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Wine protein instability depends on several factors, but wine grape proteins are the main haze factors, being mainly caused by pathogenesis-related proteins (thaumatin-like proteins and chitinases) with a molecular weight between 10~40 kDa and an isoelectric point below six. Wine protein stability tests are needed for the routine control of this wine instability, and to select the best technological approach to remove the unstable proteins. The heat test is the most used, with good correlation with the natural proteins’ precipitations and because high temperatures are the main protein instability factor after wine bottling. Many products and technological solutions have been studied in recent years; however, sodium bentonite is still the most efficient and used treatment to remove unstable proteins from white wines. This overview resumes and discusses the different aspects involved in wine protein instability, from the wine protein instability mechanisms, the protein stability tests used, and technological alternatives available to stabilise wines with protein instability problems.

Preparation of serum in the form of extract nanoemulsions allows effective delivery of active ingredients to the skin due to the more stable nanoemulsions, lower viscosity, transparent visual aspects, and high surface area caused by the small globule size. This study aims to obtain an optimal 96% ethanol concentration and sonication time in forming stable nanoemulsions at temperatures of 4° and 40°C with an active ingredient of moringa leaf extracts. The experiment was performed in four sets of 96% ethanol concentration (5%, 10%, 15%, and 20%) and three sonication periods (30, 60, and 90 minutes). The freeze-and-thaw method was utilized to evaluate the stability of the nanoemulsions. The analysis unveiled that a 96% ethanol concentration of 10% and a sonication time of 46 minutes was the most appropriate formula, generating a particle size of 30.49 nm with a volume of 73.35%. At the same time, the stability test of the preparation revealed that storage time significantly affected the pH response. However, it did not significantly affect the viscosity response.

Carboxymethyl chitosan (CMCH) from native chitosan of high molecular weight (H, 310–375 kDa) was synthesized for improving water solubility. The water solubility of high-molecular-weight carboxymethyl chitosan (H-CMCH) was higher than that of native chitosan by 89%. The application of H-CMCH as enhancing the moisturizer in mangosteen extract deodorant cream was evaluated. Different concentrations of H-CMCH (0.5–2.5%) were investigated in physicochemical characteristics of creams, including appearance, phase separation, pH, and viscosity, by an accelerated stability test. The different degrees of skin moisturizing (DM) on pig skin after applying H-CMCH solution, compared with untreated skin, water, and propylene glycol for 15 and 30 min using a Corneometer®, were investigated. The results showed that the 0.5% H-CMCH provided the best DM after applying the solution on pig skin for 30 min. Trans-2-nonenal, as an unsatisfied odor component, was also evaluated against components of the mangosteen extract deodorant cream, which were compared to the standard, epigallocatechin gallate (EGCG). In addition, DPPH and ABTS radical scavenging activity, ferric reducing antioxidant power (FRAP), and antibacterial activities were examined for the mangosteen extract deodorant cream using 0.5% H-CMCH. Results indicated that the mangosteen extract synergized with H-CMCH, which had a good potential as an effective skin moisturizing agent enhancer, deodorizing activity on trans-2-nonenal odor, antioxidant properties, and antibacterial properties.

In agricultural nations such as Jordan, olive oil production generates substantial quantities of a byproduct known as olive husk. Traditionally utilized for heating purposes, olive husk is now being employed in the production of cleaning solutions and cosmetic products. This study investigates the potential use of olive husk ash (OHA) as a filler in bitumen, when combined with aggregate to produce asphalt mixtures typically employed in road pavement construction. The impact of moisture on the properties of asphalt mixtures containing OHA filler was examined using the Marshall Stability test method. OHA was incorporated as a replacement for bitumen at varying volumes (0, 5, 10, 15, 20%). The optimum bitumen content was added to limestone aggregate to prepare asphalt mixture specimens. Furthermore, the effect of Dryback on the properties of asphalt mixtures was assessed. Findings indicate that the inclusion of OHA in bitumen (by volume) reduced the moisture resistance of specimens, with an optimal performance observed at 10-15% replacement. Additionally, it was found that the moisture effect on asphalt mixtures was reversible, and the observed degradations in strength and stiffness after wet conditioning were not predominantly due to the adverse effects of water. Consequently, the utilization of OHA as a pavement material in the field could potentially reduce production costs and enhance performance, leading to notable environmental benefits.

Background The ideal treatment of terrble triad injuries and whether fixation of coronoid process fractures is needed or not are still debated. Therefore, we aimed to investigate if terrible triad injuries necessitate coronoid fracture fixation and evaluate if non-fixation treatments have similar efficacies and outcomes as fixation-treatments in cases of terrible triad injuries. Methods From August 2011 to July 2020, 23 patients with acute terrible triad injuries without involvement of the anteromedial facet of the coronoid process were included to evaluate the postoperative clinical and radiological outcomes (minimum follow-up of 20 months). According to the preoperative height loss evaluation of the coronoid process and an intraoperative elbow stability test, seven patients underwent coronoid fracture fixation, and the other eight patients were treated conservatively. The elbow range of motion (ROM), Mayo Elbow Performance Score (MEPS), and modified Broberg-Morrey score were evaluated at the last follow-up. In addition, plain radiographs were reviewed to evaluate joint congruency, fracture union, heterotopic ossification, and the development of arthritic changes. Results At the last follow-up, the mean arcs of flexion-extension and supination-pronation values were 118.2° and 146.8° in the fixation group and 122.5° and 151.3° in the non-fixation group, respectively. The mean MEPSs were 96.4 in the fixation group (excellent, nine cases; good, tow cases) and 96.7 in the non-fixation group (excellent, ten cases; good, two cases). The mean modified Broberg-Morrey scores were 94.0 in the fixation group (excellent, sevev cases; good, four cases) and 94.0 in the non-fixation group (excellent, ten cases; good, tow cases). No statistically significant differences in clinical scores and ROM were identified between the two groups. However, the non-fixation group showed a significantly lower height loss of the coronoid process than the fixation group (36.3% versus 54.5%). Conclusions There were no significant differences in clinical outcomes between the fixation and non-fixation groups in terrible triad injuries.

Based on the current situation of student cultivation mode and student management in colleges and universities, this paper puts forward six basic assumptions on student cultivation and management, and combines the assumptions to obtain the game payment matrix of student cultivation mode and student management. The dynamic equations of the cultivation and management process are reproduced by using mathematical calculus to derive the game payment matrix. Under the constraints, the game evolution model equilibrium point is tested for stability, the game evolution state is derived, and the game evolution model is completed to optimize the innovation of college student training mode and student management mechanism. Numerical simulation analysis is performed on the evolutionary game of college student cultivation and management based on the parameter settings of the evolutionary game model. The results show that the evolutionary game model will converge to a stable strategy point when the ratio of managers (teachers) and students’ initial participation in cultivation and management activities is set to (0.05, 0.95), (0.05, 0.05), (0.95, 0.05) or (0.95, 0.95). This study has a beneficial impact on cultivating exceptional talents, and it also provides a solid resource for society to deliver top-notch talent.

Metal halide perovskite solar cells (PSCs) represent a promising low-cost thin-film photovoltaic technology, with unprecedented power conversion efficiencies obtained for both single-junction and tandem applications 1 – 8 . To push PSCs towards commercialization, it is critical, albeit challenging, to understand device reliability under real-world outdoor conditions where multiple stress factors (for example, light, heat and humidity) coexist, generating complicated degradation behaviours 9 – 13 . To quickly guide PSC development, it is necessary to identify accelerated indoor testing protocols that can correlate specific stressors with observed degradation modes in fielded devices. Here we use a state-of-the-art positive-intrinsic-negative (p–i–n) PSC stack (with power conversion efficiencies of up to approximately 25.5%) to show that indoor accelerated stability tests can predict our six-month outdoor ageing tests. Device degradation rates under illumination and at elevated temperatures are most instructive for understanding outdoor device reliability. We also find that the indium tin oxide/self-assembled monolayer-based hole transport layer/perovskite interface most strongly affects our device operation stability. Improving the ion-blocking properties of the self-assembled monolayer hole transport layer increases averaged device operational stability at 50 °C–85 °C by a factor of about 2.8, reaching over 1,000 h at 85 °C and to near 8,200 h at 50 °C, with a projected 20% degradation, which is among the best to date for high-efficiency p–i–n PSCs 14 – 17 . We correlate lab test and field test results to better predict the performance of perovskite photovoltaics as a step towards real-world implementation.

The paper discusses the problem of performing qualification sedimentation stability tests of paraffinic gas condensate aiming at selecting the most effective depressor-dispersing additive for transportation of raw materials by railroad transport in the cold season. It is shown that the methods of determination of low-temperature properties (pour point, sedimentation stability during cold storage) used for analysis of diesel fuels cannot be fully applied in testing the resistance to stratification of gas condensate mixtures in conditions of transportation by rail. The paper proposes a method for testing paraffin raw materials in railroad tank car simulators with estimation of the volume of non-dissolved residue, under realistic conditions. Comparison of the results of laboratory tests of gas-condensate mixtures containing four different depressor-dispersing additives with the pilot-scale tests data showed satisfactory correlation.

This paper analytically derives a stability test for the probability distribution of a random variable that follows the Edgeworth–Sargan density, also called Gram–Charlier. The distribution of the test is a weighted sum of Chi-squared densities of increasing degrees of freedom, starting with the standard equivalent Chi-squared under the same conditions. The weights turn out to be linear combinations of the parameters of the distribution and the moments of a Gaussian density, and can be computed exactly. This is a convenient result, since then the probability intervals can be easily calculated from existing Chi-squared distribution tables. The test is applied to assess the weekly solar irradiance data stability for a twelve-year period. It shows that the density is acceptably stable overall, except for some eventual and localised dates. It is also shown that the usual probability intervals implemented in stability testing are larger than those of the equivalent Chi-squared distribution under comparable conditions. This implies that the common upper tail interval values for rejecting the null stability hypothesis are larger.

Pulmonary drug transport has numerous benefits. Large surface areas for absorption and limited drug degradation of the gastrointestinal system are provided through the respiratory tract. The administration is painless and easy for the patient. Due to their better stability when compared to liquid formulations, powders have gained popularity among pulmonary formulations. In the pharmaceutical sector, quality assurance and product stability have drawn a lot of attention. Due to this, it was decided to perform a long-term stability study on a previously developed, nanosized dry powder inhaler (DPI) formulation that contained meloxicam. Wet milling was implemented to reduce the particle size, and nano spray-drying was used to produce the extra-fine inhalable particles. The particle diameter was determined using dynamic light scattering and laser diffraction. Scanning electron microscopy was utilized to describe the morphology. X-ray powder diffraction and differential scanning calorimetry were applied to determine the crystallinity. In an artificial lung medium, the in vitro dissolution was studied. The Andersen Cascade Impactor was used to investigate the in vitro aerodynamic characteristics. The stability test results demonstrated that the DPI formulation maintained its essential qualities after 6 and 12 months of storage. Consequently, the product might be promising for further studies and development.