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Bilateral vestibulopathy (BVP) is defined as the impairment or loss of function of either the labyrinths or the eighth nerves. Patients with total BVP due to bilateral vestibular nerve section exhibit difficulties in spatial memory and navigation and show a loss of hippocampal volume. In clinical practice, most patients do not have a complete loss of function but rather an asymmetrical residual functioning of the vestibular system. The purpose of the current study was to investigate navigational ability and hippocampal atrophy in BVP patients with residual vestibular function. Fifteen patients with BVP and a group of age- and gender- matched healthy controls were examined. Self-reported questionnaires on spatial anxiety and wayfinding were used to assess the applied strategy of wayfinding and quality of life. Spatial memory and navigation were tested directly using a virtual Morris Water Maze Task. The hippocampal volume of these two groups was evaluated by voxel-based morphometry. In the patients, the questionnaire showed a higher spatial anxiety and the Morris Water Maze Task a delayed spatial learning performance. MRI revealed a significant decrease in the gray matter mid-hippocampal volume (Left: p = 0.006, Z = 4.58, Right: p < 0.001, Z = 3.63) and posterior parahippocampal volume (Right: p = 0.005, Z = 4.65, Left: p < 0.001, Z = 3.87) compared to those of healthy controls. In addition, a decrease in hippocampal formation volume correlated with a more dominant route-finding strategy. Our current findings demonstrate that even partial bilateral vestibular loss leads to anatomical and functional changes in the hippocampal formation and objective and subjective behavioral deficits.

Spatial anxiety (i.e., feelings of apprehension and fear about navigating everyday environments) can adversely impact people’s ability to reach desired locations and explore unfamiliar places. Prior research has either assessed spatial anxiety as an individual-difference variable or measured it as an outcome, but there are currently no experimental inductions to investigate its causal effects. To address this lacuna, we developed a novel protocol for inducing spatial anxiety within a virtual environment. Participants first learnt a route using directional arrows. Next, we removed the directional arrows and randomly assigned participants to navigate either the same route ( n = 22; control condition) or a variation of this route in which we surreptitiously introduced unfamiliar paths and landmarks ( n = 22; spatial-anxiety condition). The manipulation successfully induced transient (i.e., state-level) spatial anxiety and task stress but did not significantly reduce task enjoyment. Our findings lay the foundation for an experimental paradigm that will facilitate future work on the causal effects of spatial anxiety in navigational contexts. The experimental task is freely available via the Open Science Framework ( https://osf.io/uq4v7/ ).

•Long-term blue light exposure to mice lead to spatial anxiety, which is related to Per2 upregulation.•Altered ALFF in hippocampus and retrosplenial cortex after long term blue light exposure.•The blue light induced spatial anxiety is associated with changes in brain activity. Blue light (BL) is the primary component of light emitted from 3C devices. The use of 3C (computers, consumer electronics, and communication) devices has been increasing among all age groups. How social interaction and spatial cognition are affected in adolescents after long-term 3C device usage at night remains unclear. Five-week-old mice were exposed to BL. Subsequently, these mice were subjected to social behavior tests, functional magnetic resonance imaging, and histopathologic analyses. BL exposure increased spatial anxiety but did not affect sociability, social novelty, or motor coordination. Also, BL exposure altered brain connectivity in the hippocampus (Hip), thalamus, and striatum, and it reduced brain activity in the retrosplenial cortex and dorsal part of the Hip. Spatial anxiety was associated with brain alterations. Although BL exposure reduced the size of retinal oligodendrocytes and increased the expression of the Period 2 circadian protein, it did not result in brain inflammation, at least not in the Hip. Our findings highlight that long-term BL exposure in adolescents induces spatial anxiety. The underlying mechanisms include changes in brain activity and connectivity and the disruption of the circadian rhythm. [Display omitted]

Spatial navigation is pivotal for orientation in both familiar and unfamiliar environments. Internal factors, such as spatial anxiety, can potentially influence this process. Mindfulness, a psychological intervention, has demonstrated efficacy in reducing anxiety. Consequently, this study investigates the novel application of mindfulness training in virtual reality on spatial anxiety and its correlation with spatial navigation, aiming to propose interventions that could mitigate spatial anxiety and enhance navigational capability. The current experiment incorporated assessment time points at baseline and post-treatment after 4 weeks. A total of 42 students were randomly allocated to either ‘virtual reality mindfulness’, ‘audio mindfulness’, or ‘active control’ (listening). Repeated measures ANOVAs and mediation analyses were conducted to gauge the effectiveness of the training. The results suggest that both virtual reality and audio mindfulness effectively reduce spatial anxiety and bolster spatial orientation. Furthermore, an improvement in therapy adherence and appraisal was observed when integrating virtual reality nature with mindfulness training. Path analysis further revealed that a reduction in spatial anxiety mediated the effect of mindfulness training on one’s spatial navigational ability. The findings of this study indicate that long-term daily exposure to virtual reality mindfulness and audio mindfulness for 10 min each, compared to listening, can effectively reduce spatial anxiety and enhance spatial navigational ability.

Spatial memory and orientation deficits often precede cognitive impairment in incipient dementia, e.g., Alzheimer's disease. Therefore, early diagnosis of spatial impairment may be crucial to the initiation of an adequate therapeutic intervention. Subjective tests, such as spatial anxiety and spatial discomfort questionnaires, and objective tests in the form of quantitative measures of orientation, are available. In these tests, vestibular hypofunction has often been neglected as a potential confounder. The major research question in this study was how self-assessed questionnaires correlate with the data from objective measures in participants with proven normal vestibular function. A heterogeneous group of 135 participants (72 females, 63 males, mean age 62.75 ± 14.46 years) from a tertiary center for vertigo and balance disorders consisting of two cohorts, with (  = 49) and without (  = 86) cognitive deficits in a screening test (MoCA), was examined (a) with a newly introduced inventory for subjective spatial discomfort (Extended Inventory for Spatial Orientation Discomfort, EISOD), (b) a well-established questionnaire for subjective spatial skills (Santa Barbara Sense of Direction Scale, SBSODS), and (c) the objective three-dimensional real-world pointing task (3D-RWPT) before and after horizontal body rotations. In all patients, acute central or peripheral vestibular deficits were ruled out by neuro-orthoptics, bithermal water calorics and video head impulse testing. Self-assessed spatial orientation discomfort (EISOD) correlated with the amount of spatial impairment in the 3D-RWPT for both cohorts. The cognitively impaired patients showed significantly higher levels of spatial discomfort (i.e., lower scores; Welch's -test t-2.58,  < 0.01, Cohen's d - 0.46), and higher angular deviations in the (cognitively demanding) transformation paradigm of the 3D-RWPT (t 2.37, p 0.02, Cohen's d 0.44). They preferred retinotopic/egocentric spatial encoding strategies in the pointing task (Welch's -test t-2.61,  < 0.01, Cohen's d - 0.47). In contrast, the self-report of spatial abilities (SBSODS) yielded no significant group differences (t - 1.66, p 0.10) and was not reliably associated with objective accuracy in the pointing task. In patients without vestibular deficits, subjective spatial discomfort (EISOD) correlated with the accuracy in an objective 3D-pointing task for both cohorts, and higher discomfort was associated with more severe cognitive impairment. EISOD-scores showed higher correlation indices than a self-report of spatial skills using the SBSODS. When investigating spatial abilities in patients with suspected cognitive impairment, it appears reasonable that both subjective spatial discomfort, subjective spatial abilities, and objective spatial measures should be combined. Future research in patients with vestibular dysfunction is needed to understand the role of vestibular deficits for the development of spatial orientation discomfort.

Mental rotation ability is associated with successful advances in STEM (science, technology, engineering, and mathematics) education and occupations. Meta-analyses have shown consistent sex disparities in mental rotation, where men outperform women on one measure of mental rotation ability, the Mental Rotations Test ( MRT ). Spatial anxiety, or the fear and apprehension felt when completing a task that requires spatial thinking, was proposed as a mechanism explaining the relation between sex and mental rotation test performance. This study modified the Spatial Anxiety Scale ( SAS ) to include questions about how anxious individuals feel when they must mentally rotate items to accomplish a task (e.g., playing Tetris). An exploratory factor analysis was conducted to assess the factorial structure of the modified spatial anxiety scale. Three factor loadings were extracted representing the ability to navigate, mentally rotate objects, and visualize objects. Furthermore, we analyzed the role of spatial anxiety and trait anxiety as potential mediators of the relation between participant sex and mental rotation performance. Spatial anxiety partially mediated the link between the sex of the participants and the MRT performance controlling for trait anxiety. Only navigation and mental rotation anxiety significantly mediated the relation between participant sex and mental rotation performance. We posit spatial anxiety as a barrier to efficient and accurate spatial thinking, and suggest that reducing spatial anxiety has the potential to improve spatial skills and reduce sex differences in mental rotation test performance. To ascertain this, an experimental design can determine whether a reduction in spatial anxiety causes changes in mental rotation test scores.

Wayfinding (WF) is the ability to move around efficiently and find the way from a starting point to a destination. It is a component of spatial navigation, a coordinate and goal-directed movement of one's self through the environment. In the present study, the relationship between WF tasks (route tracing and shortcut finding) and individual factors were explored with the hypothesis that WF tasks would be predicted by different types of cognitive, affective, motivational variables, and personality factors. A group of 116 university students (88 F.) were conducted along a route in a virtual environment and then asked first to trace the same route again, and then to find a shortcut between the start and end points. Several instruments assessing visuospatial working memory, mental rotation ability, self-efficacy, spatial anxiety, positive attitude to exploring, and personality traits were administered. The results showed that a latent spatial ability factor (measured with the visuospatial working memory and mental rotations tests) - controlled for gender - predicted route-tracing performance, while self-report measures of anxiety, efficacy, and pleasure in exploring, and some personality traits were more likely to predict shortcut-finding performance. We concluded that both personality and cognitive abilities affect WF performance, but differently, depending on the requirements of the task.

Research has demonstrated a link between spatial and mathematics skills, although less research has addressed the directionality of this relation and what factors may impact the spatial–mathematics link. Two such factors may be spatial and mathematics anxiety, which are related to performance in their respective domains, but may also play a cross-domain role in the relation between spatial and mathematics skills. Importantly, these relations are prudent to investigate in children when mathematics and spatial skills are early in their development. To bridge the gap, the present study examined the direction of the relation between spatial and mathematics skills across two waves of data and the domain specificity of cognitive anxieties (spatial and mathematics anxiety) as they relate to their respective skill in children. In a sample of 647 U.S. first-graders (Mage = 6 years 8 months), we found bidirectional relations between spatial and mathematics skills across two waves of data collection. We found domain-specific, but not cross-domain, relations between mathematics anxiety and skills, but no evidence of links between spatial anxiety and spatial or mathematics skills at this age. These results provide support for the bidirectional spatial–mathematics link in young children and suggest that mathematics anxiety may be a useful target for interventions to improve mathematics outcomes.

Older adults often need guidance when visiting new buildings for the first time. However, indoor navigation remains challenging due to the lack of Global Positioning System (GPS) availability, visually repetitive corridors, and frequent location failures. This article presents a multimodal indoor navigation assistant that combines graph-based route planning with visual landmark verification to provide step-by-step guidance. The environment is modelled as a directed graph whose nodes are annotated with semantic landmarks, and the graph is constructed primarily from a video of the building, reducing the need for 3D scanners, beacons, or other specialised instruments. Routes are calculated using Dijkstra’s shortest-path algorithm over the semantic graph. During navigation, camera frames are analysed using a restricted vision-language recognition strategy that only considers candidate landmarks from the current and next nodes, reducing false detections and improving interpretability. To increase robustness, a temporary voting mechanism was introduced to confirm node transitions, as well as a hierarchical redirection strategy with local and global recovery. The system is implemented in two modes: handheld mode with visual cues using augmented reality arrows, mini map and voice instructions, and hands-free mode with front camera using voice instructions and keywords. Evaluation involved preliminary technical testing in the United Kingdom followed by formal user validation in Spain. During these trials, participants reported high usability, strong confidence and safety, and increased perceived independence.

Spatial orientation is essential for daily life, but it deteriorates with aging. The present study was aimed at investigating age changes across the adult lifespan in the self-reported use of navigation aids and everyday orientation experiences, as well as investigating to what extent these are related to visuospatial working memory (VSWM) and self-reported wayfinding inclinations. A sample of 456 people aged 25–84 years rated how much they use navigation aids (maps, GPS, verbal directions), how much they went out, and how much they reached or lost their way to unfamiliar destinations (in 2016). Then, they performed the jigsaw puzzle test (VSWM) and questionnaires on sense of direction, pleasure in exploring, and spatial anxiety. The results showed that increasing age is related to a lower tendency to go out, fewer experiences of finding one’s way and getting lost, a lower level of GPS use, and increased verbal directions use. After age changes were accounted for, VSWM was related to aid use and orientation experiences (except for losing one’s way), wayfinding inclinations (especially spatial anxiety) to using a map, and orientation experiences. Overall, other than age, VSWM and one’s wayfinding attitudes can play a role–albeit it a modest one–in spatial behaviors.