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Superfund sites could affect life expectancy (LE) via increasing the likelihood of exposure to toxic chemicals. Here, we assess to what extent such presence could alter the LE independently and in the context of sociodemographic determinants. A nationwide geocoded statistical modeling at the census tract level was undertaken to estimate the magnitude of impact. Results showed a significant difference in LE among census tracts with at least one Superfund site and their neighboring tracts with no sites. The presence of a Superfund site could cause a decrease of −0.186 ± 0.027 years in LE. This adverse effect could be as high as −1.22 years in tracts with Superfund sites and high sociodemographic disadvantage. Specific characteristics of Superfund sites such as being prone to flooding and the absence of a cleanup strategy could amplify the adverse effect. Furthermore, the presence of Superfund sites amplifies the negative influence of sociodemographic factors at lower LEs. Superfund sites have hazardous wastes that could affect the health of those who live near them, but this has not been assessed across the USA. Here the authors find that proximity to superfund sites decreases life expectancy and is further exacerbated by sociodemographic and climate change factors.

Exposure to inorganic and organic arsenic compounds is a major public health problem that affects hundreds of millions of people worldwide. Exposure to arsenic is associated with cancer and noncancer effects in nearly every organ in the body, and evidence is mounting for health effects at lower levels of arsenic exposure than previously thought. Building from a tremendous knowledge base with > 1,000 scientific papers published annually with \"arsenic\" in the title, the question becomes, what questions would best drive future research directions? The objective is to discuss emerging issues in arsenic research and identify data gaps across disciplines. The National Institutes of Health's National Institute of Environmental Health Sciences Superfund Research Program convened a workshop to identify emerging issues and research needs to address the multi-faceted challenges related to arsenic and environmental health. This review summarizes information captured during the workshop. More information about aggregate exposure to arsenic is needed, including the amount and forms of arsenic found in foods. New strategies for mitigating arsenic exposures and related health effects range from engineered filtering systems to phytogenetics and nutritional interventions. Furthermore, integration of omics data with mechanistic and epidemiological data is a key step toward the goal of linking biomarkers of exposure and susceptibility to disease mechanisms and outcomes. Promising research strategies and technologies for arsenic exposure and adverse health effect mitigation are being pursued, and future research is moving toward deeper collaborations and integration of information across disciplines to address data gaps. Carlin DJ, Naujokas MF, Bradham KD, Cowden J, Heacock M, Henry HF, Lee JS, Thomas DJ, Thompson C, Tokar EJ, Waalkes MP, Birnbaum LS, Suk WA. 2016. Arsenic and environmental health: state of the science and future research opportunities. Environ Health Perspect 124:890-899; http://dx.doi.org/10.1289/ehp.1510209.

Thousands of contaminated sites exist across the United States, where hazardous wastes were dumped or improperly managed (U.S. EPA 2021a). In 1980, Congress established the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) in response to growing concerns over the health and environmental risks posed by hazardous waste sites. Administered by the U.S. Environmental Protection Agency (U.S. EPA), CERCLA is commonly known as the Superfund Program. In collaboration with state and tribal governments, the Superfund Program is designed to clean up contaminated media, such as soil, to protect human health and the environment. Cleaning up Superfund sites is a complex and costly multiphase process, the tangible benefits of which can be challenging to document. In this issue of Environmental Health Perspectives, Ye et al. (2022) combined large data sets of local soil lead levels and children's blood lead levels to estimate the impact of remediation at the Omaha Lead Superfund Site, one of the largest cleanup efforts in the history of the Superfund Program.

The Little St. Francis River and its tributaries drain metals-contaminated areas of the Madison County Mines National Priority List Superfund site (MCM) which was designated in 2003 to facilitate remediation of metals contamination within the MCM. One concern for natural resource trustees in the MCM is the potential effects of elevated metals concentrations on the federally threatened St. Francis River crayfish, Faxonius quadruncus, which has a geographic range that is limited to the St. Francis River watershed. A survey of riffle-dwelling crayfish, in-situ cage study, and laboratory toxicity tests were conducted to assess the effects of mining-derived metals on F. quadruncus and other crayfish species in the MCM. Crayfish densities were significantly greater at sites upstream of metals releases from historical mining (henceforth mining releases) compared to densities at sites downstream of mining releases, and metals concentrations in whole-body crayfish, surface water, sediments, macroinvertebrates, fish, and plant material were greater at sites downstream of mining releases compared to sites upstream of mining releases. Crayfish densities were also negatively correlated with consensus-based adverse effects indices, expressed as surface-water toxic units and sediment probable effects quotients. Decreased growth and increased mortality during cage and laboratory studies were likely due to exposure to, and subsequently uptake of, elevated concentrations of metals. Crayfish in all studies were found to bioaccumulate metals, which supports their utility as bioindicators of metals contamination. Study results show that elevated metals concentrations associated with mining releases in the MCM continue to adversely affect biota, including the federally threatened F. quadruncus.

Restores the river to its central place in the city's historyWith bountiful salmon and fertile plains, the Duwamish River has drawn people to its shores over the centuries for trading, transport, and sustenance. Chief Se'alth and his allies fished and lived in villages here and white settlers established their first settlements nearby. Industrialists later straightened the river's natural turns and built factories on its banks, floating in raw materials and shipping out airplane parts, cement, and steel. Unfortunately, the very utility of the river has been its undoing, as decades of dumping led to the river being declared a Superfund cleanup site.Using previously unpublished accounts by Indigenous people and settlers, BJ Cummings's compelling narrative restores the Duwamish River to its central place in Seattle and Pacific Northwest history. Writing from the perspective of environmental justice-and herself a key figure in river restoration efforts-Cummings vividly portrays the people and conflicts that shaped the region's culture and natural environment. She conducted research with members of the Duwamish Tribe, with whom she has long worked as an advocate. Cummings shares the river's story as a call for action in aligning decisions about the river and its future with values of collaboration, respect, and justice.

Atlantic killifish (Fundulus heteroclitus) is a valuable model in evolutionary toxicology to study how the interactions between genetic and environmental factors serve the adaptive ability of organisms to resist chemical pollution. Killifish populations inhabiting environmental toxicant-contaminated New Bedford Harbor (NBH) show phenotypes tolerant to polychlorinated biphenyls (PCBs) and differences at the transcriptional and genomic levels. However, limited research has explored epigenetic alterations and metabolic effects in NBH killifish. To identify the involvement of epigenetic and metabolic regulation in the adaptive response of killifish, we investigated tissue- and sex-specific differences in global DNA methylation and metabolomic profiles of NBH killifish populations, compared to sensitive populations from a non-polluted site, Scorton Creek (SC). The results revealed that liver-specific global DNA hypomethylation and differential metabolites were evident in fish from NBH compared with those from SC. The sex-specific differences were not greater than the tissue-specific differences. We demonstrated liver-specific enriched metabolic pathways (e.g., amino acid metabolic pathways converged into the urea cycle and glutathione metabolism), suggesting possible crosstalk between differential metabolites and DNA hypomethylation in the livers of NBH killifish. Additional investigation of methylated gene regions is necessary to understand the functional role of DNA hypomethylation in the regulation of enzyme-encoding genes associated with metabolic processes and physiological changes in NBH populations.