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"TERATOLOGY"
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Morbid curiosities : medical museums in nineteenth-century Britain
'Morbid Curiosities' is a comprehensive study of 19th-century medical museums in Britain. This book looks at the variety of collections of human remains in Britain and is a history of the material culture of medical knowledge.
Book
Identification of a Primary Target of Thalidomide Teratogenicity
Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing multiple birth defects. Today, thalidomide is still used in the treatment of leprosy and multiple myeloma, although how it causes limb malformation and other developmental defects is unknown. Here, we identified cereblon (CRBN) as a thalidomide-binding protein. CRBN forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1) and Cul4A that is important for limb outgrowth and expression of the fibroblast growth factor Fgf8 in zebrafish and chicks. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin ligase activity. This study reveals a basis for thalidomide teratogenicity and may contribute to the development of new thalidomide derivatives without teratogenic activity.
Journal Article
When Teratology and Augmented Reality Entwine: A Qualitative Phenomenological Analysis in a Museal Setting
Background: The Museum for Anatomy and Pathology at the Radboud University (The Netherlands) has created a permanent teratological exhibition, which is enhanced with augmented reality (AR) modalities. This exhibition serves various (post)graduate educational purposes and is open to the general public. However, data on visitors’ views and experiences regarding the teratological collection and AR models are currently lacking. Methods: To address this, a qualitative study was conducted to explore visitors’ opinions and experiences. One-on-one in-depth interviews were conducted using a predefined topic list, with audio recordings transcribed verbatim. Thematic analysis was applied to the twenty-six interview transcripts. Results: The findings indicate that publicly displaying teratological specimens alongside AR modalities is valued and positively received by both (bio)medical students and laypeople alike. AR enhances understanding of dysmorphology and provides a more interactive and engaging learning experience for complex topics. Conclusion: The use of AR within a teratological exposition holds tremendous educational potential and improves public awareness and acceptance of developmental anomalies. Moreover, it provides a unique opportunity to reflect on both historical and contemporary bioethical issues.
Journal Article
The first teratological case for the Australian Omorgus Erichson, 1847 species (Coleoptera, Scarabaeoidea, Trogidae)
A new case of hemidystrophy in Trogidae is here described and illustrated. The teratological specimen was identified as a male of Omorgus (Omorgus) alternans (MacLeay, 1827), being the first record of a teratological specimen of a trogid from Australia. While teratological cases provide limited taxonomic insights, they offer significant understanding of the environmental influences on insect development. The study emphasizes the importance of documenting such anomalies, contributing to the broader knowledge of developmental biology in insects, particularly within the under-researched Australian Trogidae
Journal Article
How to translate neuro-cognitive and behavioural outcome data in animals exposed to paracetamol to the human perinatal setting?
Introduction There are epidemiological – not necessary causal – observations that link perinatal paracetamol (acetaminophen) exposure to impaired neuro-cognition and behaviour, but animal models may assist to better understand the mechanisms. Material and methods To provide an overview on preclinical data and mechanisms explored, we conducted a structured literature search on animal models and neuro-cognition and behavioural outcome following perinatal paracetamol exposure. Results This search resulted in 20 papers (rat (n = 9), zebrafish larvae (n = 6), mice (n = 5)), published between 2009 and 2020. Eight discussed pregnancy/fetal paracetamol exposure, 6 juvenile, 6 studies combined pregnancy and juvenile exposure. Quality assessment (SYRCLE’s bias risk) showed a heterogeneous pattern with blinding issues. Most papers (n = 16) described paracetamol exposure without indication, except for an induced fever and repetitive needle pricking (rat), brain injury (mice), and a zebrafish nociception model. Reported outcomes related to biochemistry (mono-amines, amino acids, protein expression), anatomy (teratogen, morphology, nuclear size) or behaviour (spatial memory, motor, social behaviour and exploration, sexual behaviour). On mechanisms, the cumulative data support an interesting ‘cannabinoid’ hypothesis to link paracetamol to neuro-cognitive and behavioural outcome. Besides limited species diversity, there is relevant within-species paracetamol dosing variability (dose, duration) with undocumented exposure. Conclusions Models should further integrate clinical indications, as non-exposure is the obvious safest setting in the absence of an indication. Besides pain and fever and related to the cannabinoid hypothesis, this should include perinatal brain injury, as there is animal experimental evidence that cannabinoids are neuroprotective in newborn brain injury or asphyxia, further supported by evidence from non-perinatal models of paracetamol-related neuroprotective effects.
Journal Article
A teratological case in antenna of Nysson tridens Gerstäcker, 1867 (Hymenoptera: Crabronidae)
A case of asymmetry and hypertrophy on the right antenna in the kleptoparasite wasp Nysson tridens Gerstaecker, 1867 is described from Russia. This is the first antennal teratology in the family Crabronidae (Hymenoptera).
Journal Article
Forces Driving Epithelial Spreading in Zebrafish Gastrulation
Contractile actomyosin rings drive various fundamental morphogenetic processes ranging from cytokinesis to wound healing. Actomyosin rings are generally thought to function by circumferential contraction. Here, we show that the spreading of the enveloping cell layer (EVL) over the yolk cell during zebrafish gastrulation is driven by a contractile actomyosin ring. In contrast to previous suggestions, we find that this ring functions not only by circumferential contraction but also by a flow-friction mechanism. This generates a pulling force through resistance against retrograde actomyosin flow. EVL spreading proceeds normally in situations where circumferential contraction is unproductive, indicating that the flow-friction mechanism is sufficient. Thus, actomyosin rings can function in epithelial morphogenesis through a combination of cable-constriction and flow-friction mechanisms.
Journal Article
Distinct stem cells contribute to mammary gland development and maintenance
The mammary epithelium is composed of several cell lineages including luminal, alveolar and myoepithelial cells. Transplantation studies have suggested that the mammary epithelium is maintained by the presence of multipotent mammary stem cells. To define the cellular hierarchy of the mammary gland during physiological conditions, we performed genetic lineage-tracing experiments and clonal analysis of the mouse mammary gland during development, adulthood and pregnancy. We found that in postnatal unperturbed mammary gland, both luminal and myoepithelial lineages contain long-lived unipotent stem cells that display extensive renewing capacities, as demonstrated by their ability to clonally expand during morphogenesis and adult life as well as undergo massive expansion during several cycles of pregnancy. The demonstration that the mammary gland contains different types of long-lived stem cells has profound implications for our understanding of mammary gland physiology and will be instrumental in unravelling the cells at the origin of breast cancers.
Mammary stem cells
Using lineage-tracing approaches in mice, Cédric Blanpain and colleagues decipher the cellular hierarchy of the mammary epithelium during development, homeostasis and lactation. They find that the various cell lineages of mammary epithelium originate from and are maintained by different classes of unipotent stem cells rather than by multipotent stem cells, as was previously thought. As well as having implications for our understanding of mammary gland physiology, this finding is of relevance to attempts to identify the cells at the origin of breast cancers.
Journal Article
Reaction-Diffusion Model as a Framework for Understanding Biological Pattern Formation
The Turing, or reaction-diffusion (RD), model is one of the best-known theoretical models used to explain self-regulated pattern formation in the developing animal embryo. Although its real-world relevance was long debated, a number of compelling examples have gradually alleviated much of the skepticism surrounding the model. The RD model can generate a wide variety of spatial patterns, and mathematical studies have revealed the kinds of interactions required for each, giving this model the potential for application as an experimental working hypothesis in a wide variety of morphological phenomena. In this review, we describe the essence of this theory for experimental biologists unfamiliar with the model, using examples from experimental studies in which the RD model is effectively incorporated.
Journal Article