"The most comprehensive book on Kodojin's art ever published--beautiful and mysterious--a collection of more than 100 paintings with English translations of the inscribed poems.The Art and Life of Fukuda Kodōjin is the first publication in English to offer an in-depth examination of Kodōjin's life, painting, and poetry. This fully illustrated publication draws from institutions and private collections worldwide, and is the result of fifteen years of extensive research into almost eight hundred works of inscribed poetry, literati landscapes, brush paintings and calligraphy. A beautiful and contemplative look into the world of Kodōjin, this coveted edition accompanies a special exhibition held at the Minneapolis Institute of Art.Fukuda Kodōjin (1865-1944) was a multifaceted artist, recognized for his poetry, painting and calligraphy, and is one of a handful of artists who continued the tradition of Japanese literati painting (nanga) into the twentieth century. Kodōjin's painting style is characterized by bizarrely shaped mountain forms rendered in vivid color or monochromatic ink, often with a solitary scholar enjoying the expansive beauty of nature and bits of inscribed poetry. Creating over 700 works in his lifetime, he also made simple paintings of plants and flowers in his dramatic brushwork, and distinctive literati landscapes.Kodōjin literally means 'Old Taoist' which seems to reflect the path he chose of resilience of an old tradition facing new conditions and new challenges, and is theme felt throughout his art. There is both beauty and mystery in his life and work, and his landscapes can be rich in costly green and blue pigments, detailed layers of ink shading and strokes, or purely abstract.Unique, mysterious and distinctively expressive, The Art and Life of Fukuda Kodojin offers an unprecedented walk through the Old Taoist's mind, sure to both surprise and enlighten the curious reader, scholar, or literati enthusiast.\"-- Provided by publisher.
BOOK
The Elusive Republic
By investigating eighteenth-century social and economic thought--an intellectual world with its own vocabulary, concepts, and assumptions--Drew McCoy smoothly integrates the history of ideas and the history of public policy in the Jeffersonian era. The book was originally published by UNC Press in 1980.
eBook
Epidemiology, definition and treatment of complicated urinary tract infections
UTIs are amongst the most frequent bacterial infections. However, the clinical phenotypes of UTI are heterogeneous and range from rather benign, uncomplicated infections to complicated UTIs (cUTIs), pyelonephritis and severe urosepsis. Stratification of patients with UTIs is, therefore, important. Several classification systems exist for the description and classification of UTIs, with the common rationale that cUTIs have a higher risk of recurrence or chronification, progression or severe outcome than uncomplicated UTIs. The pathophysiology and treatment of cUTIs and pyelonephritis are driven more by host factors than by pathogen attributes. cUTIs and pyelonephritis are associated with high antimicrobial resistance rates among causative pathogens. However, antimicrobial resistance rates can differ substantially, depending on the population being studied and whether the data being analysed are from surveillance studies, registry data or interventional studies, in which specific inclusion and exclusion criteria are used for patient selection. For example, antibiotic resistance rates are higher in patients with urosepsis than in those with less severe infections. Thus, treatment outcomes differ substantially among studies, ranging from 50% to almost 100% clearance of infection, depending on the patient population analysed, the UTI entities included and the primary outcome of the study. Pyelonephritis and cUTIs have emerged as infection models for the study of novel antibiotics, including extensive investigation of novel substances active against Gram-negative bacteria.Complicated UTI (cUTI) incidence and the prevalence of antibiotic resistance among uropathogens are increasing. Here, the authors discuss different cUTI classification systems, describe current understanding of the aetiology of cUTIs and outline clinical studies of novel antibiotics in patients with cUTIs or pyelonephritis and the use of UTI as a model for other infection types in clinical studies.
Journal Article
Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics
Urinary tract infections (UTIs), which include any infection of the urethra, bladder or kidneys, account for an estimated 400 million infections and billions of dollars in health-care spending per year. The most common bacterium implicated in UTI is uropathogenic
Escherichia coli
, but diverse pathogens including
Klebsiella
,
Enterococcus
,
Pseudomonas
,
Staphylococcus
and even yeast such as
Candida
species can also cause UTIs. UTIs occur in both women and men and in both healthy and immunocompromised patients. However, certain patient factors predispose to disease: for example, female sex, history of prior UTI, or the presence of a urinary catheter or other urinary tract abnormality. The current clinical paradigm for the treatment of UTIs involves the use of antibiotics. Unfortunately, the efficacy of this approach is dwindling as the prevalence of antimicrobial resistance rises among UTI isolates, and the immense quantity of antibiotics prescribed annually for these infections contributes to the emergence of resistant pathogens. Therefore, there is an urgent need for new antibiotics and non-antibiotic treatment and prevention strategies. In this Review, we discuss how recent studies of bacterial pathogenesis, recurrence, persistence, host–pathogen interactions and host susceptibility factors have elucidated new and promising targets for the treatment and prevention of UTIs.
In this Review, Timm, Russell and Hultgren provide an overview of the bacterial and host factors contributing to the development of urinary tract infections, and they highlight new treatment strategies currently under development.
Journal Article
Risk factors and an optimized prediction model for urosepsis in diabetic patients with upper urinary tract stones
To identify independent risk factors for urosepsis in diabetic patients with upper urinary tract stones (UUTS) and develop a prediction model to facilitate early detection and diagnosis, we retrospectively reviewed medical records of patients admitted between January 2020 and June 2023. Patients were divided based on the quick Sequential Organ Failure Assessment (qSOFA) score. The least absolute shrinkage and selection operator (LASSO) regression analysis was used for variable selection to form a preliminary model. The model was optimized and validated using the receiver operating characteristic (ROC) curve, the Hosmer-Lemeshow test and calibration curve, and decision curve analysis (DCA). A nomogram was constructed for visualization. A total of 434 patients were enrolled, with 66 cases and 368 controls. Six optimal predictors were identified: underweight, sarcopenia, poor performance status, midstream urine culture, urinary leukocyte count, and albumin-globulin ratio (AGR). The midstream urine culture was excluded due to its inability to provide rapid results. The final model demonstrated good prediction accuracy and clinical utility, with no significant difference in performance compared to the initial model. The study developed a prediction model for urosepsis risk in diabetic patients with UUTS, presenting a convenient tool for timely diagnosis, particularly in non-operated patients.
Journal Article
A novel infrared spectroscopy marker for assessing the postoperative infection risk in patients with upper urinary tract calculus
The aim of this study is to evaluate the ability of infrared wavenumber of calculus to predict postoperative infection in patients with upper urinary tract calculus (UUTC), and to establish a predictive model based on this. From March 2018 to March 2023, 480 UUTC patients from Fujian Provincial Hospital were included in this study. The infrared-wavenumbers related infection score (IR-infection score) was constructed by univariate analysis, multicollinearity screening, and Lasso analysis to predict postoperative infection. Continually, the Delong test was used to compare the predictive power between the IR-infection score and traditional indicators. Afterward, we performed urine metagene sequencing and stone culture to prove the correlation between calculus toxicity and IR-infection score. Finally, logistic regression was used to build a nomogram. IR-infection score composed of four independent wavenumbers could precisely predict postoperative infection (AUC
validation cohort
= 0.707) and sepsis (AUC
validation cohort
= 0.824). IR-infection score had better predictive ability than commonly used clinical indicators. Moreover, metagenomics sequencing and calculus culture confirmed the correlation between IR-infection score and calculus toxicity (all
P
< 0.05). The nomogram based on the IR-infection score had high predictive power (all AUCs > 0.803). Our study first developed a novel infrared spectroscopy marker and nomogram, which can help urologists better predict postoperative infection in UUTC patients.
Journal Article