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Introduction Cryotherapy is an efficient method to treat various cutaneous lesions. In the current clinical evaluation, the efficacy of the Pixie ® Skin Tag cryogenic pen as a home treatment for benign skin tags was evaluated against a marketed comparator device. In addition, the safety, tolerability, and expected visual effects of the treatment were assessed. Methods Fifty-six healthy volunteers presenting with skin tags were included and randomized in a prospective, single-blinded, parallel, single-center, comparative trial and subjected to treatment with either Pixie ® Skin Tag or a comparator device, Wortie ® skin tag remover. Selected skin tags located on the neck, breast, and under the armpits were topically treated according to device prescriptions for maximally three times with a 15-day interval between treatments. Results Of the skin tags treated with Pixie ® Skin Tag, 64.3% completely disappeared during the study, of which half of the skin tags were cleared after one treatment, compared with 7.1% of the study population treated with Wortie ® skin tag remover ( p  < 0.001). Both medical devices were safe to use, painless, and very well tolerated by 64.3% in the Pixie ® Skin Tag and 96.4% in the Wortie ® skin tag remover group. In addition, 72% of the subjects using Pixie ® Skin Tag were satisfied with the results, and two-thirds of this study group would buy and use the device for the treatment of other skin tags. For the comparator device, only 11.0% were satisfied and 7.0% would buy the device. Conclusion Treatment of skin tags with Pixie ® Skin Tag showed superior clinical performance when compared to Wortie ® skin tag remover. Both treatments were safe and well tolerated, with the majority of skin response serving as a predictor for clinical performance in the Pixie ® Skin Tag treated group. Trial Registration Number ANSL Registration: 2018-A01804-51.

Fibroma pendulans, commonly known as skin tag, is a benign protrusion of connective tissue that often develops groupwise in areas subjected to mechanical friction. Although generally harmless, they can become cosmetically concerning or painful if infarcted. Traditional removal methods, such as electrocautery and cryotherapy, often result in hypopigmentation or scarring. Lasers became interesting for skin-tag removal, but are they really more effective than classical scissor snip exisions? This study aimed to compare the efficacy, healing outcomes, and patient acceptance of scissor snip excision versus 532 nm LBO laser therapy for the removal of skin tags. 68 patients with a total of 1,257 fibromas located on the neck or axillae were treated. Each patient received both treatments in a randomized split-neck/axillar manner. Fibromas were either excised using scissors or treated with the non-ablative 532 nm LBO laser. Outcomes were evaluated at 4 and 12 weeks post-treatment, focusing on complete healing, patient preference, pain perception, and cosmetic results. At 12 weeks, the scissor excision group exhibited a significantly higher healing rate of 85% compared to 71% in the laser group ( p  = 0.00001). The adjusted overall response rate was 92.64% for scissor excision and 84.19% for laser treatment. Patient preference favored scissor excision, with 63% of patients opting for this method for future treatments, while 19% preferred the laser, and 18% were indifferent. Pain scores were lower for scissor excision (mean: 2.6) compared to laser treatment (mean: 3.42). Laser therapy was 39% faster than scissor excision when accounting for wound dressing, although it had higher rates of redness, hyper- and hypopigmentation. The bloodless nature of the laser and the absence of dressings were perceived as advantages, but the persistence of necrotic fibromas for up to three weeks was a notable drawback. Despite the perceived advantages of a bloodless and dressing-free procedure with the 532 nm LBO laser, scissor snip excision demonstrated superior healing outcomes, lower pain scores, and higher patient satisfaction. These findings suggest that scissor snip excision remains the gold standard for treating pedunculated fibromas, though further studies exploring the effect of the 532 nm laser on small disseminated fibromas and other laser modalities are warranted.

Vulvar fibroepithelial polyp in a pregnant woman is a rare clinical condition. In this study, a case of a giant fibroepithelial polyp of vulva in a pregnant woman is reported. A pregnant woman presented with a pedunculated mass over right labium majus that grew up during pregnancy period was surgically removed. Surgical excision of the tumour was performed and postoperative recovery and pregnancy follow-up were uneventful. Fibroepithelial polyps are common lesions of skin but unusual locations have been rarely reported in literature. To the best of our knowledge, the presented case is one of the largest fibroepithelial polyp of vulva in a pregnant woman.

Giant acrochordons are extremely rare in sizes bigger than 5 cm and even more extreme in postmenopausal women. Treatment of vulvar diseases can present significant challenges, particularly when dealing with older patients with co‐morbidities. Gynecological and dermatological consultations for early identification of malignant transformation or recurrence are essential.

Objective We aimed to document the treatment outcomes of African patients treated with low‐intensity electrodesiccation for DPN's. Other treatment options for DPN's include snip excision, light curettage, cryotherapy, and lasers devices such as PDL, Nd: YAG, KTP, and CO2, which are generally unsafe for darker skin types and come with high costs. Methods Nonprobability convenience sampling of patient records was used to extract retrospective data on demographics and treatment outcomes according to the inclusion criteria. The retrospective data analysis included chi‐squared tests for associations, Kaplan–Meier survival analysis, and logistic regression analysis to examine relationships between dependent and independent variables. Results A total of 137 patients were included in the study, with the majority being female (n = 129; 94.16%) compared with their male counterparts (n = 8; 5.84%). Most patients were under 40 years of age (n = 74; 54.00%), whereas the remaining were above 40 years of age (n = 63; 46.00%). The majority of patients had Fitzpatrick skin type V (n = 99; 72.26%). Adverse events such as milia (n = 4) and scarring (n = 2) were observed, but these were not associated with age, sex, or survival rate (p value > 0.05). Limitations The study was conducted at a single center, which limits the ability to generalize the results. Conclusion The low‐intensity electrodesiccation technique was found to be a safe and cost‐effective method for treating DPN's in African patients.

Background: Low-risk human papillomavirus (HPV) infections are related to the genesis of various benign lesions. In an isolated report available, HPVs have been implicated in the causation of skin tags too. Aims: The present study was designed to detect the existence of low-risk HPV types 6 and 11 in cutaneous soft fibromas (skin tag) in north Indians. Methods: A total of 37 cases of skin tags from various sites were analyzed. Highly sensitive and comprehensive polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) assays were done for the detection of low-risk HPV types 6 and 11. Results: The results revealed the presence of HPV DNA 6/11 in 48.6% of the skin tags examined by PCR-RFLP. Conclusion: This result corroborates the hypothesis that HPV plays a part in the etiology of benign lesions like cutaneous soft fibromas. The identification of HPV 6/11 in these lesions, which are benign proliferations of the skin, further expands the spectrum of HPV-linked lesions.

Background Cryotherapy and electrosurgery are two commonly used methods to remove sebaceous hyperplasia, seborrheic keratosis, cherry angioma, and skin tags, which can be bothersome and uncomfortable. We compare the effectiveness and adverse effects of cryotherapy and electrosurgery in treating these skin conditions. Method The study was conducted as an assessor‐blind trial. The 32 lesions in each lesion group were divided into two treatment groups, cryotherapy and electrosurgery, using sealed envelopes. We collected baseline information, which included age, gender, lesion location, and consent, from the patients. Follow‐up visits were scheduled at 2 weeks, 1 month, and 3 months after the initial treatment session to evaluate the response rate of the lesions. Based on before‐after clinical images, this evaluation encompassed patient and physician satisfaction (no change, little, somewhat, good, and excellent), and any potential complications. Results The mean age of cryotherapy group was 52.04 ± 11.59 years, while the mean age in the electrosurgery group was 50.48 ± 10.70 years (p > 0.05). Regarding gender, 15 (23.4%) in the cryotherapy and 24 (37.5%) in the electrosurgery were female (p > 0.05). Physician and patient satisfaction increased significantly over time in the cryotherapy and electrosurgery groups (p < 0.001). For sebaceous hyperplasia, cherry angioma and skin tags, the degree of satisfaction of patients and physicians was significantly higher for electrosurgery than cryotherapy during follow‐up (p < 0.05). However, seborrheic keratosis responded better to cryotherapy. Hypopigmentation and depigmentation occurred in 2 (3.1%) and 4 (6.3%) of the cryotherapy cases, respectively. Hypopigmentation and atrophic scars also occurred in 4 (6.3%) and 2 (3.1%) of the cases in the electrosurgical group in different sessions. Conclusion It appears that electrosurgery is more effective in the treatment of sebaceous hyperplasia, cherry angioma and skin tags, while cryotherapy is more effective in the treatment of seborrheic keratosis.

We present a case of 20-year-old woman who presented with a large pedunculated skin covered mass lesion arising from the left thigh, measuring 40 × 25 cm, with no history of pain or skin ulceration and a feeling of a lump with dragging pain in the left side of the abdomen for about 7 years. Subsequently, ultrasound, contrast-enhanced computed tomography, and magnetic resonance imaging of abdomen and left thigh region were carried out. The lesion was broad-based toward the left upper thigh with a central core of interspersed fat supplied by branches of the superficial and deep femoral arteries. Another lesion was seen in the left retroperitoneum anterior to the psoas muscle in a left paravertebral location encasing the left common iliac vessels extending into the left pelvic cavity and inguinal region inferiorly. The lesion showed dense post-acoustic shadowing on ultrasound, mild enhancement on contrast-enhanced computed tomography, and appeared hypointense on T1- and T2-weighted images. A left thigh lesion was excised, whereas incisional biopsy was done for the left retroperitoneal lesion. The diagnosis of a giant fibroepithelial polyp arising from the left thigh and left retroperitoneal fibromatosis was made. This is the first report of such a giant fibroepithelial polyp arising from the thigh with associated retroperitoneal fibromatosis.

We present the case of a 37-year-old male diagnosed with Mycosis fungoides (MF) after gradually developing multiple skin tags and brownish lichenoid papules. The patient had pre-existing erythema over his entire body, especially his face, upper extremities, and trunk, for over 1.5 years. Microscopic examination of the papule and the skin tag (ST) exhibited similar features mainly characterized by superficial dense band-like lymphoid infiltrates and epidermotropism of atypical lymphocytes (Pautrier's micro-abscesses). Immunohistochemistry further revealed the lymphoid infiltrates predominantly expressed LCA, CD3, CD4, and CD45RO but lacked CD7, CD8, CD30, CD20, and CD79a. The finding of this study that reports MF characterized by unusual STs suggests that some causes and effects have not been previously described in MF.