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2018 international building code illustrated handbook
A comprehensive visual companion to the International Building Code, 2018 edition. Thoroughly updated to address the provisions of the ICC's 2018 International Building Code, this fully illustrated guide makes it easy to understand and apply the most critical code requirements. Covering both fire- and life-safety and structural provisions, this practical resource contains hundred of user-friendly diagrams designed to clarify the application and intent of the IBC.--Page 4 of cover.
Book
Minimum Design Loads and Associated Criteria for Buildings and Other Structures
Standard ASCE/SEI 7-22 provides requirements for general structural design and includes means for determining various loads and their combinations, which are suitable for inclusion in building codes and other documents.
eBook
Controlled Cell-Seeding Methodologies: A First Step Toward Clinically Relevant Bone Tissue Engineering Strategies
The repair of large and complex bone defects could be helped by a cell-based bone tissue engineering strategy. A reliable and consistent cell-seeding methodology is a mandatory step in bringing bone tissue engineering into the clinic. However, optimization of the cell-seeding step is only relevant when it can be reliably evaluated. The cell seeding efficiency (CSE) plays a fundamental role herein. Results showed that cell lysis and the definition used to determine the CSE played a key role in quantifying the CSE. The definition of CSE should therefore be consistent and unambiguous. The study of the influence of five drop-seeding-related parameters within the studied test conditions showed that (i) the cell density and (ii) the seeding vessel did not significantly affect the CSE, whereas (iii) the volume of seeding medium-to-free scaffold volume ratio (MFR), (iv) the seeding time, and (v) the scaffold morphology did. Prolonging the incubation time increased the CSE up to a plateau value at 4 h. Increasing the MFR or permeability by changing the morphology of the scaffolds significantly reduced the CSE. These results confirm that cell seeding optimization is needed and that an evidence-based selection of the seeding conditions is favored.
Journal Article
Sex and gender analysis improves science and engineering
The goal of sex and gender analysis is to promote rigorous, reproducible and responsible science. Incorporating sex and gender analysis into experimental design has enabled advancements across many disciplines, such as improved treatment of heart disease and insights into the societal impact of algorithmic bias. Here we discuss the potential for sex and gender analysis to foster scientific discovery, improve experimental efficiency and enable social equality. We provide a roadmap for sex and gender analysis across scientific disciplines and call on researchers, funding agencies, peer-reviewed journals and universities to coordinate efforts to implement robust methods of sex and gender analysis.
The authors discuss the potential for sex and gender analysis to foster scientific discovery, improve experimental efficiency and enable social equality.
Journal Article
Modern geotechnical design codes of practice : implementation, application and development
The ground is one of the most highly variable of engineering materials. It is therefore not surprising that geotechnical designs depend on local site conditions and local engineering experience. Engineering practices, relating to investigation and design methods (site understanding) and to safety levels acceptable to society, will therefore vary between different regions. The challenge in geotechnical engineering is to make use of worldwide geotechnical experience, established over many years, to aid in the development and harmonization of geotechnical design codes. Given the significant uncertainties involved, empiricism and engineering judgment will undoubtedly always be an essential element of geotechnical design. However, rigorous and scientific approaches based on probability theory are finding increased attention in the calibration of modern geotechnical codes of practice and these codes can and should be used to aid fundamental engineering judgment. Containing contributions on Code Implementation, Code Application and Code Development, this book provides a single resource that code developers, practitioners, and researchers can use to understand the different choices made by national code developers around the world. Furthermore, the book highlights some of the key challenges faced worldwide concerning the ongoing process of harmonizing geotechnical design code specifications.
eBook
Physiological limitations and opportunities in microbial metabolic engineering
Metabolic engineering can have a pivotal role in increasing the environmental sustainability of the transportation and chemical manufacturing sectors. The field has already developed engineered microorganisms that are currently being used in industrial-scale processes. However, it is often challenging to achieve the titres, yields and productivities required for commercial viability. The efficiency of microbial chemical production is usually dependent on the physiological traits of the host organism, which may either impose limitations on engineered biosynthetic pathways or, conversely, boost their performance. In this Review, we discuss different aspects of microbial physiology that often create obstacles for metabolic engineering, and present solutions to overcome them. We also describe various instances in which natural or engineered physiological traits in host organisms have been harnessed to benefit engineered metabolic pathways for chemical production.In this Review, Avalos and colleagues discuss different aspects of microbial physiology that can have an impact on engineered metabolic pathways, and they describe instances in which natural or engineered physiological traits in host organisms have been harnessed to benefit engineered metabolic pathways for chemical production.
Journal Article