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"Stomach diseases"
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Healthy gut cookbook : 150 stage-by-stage healing recipes to improve your digestive health
If you're seeking to alleviate Leaky Gut Syndrome--or if you follow a GAPS, Specific Carbohydrate Diet, Paleo, or gluten-free diet--you will find delicious relief within the pages of Healthy Gut Cookbook. With 120 recipes--and up to 30 variations--for bone broths, fermented foods, soups, yogurt, meat and fish dishes, appetizers, and desserts, you can heal yourself without having to compromise on flavor.
Book
Management factors and clinical implications of glandular and squamous gastric disease in horses
Background To date, risk factors for equine glandular gastric disease (EGGD) have not been described in Thoroughbred racehorses. Objectives To determine management factors associated with EGGD, identify clinical signs in affected horses, and compare these to equine squamous gastric disease (ESGD). Animals The study was carried out on 109 Thoroughbred racehorses from 8 training yards (3 in the United Kingdom and 5 in Australia). Methods Gastroscopic examination alongside a questionnaire regarding management, feeding, exercise, and health. Results Management factors and clinical signs were different for EGGD versus ESGD. Exercising ≥5 days per week was associated with a 10.4 times (95% CI [confidence interval]: 1.34‐26.9) increased risk of EGGD. Horses racing below expectation were 3.7 times (95% CI: 1.1‐16.7) more likely to have EGGD. Trainer was also identified as a risk factor for EGGD. Time in work ≤6 weeks was associated with a decreased risk of ESGD (odds ratio [OR] 0.3; 95% CI: 0.1‐0.99). Horses aggressive to humans were less likely to have ESGD (OR 0.12; 95% CI: 0.03‐0.54). Horses with stereotypies were more likely to have ESGD (OR 5.0; 95% CI: 1.6‐15.9). Conclusions and Clinical Importance The findings of our study further support the notion that EGGD should be considered as a distinct disease entity to ESGD. Exercising ≤4 days per week could reduce the risk of EGGD. Horses with EGGD are more likely to perform below expectation and, as such, EGGD might be performance limiting in some affected individuals. Stress minimization could reduce the risk of EGGD.
Journal Article
The plant paradox cookbook : 100 delicious recipes to help you lose weight, heal your gut, and live lectin-free
\"In [his book] The Plant Paradox, Dr. Steven Gundry introduced readers to the hidden toxins lurking in seemingly healthy foods like tomatoes, zucchini, quinoa, and brown rice: a class of plant-based proteins called lectins. Many people are familiar with one of the most predominant lectins--a substance called gluten, which is found in wheat and other grains. But while cutting out the bread and going gluten-free is relatively straightforward, going lectin-free is no small task. Now, in [this] cookbook, Dr. Gundry breaks down lectin-free eating step by step and shares one hundred of his favorite healthy recipes\"--Amazon.com.
Book
Curcumin: A Potent Protectant against Esophageal and Gastric Disorders
Turmeric obtained from the rhizomes of Curcuma longa has been used in the prevention and treatment of many diseases since the ancient times. Curcumin is the principal polyphenol isolated from turmeric, which exhibits anti-inflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic activities. The existing evidence indicates that curcumin can exert a wide range of beneficial pleiotropic properties in the gastrointestinal tract, such as protection against reflux esophagitis, Barrett’s esophagus, and gastric mucosal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs) and necrotizing agents. The role of curcumin as an adjuvant in the treatment of a Helicobacter pylori infection in experimental animals and humans has recently been proposed. The evidence that this turmeric derivative inhibits the invasion and proliferation of gastric cancer cells is encouraging and warrants further experimental and clinical studies with newer formulations to support the inclusion of curcumin in cancer therapy regimens. This review was designed to analyze the existing data from in vitro and in vivo animal and human studies in order to highlight the mechanisms of therapeutic efficacy of curcumin in the protection and ulcer healing of the upper gastrointestinal tract, with a major focus on addressing the protection of the esophagus and stomach by this emerging compound.
Journal Article
Guts
\"Raina wakes up one night with a terrible upset stomach. Her mom has one, too, so it's probably just a bug. Raina eventually returns to school, where she's dealing with the usual highs and lows: friends, not-friends, and classmates who think the school year is just one long gross-out session. It soon becomes clear that Raina's tummy trouble isn't going away--and it coincides with her worries about food, school, and changing friendships. What's going on?\"--Dust jacket flap.
BOOK
Clinical Efficiency and Safety of Magnetic-Controlled Capsule Endoscopy for Gastric Diseases in Aging Patients: Our Preliminary Experience
BackgroundThe elderly assess higher incidence of gastric diseases and may meet challenges and contraindications when flexible esophagogastroduodenoscopy intubating. Magnetic-controlled capsule endoscopy (MCE) is declared as a promising alternative, but its applications in elderly population do not attach enough importance.AimsTo explore MCE’s efficiency and safety in the elderly.MethodsA single-center retrospective study has been conducted. Data from the elderly group (>65 year-old) who underwent MCE examination, including indications, MCE outcomes, gastric conditions, evaluations from MCE manipulators and endoscopists, subjective discomforts, adverse events, etc., had been collected, then analyzed, and compared with the ones from the middle-aged group (>40, ≤ 65 year-old).ResultsDuring April 2015 and September 2018, 98 elderly patients and 72 middle-aged patients underwent MCE examination. In the elderly, the indications included poor physical condition (28.6%), severe angiocardiopathy (39.8%), EGD rejection (13.3%), severe respiratory disorder (8.2%), craniocerebral injury (8.2%), and allergy to anesthetics (2.0%). Rate of complete gastric observation and positive finding were 98.0% and 72.4% (vs. middle-aged group, 94.4%, 56.9%, P = 0.220, 0.035), and gastric conditions showed relatively inferior. Gastric preparation and MCE procedure were generally tolerated, but three elderly patients (3.1%) experienced capsule blockage in stomach.ConclusionsOur preliminary data support that MCE offers considerable benefit and is general safe for the elderly. We hope such data promote greater awareness of innovative attempts for the specific elderly, and expect multi-center, large-scale trials with randomized controlled design bring optimized strategies for better gastric visibility, efficacy and lower potential risk.
Journal Article
Etiology and risk factors of hemorrhagic abomasitis in goat kids
Hemorrhagic abomasitis, also known as Salivary Abomasum Disease (SAD), is a largely under-researched condition affecting young lambs and kids, often leading to high mortality rates and significant economic losses. The disease’s etiopathogenesis, risk factors, and clinical features remain poorly understood. Existing studies have been limited and fragmented, leading to misdiagnoses and confusion about its true nature. Given the lack of a comprehensive investigation into SAD’s incidence, risk factors, and causative agents, this study aims to provide a thorough analysis through clinical, necropsy, histopathological, microbiological, and molecular examinations. This study involved 633 kids, with 323 in the SAD group and 310 in the control group. A multifaceted approach was utilized, encompassing clinical evaluations, necropsies, histopathological assessments, risk factors, and microbiological and molecular analyses, focusing on investigating virulence genes. During the kidding season, 323 deaths were linked to SAD, with a mean disease duration of 1.34 ± 0.54 days. The highest incidence occurred in the 8–14 day age group, accounting for 51.7% of cases (
p
< 0.05). The dominant clinical symptoms included weakness, lethargy, depression, failure to suckle, reluctance to move, significantly reduced mobility, unsteady gait, and a withdrawn demeanor. Necropsy findings consistently showed dark hemorrhagic content in the abomasum and characteristic “coffee grain” lesions, with no abnormalities in other organs.
Escherichia coli
was isolated in 63% of sampled kids, significantly more than in controls (
p
< 0.03), and confirmed through molecular analysis. Examination of virulence genes highlighted the presence of
hlyA
,
stx1
,
cnf1
,
stx2
, and
eaeA
in complex combinations linked to severe abomasum damage. Poor bed and bottle hygiene were identified as the primary risk factors for SAD (
p
< 0.001), with risk escalating in the later stages of the kidding season as farm conditions deteriorated. This study thoroughly re-evaluates hemorrhagic abomasitis in young kids, delivering valuable and reliable insights into this fatal disease. Based on multifaceted analyses, it strongly indicates
E. coli
as the primary causative agent.
Journal Article
Effect of probiotics on the incidence of ventilator-associated pneumonia in critically ill patients: a randomized controlled multicenter trial
Purpose
To evaluate the potential preventive effect of probiotics on ventilator-associated pneumonia (VAP).
Methods
This was an open-label, randomized, controlled multicenter trial involving 235 critically ill adult patients who were expected to receive mechanical ventilation for ≥48 h. The patients were randomized to receive (1) a probiotics capsule containing live
Bacillus subtilis
and
Enterococcus faecalis
(Medilac-S) 0.5 g three times daily through a nasogastric feeding tube plus standard preventive strategies or (2) standard preventive strategies alone, for a maximum of 14 days. The development of VAP was evaluated daily, and throat swabs and gastric aspirate were cultured at baseline and once or twice weekly thereafter.
Results
The incidence of microbiologically confirmed VAP in the probiotics group was significantly lower than that in the control patients (36.4 vs. 50.4 %, respectively;
P
= 0.031). The mean time to develop VAP was significantly longer in the probiotics group than in the control group (10.4 vs. 7.5 days, respectively;
P
= 0.022). The proportion of patients with acquisition of gastric colonization of potentially pathogenic microorganisms (PPMOs) was lower in the probiotics group (24 %) than the control group (44 %) (
P
= 0.004). However, the proportion of patients with eradication PPMO colonization on both sites of the oropharynx and stomach were not significantly different between the two groups. The administration of probiotics did not result in any improvement in the incidence of clinically suspected VAP, antimicrobial consumption, duration of mechanical ventilation, mortality and length of hospital stay.
Conclusion
Therapy with the probiotic bacteria
B. Subtilis
and
E. faecalis
are an effective and safe means for preventing VAP and the acquisition of PPMO colonization in the stomach.
Journal Article
Sarcoidosis Involving the Gastrointestinal Tract: Diagnostic and Therapeutic Management
Involvement of the gastrointestinal (GI) tract is an infrequent extrathoracic presentation of sarcoidosis. We reviewed 305 cases of GI involvement reported in 238 patients, in whom GI sarcoidosis was the first sign of the disease in half the cases. The disease does not affect the GI tract uniformly, with a clear oral-anal gradient (80% of reported cases involved the esophagus, stomach, and duodenum). Clinicopathological mechanisms of damage may include diffuse mucosal infiltration, endoluminal exophytic lesions, involvement of the myenteric plexus, and extrinsic compressions. Ten percent of patients presented with asymptomatic or subclinical disease found on endoscopy. The diagnosis is relevant clinically because 22% of cases reviewed presented as life threatening. In addition, initial clinical/endoscopic findings may be highly suggestive of GI cancer. The therapeutic approach is heterogeneous and included wait-and-see or symptomatic approaches, glucocorticoid/immunosuppressive therapy, and surgery. Sarcoidosis of the gut is a heterogeneous, potentially life-threatening condition that requires a multidisciplinary approach and early clinical suspicion to institute personalized therapeutic management and follow-up.
Journal Article
Effect of Antecolic or Retrocolic Reconstruction of the Gastro/Duodenojejunostomy on Delayed Gastric Emptying After Pancreaticoduodenectomy: A Randomized Controlled Trial
Objective
To study the effect of antecolic vs. retrocolic reconstruction on delayed gastric emptying (DGE) after pancreaticoduodenectomy (PD) and to analyze factors which may be associated with post-PD DGE.
Summary Background Data
DGE is a troublesome complication occurring in 30–40% of patients undergoing PD leading to increased postoperative morbidity. Many factors have been implicated in the pathogenesis of DGE. Among the various methods employed to reduce the incidence, recent reports have suggested that an antecolic reconstruction of gastro/duodenojejunostomy may decrease the incidence of DGE.
Methods
Between Sep 2006 and Nov 2008, 95 patients requiring PD (for both malignant and benign conditions) were eligible for the study. Of these, 72 patients finally underwent a PD and were randomized to either a retrocolic or antecolic reconstruction of the gastro/duodenojejunostomy. All patients underwent the standard Whipple’s or a pylorus preserving pancreaticoduodenectomy (PPPD), and the randomization was stratified according to the type of PD done. DGE was assessed clinically using the Johns Hopkins criteria (Yeo et al. in Ann Surg 218: 229–37,
1993
). In patients suspected to have DGE, mechanical causes were excluded by imaging and/or endoscopy. Occurrence of DGE was the primary endpoint, whereas duration of hospital stay and occurrence of intra-abdominal complications were the secondary end points.
Results
The antecolic and retrocolic groups were comparable with regard to patient demographics, diagnosis, and other preoperative, intraoperative, and postoperative factors. Overall, DGE occurred in 21 patients (30.9%). There was no significant difference in the incidence of DGE in the antecolic vs. the retrocolic group (34.4% vs. 27.8%;
p
= 0.6). On univariate analysis, older age, use of octreotide, and intra-abdominal complications were significantly associated with the occurrence of DGE; however, on a multivariate analysis, only age was found to be significant (
p
= 0.02). The mean postoperative stay was longer among patients who developed DGE (21.9 ± 9.3 days vs. 13 ± 6.9 days;
p
= 0.0001).
Conclusions
Delayed gastric emptying is a cause of significant morbidity and prolongs the duration of hospitalization following pancreaticoduodenectomy. The incidence of DGE does not appear to be related to the method of reconstruction (antecolic or retrocolic). Older age may be a risk factor for its occurrence.
Journal Article