Explore the vast range of titles available.

Smartphones typically compute position using duty-cycled Global Navigation Satellite System (GNSS) L1 code measurements and Single Point Positioning (SPP) processing with the aid of cellular and other measurements. This internal positioning solution has an accuracy of several tens to hundreds of meters in realistic environments (handheld, vehicle dashboard, suburban, urban forested, etc.). With the advent of multi-constellation, dual-frequency GNSS chips in smartphones, along with the ability to extract raw code and carrier-phase measurements, it is possible to use Precise Point Positioning (PPP) to improve positioning without any additional equipment. This research analyses GNSS measurement quality parameters from a Xiaomi MI 8 dual-frequency smartphone in varied, realistic environments. In such environments, the system suffers from frequent phase loss-of-lock leading to data gaps. The smartphone measurements have low and irregular carrier-to-noise (C/N 0 ) density ratio and high multipath, which leads to poor or no positioning solution. These problems are addressed by implementing a prediction technique for data gaps and a C/N 0 -based stochastic model for assigning realistic a priori weights to the observables in the PPP processing engine. Using these conditioning techniques, there is a 64% decrease in the horizontal positioning Root Mean Square (RMS) error and 100% positioning solution availability in sub-urban environments tested. The horizontal and 3D RMS were 20 cm and 30 cm respectively in a static open-sky environment and the horizontal RMS for the realistic kinematic scenario was 7 m with the phone on the dashboard of the car, using the SwiftNav Piksi Real-Time Kinematic (RTK) solution as reference. The PPP solution, computed using the YorkU PPP engine, also had a 5–10% percentage point more availability than the RTK solution, computed using RTKLIB software, since missing measurements in the logged file cause epoch rejection and a non-continuous solution, a problem which is solved by prediction for the PPP solution. The internal unaided positioning solution of the phone obtained from the logged NMEA (The National Marine Electronics Association) file was computed using point positioning with the aid of measurements from internal sensors. The PPP solution was 80% more accurate than the internal solution which had periodic drifts due to non-continuous computation of solution.

Background and objective Mechanical ventilation (MV) is the primary form of care for respiratory failure patients. MV settings are based on general clinical guidelines, intuition, and experience. This approach is not patient-specific and patients may thus experience suboptimal, potentially harmful MV care. This study presents the Stochastic integrated VENT (SiVENT) protocol which combines model-based approaches of the VENT protocol from previous works, with stochastic modelling to take the variation of patient respiratory elastance over time into consideration. Methods A stochastic model of E rs is integrated into the VENT protocol from previous works to develop the SiVENT protocol, to account for both intra- and inter-patient variability. A cohort of 20 virtual MV patients based on retrospective patient data are used to validate the performance of this method for volume-controlled (VC) ventilation. A performance evaluation was conducted where the SiVENT and VENT protocols were implemented in 1080 instances each to compare the two protocols and evaluate the difference in reduction of possible MV settings achieved by each. Results From an initial number of 189,000 possible MV setting combinations, the VENT protocol reduced this number to a median of 10,612, achieving a reduction of 94.4% across the cohort. With the integration of the stochastic model component, the SiVENT protocol reduced this number from 189,000 to a median of 9329, achieving a reduction of 95.1% across the cohort. The SiVENT protocol reduces the number of possible combinations provided to the user by more than 1000 combinations as compared to the VENT protocol. Conclusions Adding a stochastic model component into a model-based approach to selecting MV settings improves the ability of a decision support system to recommend patient-specific MV settings. It specifically considers inter- and intra-patient variability in respiratory elastance and eliminates potentially harmful settings based on clinically recommended pressure thresholds. Clinical input and local protocols can further reduce the number of safe setting combinations. The results for the SiVENT protocol justify further investigation of its prediction accuracy and clinical validation trials.

Vesicles carry out many essential functions within cells through the processes of endocytosis, exocytosis, and passive and active transport. This includes transporting and delivering molecules between different parts of the cell, and storing and releasing neurotransmitters in neurons. To date, computational simulation of these key biological players has been rather limited and has not advanced at the same pace as other aspects of cell modeling, restricting the realism of computational models. We describe a general vesicle modeling tool that has been designed for wide application to a variety of cell models, implemented within our software STochastic Engine for Pathway Simulation (STEPS), a stochastic reaction-diffusion simulator that supports realistic reconstructions of cell tissue in tetrahedral meshes. The implementation is validated in an extensive test suite, parallel performance is demonstrated in a realistic synaptic bouton model, and example models are visualized in a Blender extension module. A computational study describing a parallel extension to software “STochastic Engine for Pathway Simulation\" that simulates vesicles and their interactions with the cellular environment, including endocytosis, docking, fusion and active transport.

Many physical systems characterized by nonlinear multiscale interactions can be modelled by treating unresolved degrees of freedom as random fluctuations. However, even when the microscopic governing equations and qualitative macroscopic behaviour are known, it is often difficult to derive a stochastic model that is consistent with observations. This is especially true for systems such as turbulence where the perturbations do not behave like Gaussian white noise, introducing non-Markovian behaviour to the dynamics. We address these challenges with a framework for identifying interpretable stochastic nonlinear dynamics from experimental data, using forward and adjoint Fokker–Planck equations to enforce statistical consistency. If the form of the Langevin equation is unknown, a simple sparsifying procedure can provide an appropriate functional form. We demonstrate that this method can learn stochastic models in two artificial examples: recovering a nonlinear Langevin equation forced by coloured noise and approximating the second-order dynamics of a particle in a double-well potential with the corresponding first-order bifurcation normal form. Finally, we apply Langevin regression to experimental measurements of a turbulent bluff body wake and show that the statistical behaviour of the centre of pressure can be described by the dynamics of the corresponding laminar flow driven by nonlinear state-dependent noise.

Climate trends over multiple decades are important drivers of regional climate change that need to be considered for climate resilience. Of particular importance are extreme trends that society may not be expecting and is not well adapted to. This study investigates approaches to assess the likelihood of maximum moving window trends in historical records of climate indices by making use of simulations from climate models and stochastic time series models with short- and long-range dependence. These approaches are applied to assess the unusualness of the large positive trend that occurred in the North Atlantic Oscillation (NAO) index between the 1960s to 1990s. By considering stochastic models, we show that the chance of extreme trends is determined by the variance of the trend process, which generally increases when there is more serial correlation in the index series. We find that the Coupled Model Intercomparison Project (CMIP5 + 6) historical simulations have very rarely (around 1 in 200 chance) simulated maximum trends greater than the observed maximum. Consistent with this, the NAO indices simulated by CMIP models were found to resemble white noise, with almost no serial correlation, in contrast to the observed NAO which exhibits year-to-year correlation. Stochastic model best fits to the observed NAO suggest an unlikely chance (around 1 in 20) for there to be maximum 31-year NAO trends as large as the maximum observed since 1860. This suggests that current climate models do not fully represent important aspects of the mechanism for low frequency variability of the NAO.

Cancer is a major burden of disease around the globe and one of the leading causes of premature death. The key to improve patient outcomes in modern clinical cancer research is to gain insights into dynamics underlying cancer evolution in order to facilitate the search for effective therapies. However, most cancer data analysis tools are designed for controlled trials and cannot leverage routine clinical data, which are available in far greater quantities. In addition, many cancer models focus on single disease processes in isolation, disregarding interaction. This work proposes a unified stochastic modelling framework for cancer progression that combines (stochastic) processes for tumour growth, metastatic seeding, and patient survival to provide a comprehensive understanding of cancer progression. In addition, our models aim to use non-equidistantly sampled data collected in clinical routine to analyse the whole patient trajectory over the course of the disease. The model formulation features closed-form expressions of the likelihood functions for parameter inference from clinical data. The efficacy of our model approach is demonstrated through a simulation study involving four exemplary models, which utilise both analytic and numerical likelihoods. The results of the simulation studies demonstrate the accuracy and computational efficiency of the analytic likelihood formulations. We found that estimation can retrieve the correct model parameters and reveal the underlying data dynamics, and that this modelling framework is flexible in choosing the precise parameterisation. This work can serve as a foundation for the development of combined stochastic models for guiding personalized therapies in oncology.

This study assessed the farm-level economic loss due to LSD in India and at disaggregate (state) level by collecting data from 2351 cattle farms covering seven states. Data were analyed using descriptive statistics and stochastic modeling with Monte Carlo simulations. Gujarat state reported the highest milk loss, with a median reduction of 74, 90, 60, 45, 15, 15, and 8 L per animal in Rajasthan, Gujarat, Tamil Nadu, Karnataka, Madhya Pradesh, Assam, and Odisha, respectively. Crossbred cattle experienced more milk loss per animal, ranging from USD 0.0 to 237.8. The median mortality loss per animal varied between USD 12.2 and 1,084. The substantial national loss was due to decreased milk production, followed by the loss of draught power, treatment cost, and vector management cost. Stochastic modelling estimated economic loss due to LSD in cattle in India was USD 2440.29 million (90% CI 2162.55–2716.15) / (INR 202,544.07 million (90% 179,491.65—2,225,440.45) during 2022 & 2023 with a highest loss of USD 314.18 million (90% CI 279.10–349.34)) in Rajasthan state.

While lung protective mechanical ventilation (MV) guidelines have been developed to avoid ventilator-induced lung injury (VILI), a one-size-fits-all approach cannot benefit every individual patient. Hence, there is significant need for the ability to provide patient-specific MV settings to ensure safety, and optimise patient care. Model-based approaches enable patient-specific care by identifying time-varying patient-specific parameters, such as respiratory elastance, Ers, to capture inter- and intra-patient variability. However, patient-specific parameters evolve with time, as a function of disease progression and patient condition, making predicting their future values crucial for recommending patient-specific MV settings. This study employs stochastic modelling to predict future Ers values using retrospective patient data to develop and validate a model indicating future intra-patient variability of Ers. Cross validation results show stochastic modelling can predict future elastance ranges with 92.59 and 68.56% of predicted values within the 5–95% and the 25–75% range, respectively. This range can be used to ensure patients receive adequate minute ventilation should elastance rise and minimise the risk of VILI should elastance fall. The results show the potential for model-based protocols using stochastic model prediction of future Ers values to provide safe and patient-specific MV. These results warrant further investigation to validate its clinical utility.

As human labour is limited and therefore expensive, computer vision has emerged as a solution with encouraging results for monitoring and sorting tasks in the agrifood sector, where conventional methods for inspecting fruit browning that are generally subjective, time-consuming, and costly. Thus, this study investigated the application of computer vision techniques and various RGB cameras in the detection and classification of enzymatic browning in cut pears, comparing convolutional neural networks (CNNs) with stochastic modelling. More specifically, light is shed on the potential of CNN-based approaches for high-throughput and easily adapted applications and the potential of stochastic methods for precise, quantitative analyses. In particular, the developed CNN model was easily trained and achieved an accuracy of 96.6% and an F1-score greater than 0.96 during testing with real pear slices. On the other hand, stochastic modelling provided quantitative indices (i.e., the Browning Index (BI) and Yellowing Index (YI)) derived from the CIE Lab* colour model, thus offering accurate monitoring of enzymatic browning and related optical changes but it was less versatile as it required human expertise for implementation and tuning. Using both the BI and YI as input vectors in the NN Bayesian classifier increased the correct classification rate of control samples to 82.85% (4.6% increase) and to 89.81% (15% increase) for treated samples. Finally, a future need for a hybrid approach combining the strengths of both methods was identified, with improved robustness and practicality of image analysis systems in agricultural quality control to enable higher levels of automation in this area.

Recent advances in stochastic modelling of reflectorless rangefinders revealed an inherent relationship among raw intensity values and the corresponding precision of observed distances. In order to derive the stochastic properties of a terrestrial laser scanner’s (TLS) rangefinder, distances have to be observed repeatedly. For this, the TLS of interest has to be operated in the so-called 1D-mode—a functionality which is offered only by a few manufacturers due to laser safety regulations. The article at hand proposes two methodologies to compute intensity-based stochastic models based on capturing geometric primitives in form of planar shapes utilising 3D-point clouds. At first the procedures are applied to a phase-based Zoller + Fröhlich IMAGER 5006h. The generated results are then evaluated by comparing the outcome to the parameters of a stochastic model which has been derived by means of measurements captured in 1D-mode. Another open research question is if intensity-based stochastic models are applicable for other rangefinder types. Therefore, one of the suggested procedures is applied to a Riegl VZ-400i impulse scanner, as well as a Leica ScanStation P40 TLS that deploys a hybrid rangefinder technology. The generated results successfully demonstrate alternative methods for the computation of intensity-based stochastic models as well as their transferability to other rangefinder technologies.