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Skin exposure to ultraviolet radiation (UVR) causes oxidative stress, inflammation, and collagen degradation and can trigger erythema. While topical formulas protect the skin from UV damage, there is growing evidence that certain botanical ingredients taken orally may have an added benefit. This study evaluated the photoprotective, anti-photoaging, and anti-erythema efficacy of a combination of rosemary and grapefruit extract (Nutroxsun®). Radical oxygen species (ROS) generation and interleukin production were determined in UV-irradiated keratinocytes (HaCaT). Also, collagen and elastin secretion and metalloproteinase (MMP-1 and MMP-3) content were assessed in UV-irradiated fibroblasts (NHDFs). Furthermore, a placebo-controlled, randomized, crossover study was conducted in 20 subjects (phototypes I to III) receiving two doses, 100 and 200 mg, of the ingredient. Skin redness (a* value, CIELab) after exposure to one minimal erythemal dose of UVR was assessed. As a result, the botanical blend significantly attenuated the UVR-induced reductions of procollagen I and elastin and lowered MMP-1 and MMP-3 protein secretion. Also, a reduction in ROS and proinflammatory interleukins (IL-1, IL-8, and IL-6) was observed. Finally, the botanical blend, at both doses, significantly reduced UV-induced erythema reaction from the first day of intake and accelerated recovery. These findings reinforce the potential of this ingredient as an effective dietary solution to protect the skin against UV-induced damage.

Skin ageing is a complex and multifaceted biological process that involves the accumulation of senescent dermal fibroblasts. While fractional microneedle radiofrequency (MNRF) is widely used for skin rejuvenation, the underlying molecular mechanisms are unknown. This study aimed to investigate the efficacy of fractional MNRF in altering the cellular milieu of aged skin and to evaluate clinical skin improvements. Thirty female volunteers aged ≥ 60 years with visible periorbital wrinkles received four consecutive treatments of either microneedling or MNRF on randomly assigned facial sides. Based on biophysical measurements, MNRF treatment improved wrinkles, elasticity, hydration, and transepidermal water loss compared to baseline. Histological analysis revealed that the MNRF-treated sides exhibited increased proliferation of non-senescent fibroblasts, a reduced number of senescent fibroblasts, and elevated collagen and elastin levels, compared to the MN-treated sides. In additional analyses, differences in collagen density and hydration between the two sides of the face were statistically significant only in subjects with a marked reduction in senescent fibroblasts in MNRF-treated sides. Our data suggest that, compared to MN, MNRF induces greater clinical and histological improvements in aged skin, likely by altering the dermal fibroblast milieu through the dual effect of eliminating senescent fibroblasts and increasing the number of non-senescent fibroblasts.

Background Skin aging is one of the most abundant aging‐related disorders that can be accelerated by excessive exposure to ultraviolet irradiation. Topically applied fermented skincare ingredients have gained mounting attentions due to their high concentration of various skin nourishing nutrients and bioactive components and low skin irritation potency. Aims In the present study, we aim to fully demonstrate the skin‐related benefits of a novel extract of Thermus thermophilus and Bacillus subtilis mixed‐culture ferment (TBFE). Methods TBFE was prepared through an innovative mixed‐culture fermentation process. The contents of nutrients and bioactive ingredients were quantified by different methods accordingly. Both in vitro tests and randomized controlled human trial were utilized to further demonstrate multifaceted beneficial effects on human skin, as well as the potential mechanisms. Results Our results showed that TBFE upregulated the expression of type IV collagen, elastin, aquaporin‐3, and dermal‐epidermal junction markers, while inhibited production of melanin, in different skin cell models. Moreover, TBFE inhibited the generation of reactive oxygen species and pro‐inflammatory mediators induced by ultraviolet irradiation in normal human keratinocytes, while stimulated autophagy in senescent keratinocytes. Results from clinical studies confirmed those in vitro findings, demonstrating that TBFE at 5% and 20% concentration provides anti‐aging properties in subjects with sensitive skin, in terms of improving wrinkles, moisturization, and skin lightening. Conclusions In summary, we demonstrate that a novel mixed‐culture ferment extract has promising anti‐aging effects, which may be attributed to anti‐oxidation, anti‐inflammation, and promotion of autophagy in skin cells.

Background Photorejuvenation is commonly employed to improve skin appearance but frequently leads to transient irritation and temporary impairment of skin barrier function. Incorporating platinum (Pt)‐liposome technology along with soothing ingredients such as panthenol, dipotassium glycyrrhizate, madecassoside, and Portulaca oleracea extract is expected to offer enhanced reparative and anti‐inflammatory effects, helping to alleviate post‐procedural skin sensitivity and restore barrier integrity. Aims This study aimed to evaluate the efficacy of a Pt‐liposome‐based facial mask in promoting skin recovery and soothing irritation post‐photorejuvenation. Furthermore, the study assessed potential synergistic benefits from combining Pt‐liposomes with established soothing agents. Patients/Methods We initially assessed the reparative effects of Pt‐liposomes using a 3D epidermal skin model and normal human epidermal keratinocytes (NHEK), evaluating parameters such as stratum corneum thickness, cholesterol content, ceramide chain length, and inflammatory responses (IL‐8 mRNA expression) following lipopolysaccharide (LPS) stimulation. A randomized, split‐face clinical trial involving 30 subjects who underwent photorejuvenation treatment was then conducted. Each participant applied the Pt‐liposome‐infused facial mask to one side of the face and a control product on the other side. Skin hydration, transepidermal water loss (TEWL), and erythema, tightness, dryness, and scaliness were assessed using objective instrumentation and subjective evaluations at baseline and various intervals up to 14 days post‐treatment. Results In vitro testing showed that Pt‐liposomes significantly increased stratum corneum thickness, cholesterol levels, and ceramide chain length (p < 0.01). Pt‐liposomes also reduced histamine‐induced calcium influx in NHEK cells (p < 0.01). In LPS‐stimulated THP‐1 cells, combined treatment with Pt‐liposomes and soothing agents resulted in a greater reduction in IL‐8 mRNA expression compared to either component alone (p < 0.01). Clinical measurements indicated that the application of the Pt‐liposome‐based facial mask significantly increased skin hydration and reduced TEWL compared to control (p < 0.001) from Day 1 to Day 14. Subjective and dermatological evaluations showed statistically significant improvements in erythema, tightness, dryness, and scaliness on the treated side at all measured time points. No adverse reactions were reported. Conclusion The Pt‐liposome‐infused facial mask can effectively promote skin barrier repair, alleviate irritation, and enhance hydration following photorejuvenation. Its synergistic combination with soothing ingredients provides rapid relief from irritation and sustained therapeutic benefits, supporting its potential as a safe and effective option for post‐procedural skincare.

Background Exosomes, an emerging treatment of interest to aesthetic dermatology, have therapeutic applications in skin rejuvenation, alopecia, atopic dermatitis, acne scarring, and wound healing. Platelet‐rich plasma has been widely utilized for the same indications, among others. Currently, there are no trials comparing the two regenerative modalities in aesthetic dermatology. Aims To compare the efficacy and safety of adipose mesenchymal stem cell‐derived (ASC) exosomes versus platelet‐rich plasma for photoaged facial skin. Methods An investigator‐blinded, split‐face trial was conducted. Participants with mild to moderate photoaging underwent three radiofrequency microneedling treatments with PRP and topical exosomes each applied to one half of the face. Results Both exosomes and PRP equally improved wrinkling, dyschromia, erythema, texture, and overall skin appearance. Histological analysis confirmed increased collagen I and glycosaminoglycans, without significant differences between treatment arms. Conclusion ASC exosomes are a promising PRP‐alternative that may be attractive to needle‐averse patients and can hasten the office visit duration, as phlebotomy and centrifugation are not required.

BACKGROUNDThe loss of insulin-like growth factor 1 (IGF-1) expression in senescent dermal fibroblasts during aging is associated with an increased risk of nonmelanoma skin cancer (NMSC). We tested how IGF-1 signaling can influence photocarcinogenesis during chronic UVB exposure to determine if fractionated laser resurfacing (FLR) of aged skin, which upregulates dermal IGF-1 levels, can prevent the occurrence of actinic keratosis (AK) and NMSC.METHODSA human skin/immunodeficient mouse xenografting model was used to test the effects of a small molecule inhibitor of the IGF-1 receptor on chronic UVB radiation. Subsequently, the durability of FLR treatment was tested on a cohort of human participants aged 65 years and older. Finally, 48 individuals aged 60 years and older with considerable actinic damage were enrolled in a prospective randomized clinical trial in which they underwent a single unilateral FLR treatment of one lower arm. Numbers of AKs/NMSCs were recorded on both extremities for up to 36 months in blinded fashion.RESULTSXenografting studies revealed that chronic UVB treatment with a topical IGF-1R inhibitor resulted in a procarcinogenic response. A single FLR treatment was durable in restoring appropriate UVB response in geriatric skin for at least 2 years. FLR resulted in sustained reduction in numbers of AKs and decreased numbers of NMSCs in the treated arm (2 NMSCs) versus the untreated arm (24 NMSCs).CONCLUSIONThe elimination of senescent fibroblasts via FLR reduced the procarcinogenic UVB response of aged skin. Thus, wounding therapies are a potentially effective prophylaxis for managing high-risk populations.TRIAL REGISTRATIONClinicalTrials.gov (NCT03906253).FUNDINGNational Institutes of Health, Veterans Administration.

Background/Objectives: UV radiation is a primary cause of skin damage and photoaging. β-carotene, a potent antioxidant, aids in mitigating UV-induced oxidative stress and enhancing skin photoprotection. This research aimed to evaluate the efficacy of a nutraceutical product designed to prevent photoaging. Methods: The product consists of a blend of hemp seed oil and banana (Musa AA), formulated as a chewable tablet. Healthy male participants aged 35–50 years were enrolled in a randomized, parallel, single-blind, placebo-controlled clinical trial. Participants received either the chewable nutraceutical (five tablets after meals in the morning and evening, equivalent to 8 ± 2 mg/day of β-carotene and 400 mg/day of PUFA) or a chewable placebo for 16 weeks. A total of thirty-six participants successfully completed the entire 16-week study. Results: Administration of the nutraceutical resulted in a significant reduction (p < 0.05) in UV solar light stimulator-induced erythema on the dorsal skin at week 4, with a mean value of 3.76 ± 0.46 AU, compared to the initial value of 4.88 ± 0.62 AU at week 0. Additionally, serum β-carotene concentration significantly increased from 0.45 ± 0.02 µg/mL at week 0 to 0.61 ± 0.06 µg/mL at week 16 (p < 0.05). Moreover, skin intensity in the sun-exposed arm area also significantly improved at week 16, increasing from 71.33 ± 3.50 at week 0 to 81.80 ± 4.45 (p < 0.05). Conclusions: The results indicate that the developed nutraceutical may offer effective protection against erythema, making it a promising option for preventing photoaging.

Background Skin radiance represents both healthy and esthetic aspects of human skin, usually influenced by a compromised barrier and the aging process. The reduction of the stratum corneum by chemical peels is a prevalent procedure employed to enhance facial radiance, but peeling is not suitable for compromised skin. Objectives Prinsepia utilis Royle polysaccharides (PURP) is a natural extract with repairing properties, which has been reported as a barrier repairing agent. ESETRILLQ (EQ) peptide has been recently reported as a novel antiaging bioactive peptide. This study aims to investigate the combined efficacy of these two ingredients on skin radiance enhancement. Methods Reconstructed human full‐thickness skin models were subjected to UVA exposure, followed by treatment with 1000 ppm PURP, 20 ppm EQ9, and their combinations: PUR9‐1 (1000 ppm PURP + 10 ppm EQ9) and PUR9‐2 (1000 ppm PURP + 20 ppm EQ9). Transcriptomic profiling was performed as a preliminary study to define the synergistic effect. RT‐qPCR was performed assessing the regulation of skin barrier‐related genes. Thirty‐three Chinese sensitive skin individuals were enrolled in a placebo‐controlled split‐face clinical research for 2 weeks to evaluate a PUR9‐2 containing lotion. Instrument measurement and expert evaluation were conducted to evaluate the parameters of glossiness and skin tone at baseline, Day 7, and Day 14. Skin glossiness was determined by VISIA 7, Glossymeter, and Translucency Meter. TEWL was determined by Tewameter Hex. Wrinkel number and area were obtained by VISIA 7. Results Transcriptomic profiling identified PUR9‐2 to regulate significantly different genes distinct from PURP and EQ9. The combination increased the gene expression levels of TNFAIP3 and CRNN. PUR9‐2 also increased the expression of FLG, LOR, and DSG1on UVA‐irradiated skin model. PUR9‐2 containing lotion significantly decreased TEWL by 16.96%. Clinical evaluations demonstrated a statistically significant 22.32% (Glossymeter) and 35.56% (VISIA 7) improvement in skin glossiness on the PUR9‐2 lotion‐treated side by Day 14 compared to baseline. Translucency demonstrated a statistically significant 13.06% increase of K value, which all aligned with the expert evaluation of skin radiance enhancement. Conclusion PCA analysis revealed PUR9‐2 uniquely modulated gene expression compared to PURP and EQ9. Functional enrichment analysis based on Gene Ontology (GO) demonstrated PUR9‐2 restored UVA‐suppressed TNFAIP3 and CRNN gene. The results of RT–PCR also indicated that PUR9‐2 enhanced skin barrier integrity in 3D models via upregulated expression of FLG, LOR, and DSG1. The Chou‐Talalay method further validated PUR9‐2's synergistic potency (CI < 1) in accelerating keratinocyte scratch wound closure. The clinical research demonstrated protective effects of PUR9‐2 on compromised skin barrier and enhanced both glossiness of the sensitive skin surface and translucency within the skin structure. This study provides a potential solution for improving the radiance and overall conditions of compromised skin.

Background Radiofrequency (RF) microneedling produces patient discomfort which deters patients from completing the recommended treatment series. Objective The primary objective was to determine the tolerability, safety, and efficacy of a neurocosmetic postprocedure cream post‐RF microneedling in reducing patient discomfort and enhancing recovery across the length of the study and, secondarily, to evaluate against a leading comparator. The third objective was to evaluate the efficacy of the neurocosmetic on self‐perceived improvement and objective grading. Materials and Methods An Institutional Review Board (IRB) approved, fourteen‐day, randomized, single‐center, double‐blind, controlled clinical case study was conducted with 11 healthy female subjects, 6 randomized to the neurocosmetic and 5 to the comparator cell. Following a 7‐day washout period, subjects received RF microneedling (face and neck) and applied the postprocedure cream twice daily for 7 days. Objective and subjective tolerability, self‐assessments, and clinical photography were performed immediately postprocedure, 24 h, three and seven days following the procedure. Results The neurocosmetic was tolerable and safe. Erythema and stinging immediately decreased postprocedure, postneurocosmetic application. After 24 h, 83% favorably agreed the neurocosmetic “reduced irritation on the skin post‐procedure,” and after 7 days, 100% favorably agreed “experience with the product was positive and I would be interested in returning for a second treatment.” The neurocosmetic reduced skin tone redness in the face and neck faster and to a greater degree when measured against a comparator. Conclusion The neurocosmetic postprocedure cream improved patient discomfort and enhanced recovery when used immediately post‐RF microneedling and after 7 days. IRB Protocol Number Pro00064211

Background Following Nonablative fractional Fraxel laser (NAFL), a well‐established treatment for skin rejuvenation, immediate post‐procedural care is essential to address any potential complications and accelerate the healing process. Aims To evaluate the efficacy and patient satisfaction of a topical skincare regimen containing vitamin C, vitamin E, and ferulic acid—CE Ferulic serum (CEF) following NAFL treatment in the Chinese population. Methods In this randomized, investigator‐blinded, split‐face, controlled trial, patients with mild‐to‐moderate facial photodamage were randomized to receive CEF treatment on one side of the face and normal saline (NS) on the other side immediately after the NAFL procedure and daily during the 7‐day follow‐up. The primary endpoint was the change from baseline in erythema score on Day 7, with key secondary endpoints including changes from baseline in erythema index (EI), melanin index (MI), transepidermal water loss, skin hydration, skin sebum content, scabbing, edema, overall patient satisfaction, and post‐procedure pain. Results In total, 50 patients (female 45/50) were enrolled in this study, with a mean age of 31.6 years. The mean change from baseline in erythema score was significantly lower on the CEF side than on the NS side on Day 7 post‐NAFL treatment (0.04 ± 0.40 vs. 0.18 ± 0.48, p = 0.011). The CEF side also exhibited improved changes in EI, MI, and skin hydration, as well as higher overall satisfaction and less pain compared with the NS side. Conclusions Applying CEF after NAFL treatment reduced erythema progression, maintained skin hydration, and promoted the healing process compared with NS. Trial Registration Chinese Clinical Trial Registry: ChiCTR2300069246