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Spaceflight in the shuttle era and beyond : redefining humanity's purpose in space
An exploration of the changing conceptions of the iconic Space Shuttle and a call for a new vision of spaceflight. The thirty years of Space Shuttle flights saw contrary changes in American visions of space. Valerie Neal, who has spent much of her career examining the Space Shuttle program, uses this iconic vehicle to question over four decades' worth of thinking about, and struggling with, the meaning of human spaceflight. She examines the ideas, images, and icons that emerged as NASA, Congress, journalists, and others sought to communicate rationales for, or critiques of, the Space Shuttle missions. At times concurrently, the Space Shuttle was billed as delivery truck and orbiting science lab, near-Earth station and space explorer, costly disaster and pinnacle of engineering success. The book's multidisciplinary approach reveals these competing depictions to examine the meaning of the spaceflight enterprise. Given the end of the Space Shuttle flights in 2011, Neal makes an appeal to reframe spaceflight once again to propel humanity forward.
Book
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.
Journal Article
Explore space using swarms of tiny satellites
Sand-grain-sized computers, self-healing materials and constellations of craft would reboot our reach, explain Igor Levchenko, Michael Keidar and colleagues.
Sand-grain-sized computers, self-healing materials and constellations of craft would reboot our reach.
Journal Article
Dreams of other worlds : the amazing story of unmanned space exploration
Dreams of Other Worlds describes the unmanned space missions that have opened new windows on distant worlds. Spanning four decades of dramatic advances in astronomy and planetary science, Impey and Henry tell the story of eleven iconic exploratory missions and how they have fundamentally transformed our scientific and cultural perspectives on the universe and our place in it.
Book
A second space age spanning omics, platforms and medicine across orbits
The recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a ‘second space age’. This era is also poised to leverage, for the first time, modern tools and methods of molecular biology and precision medicine, thus enabling precision aerospace medicine for the crews. The applications of these biomedical technologies and algorithms are diverse, and encompass multi-omic, single-cell and spatial biology tools to investigate human and microbial responses to spaceflight. Additionally, they extend to the development of new imaging techniques, real-time cognitive assessments, physiological monitoring and personalized risk profiles tailored for astronauts. Furthermore, these technologies enable advancements in pharmacogenomics, as well as the identification of novel spaceflight biomarkers and the development of corresponding countermeasures. In this Perspective, we highlight some of the recent biomedical research from the National Aeronautics and Space Administration, Japan Aerospace Exploration Agency, European Space Agency and other space agencies, and detail the entrance of the commercial spaceflight sector (including SpaceX, Blue Origin, Axiom and Sierra Space) into aerospace medicine and space biology, the first aerospace medicine biobank, and various upcoming missions that will utilize these tools to ensure a permanent human presence beyond low Earth orbit, venturing out to other planets and moons.
The current ‘second space age’ has enabled multiple studies on the effects of spaceflight on human physiology and health, which are contributing to the development of measures that will be needed to maintain astronaut health in future space missions.
Journal Article
Longitudinal metabolomic profiles reveal sex-specific adjustments to long-duration spaceflight and return to Earth
Spaceflight entails a variety of environmental and psychological stressors that may have long-term physiological and genomic consequences. Metabolomics, an approach that investigates the terminal metabolic outputs of complex physiological alterations, considers the dynamic state of the human body and allows the identification and quantification of down-stream metabolites linked to up-stream physiological and genomic regulation by stress. Employing a metabolomics-based approach, this study investigated longitudinal metabolic perturbations of male (
n
= 40) and female (
n
= 11) astronauts on 4–6-month missions to the International Space Station (ISS). Proton nuclear magnetic resonance (
1
H-NMR) spectroscopy followed by univariate, multivariate and machine learning analyses were used on blood serum to examine sex-specific metabolic changes at various time points throughout the astronauts’ missions, and the metabolic effects of long-duration space travel. Space travel resulted in sex-specific changes in energy metabolism, bone mineral and muscle regulation, immunity, as well as macromolecule maintenance and synthesis. Additionally, metabolic signatures suggest differential metabolic responses—especially during the recovery period—with females requiring more time to adjust to return to Earth. These findings provide insight into the perturbations in glucose and amino acid metabolism and macromolecule biosynthesis that result from the stressors of long-duration spaceflight. Metabolomic biomarkers may provide a viable approach to predicting and diagnosing health risks associated with prolonged space travel and other physiological challenges on Earth.
Journal Article
Space blog
Take a trip to outer space! Watch out for huge yellow clouds filled with acid, solar gas explosions, giant flying snowballs made of ice. Join these astronauts on a daring and dangerous adventure through space.
Book
Molecular and physiological changes in the SpaceX Inspiration4 civilian crew
Human spaceflight has historically been managed by government agencies, such as in the NASA Twins Study
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, but new commercial spaceflight opportunities have opened spaceflight to a broader population. In 2021, the SpaceX Inspiration4 mission launched the first all-civilian crew to low Earth orbit, which included the youngest American astronaut (aged 29), new in-flight experimental technologies (handheld ultrasound imaging, smartwatch wearables and immune profiling), ocular alignment measurements and new protocols for in-depth, multi-omic molecular and cellular profiling. Here we report the primary findings from the 3-day spaceflight mission, which induced a broad range of physiological and stress responses, neurovestibular changes indexed by ocular misalignment, and altered neurocognitive functioning, some of which match those of long-term spaceflight
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, but almost all of which did not differ from baseline (pre-flight) after return to Earth. Overall, these preliminary civilian spaceflight data suggest that short-duration missions do not pose a significant health risk, and moreover present a rich opportunity to measure the earliest phases of adaptation to spaceflight in the human body at anatomical, cellular, physiological and cognitive levels. Finally, these methods and results lay the foundation for an open, rapidly expanding biomedical database for astronauts
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, which can inform countermeasure development for both private and government-sponsored space missions.
SpaceX’s Inspiration4 mission sent an all-civilian crew into orbit to study physiological, neurovestibular and neurocognitive changes in the astronauts and found that short-duration civilian space missions do not pose a major health risk.
Journal Article