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Mad Dogs and Meerkats
Through the ages, rabies has exemplified the danger of diseases that transfer from wild animals to humans and their domestic stock. In South Africa, rabies has been on the rise since the latter part of the twentieth century despite the availability of postexposurevaccines and regular inoculation campaigns for dogs.InMad Dogs and Meerkats: A History of Resurgent Rabies in Southern Africa,Karen Brownlinks the increase of rabies to the HIV/AIDS epidemic. Her study shows that the most afflictedregions of South Africa have seen a dangerous rise in feral dog populations as people lack the education, means, or will to care for their pets or take them to inoculation centers. Most victims are poor black children. Ineffective disease control, which in part depends on management policies in neighboring states and the diminished medical and veterinary infrastructures in Zimbabwe, has exacerbated the problem.This highly readable book is the first study of rabies in Africa, tracing its history in South Africa and neighboring states from 1800 to the present and showing how environmental and economicchanges brought about by European colonialism and global trade have had long-term effects.Mad Dogs and Meerkatsis recommended for public health policy makers and anyone interested in human-animal relations and how societies and governmentshave reacted to one of the world's most feared diseases.
eBook
Operation Lock and the war on Rhino poaching
\"The aggressive poaching of rhinos needs to be countered with equal aggression. So argued Prince Bernhard of the Netherlands, the founder president of the World Wide Fund for Nature (WWF), at a 1987 meeting with John Hanks, conservation expert and WWF's head in Africa. The result was Operation Lock, a secret initiative funded by Prince Bernhard and staffed by former SAS operatives. Operation Lock set up headquarters in Johannesburg and extended its reach into neighbouring states: Namibia, Zambia, Botswana, Swaziland and Mozambique. Its operatives planned to train game rangers, to pose as rhino horn traders in order to entrap buyers, and to expose the kingpins who were driving the trade. It was a controversial approach, all the more because it was working within apartheid South Africa in the late 1980s. When the existence of the project was finally leaked, WWF denied any involvement, and John Hanks took the fall. In Operation Lock and the War on Rhino Poaching, John Hanks finally tells the story of these explosive events from 25 years ago. As a leading international authority on conservation, he also deals with the scourge of rhino poaching up to the present, and gives powerful and controversial criticism of some of the current policies to curb poaching.\" -- Back cover.
Book
Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women
Development of HIV-1 prevention methods is a global priority. In this randomized, controlled trial in sub-Saharan Africa, a vaginal ring containing the antiretroviral dapivirine was 27% effective in protecting against HIV-1 acquisition.
More than half of the 35 million persons currently living with human immunodeficiency virus type 1 (HIV-1) infection are women. A majority of these women reside in sub-Saharan Africa,
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a region that has some of the highest incidences of HIV-1 infection in any population worldwide.
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The use of antiretroviral medications as pre-exposure prophylaxis is a promising approach to the prevention of HIV-1 acquisition.
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Several clinical trials of the antiretroviral tenofovir showed such protection against HIV-1.
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However, in three trials involving African women, adherence to tenofovir-containing pills and vaginal gels was low, and HIV-1 protection was not shown. . . .
Journal Article
Genomic history of the seventh pandemic of cholera in Africa
The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.
Journal Article
Themes in the Christian History of Central Africa
This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1975.
eBook
Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study
Hormonal contraceptives are used widely but their effects on HIV-1 risk are unclear. We aimed to assess the association between hormonal contraceptive use and risk of HIV-1 acquisition by women and HIV-1 transmission from HIV-1-infected women to their male partners.
In this prospective study, we followed up 3790 heterosexual HIV-1-serodiscordant couples participating in two longitudinal studies of HIV-1 incidence in seven African countries. Among injectable and oral hormonal contraceptive users and non-users, we compared rates of HIV-1 acquisition by women and HIV-1 transmission from women to men. The primary outcome measure was HIV-1 seroconversion. We used Cox proportional hazards regression and marginal structural modelling to assess the effect of contraceptive use on HIV-1 risk.
Among 1314 couples in which the HIV-1-seronegative partner was female (median follow-up 18·0 [IQR 12·6–24·2] months), rates of HIV-1 acquisition were 6·61 per 100 person-years in women who used hormonal contraception and 3·78 per 100 person-years in those who did not (adjusted hazard ratio 1·98, 95% CI 1·06–3·68, p=0·03). Among 2476 couples in which the HIV-1-seronegative partner was male (median follow-up 18·7 [IQR 12·8–24·2] months), rates of HIV-1 transmission from women to men were 2·61 per 100 person-years in couples in which women used hormonal contraception and 1·51 per 100 person-years in couples in which women did not use hormonal contraception (adjusted hazard ratio 1·97, 95% CI 1·12–3·45, p=0·02). Marginal structural model analyses generated much the same results to the Cox proportional hazards regression.
Women should be counselled about potentially increased risk of HIV-1 acquisition and transmission with hormonal contraception, especially injectable methods, and about the importance of dual protection with condoms to decrease HIV-1 risk. Non-hormonal or low-dose hormonal contraceptive methods should be considered for women with or at-risk for HIV-1.
US National Institutes of Health and the Bill & Melinda Gates Foundation.
Journal Article