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Open-access, multimodality, and writing center studies
\"The disciplinary triad of open-access, multimodality, and writing center studies presents a timely, critical lens for discussing academic publishing in a moment of crucibilic change, where rapid technological advancements force scholars and institutions to question what is produced and \"counts\" as academic writing. Using historiographic, quantitative, and qualitative analysis, Open-Access, Multimodality, and Writing Center Studies sees writing center scholarship as a microcosm of many of the larger issues at play in the contemporary academic publishing landscape. This case study approach reveals the complex, imbricated ways that questions about publishing manifest both within the content of journals, and as related to academics' perceptions as signifiers of disciplinary visibility, identity, and transformation. More than just reaffirming the conventional wisdom about these changes in publishing--that these shifts are happening and we do not always know how to pinpoint the--Open-Access, Multimodality, and Writing Center Studies suggests that scholars in all fields, compositionists, and writing center practitioners be conscious of the ways they are complicit in maintaining barriers to accessibility and innovation.\"-- Publisher's description.
Book
A Retrospective Pragmatic Two‐Center Clinical Study to Evaluate the Clinical Outcome of Triple‐Frequency Ultrasound in the Treatment of Mild‐to‐Severe Acne Vulgaris
Objectives Earlier, quickly alternating dual‐frequency ultrasound waves (LDM technology) were successfully applied for the treatment of different inflammatory skin conditions such as rosacea and acne. In this retrospective pragmatic two‐center clinical study, we applied the triple‐frequency LDM (TF‐LDM) technology with frequencies of 1/3/10 and 3/10/19 MHz for the treatment of mild‐to‐severe acne skin to assess the effectivity and sustainability of the treatment outcomes. Methods Twenty‐two patients with mild‐to‐severe acne were included in this study: 11 patients were treated with TF‐LDM (1/3/10 MHz), and other 11 patients—with TF‐LDM (3/10/19 MHz). Assessment of the acne severity was done using the bilateral facial photographs. The photos were evaluated at baseline (T1), on the day of the last treatment (T2), and during the follow‐up controls (T3). Assessment of the acne severity was provided in accordance with a modified Global Evaluation Acne (mGEA) scale by nine independent dermatologists who were blinded to treatment assignments. Results The average improvement of the mGEA scoring between T1 and T2 across all patients was 73.69% ± 13.90% (p < 0.01), whereas the skin improvement between T1 and T3 was 90.14% ± 8.35% (p < 0.01). The state of the skin was also statistically significantly improved between T2 and T3 (53.26% ± 29.24%, p < 0.02). There was no difference in treatment outcomes between the patients treated with TF‐LDM (1/3/10 MHz) and TF‐LDM (3/10/19 MHz). Conclusions TF‐LDM is an effective method for the treatment of the mild‐to‐severe acne skin that provides a significant skin improvement and long‐lasting treatment results. The method demonstrates no significant side effects, is pain‐free, well tolerated, and highly accepted by patients.
Journal Article
Normal reference intervals of prognostic nutritional index in healthy adults: A large multi‐center observational study from Western China
Background It has been widely reported that the prognostic nutritional index (PNI) played a pivotal role in nutritional assessment of surgical patients and tumor prognosis. In order to improve the accuracy of evaluation in Western China, we established reference intervals (RIs) of PNI in healthy controls. Methods A retrospective cohort study on healthy ethnic Han adults (18–79 years) was conducted to explore the influences of age, gender, study centers, and instruments on PNI and to establish RIs. The data came from a healthy routine examination center database and laboratory information system (LIS) of four centers in Western China, and there were 200 persons selected randomly for verification of RIs. Results Five thousand eight hundred and thirty‐nine healthy candidates were enrolled. PNI showed a marked gender dependence, and males had significantly higher PNI than females across all ages (p < 0.01). We found that PNI is significantly different between age groups (p < 0.01), the value of PNI tended to decrease with age increasing. There is also an obvious influence of centers and instruments on PNI (p < 0.01). Conclusions We established reference intervals of PNI in healthy Han Chinese population in Western China and validated successfully. Further established RIs will lead to better standardizations of PNI for clinical applications. A retrospective cohort study on healthy ethnic Han adults (18–79 years) was conducted to explore the influences of age, gender, study centers, and instruments on prognostic nutritional index (PNI) and to establish reference intervals (RIs). We established reference intervals of PNI in healthy Han Chinese population in Western China, and validated successfully. Further established RIs will lead to better standardizations of PNI for clinical applications.
Journal Article
The clinical application of PIVKA‐II in hepatocellular carcinoma and chronic liver diseases: A multi‐center study in China
Background Due to the absence of specific symptoms and low survival rate, efficient biomarkers for hepatocellular carcinoma (HCC) diagnosis are urgently required. The purpose of this study was to evaluate the diagnostic performance of protein induced by vitamin K absence or antagonist‐II (PIVKA‐II) and to determine the optimal cutoff values for HBV infection‐related HCC. Methods We conducted a cross‐sectional, multi‐center study in China to ascertain the cutoff value for HCC patients in the context of CHB‐ and HBV‐related cirrhosis. The receiver operating characteristic curve (ROC) and the area under the curve (AUC) were used to evaluate the diagnostic performance of PIVKA‐II. Results This study enrolled 784 subjects and demonstrated that PIVKA‐II had a sensitivity of 84.08% and a specificity of 90.43% in diagnosis HCC from chronic liver diseases. PIVKA‐II at a cutoff of 37.5 mAU/mL yielded an AUC of 0.9737 (sensitivity 91.78% and specificity 96.30%) in discriminating HCC from chronic hepatitis B (CHB) patients. PIVKA‐II at a cutoff of 45 mAU/mL yielded an AUC of 0.9419 (sensitivity 77.46% and specificity 95.12%) in discriminating HCC‐ from HBV‐related cirrhosis patients. Furthermore, using a cutoff value of 40 mAU/mL for PIVKA‐II as an HCC marker, only 4.81% (15/312) was positive in chronic hepatitis and 12.80% (37/289) in cirrhosis patients, revealing the satisfactory specificity of PIVKA‐II in chronic liver disease of different etiologies. Conclusion Our data indicated that PIVKA‐II had satisfactory diagnostic efficiencies and could be used as a screening or surveillance biomarker in HCC high‐risk population. Multi‐center study showed the satisfactory diagnostic performance of PIVKA‐II in hepatocellular carcinoma. PIVKA‐II has excellent specificity in distinguishing benign liver diseases. The distribution of PIVKA‐II among chronic liver diseases.
Journal Article
Cerebrospinal Fluid Flow Cytometry in Pediatric Acute Lymphoblastic Leukemia: A Multicenter Retrospective Study in China
Objective The central nervous system (CNS) is a frequent site of relapse in childhood acute lymphoblastic leukemia (ALL). This study aims to investigate the utility of cerebrospinal fluid (CSF) flow cytometry in detecting CNS infiltration and relapse. Methods Flow cytometry was used to detect CSF leukemia cells, and patients were categorized into the CSF Flow+ and CSF Flow− groups. The primary outcome was the cumulative incidence of relapse (CIR) in the CSF Flow+ and CSF Flow− groups. Results A total of 1301 patients were enrolled, 159 patients (12.2%) showed positive CSF flow cytometry results. The CNS Flow+ patients exhibited significantly higher rates of any CNS relapse (22.5% vs. 0.2%, p < 0.01) and isolated CNS relapse (10.7% vs. 0%, p < 0.01) compared to CNS Flow− patients. Cox regression analysis revealed that risk factors for isolated CNS relapse included a positive result of D46 minimal residual disease (MRD) and CSF Flow+ at a non‐initial diagnosis. For any CNS relapse, the significant risk factors were CSF Flow+ at the initial diagnosis and CSF Flow+ at a non‐initial diagnosis. Conclusions CSF flow cytometry may have clinical utility in detecting CNS infiltration among pediatric ALL patients. It could contribute to more effective risk stratification and treatment adjustments and potentially reduce the risk of CNS relapse.
Journal Article
Writing programs, collaborations, and partnerships : transcending boundaries
\"This book demonstrates how to develop and engage in successful academic collaborations that are both practical and sustainable across campuses and within local communities. Authored by experienced writing program administrators, this edited collection includes a wide range of information addressing collaborative partnerships and projects, theoretical explorations of collaborative praxis, and strategies for sustaining collaborative initiatives. Contributors offer case studies of writing program collaborations and honestly address both the challenges of academic collaboration and the hallmarks of successful partnerships.\"--Publisher description.
Book
Performance comparison of two nucleic acid amplification systems for SARS‐CoV‐2 detection: A multi‐center study
Background Many rapid nucleic acid testing systems have emerged to halt the development and spread of COVID‐19. However, so far relatively few studies have compared the diagnostic performance between these testing systems and conventional detection systems. Here, we performed a retrospective analysis to evaluate the clinical detection performance between SARS‐CoV‐2 rapid and conventional nucleic acid detection system. Methods Clinical detection results of 63,352 oropharyngeal swabs by both systems were finally enrolled in this analysis. Sensitivity (SE), specificity (SP), and positive and negative predictive value (PPV, NPV) of both systems were calculated to evaluate their diagnostic accuracy. Concordance between these two systems were assessed by overall, positive, negative percent agreement (OPA, PPA, NPA) and κ value. Sensitivity of SARS‐CoV‐2 rapid nucleic acid detection system (Daan Gene) was further analyzed with respect to the viral load of clinical specimens. Results Sensitivity of Daan Gene was slightly lower than that of conventional detection system (0.86 vs. 0.979), but their specificity was equivalent. Daan Gene had ≥98.0% PPV and NPV for SARS‐CoV‐2. Moreover, Daan Gene demonstrated an excellent test agreement with conventional detection system (κ = 0.893, p = 0.000). Daan Gene was 99.31% sensitivity for specimens with high viral load (Ct < 35) and 50% for low viral load (Ct ≥ 35). Conclusions While showing an analytical sensitivity slightly below than that of conventional detection system, rapid nucleic acid detection system may be a diagnostic alternative to rapidly identify SARS‐CoV‐2‐infected individuals with high viral loads and a powerful complement to current detection methods. Many rapid nucleic acid testing systems have emerged to halt the development and spread of COVID‐19. However, so far relatively few studies have compared the diagnostic performance between these testing systems and conventional detection systems. Here, we performed a retrospective analysis to evaluate the clinical detection performance between SARS‐CoV‐2 rapid and conventional nucleic acid detection system. While showing an analytical sensitivity slightly below than that of conventional detection system, rapid nucleic acid testing systems may be a diagnostic alternative to rapidly identify SARS‐CoV‐2 infected individuals with high viral loads and a powerful complement to current detection methods.
Journal Article