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Guide to astronomy and space science, compiled by leading space experts. Includes the facts and figures from the latest missions to the planets, and images from the Hubble Space Telescope.

Many proteins regulate the expression of genes by binding to specific regions encoded in the genome 1 . Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part of the Encyclopedia of DNA Elements (ENCODE) project phase III. This class of regulatory elements functions only when transcribed into RNA, as they serve as the binding sites for RBPs that control post-transcriptional processes such as splicing, cleavage and polyadenylation, and the editing, localization, stability and translation of mRNAs. We describe the mapping and characterization of RNA elements recognized by a large collection of human RBPs in K562 and HepG2 cells. Integrative analyses using five assays identify RBP binding sites on RNA and chromatin in vivo, the in vitro binding preferences of RBPs, the function of RBP binding sites and the subcellular localization of RBPs, producing 1,223 replicated data sets for 356 RBPs. We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs. A combination of five assays is used to produce a catalogue of RNA elements to which RNA-binding proteins bind in human cells.

Presents an introductory look at space, including information on the solar system, the history of space exploration, and space in the future.

NASA's periodic selection of astronauts is a highly selective process accepting applications from the general population, wherein the mechanics of selection are not made public. This research was an effort to determine if biases (specifically age) exist in the process and, if so, at which points they might manifest. Two sets of analyses were conducted. The first utilized data requested via the Freedom of Information Act (FOIA) on NASA astronaut applicants for the 2009 and 2013 selection years. Using a series of multinomial and logistic regressions, the data were analyzed to uncover whether age of the applicants linearly or nonlinearly affected their likelihood of receiving an invitation, as well as their likelihood of being selected into the astronaut program. The second used public data on age at selection and age at other career milestones for every astronaut selected from 1959 to 2013 to analyze trends in age over time using ordinary least-squares (OLS) regression and Pearson's correlation. The results for the FOIA data revealed a nonlinear relationship between age and receiving an interview, as well as age and selection into the astronaut program, but the most striking observation was the loss of age diversity at each stage of selection. Applicants younger or older than approximately 40 years were significantly less likely to receive invitations for interviews and were significantly less likely to be selected as an astronaut. Analysis of the public-source data for all selections since the beginning of the astronaut program revealed significant age trends over time including a gradual increase in selectee age and decreased tenure at NASA after last flight, with average age at retirement steady over the entire history of the astronaut program at approximately 48 years.

Wikipedia has become increasingly prominent in online search results, serving as an initial path for the public to access “facts,” and lending plausibility to its autobiographical claim to be “the sum of all human knowledge.” However, this self-conception elides Wikipedia’s role as the world’s largest online site of encyclopedic knowledge production. A repository for established facts, Wikipedia is also a social space in which the facts themselves are decided. As a community, Wikipedia is guided by the five pillars—principles that inform and undergird the prevailing epistemic and social norms and practices for Wikipedia participation and contributions. We contend these pillars lend structural support to and help entrench Wikipedia’s gender gap as well as its lack of diversity in both participation and content. In upholding these pillars, Wikipedians may unknowingly undermine otherwise reasonable calls for inclusivity, subsequently reproducing systemic biases. We propose an alternative set of pillars developed through the lens of feminist epistemology, drawing on Lorraine Code’s notion of epistemic responsibility and Helen Longino’s notion of procedural objectivity. Our aim is not only to reduce bias, but also to make Wikipedia a more robust, reliable, and transparent site for knowledge production.

The morphology and the drug sensitivity of the strain GYX2014-1 isolated from the hepatic pancreatic tissue of moribund Litopenaeus vannamei were evaluated by conventional culture characteristics, physical and chemical characteristics, and molecular biology methods. Detection of extracellulase and hemolysin activity shows that the isolated GYX2014-1 has protease, lipase, gelatinase activity, but none of amylase, or lecithinase activity. The 16S rRNA gene (GenBank accession number: KT781675) was analyzed, and a phylogenetic tree analysis showed that the isolated pathogen was most closely related to V. vulnificus (GenBank accession number: NR 118570)-a match of more than 99%. The phenotypic traits and molecular biology of isolated bacteria, determined their identity as Vibrio vulnificus (V. vulnificus). In addition, artificially infected L. vannamei with Vibrio vulnificus appeared with the same disease symptoms as those of naturally infected shrimp. Drug sensitivity tests showed that V. vulnificus is highly sensitive to fosfomycin, cefradine and sinomin, and was resistant to penicillin, amikacin and kanamycin. This experiment is the first to separate V. vulnificus from L. vannamei, and the findings of this study can be used as a reference for disease control and health management.

Introduction: Since Gagarin became the first human to travel into space and complete one orbit around the Earth, on 12 April 1961, the number of manned spaceflights has increased significantly. Spaceflight is still complex and has potential risk for incidents and accidents. The aim of this study was to analyze how safe it is for humans to travel in space. Objectives: This paper, therefore, summarizes incidents and accidents covering the six decades of manned spaceflight (1961–2020). Material and methods: Extensive PubMed, Cochrane, and Google Scholar searches were made with search strings of “incidents”, “accident”, “spaceflight”, and “orbit”, and including all vehicles so far. Search terms were combined by AND or OR in search strings. Of the results obtained, studies which evaluated manned spaceflight were included in the study. Data from the National Aeronautics Space Agency (NASA), the Russian Space Agency (ROSCOSMOS), the European Space Agency (ESA), and the Chinese Space Agency (CNSA), as well as from the Virgin Galactic and the SpaceX databases, were searched to complete data and to identify all the accomplished manned spaceflights, as well as all incidents and accidents that have occurred in the specific period. Search results were compared to findings on Wikipedia, Encyclopedia Astronautica, and other public webpages. Reference lists of included articles/homepages were also included for further potential data. Results: From 1961–2020, our data revealed an increasing number of manned space flights, n = 327. The number of times an astronaut has been sent to space, n = 1294, resulted in an accumulated n = 19,414 days spent in space. The number of days spent in orbit has constantly increased from 1961 until today. The number of incidents (altogether n = 36) and accidents (altogether n = 5) has constantly decreased. The number of astronauts who have died during spaceflight is represented by n = 19. The current statistical fatality rate is 5.8% (deaths per spaceflight) with the highest fatality rate in the 1960s (0.013 deaths/day spent in space), and the lowest rates in the 1990s and the period from 2010 until the present (no deaths). The most dangerous phases of spaceflight are launch, landing and staying in orbit. Altogether, n = 12 incidents (incident rate per spaceflight: 0.04) and one accident (accident rate: 0.003) during launch have been reported, n = 9 incidents (incident rate: 0.03) and two accidents (accident rate: 0.006) have been reported during landing and n = 10 incidents (incident rate: 0.03) have been reported in orbit. Discussion: Manned spaceflight over the last six decades has become significantly safer. Since 2003, no astronaut fatality has been reported. With greater international cooperation and maintaining of the International Space Station (ISS), the number of manned spaceflights and days spent in space has constantly increased, with constantly lower rates of incidents and accidents.

Long before Galileo published his discoveries about Jupiter, lunar craters, and the Milky Way in the Starry Messenger in 1610, people were fascinated with the planets and stars around them. That interest continues today, and scientists are making new discoveries at an astounding rate. Ancient lake beds on Mars, robotic spacecraft missions, and new definitions of planets now dominate the news. How can you take it all in? Start with the new Encyclopedia of the Solar System, Second Edition.This self-contained reference follows the trail blazed by the bestselling first edition. It provides a framework for understanding the origin and evolution of the solar system, historical discoveries, and details about planetary bodies and how they interact-and has jumped light years ahead in terms of new information and visual impact. Offering more than 50% new material, the Encyclopedia includes the latest explorations and observations, hundreds of new color digital images and illustrations, and more than 1,000 pages. It stands alone as the definitive work in this field, and will serve as a modern messenger of scientific discovery and provide a look into the future of our solar system. · Forty-seven chapters from 75+ eminent authors review fundamental topics as well as new models, theories, and discussions· Each entry is detailed and scientifically rigorous, yet accessible to undergraduate students and amateur astronomers· More than 700 full-color digital images and diagrams from current space missions and observatories amplify the chapters· Thematic chapters provide up-to-date coverage, including a discussion on the new International Astronomical Union (IAU) vote on the definition of a planet· Information is easily accessible with numerous cross-references and a full glossary and index

The Encyclopedia of the Solar System, Third Edition-winner of the 2015 PROSE Award in Cosmology & Astronomy from the Association of American Publishers-provides a framework for understanding the origin and evolution of the solar system, historical discoveries, and details about planetary bodies and how they interact-with an astounding breadth of content and breathtaking visual impact. The encyclopedia includes the latest explorations and observations, hundreds of color digital images and illustrations, and over 1,000 pages. It stands alone as the definitive work in this field, and will serve as a modern messenger of scientific discovery and provide a look into the future of our solar system. New additions to the third edition reflect the latest progress and growth in the field, including past and present space missions to the terrestrial planets, the outer solar systems and space telescopes used to detect extrasolar planets. Winner of the 2015 PROSE Award in Cosmology & Astronomy from the Association of American PublishersPresents 700 full-color digital images and diagrams from current space missions and observatories, bringing to life the content and aiding in the understanding and retention of key concepts.Includes a substantial appendix containing data on planetary missions, fundamental data of relevance for planets and satellites, and a glossary, providing immediately accessible mission data for ease of use in conducting further research or for use in presentations and instruction.Contains an extensive bibliography, providing a guide for deeper studies into broader aspects of the field and serving as an excellent entry point for graduate students aiming to broaden their study of planetary science.

— In order to study global experience for legislation changing and rule-making necessitates, tools for information retrieval of regulatory documents written in different languages become increasingly necessary. One of the aspects of information identification is retrieval of thematically similar documents for a given input document. In this context, an important task of cross-lingual search arises when the user of an information system specifies a reference document in one language, and the search results contain relevant documents in other languages. The article describes different approaches to solving this problem: from classic mediator-based methods to more modern solutions, based on distributional semantics. The test collection used in the study was taken from the United Nations Digital Library, which provides legal documents in both the original English and their Russian translations.