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Bangkok suffered from the world’s worst traffic congestion in the 1990s due to rapidly increasing car ownership, reflecting the economic growth and road-dependent transport policy beginning in the 1960s. Due to its monocentric but scattered urban structure, traffic congestion is severe, causing tremendous economic loss, deteriorating air quality, and badly affecting the quality of life. A historical review reveals that the urban and transport plan and development were not efficiently coordinated, resulting in unorganized suburbanization and progressively more severe traffic congestion. It is important to reveal the impact of the transportation project on the housing market in order to incorporate the policies for transportation and urban development. To define the impact, the OLS hedonic price model and the local multiscale geographically weighted regression (MGWR) model were estimated, along with the condominium sales data. The results revealed that the impact of rail transit on a rise in property value significantly varied across the study area. It was estimated that, for the area along the major rail transit corridor in the city center, a premium of a location 100-m closer to the station would be more than 200 USD per square meter. At the same time, the value would be less than 80 USD for the area along the rail corridor in the suburb. These findings provide policy insights for future urban and railway development, including the proper coordination of rail transit development and urban development with subcenters, transit-oriented development, and improved pedestrian flow around transit stations.

To elucidate the tempo‐spatial effect and the corresponding mechanism of hydraulic fracturing on gas desorption, the experiments of the hydraulic fracturing in the field and the gas adsorption‐desorption in the laboratory were carried out, respectively. The difference of the effects on the total amount of gas desorption, desorption proportion, moisture content, and in situ gas drainage concentration of the original and fracturing coal samples were studied. The results show that coal moisture increase in the 29 m area of hydraulic fracturing, the greater moisture content and the smaller amount of gas desorption, and the 9 m coal samples moisture content is 2.77 times greater than that of the original coal samples, and whose total amount of gas desorption for 29.8% of the original coal samples. In addition, the closer to the fracturing borehole, the smaller the desorption velocity, which is the fastest in the initial 5 minutes. The desorption velocity of the original coal samples is 5.6 times greater than that of the 9 m coal samples. The desorption proportion of the coal samples is high in early stages, η30 min is 64% (ηi is the proportion of the instantaneous total of gas desorption to the total gas desorption, %), and for η6 h‐12 h is 10%. The tempo‐spatial effects of desorption characteristics can be expressed as the time‐delay effect and a space‐reduction effect. Furthermore, the upper limit of deformation of the coal seam is 3.3‰ and the ability of gas desorption in coal seam significantly decreases. The time of gas drainage concentration exhibits more than 30% increases from the 10 days in the nonfracturing area to 90 days in the fracturing area. Finally, hydraulic fracturing crushes coal, replaces absorption gas, increases the moisture content of coal, reduces various stresses, makes coal shrink, and ultimately achieves the effects of pressure relief and permeability improvement. To elucidate the tempo‐spatial effect and the corresponding mechanism of hydraulic fracturing by drilling through underground coal mine strata on gas desorption, the experiments of the hydraulic fracturing in the field and the gas adsorption‐desorption in the laboratory were carried out, respectively. The difference of the effects by fracturing methods on the total amount of gas desorption, desorption proportion, moisture content, and in situ gas drainage concentration of the original and fracturing area coal samples were studied. Hydraulic fracturing crushes coal, replaces absorption gas, increases the moisture content of coal, reduces various stresses, gradually causes fatigue damage of coal body, makes coal shrink, and ultimately achieves the effects of pressure relief and permeability improvement.

Rationale The purpose of this study is to evaluate the single dose effect of intranasal esketamine (84 mg) compared to placebo on on-road driving performance. Mirtazapine (oral, 30 mg) was used as a positive control, as this antidepressant drug is known to negatively affect driving performance. Methods Twenty-six healthy volunteers aged 21 to 60 years were enrolled in this study. In the evening, 8 h after treatment administration, participants conducted the standardized 100-km on-road driving test. Primary outcome measure was the standard deviation of lateral position (SDLP), i.e., the weaving of the car. Mean lateral position, mean speed, and standard deviation of speed were secondary outcome measures. For SDLP, non-inferiority analyses were conducted, using +2.4 cm (relative to placebo) as a predefined non-inferiority margin for clinical relevant impairment. Results Twenty-four participants completed the study. No significant SDLP difference was found between esketamine and placebo ( p  = 0.7638), whereas the SDLP after mirtazapine was significantly higher when compared to placebo ( p  = 0.0001). The upper limit of the two-sided 95% confidence interval (CI) of the mean difference between esketamine and placebo was +0.86 cm, i.e., <+2.4 cm, thus demonstrating that esketamine was non-inferior to placebo. Non-inferiority could not be concluded for mirtazapine (+3.15 cm SDLP relative to placebo). No significant differences in mean speed, standard deviation of speed, and mean lateral position were observed between the active treatments and placebo. Conclusions No significant difference in driving performance was observed 8 h after administering intranasal esketamine (84 mg) or placebo. In contrast, oral mirtazapine (30 mg) significantly impaired on road driving performance.

Technological innovation and high-quality economic development are inevitable requirements of sustainable development, and the digital economy has gradually become a new engine to enhance technological innovation and the high-quality development of China’s economy. Deeply discussing the effect of digital economy on high-quality economic development and clarifying the mechanism behind it can effectively grant the boosting power of digital economy to China’s high-quality development, which is of great practical significance to China’s sustainable economic development. In this study, the mechanism, effect, and regional heterogeneity of the impact of the digital economy on the level of high-quality economic development in 30 Chinese provinces from 2011–2019 were measured and empirically tested using a mediating effects model and a spatial Durbin model, among others. The results showed that the overall level of digital economy and high-quality development is not high, and there were both high agglomeration and low agglomeration, with obvious spatial path dependence and spatial lock-in. Digital economy could promote the high-quality development level of the economy, and the spatial spillover effect was remarkable. In addition, the function of digital economy in promoting high-quality economic development in the eastern, central, and western regions was gradually weakened. Besides, the technological innovation was an important transmission path of digital economy to high-quality economic development. Based on these findings, it is proposed that decision-makers should strengthen digitalization efforts so that the digital economy can become a powerful tool to narrow the digital divide. Further, the dynamic and differentiated digital economy development strategy should be implemented to reduce regional development imbalances in an effective manner.

As digital transformation (Digital) accelerates globally, conventional enterprise production models are proving increasingly insufficient to meet the demands of today’s dynamic market landscape. China has innovated the concept of New Quality Productivity (NQPF), and exploring its functioning is critical to promoting high-quality enterprise development. This study examines the impact mechanism of Digital on NQPF in manufacturing firms by applying spatial econometric models—including the spatial Durbin model, spatial mediation model, and spatial threshold model—to panel data from A-share listed manufacturers (2013–2022). The results indicate that digital transformation significantly influences the level of NQPF, exhibiting spatial spillover effects and spatial attenuation boundaries. This influence initially promotes and subsequently inhibits productivity. The analysis of the spatial mediation effect reveals that Digital affects enterprise productivity levels by influencing total factor productivity. Furthermore, the spatial threshold effect analysis indicates that higher total enterprise assets enhance the positive impact of Digital on NQPF. These results provide robust micro-level empirical evidence to inform manufacturing enterprise development strategies.

Stress is assumed to cause a shift from flexible 'cognitive' memory to more rigid 'habit' memory. In the spatial memory domain, stress impairs place learning depending on the hippocampus whereas stimulus-response learning based on the striatum appears to be improved. While the neural basis of this shift is still unclear, previous evidence in rodents points towards cortisol interacting with the mineralocorticoid receptor (MR) to affect amygdala functioning. The amygdala is in turn assumed to orchestrate the stress-induced shift in memory processing. However, an integrative study testing these mechanisms in humans is lacking. Therefore, we combined functional neuroimaging of a spatial memory task, stress-induction, and administration of an MR-antagonist in a full-factorial, randomized, placebo-controlled between-subjects design in 101 healthy males. We demonstrate that stress-induced increases in cortisol lead to enhanced stimulus-response learning, accompanied by increased amygdala activity and connectivity to the striatum. Importantly, this shift was prevented by an acute administration of the MR-antagonist spironolactone. Our findings support a model in which the MR and the amygdala play an important role in the stress-induced shift towards habit memory systems, revealing a fundamental mechanism of adaptively allocating neural resources that may have implications for stress-related mental disorders.

Chernozhukov et al. (2016) provide a generic double/de-biased machine learning (ML) approach for obtaining valid inferential statements about focal parameters, using Neyman-orthogonal scores and cross-fitting, in settings where nuisance parameters are estimated using ML methods. In this note, we illustrate the application of this method in the context of estimating average treatment effects and average treatment effects on the treated using observational data.

Chronic exposure to arsenic via drinking water throughout the globe is assumed to cause a developmental neurotoxicity. Here, we investigated the effect of perinatal arsenic exposure on the neurobehavioral and neurochemical changes in the corpus striatum, frontal cortex, and hippocampus that is critically involved in motor and cognition functions. In continuation of previous studies, this study demonstrates that perinatal exposures (GD6–PD21) to arsenic (2 or 4 mg/kg body weight, p.o.) cause hypo-activity in arsenic-exposed rats on PD22. The hypo-activity was found to be linked with a decrease in the mRNA and protein expression of the DA-D2 receptor. Further, a protein expression of tyrosine hydroxylase (TH), levels of dopamine, and its metabolites were also significantly impaired in corpus striatum. The arsenic-exposed groups showed spatial learning and memory significantly below the average in a dose-dependent manner for the controls. Here, we evaluated the declined expression of CHRM2 receptor gene and protein expression of ChAT, PKCβ-1 in the frontal cortex and hippocampus, which are critically involved in cognition functions including learning and memory. A trend of recovery was found in the cholinergic and dopaminergic system of the brain, but changes remained persisted even after the withdrawal of arsenic exposure on PD45. Taken together, our results indicate that perinatal arsenic exposure appears to be critical and vulnerable as the development of cholinergic and dopaminergic system continues during this period.

Preclinical research demonstrates that cannabinoids have differing effects in adolescent and adult animals. Whether these findings translate to humans has not yet been investigated. Here we believe we conducted the first study to compare the acute effects of cannabis in human adolescent ( n= 20; 16–17 years old) and adult ( n= 20; 24–28 years old) male cannabis users, in a placebo-controlled, double-blind cross-over design. After inhaling vaporized active or placebo cannabis, participants completed tasks assessing spatial working memory, episodic memory and response inhibition, alongside measures of blood pressure and heart rate, psychotomimetic symptoms and subjective drug effects (for example, ‘stoned’, ‘want to have cannabis’). Results showed that on active cannabis, adolescents felt less stoned and reported fewer psychotomimetic symptoms than adults. Further, adults but not adolescents were more anxious and less alert during the active cannabis session (both pre- and post-drug administration). Following cannabis, cognitive impairment (reaction time on spatial working memory and prose recall following a delay) was greater in adults than adolescents. By contrast, cannabis impaired response inhibition accuracy in adolescents but not in adults. Moreover, following drug administration, the adolescents did not show satiety; instead they wanted more cannabis regardless of whether they had taken active or placebo cannabis, while the opposite was seen for adults. These contrasting profiles of adolescent resilience (blunted subjective, memory, physiological and psychotomimetic effects) and vulnerability (lack of satiety, impaired inhibitory processes) show some degree of translation from preclinical findings, and may contribute to escalated cannabis use by human adolescents.