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"Sphynx cat."
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Sphynx cats
\"A photo-illustrated book for early readers about the unique hairless Sphynx cats. Describes the Sphynx's unique features, how they were bred to be hairless, their social behaviors, and how they act as pets\"-- Provided by publisher.
Book
Atypical fibroepithelial hyperplasia of the teats in a Sphynx cat: a case report
This study was conducted on a three-year-old Sphynx breed female cat which was brought to the clinic for masses on the teats. The medical history showed that these masses had developed slowly within the period of six months to one year. Following the clinical examination, these masses were removed via surgery. They were between 0.6 cm and 1.5 cm in diameter. Ulcer areas 2 mm to 5 mm in size were observed over the skin. Their sectional surface was uniformly grayish in colour. Histopathological examination of the masses revealed that the cells originated from the glandular duct and had given rise to hyperplasia; connective tissue was densely attached to the masses. Moreover, inflammatory changes and areas of ulceration were observed. Immunohistochemical analysis showed that the cells surrounding the epithelial hyperplasia were vimentin-positive and the proliferative activity of epithelial cells was measured to be 50% by analysis of proliferating cell nuclear antigen (PCNA). Based on clinical, histological and immunohistochemical findings, it was found the masses were diagnosed as atypical fibroepithelial hyperplasia. This case is the first to present a fibroepithelial hyperplasia in the teats of a cat.
Journal Article
Hairless Cat
\"Most people imagine cats as furry, cuddly, and fuzzy pets. However, there is a breed of 'hairless' cat called a Sphynx.\" (Boys' Quest) Read about the Sphynx cat's appearance and personality and learn about the special needs of this \"hairless\" breed.
Magazine Article
Wrinkled Wonders of the Cat World
\"Through a genetic slip of the hand and some intensive breeding, Sphynxes are naked as a jaybird. No sleek, luxuriant fur, just bare skin with a light, downy coat.\" (DALLAS MORNING NEWS) Learn why Sphynxes eat constantly and why they are growing in popularity. The benefits of owning this cat breed are identified and other facts about the Sphynx are presented.
Newspaper Article
Naked Animals
\"Of the 5,000 kinds of wild mammals, only a few are nearly hairless. These creatures developed other ways to thrive comfortably.\" (National Geographic Kids) Learn about several different types of hairless mammals and find out why they do not need hair. The amount of hair on the human body is mentioned.
Magazine Article
A deleterious mutation in the ALMS1 gene in a naturally occurring model of hypertrophic cardiomyopathy in the Sphynx cat
Background
Familial hypertrophic cardiomyopathy is a common inherited cardiovascular disorder in people. Many causal mutations have been identified, but about 40% of cases do not have a known causative mutation. Mutations in the
ALMS1
gene are associated with the development of Alstrom syndrome, a multisystem familial disease that can include cardiomyopathy (dilated, restrictive). Hypertrophic cardiomyopathy has not been described. The
ALMS1
gene is a large gene that encodes for a ubiquitously expressed protein. The function of the protein is not well understood although it is believed to be associated with energy metabolism and homeostasis, cell differentiation and cell cycle control. The ALMS1 protein has also been shown to be involved in the regulation of cell cycle proliferation in perinatal cardiomyocytes. Although cardiomyocyte cell division and replication in mammals generally declines soon after birth, inhibition of ALMS1 expression in mice lead to increased cardiomyocyte proliferation, and deficiency of Alstrom protein has been suggested to impair post-natal cardiomyocyte cell cycle arrest. Here we describe the association of familial hypertrophic cardiomyopathy in Sphynx cats with a novel
ALMS1
mutation.
Results
A G/C variant was identified in exon 12 (human exon 13) of the
ALMS1
gene in affected cats and was positively associated with the presence of hypertrophic cardiomyopathy in the feline population (
p
< 0.0001). The variant was predicted to change a highly conserved nonpolar Glycine to a positively charged Arginine. This was predicted to be a deleterious change by three in silico programs. Protein prediction programs indicated that the variant changed the protein structure in this region from a coil to a helix. Light microscopy findings included myofiber disarray with interstitial fibrosis with significantly more nuclear proliferative activity in the affected cats than controls (
p
< 0.0001).
Conclusion
This study demonstrates a novel form of cardiomyopathy associated with
ALMS1
in the cat. Familial hypertrophic cardiomyopathy is a disease of genetic heterogeneity; many of the known causative genes encoding for sarcomeric proteins. Our findings suggest that variants in genes involved with cardiac development and cell regulation, like the
ALMS1
gene, may deserve further consideration for association with familial hypertrophic cardiomyopathy.
Journal Article
Radial head subluxation in a chondrodystrophic cat: aetiology, surgical treatment and outcome
Case summary
A 10-month-old male neutered Dwelf cat with bilateral thoracic angular limb deformity secondary to chondrodystrophism presented with an acute onset of left thoracic lameness due to elbow subluxation and radial head displacement. Financial restrictions limited treatment to a single surgical procedure consisting of a left ulnar osteotomy, radioulnar polypropylene toggle placement and two temporary radioulnar transosseous K-wires. The lameness resolved but a degree of radial head subluxation persisted, radiographically similar in degree to the contralateral limb.
Relevance and novel information
Chondrodystrophism is not common in cats. Inbreeding and chondrodystrophism is likely to result in the diagnosis of musculoskeletal diseases that have not previously been reported in this species. To the authors’ knowledge, this is the first case report of a developmental radial head subluxation in a chondrodystrophic cat.
Journal Article